LOCUS       NM_001134864            3074 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus AFG3 like matrix AAA peptidase subunit 2
            (Afg3l2), mRNA.
ACCESSION   NM_001134864 XM_225866
VERSION     NM_001134864.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3074)
  AUTHORS   Yang,X., Liu,Y., Zhong,W., Li,Y. and Zhang,W.
  TITLE     Netrin-1 attenuates cerebral ischemia/reperfusion injury by
            limiting mitochondrial ROS and Ca2+ levels via activation of AKT
            phosphorylation and mitochondrial m-AAA protease AFG3L2
  JOURNAL   FASEB J 37 (3), e22805 (2023)
   PUBMED   36786711
  REMARK    GeneRIF: Netrin-1 attenuates cerebral ischemia/reperfusion injury
            by limiting mitochondrial ROS and Ca[2+] levels via activation of
            AKT phosphorylation and mitochondrial m-AAA protease AFG3L2.
REFERENCE   2  (bases 1 to 3074)
  AUTHORS   Svenstrup,K., Nielsen,T.T., Aidt,F., Rostgaard,N., Duno,M.,
            Wibrand,F., Vinther-Jensen,T., Law,I., Vissing,J., Roos,P.,
            Hjermind,L.E. and Nielsen,J.E.
  TITLE     SCA28: Novel Mutation in the AFG3L2 Proteolytic Domain Causes a
            Mild Cerebellar Syndrome with Selective Type-1 Muscle Fiber Atrophy
  JOURNAL   Cerebellum 16 (1), 62-67 (2017)
   PUBMED   26868664
REFERENCE   3  (bases 1 to 3074)
  AUTHORS   Konig,T., Troder,S.E., Bakka,K., Korwitz,A., Richter-Dennerlein,R.,
            Lampe,P.A., Patron,M., Muhlmeister,M., Guerrero-Castillo,S.,
            Brandt,U., Decker,T., Lauria,I., Paggio,A., Rizzuto,R.,
            Rugarli,E.I., De Stefani,D. and Langer,T.
  TITLE     The m-AAA Protease Associated with Neurodegeneration Limits MCU
            Activity in Mitochondria
  JOURNAL   Mol Cell 64 (1), 148-162 (2016)
   PUBMED   27642048
REFERENCE   4  (bases 1 to 3074)
  AUTHORS   Maltecca,F., Baseggio,E., Consolato,F., Mazza,D., Podini,P.,
            Young,S.M. Jr., Drago,I., Bahr,B.A., Puliti,A., Codazzi,F.,
            Quattrini,A. and Casari,G.
  TITLE     Purkinje neuron Ca2+ influx reduction rescues ataxia in SCA28 model
  JOURNAL   J Clin Invest 125 (1), 263-274 (2015)
   PUBMED   25485680
REFERENCE   5  (bases 1 to 3074)
  AUTHORS   Smets,K., Deconinck,T., Baets,J., Sieben,A., Martin,J.J.,
            Smouts,I., Wang,S., Taroni,F., Di Bella,D., Van Hecke,W.,
            Parizel,P.M., Jadoul,C., De Potter,R., Couvreur,F., Rugarli,E. and
            De Jonghe,P.
  TITLE     Partial deletion of AFG3L2 causing spinocerebellar ataxia type 28
  JOURNAL   Neurology 82 (23), 2092-2100 (2014)
   PUBMED   24814845
REFERENCE   6  (bases 1 to 3074)
  AUTHORS   Di Bella,D., Lazzaro,F., Brusco,A., Plumari,M., Battaglia,G.,
            Pastore,A., Finardi,A., Cagnoli,C., Tempia,F., Frontali,M.,
            Veneziano,L., Sacco,T., Boda,E., Brussino,A., Bonn,F.,
            Castellotti,B., Baratta,S., Mariotti,C., Gellera,C., Fracasso,V.,
            Magri,S., Langer,T., Plevani,P., Di Donato,S., Muzi-Falconi,M. and
            Taroni,F.
