LOCUS       NM_012493               1986 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus alpha-fetoprotein (Afp), mRNA.
ACCESSION   NM_012493
VERSION     NM_012493.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1986)
  AUTHORS   Hu,J., Zhang,J., Chan,Y. and Zhu,B.
  TITLE     A rat model of placental inflammation explains the unexplained
            elevated maternal serum alpha-fetoprotein associated with adverse
            pregnancy outcomes
  JOURNAL   J Obstet Gynaecol Res 45 (10), 1980-1988 (2019)
   PUBMED   31381236
  REMARK    GeneRIF: maternal serum level associated with adverse pregnancy
            outcome in placental inflammation
REFERENCE   2  (bases 1 to 1986)
  AUTHORS   Farouk,S., Sabet,S., Abu Zahra,F.A. and El-Ghor,A.A.
  TITLE     Bone marrow derived-mesenchymal stem cells downregulate IL17A
            dependent IL6/STAT3 signaling pathway in CCl4-induced rat liver
            fibrosis
  JOURNAL   PLoS One 13 (10), e0206130 (2018)
   PUBMED   30346985
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1986)
  AUTHORS   Kobayashi,S., Tomokuni,A., Takahashi,H., Akita,H., Sugimura,K.,
            Miyoshi,N., Moon,J.H., Yasui,M., Omori,T., Ohue,M., Fujiwara,Y.,
            Yano,M. and Sakon,M.
  TITLE     The Clinical Significance of Alpha-Fetoprotein mRNAs in Patients
            with Hepatocellular Carcinoma
  JOURNAL   Gastrointest Tumors 3 (3-4), 141-152 (2017)
   PUBMED   28611981
REFERENCE   4  (bases 1 to 1986)
  AUTHORS   Garcia-Garcia,A.G., Polo-Hernandez,E., Tabernero,A. and Medina,J.M.
  TITLE     Alpha-fetoprotein (AFP) modulates the effect of serum albumin on
            brain development by restraining the neurotrophic effect of oleic
            acid
  JOURNAL   Brain Res 1624, 45-58 (2015)
   PUBMED   26210615
  REMARK    GeneRIF: In this work show that alpha-fetoprotein (AFP) is present
            in the brain during embryonic development, its concentrations
            peaking at E15.5 and at E19.5. AFP concentrations plummeted
            concurrently with a sharp increase in serum albumin concentrations.
REFERENCE   5  (bases 1 to 1986)
  AUTHORS   Zhang,C.L., Zeng,T., Zhao,X.L. and Xie,K.Q.
  TITLE     Garlic Oil Suppressed Nitrosodiethylamine-Induced Hepatocarcinoma
            in Rats by Inhibiting PI3K-AKT-NF-kappaB Pathway
  JOURNAL   Int J Biol Sci 11 (6), 643-651 (2015)
   PUBMED   25999787
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1986)
  AUTHORS   Watanabe,T., Jimenez-Molina,J.L. and Chou,J.Y.
  TITLE     Characterization of a rat variant alpha-fetoprotein
  JOURNAL   Biochem Biophys Res Commun 185 (2), 648-656 (1992)
   PUBMED   1376990
REFERENCE   7  (bases 1 to 1986)
  AUTHORS   Dexeus,F.H., Logothetis,C.J., Sella,A., Fitz,K., Striegel,A.,
            Amato,R.J. and Liu,F.J.
  TITLE     Serum biomarkers in metastatic renal cell carcinoma
  JOURNAL   Urology 38 (1), 6-10 (1991)
   PUBMED   1714107
REFERENCE   8  (bases 1 to 1986)
  AUTHORS   Okuno,M., Muto,Y., Kato,M., Ninomiya,M., Moriwaki,H., Noma,A.,
            Tagaya,O., Nozaki,Y. and Suzuki,Y.
