LOCUS       NM_001305184            4000 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus actin filament associated protein 1-like 2
            (Afap1l2), mRNA.
ACCESSION   NM_001305184 XM_006223778 XM_006231655
VERSION     NM_001305184.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4000)
  AUTHORS   Yang,X., Mao,X., Xu,G., Xing,S., Chattopadhyay,A., Jin,S. and
            Salama,G.
  TITLE     Estradiol up-regulates L-type Ca2+ channels via membrane-bound
            estrogen receptor/phosphoinositide-3-kinase/Akt/cAMP response
            element-binding protein signaling pathway
  JOURNAL   Heart Rhythm 15 (5), 741-749 (2018)
   PUBMED   29330129
  REMARK    GeneRIF: Estradiol up-regulates Cav1.2alpha1C and ICa,L via plasma
            membrane ER and by activating Pi3K, Akt, and CREB signaling. The
            promoter regions of the CACNA1C gene (human-rabbit-rat) contain
            adjacent/overlapping binding sites for p-CREB and ERalpha, which
            suggests a synergistic regulation by these pathways.
REFERENCE   2  (bases 1 to 4000)
  AUTHORS   Yamanaka,D., Akama,T., Fukushima,T., Nedachi,T., Kawasaki,C.,
            Chida,K., Minami,S., Suzuki,K., Hakuno,F. and Takahashi,S.
  TITLE     Phosphatidylinositol 3-kinase-binding protein, PI3KAP/XB130, is
            required for cAMP-induced amplification of IGF mitogenic activity
            in FRTL-5 thyroid cells
  JOURNAL   Mol Endocrinol 26 (6), 1043-1055 (2012)
   PUBMED   22496359
  REMARK    GeneRIF: cAMP-dependent induction of PI3KAP/XB130, which is
            associated with PI3K, is required for enhancement of IGF mitogenic
            activities. [PI3KAP]
REFERENCE   3  (bases 1 to 4000)
  AUTHORS   Lodyga,M., Bai,X.H., Kapus,A. and Liu,M.
  TITLE     Adaptor protein XB130 is a Rac-controlled component of lamellipodia
            that regulates cell motility and invasion
  JOURNAL   J Cell Sci 123 (Pt 23), 4156-4169 (2010)
   PUBMED   21084565
  REMARK    GeneRIF: XB130 is a Rac-controlled component of lamellipodia that
            regulates cell motility and invasion.
REFERENCE   4  (bases 1 to 4000)
  AUTHORS   Xu,J., Bai,X.H., Lodyga,M., Han,B., Xiao,H., Keshavjee,S., Hu,J.,
            Zhang,H., Yang,B.B. and Liu,M.
  TITLE     XB130, a novel adaptor protein for signal transduction
  JOURNAL   J Biol Chem 282 (22), 16401-16412 (2007)
   PUBMED   17412687
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Feb 27, 2015 this sequence version replaced
            XM_006231655.2, XM_006223778.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.6567.1,
                                           SRR26643429.6141.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-424               JAXUCZ010000001.1  266065520-266065943 c
            425-478             JAXUCZ010000001.1  266059770-266059823 c
            479-607             JAXUCZ010000001.1  266006048-266006176 c
            608-682             JAXUCZ010000001.1  266000541-266000615 c
            683-780             JAXUCZ010000001.1  265999256-265999353 c
            781-871             JAXUCZ010000001.1  265993160-265993250 c
            872-1077            JAXUCZ010000001.1  265986752-265986957 c
            1078-1257           JAXUCZ010000001.1  265984953-265985132 c
            1258-1347           JAXUCZ010000001.1  265982014-265982103 c
            1348-1432           JAXUCZ010000001.1  265980535-265980619 c
            1433-1537           JAXUCZ010000001.1  265979690-265979794 c