  TITLE     Mutations in the mitochondrial protease gene AFG3L2 cause dominant
            hereditary ataxia SCA28
  JOURNAL   Nat Genet 42 (4), 313-321 (2010)
   PUBMED   20208537
REFERENCE   7  (bases 1 to 3074)
  AUTHORS   Ehses,S., Raschke,I., Mancuso,G., Bernacchia,A., Geimer,S.,
            Tondera,D., Martinou,J.C., Westermann,B., Rugarli,E.I. and
            Langer,T.
  TITLE     Regulation of OPA1 processing and mitochondrial fusion by m-AAA
            protease isoenzymes and OMA1
  JOURNAL   J Cell Biol 187 (7), 1023-1036 (2009)
   PUBMED   20038678
REFERENCE   8  (bases 1 to 3074)
  AUTHORS   Koppen,M., Bonn,F., Ehses,S. and Langer,T.
  TITLE     Autocatalytic processing of m-AAA protease subunits in mitochondria
  JOURNAL   Mol Biol Cell 20 (19), 4216-4224 (2009)
   PUBMED   19656850
REFERENCE   9  (bases 1 to 3074)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   10 (bases 1 to 3074)
  AUTHORS   Blondet,B., Duxson,M.J., Harris,A.J., Melki,J., Guenet,J.L.,
            Pincon-Raymond,M. and Rieger,F.
  TITLE     Nerve and muscle development in paralyse mutant mice
  JOURNAL   Dev Biol 132 (1), 153-166 (1989)
   PUBMED   2917690
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Sep 10, 2008 this sequence version replaced XM_225866.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.60106.1,
                                           SRR26643293.77643.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-289               JAXUCZ010000018.1  63268712-63269000   c
            290-389             JAXUCZ010000018.1  63264784-63264883   c
            390-467             JAXUCZ010000018.1  63264345-63264422   c
            468-571             JAXUCZ010000018.1  63262131-63262234   c
            572-724             JAXUCZ010000018.1  63261870-63262022   c
            725-799             JAXUCZ010000018.1  63254982-63255056   c
            800-924             JAXUCZ010000018.1  63252659-63252783   c
            925-1198            JAXUCZ010000018.1  63249866-63250139   c
            1199-1336           JAXUCZ010000018.1  63247210-63247347   c
            1337-1490           JAXUCZ010000018.1  63242208-63242361   c
            1491-1598           JAXUCZ010000018.1  63238892-63238999   c
            1599-1724           JAXUCZ010000018.1  63238675-63238800   c
            1725-1835           JAXUCZ010000018.1  63235677-63235787   c
            1836-1951           JAXUCZ010000018.1  63233850-63233965   c
            1952-2152           JAXUCZ010000018.1  63228973-63229173   c
            2153-2347           JAXUCZ010000018.1  63226886-63227080   c
            2348-3074           JAXUCZ010000018.1  63224163-63224889   c
FEATURES             Location/Qualifiers
     source          1..3074
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..3074
                     /gene="Afg3l2"
                     /note="AFG3 like matrix AAA peptidase subunit 2"
                     /db_xref="GeneID:307350"
                     /db_xref="RGD:1305259"
     exon            1..289
                     /gene="Afg3l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..2584
                     /gene="Afg3l2"
                     /note="AFG3-like AAA ATPase 2; AFG3 ATPase family member
                     3-like 2"
                     /codon_start=1
                     /product="AFG3-like protein 2"
                     /protein_id="NP_001128336.1"