  TITLE     Inhibitory effect of acyclic retinoid (polyprenoic acid) on the
            secretion of alpha-fetoprotein in CCl4-treated rats
  JOURNAL   J Nutr Sci Vitaminol (Tokyo) 36 (5), 437-446 (1990)
   PUBMED   1711115
REFERENCE   9  (bases 1 to 1986)
  AUTHORS   Sakashita,S., Nishi,S., Hirai,H. and Tsuji,I.
  TITLE     Synthesis of alpha-fetoprotein and some other serum proteins in
            testicular tumors
  JOURNAL   Invest Urol 15 (1), 2-4 (1977)
   PUBMED   68943
REFERENCE   10 (bases 1 to 1986)
  AUTHORS   Olsson,M., Lindahl,G. and Ruoslahti,E.
  TITLE     Genetic control of alpha-fetoprotein synthesis in the mouse
  JOURNAL   J Exp Med 145 (4), 819-827 (1977)
   PUBMED   67170
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DY309525.1, DY317147.1, DY310963.1 and AW141770.1.
            
            On May 14, 2011 this sequence version replaced NM_012493.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X02361.1, BC097344.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-709               DY309525.1         1-709
            710-1368            DY317147.1         41-699
            1369-1837           DY310963.1         240-708
            1838-1986           AW141770.1         359-507
FEATURES             Location/Qualifiers
     source          1..1986
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1986
                     /gene="Afp"
                     /note="alpha-fetoprotein"
                     /db_xref="GeneID:24177"
                     /db_xref="RGD:2065"
     exon            1..122
                     /gene="Afp"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..1855
                     /gene="Afp"
                     /note="chloride intracellular channel 6;
                     alpha-fetoglobulin; alpha-1-fetoprotein"
                     /codon_start=1
                     /product="alpha-fetoprotein precursor"
                     /protein_id="NP_036625.2"
                     /db_xref="GeneID:24177"
                     /db_xref="RGD:2065"
                     /translation="MKQPATMKWSASISFLLLLNFAEPRVLHTNEFGIESTLDSSQCP
                     TEKNMFNVATIVVAQFVQDATKAEVNKMSSDALAAMKENTGDGCLENQLSVFLDEICH
                     ETELSNKYGFSGCCNQSGVERHQCLLARKKTAPDSVPPFHFPETAESCPAYEENRAMS
                     INTFIYDVSKRNPFLYAPTILYLAAQYDKAVPACCKADNMEECFQTKRASMAKELREG
                     SMLNEHVCAVIRKFGSRNLQAVLIIKLSQKFPKANITEIRKLALDVAHIHEQCCHGNA
                     MECLQDGESVMTHICSQQEILSSKTAECCKLPTIELGYCIIHAENGDKPEGLTLNPSE
                     FLGDRNFAQFSSEEKLLFMASFLHEYSRNHPNLPVSVILKTAKSYQEILEKCSQSETP
                     SKCQDNMEEELQKHIQESQALAKQSCDLYQKLGPYYLQNLFLIGYTRKAPQLTSAELI
                     DLTGKMVSIASMCCQLSEEKRSACGEGLADIYIGHLCLRHEANPVNSGINHCCSSSYS
                     NRRLCITSFLRDETYVPPPFSEDKFIFHKDLCQAQGRALQTMKQELLINLVKQKPEMT
                     EEQHAAVTADFSGLLEKCCKDQDQEACFAKEGPKLISKTREALGV"
     exon            123..174
                     /gene="Afp"
                     /inference="alignment:Splign:2.1.0"
     exon            175..295
                     /gene="Afp"
                     /inference="alignment:Splign:2.1.0"
     exon            296..507
                     /gene="Afp"
                     /inference="alignment:Splign:2.1.0"
     exon            508..640
                     /gene="Afp"
                     /inference="alignment:Splign:2.1.0"
     exon            641..738