            1538-1749           JAXUCZ010000001.1  265977341-265977552 c
            1750-1895           JAXUCZ010000001.1  265975038-265975183 c
            1896-2007           JAXUCZ010000001.1  265974173-265974284 c
            2008-2274           JAXUCZ010000001.1  265973405-265973671 c
            2275-2455           JAXUCZ010000001.1  265973140-265973320 c
            2456-2611           JAXUCZ010000001.1  265972704-265972859 c
            2612-2805           JAXUCZ010000001.1  265971419-265971612 c
            2806-2934           JAXUCZ010000001.1  265971132-265971260 c
            2935-4000           JAXUCZ010000001.1  265969368-265970433 c
FEATURES             Location/Qualifiers
     source          1..4000
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..4000
                     /gene="Afap1l2"
                     /gene_synonym="RGD1310668"
                     /note="actin filament associated protein 1-like 2"
                     /db_xref="GeneID:292130"
                     /db_xref="RGD:1310668"
     exon            1..424
                     /gene="Afap1l2"
                     /gene_synonym="RGD1310668"
                     /inference="alignment:Splign:2.1.0"
     CDS             409..2961
                     /gene="Afap1l2"
                     /gene_synonym="RGD1310668"
                     /note="phosphatidylinositol 3-kinase-associated protein"
                     /codon_start=1
                     /product="actin filament-associated protein 1-like 2"
                     /protein_id="NP_001292113.1"
                     /db_xref="GeneID:292130"
                     /db_xref="RGD:1310668"
                     /translation="MERYKAQGCCCLVVQRRILQVSASLEQLLTELDDFLKVLDQENL
                     SSAAVVKKSGLSELLRLYTKSSSSDEEYIYMNKVAVNKEQNPASPDKVPEEKQGPLTN
                     GEPSQHTSAPQKSLPDLPPPKMIPERKQPTIPKIESPEGYYEEAEPFDTSINEDGEAV
                     SSSYESYDEEESSKGKTAPYQWPSPEASIELMRDARICAFLWRKKWLGQWAKQLCVIR
                     DTRLLCYKSSKDHSPQLDVNLLGSSVVHKEKQVRKKEHKLKIMPMNADVIVLGLQSKD
                     QAEQWLRVIQEVSGLPSEGASEGNQYTPDAQRLNCQKPDIAEKYMSASEYGITTDGHP
                     EIPETRDVKKKCSAGLKLSNLMNLGRKKSTSLEPPDRSLETSSYLNVLVNSQWKSRWC
                     FVRDSHLHFYQDRNRGKMAQQPLSLVGCDVLPDPSPDHLYSFRILHNGEELAKLEAKS
                     SEEMGHWLGLLLSESGSKTDPEELTYDYVDAERVSCIVSAAKTSLLLMQRKFSEPNTY
                     IDGLPSRDCQEELYDDVEMSELMAAVEPAEEATLAGDATPAVDANSGSDLDRVYLDLT
                     PVKSFLHNTSEVQVQASLPAVPHLDDVAETLTVDPKPGTTPEEPCTESPGGQEMQQRQ
                     PEGQEPSEPIEPTPRVTTVKLQAEQQRISFPANCPDTMASVPISASPPVKDKLRVTSA
                     EIKLGKNRTEAEVKRYTEEKRRLERSKEEIRGHLAQLRREKRELKETLLRCTDKGVVA
                     KLEQALKRIDEECRLEESRRVDLELSIVEVKDNLKKAEAGPVTLGTTVDTTHLDNMSP
                     RPQPKAATPTSTPDSTPVNSASVLKNRPLSVMVTGKGTVLQKAKEWEKKGAS"
     exon            425..478
                     /gene="Afap1l2"
                     /gene_synonym="RGD1310668"
                     /inference="alignment:Splign:2.1.0"
     exon            479..607
                     /gene="Afap1l2"
                     /gene_synonym="RGD1310668"
                     /inference="alignment:Splign:2.1.0"
     exon            608..682
                     /gene="Afap1l2"
                     /gene_synonym="RGD1310668"
                     /inference="alignment:Splign:2.1.0"
     exon            683..780
                     /gene="Afap1l2"
                     /gene_synonym="RGD1310668"
                     /inference="alignment:Splign:2.1.0"