                     /db_xref="GeneID:307350"
                     /db_xref="RGD:1305259"
                     /translation="MAHRCLLLWGRGGCRRGLPPLLVPSGCLGPGRRPCLRTLYQYAT
                     VQTANSRSSLLRDVIAAYQRFCSRPPKGFEKYFPNGKNGKKASESKEAVGEKKESQLS
                     GPQSSGGASGGGGKRRGKKEDSHWWSRFQKGDFPWDDKDFRMYFLWTALFWSGVMIYF
                     LFKSSGREITWKDFVNNYLSKGVVDRLEVVNKRFVRVTFTPGKTPVDGQYVWFNIGSV
                     DTFERNLETLQQELGIEGENRVPVVYIAESDGSFLLSMLPTVLIIAFLLYTIRRGPAG
                     IGRTGRGMGGLFSVGETTAKVLKDEIDVKFKDVAGCEEAKLEIMEFVNFLKNPKQYQD
                     LGAKIPKGAILTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPARVRDLF
                     ALARKNAPCILFIDEIDAVGRKRGRGNFGGQSEQENTLNQLLVEMDGFNTTTNVVILA
                     GTNRPDILDPALLRPGRFDRQIFIGPPDIKGRASIFKVHLRPLKLDSALEKDKLARKL
                     ASLTPGFSGADVANVCNEAALIAARHLSDAINEKHFEQAIERVIGGLEKKTQVLQPEE
                     KKTVAYHEAGHAVAGWYLEHADPLLKVSIIPRGKGLGYAQYLPKEQYLYTKEQLLDRM
                     CMTLGGRVSEEIFFGRITTGAQDDLRKVTQSAYAQIVQFGMNEKVGQISFDLPRQGDM
                     VLEKPYSEATARMIDDEVRILISEAYKRTVALLTEKKADVEKVALLLLEKEVLDKNDM
                     VELLGPRPFTEKSTYEEFVEGTGSLDEDTSLPEGLQDWNKEREKEKKEKKEKEEPVNE
                     KVVS"
     exon            290..389
                     /gene="Afg3l2"
                     /inference="alignment:Splign:2.1.0"
     exon            390..467
                     /gene="Afg3l2"
                     /inference="alignment:Splign:2.1.0"
     exon            468..571
                     /gene="Afg3l2"
                     /inference="alignment:Splign:2.1.0"
     exon            572..724
                     /gene="Afg3l2"
                     /inference="alignment:Splign:2.1.0"
     exon            725..799
                     /gene="Afg3l2"
                     /inference="alignment:Splign:2.1.0"
     exon            800..924
                     /gene="Afg3l2"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1198
                     /gene="Afg3l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1336
                     /gene="Afg3l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1490
                     /gene="Afg3l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1598
                     /gene="Afg3l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1724
                     /gene="Afg3l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1835
                     /gene="Afg3l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1951
                     /gene="Afg3l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2152
                     /gene="Afg3l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2347
                     /gene="Afg3l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..3074
                     /gene="Afg3l2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccgcacgc tggggcgggg cctgacgagc gcgcgtggag cgtgggttcg cgttctgccg
       61 cgggtctcct gcgccggtgg cgcgcagctc ccggataagt tgcggaagct gagggttgcc
      121 gaccgccggc tttggctcgg tccctgcgcg cgccccggag cgggccgggc ccatcatggc
      181 tcaccgctgc ctgctgctgt ggggtcgggg cggctgccgt cgcggccttc ctcccctgct
      241 cgtgcccagc ggctgcctgg gtcccggccg gcggccctgc ctccgtacgc tttatcagta
      301 cgctacggtc caaacagcaa acagcagaag ttctcttcta agggatgtaa ttgctgctta
      361 tcaaagattc tgttctcgac ctcccaaagg atttgaaaaa tactttccta atgggaaaaa