                     /gene="Afp"
                     /inference="alignment:Splign:2.1.0"
     exon            739..868
                     /gene="Afp"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1083
                     /gene="Afp"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1216
                     /gene="Afp"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1314
                     /gene="Afp"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1453
                     /gene="Afp"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1677
                     /gene="Afp"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1810
                     /gene="Afp"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1865
                     /gene="Afp"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1986
                     /gene="Afp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttctacca ctgtctggga tgaagcagcc agcaaccatg aagtggagcg catccatttc
       61 cttccttctc ctgctaaatt ttgctgaacc cagagtactg cacacaaatg agtttggaat
      121 agaatccaca ttagactctt cccagtgccc gacagagaaa aatatgttta acgtagctac
      181 cattgtcgtt gcccagtttg ttcaggatgc cacaaaggcc gaagtaaaca aaatgagtag
      241 cgatgcgttg gctgcaatga aggaaaacac tggcgatggg tgtttagaaa accagctatc
      301 tgtgtttctg gatgaaattt gccacgagac ggaactctct aacaagtatg gattctcagg
      361 ttgctgcaac caaagcgggg tggaaagaca ccagtgtctg ctggctcgca agaagaccgc
      421 tccagactct gtcccaccct tccactttcc agaaactgcc gagagttgcc cagcatatga
      481 agaaaacagg gcgatgtcca taaacacgtt catctacgat gtgtcgaaga ggaacccctt
      541 cctgtatgct cccaccattc tttacttagc cgctcagtat gacaaggcag ttccagcatg
      601 ctgcaaagct gacaacatgg aggaatgctt ccagacaaag agagcatcaa tggcaaagga
      661 attaagagaa ggaagcatgc tcaatgagca tgtgtgtgca gtaataagaa agtttggatc
      721 ccggaacctc caggctgtac tcatcattaa actaagtcaa aagtttccca aagcaaatat
      781 tactgagatt cggaagctgg ccctggacgt ggcccacatc cacgagcagt gctgccacgg
      841 caacgcgatg gagtgcctac aggatgggga aagcgtcatg acacatatat gttctcaaca
      901 agaaattctg tcgagcaaaa cagcagagtg ctgcaaacta cccaccatcg agctcggcta
      961 ttgcataatt catgccgaaa atggcgacaa accggaaggt ttaactctga acccaagcga
     1021 gtttttggga gacagaaatt ttgcccagtt ttcttcagag gaaaaactcc tgtttatggc
     1081 aagctttctt catgaatatt caagaaatca ccccaacctt cctgtctcag tcattctaaa
     1141 aactgctaag tcataccagg aaattttgga gaagtgctcc cagtctgaaa cgccatcgaa
     1201 atgccaggac aatatggaag aagaattgca aaaacacatc caggagagcc aggcactggc
     1261 caaacaaagt tgtgatctct accagaagtt aggaccctac tacttacaaa atctgttcct
     1321 cattggctac acgcggaagg ctcctcagct gacctcagca gagctgatag acctgacagg
     1381 gaagatggtg agcattgcct caatgtgctg ccagctcagt gaggagaaac ggtccgcctg
     1441 cggtgaggga ctggccgaca tttacattgg acacttgtgt ttaagacatg aggcaaaccc
     1501 tgtgaactcc ggtatcaacc actgctgcag ttcctcgtat tccaacagga ggctctgcat
     1561 caccagcttt ctgagggacg aaacctacgt ccctccacca ttctctgaag acaaattcat
     1621 cttccacaag gatctgtgcc aagctcaggg ccgagcccta cagaccatga aacaagagct
     1681 tctcattaac ctggtgaaac aaaagcctga aatgacagag gagcagcacg cggctgtcac
     1741 tgctgatttc tctggcctct tggagaagtg ctgcaaagac caggatcagg aagcctgttt
     1801 cgcaaaagag ggtccaaagt tgatttccaa aactcgtgag gctttggggg tttaaacatc
     1861 tccaggagga agaaaggaca aaaaaatgtg tcgacgcttt ggtgtgagct tttcggtttg
     1921 atggtaactg gtggagactt ccatgtggga tttctatgcc ttaggaataa agacttttca
     1981 actgtt
//