     exon            781..871
                     /gene="Afap1l2"
                     /gene_synonym="RGD1310668"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1077
                     /gene="Afap1l2"
                     /gene_synonym="RGD1310668"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1257
                     /gene="Afap1l2"
                     /gene_synonym="RGD1310668"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1347
                     /gene="Afap1l2"
                     /gene_synonym="RGD1310668"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1432
                     /gene="Afap1l2"
                     /gene_synonym="RGD1310668"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1537
                     /gene="Afap1l2"
                     /gene_synonym="RGD1310668"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1749
                     /gene="Afap1l2"
                     /gene_synonym="RGD1310668"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1895
                     /gene="Afap1l2"
                     /gene_synonym="RGD1310668"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2007
                     /gene="Afap1l2"
                     /gene_synonym="RGD1310668"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2274
                     /gene="Afap1l2"
                     /gene_synonym="RGD1310668"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2455
                     /gene="Afap1l2"
                     /gene_synonym="RGD1310668"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..2611
                     /gene="Afap1l2"
                     /gene_synonym="RGD1310668"
                     /inference="alignment:Splign:2.1.0"
     exon            2612..2805
                     /gene="Afap1l2"
                     /gene_synonym="RGD1310668"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..2934
                     /gene="Afap1l2"
                     /gene_synonym="RGD1310668"
                     /inference="alignment:Splign:2.1.0"
     exon            2935..4000
                     /gene="Afap1l2"
                     /gene_synonym="RGD1310668"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaaacagat cttagtggag acctatggga gcttgctggt cccggagtct cccccgggct
       61 ttaagaacgt cccaggctct tttttcctcc gcggccgccc tcgggccgac ttggaggaag
      121 tgatctgcgt tccgggcggg gagcccagtg tggggtgcgc gaagaccgga gcgccgactg
      181 tcctgacaag ctgcggagat tcctggcggg gtccaggaca gctcgcccgg gtggagtcag
      241 gatccgagga ctaggggcgc ggcggccact ccgggaggtc gggaggcgag cgtgacctca
      301 ctgggagggg ccagcgcgca gccagggctc ggagcccagc gcggagccct gcgcggagaa
      361 ctcagcgcgg agcagatagc agtgccgaga gcgcacaccg cgccggcgat ggagcgctac
      421 aaagcacagg gctgttgctg tctggtggtg cagagaagaa tcctgcaggt ctctgcttcc
      481 ctggagcagc tgctgacaga gctggacgac ttcctcaagg ttctagacca ggagaacctg
      541 agcagtgcag ccgtggtgaa gaaaagcggc ttgtcggagc tcctgcgact ttacaccaag
      601 agcagcagtt ctgatgagga atatatttac atgaacaaag tggcagtcaa caaggaacag
      661 aacccagcat ctccagacaa agttcctgag gagaagcagg gtccactgac caatggggag
      721 cccagccagc acacctcggc ccctcagaag agccttccag acctccctcc acccaagatg
      781 attccagaga ggaaacagcc taccattcca aagattgagt ctcccgaggg ctactatgaa
      841 gaggctgagc catttgacac atccatcaac gaggatggag aggctgtgag cagctcctat
      901 gagtcctacg acgaggagga gagcagcaaa ggcaagacag ccccctacca gtggccctcg
      961 cctgaggcca gcattgagct gatgcgtgac gcccgcatct gtgccttcct gtggcgcaag