      421 tggaaaaaag gccagcgaat ctaaggaagc tgttggagaa aaaaaagaat cacaactctc
      481 cggtccccag tcttctggag gtgcaagtgg tgggggaggg aagcgccgtg gcaagaaaga
      541 agattctcac tggtggtcca ggttccagaa gggtgacttt ccatgggatg acaaggattt
      601 caggatgtac tttctctgga ctgctctttt ttggagtgga gtcatgattt acttcctgtt
      661 caagagctct gggagagaaa tcacatggaa agactttgtc aataactatc tttctaaagg
      721 agtggtggac agactagaag ttgtcaacaa acgttttgtt cgtgtgacct ttactccagg
      781 aaaaactcca gttgatgggc aatacgtctg gtttaatatt ggcagtgttg acacatttga
      841 gcggaatctg gagactttgc agcaagaatt gggcatagaa ggggagaacc gggtgcctgt
      901 ggtttacatt gctgaaagcg atggctcctt cctgctgagc atgttgccca cggtactcat
      961 tattgctttt ctactctaca ccataagaag agggcccgct ggcattggtc ggaccggtcg
     1021 gggaatgggt ggactcttca gtgttgggga aacgacagcc aaggtcttaa aggatgagat
     1081 agatgtgaag tttaaagatg tggctggctg tgaggaggcc aagctagaaa taatggaatt
     1141 tgtgaatttc ttgaaaaatc caaagcagta tcaagaccta ggagcaaaaa tcccaaaggg
     1201 tgccattctc actggtcccc caggtactgg gaagacactg ctagctaagg ccacagctgg
     1261 agaagccaat gtccccttca tcactgtcag tggatctgag tttctggaga tgtttgtcgg
     1321 tgttggtcca gccagggtcc gagacttatt tgcccttgca cggaagaatg ctccttgcat
     1381 tctcttcatt gacgagattg atgctgtggg aaggaagcgt ggtagaggca actttggagg
     1441 acagagtgag caggagaaca cactcaatca gctgctcgtg gagatggacg gcttcaacac
     1501 caccaccaac gtggtcatcc tggcaggcac aaatcgacca gacatccttg atccagctct
     1561 gctgagacca ggccgctttg acaggcagat cttcattgga cccccagaca taaaaggacg
     1621 agcttcaatc ttcaaagttc accttcgacc attgaaacta gacagtgcct tggaaaaaga
     1681 taaattggcc agaaaactgg cgtccttgac tccagggttt tcaggcgctg atgttgccaa
     1741 tgtctgtaat gaagctgctt tgattgctgc cagacacctt tcagatgcca ttaacgagaa
     1801 gcacttcgaa caagcgattg agcgagtgat tggaggcttg gagaaaaaaa cccaagttct
     1861 gcaacccgag gagaagaaga ctgtggctta ccacgaagca ggccacgcag tcgccggctg
     1921 gtatctggag catgcagacc cactcttaaa ggtgtccatc atcccgcgtg gaaaggggct
     1981 gggctatgct cagtacttgc ccaaggagca gtatctgtac acaaaggagc agctgctgga
     2041 caggatgtgc atgactctgg gtggccgtgt ctccgaggag atcttctttg gaagaattac
     2101 gaccggtgcc caggatgact tgaggaaggt tacccagagt gcctatgccc agattgttca
     2161 gtttggcatg aatgagaaag tggggcagat ctcctttgac ctcccacgac agggggacat
     2221 ggtattagag aagccttaca gtgaagccac tgcaagaatg atagacgatg aagtgaggat
     2281 actcattagt gaagcctata aaagaactgt ggctcttctc acagagaaga aggctgacgt
     2341 ggagaaggtt gctctcctac tgttagagaa agaagtatta gacaagaacg acatggttga
     2401 acttctgggt cccagaccat ttacagaaaa atccacatat gaagaatttg tggaaggcac
     2461 tggcagctta gatgaggaca cttctcttcc tgaaggcctt caggattgga acaaggagcg
     2521 ggagaaggag aagaaggaga agaaggagaa ggaggagccc gtgaatgaga aggtggtcag
     2581 ctaggctctc ccagggctgg aggcccattt accttcccct ctcgggccgt cagaacagca
     2641 gccctgatgc agcccgctgc tgactcagcc aggctgagga cggcctccac tgagctgcag
     2701 tgtcagcact gcccgccctc agcctggcct cacgaacact ggctggaaca ggagagacag
     2761 caccacctgc catcgcctgt cccgtggact ctatcacgag ggagaagact cttcccatcg
     2821 atggccctct tcagtcctct tcctgcgata tctctgcagg agtgctgtga aattcggttg
     2881 gagtcctgat gagaatattt tgattcaacc aaatattttc aaatttgaat tcagatcact
     2941 cgttgatgtt ttaatggagt ggttttctat agagaactgt aacatattta aaaacatgaa
     3001 tgtattgtgt aaatatggat tctttacatt agaaataaaa ggtggacatt gtactttttt
     3061 cctgagcata tgaa
//