     1021 aagtggctag gccagtgggc caagcagctc tgtgtgatca gggacaccag gcttttgtgc
     1081 tacaaatcgt ccaaagacca cagtcctcag ctggatgtga acctgctggg cagcagtgtc
     1141 gtgcacaagg agaaacaagt gcggaagaaa gagcacaagc tcaagatcat gccaatgaac
     1201 gccgacgtga tcgtgctggg cctgcagagc aaggaccagg ctgagcagtg gcttcgggtc
     1261 atccaggagg tgagtggcct gccttctgaa ggagcctcgg agggaaacca gtacacacca
     1321 gatgcccagc gcctgaactg tcagaaacca gacatagctg agaagtacat gtcagcgtcg
     1381 gagtacggga tcaccactga tggccatcct gagatcccag agaccagaga cgtcaagaag
     1441 aaatgttctg ctggcctcaa gctgagcaac cttatgaacc tgggcaggaa gaaatctacc
     1501 tcactggagc ccccagacag atccctcgag acatccagct acctgaacgt gctggtgaac
     1561 agtcagtgga agtcacgctg gtgctttgtt agagacagcc acctgcactt ttaccaggac
     1621 cggaaccggg gcaagatggc ccagcagccc ctcagcctgg tgggttgtga tgtgcttccg
     1681 gatcccagcc ctgaccacct gtactccttc cgtatcctcc acaatggcga ggagttggcc
     1741 aagcttgagg ccaagtcatc agaggagatg ggtcactggc taggcctcct gctctcagag
     1801 tccggctcca agacagaccc ggaagagctc acctatgact atgtggatgc tgaaagggtt
     1861 tcctgcattg tcagtgcagc caaaacctct ctcttactga tgcagaggaa gttctcggag
     1921 cccaacacat acattgatgg cctgcccagc cgggactgcc aggaagagct gtatgatgat
     1981 gtggagatgt cagagctgat ggcggcggtg gagcctgctg aggaagccac cctagctggg
     2041 gatgccaccc ctgctgtgga tgccaacagt ggcagtgact tagaccgagt atacctggat
     2101 ctcacacctg tcaagtcctt cctgcataat accagtgagg tccaggtgca ggcctctctc
     2161 ccagcggtgc cacatctgga tgacgtagct gagaccctca cagtagaccc aaagccaggc
     2221 accaccccag aggagccctg cacagagtct ccaggaggcc aggagatgca gcagaggcag
     2281 ccagagggtc aagagccttc ggagcccatc gagcccaccc cgagagtcac cacggttaag
     2341 ctgcaggccg agcagcagag aatctccttc ccagccaact gcccagacac catggcttct
     2401 gtccccatca gtgccagccc acctgtgaag gacaagctga gggtgaccag tgcagaaatc
     2461 aaacttggga agaaccggac agaggcggaa gtgaagcggt acacggagga gaagaggagg
     2521 ctggagagga gtaaggagga gattcgagga cacctggctc agctccgcag ggagaagagg
     2581 gagctcaagg agaccctgtt aagatgcaca gataagggag ttgtggccaa gctggagcag
     2641 gcattgaaga gaatagatga ggaatgccgg ctggaggaga gcaggcgtgt ggacctcgag
     2701 ctcagcatcg tggaggtgaa ggacaacctg aagaaggcag aggctgggcc tgtgaccctg
     2761 ggcaccactg tggataccac ccacctggac aacatgagcc ctcgtccaca gcccaaagct
     2821 gccaccccca cctccactcc agactctacg ccagtcaact ctgcatccgt gcttaagaac
     2881 aggcctcttt ccgtcatggt cacaggcaaa ggcactgttc tgcagaaagc gaaggaatgg
     2941 gagaagaaag gagccagtta ggaaacaaga tttgcctaaa gactcttata aggtcatgga
     3001 tcttgctgac aatcctgctc cggtcaagtc ttccataaaa cagcagcaac tctgaggaaa
     3061 ggtgagtctg tttacaagaa agagcaaggg acgagatgct cgaagcttcg gtgacggccc
     3121 tgtcccctct tcaagccaaa gggaacacag cggcggcggc atcggtggcg tctccggaga
     3181 cgaaacctac tggctgtcca tgagacgaca tacttccctt tttctttcct aagatttcat
     3241 ccatcactca actgctttat caagactttt tttaggtagt gaaaaaatgg ccacatcgct
     3301 tttggttatg aggagaatct aaatttctga cccccctctc tcttatcccg tacttggcag
     3361 tgctaaggtt taaatcatgc gttgccccca tgtctgtcct ccatattggg gggcggggct
     3421 caacgtggcc tttgacgatc ttaaaagaac attagaaccc tggaatcagt agcagaggga
     3481 catactggga actgagctaa gggactgtcg ccccctaggt cactaaggac ctcgccccag
     3541 tccagacaaa ctttcaaact atgctgtatt atataggagg aaaaatcctg tgtttacaga
     3601 ctctgtcctg tggccaggct gctcttaaga aaagagttaa ttacctcttc attaccacgt
     3661 taaaggtgtt ttaaatttct ggtccccttg caaggaaaac agccgtgaat tagagtagcc
     3721 tttcttgtca gtcagattgg cagccagtgc tgtcttcaca cactgtctcc ctgtgacagc
     3781 attaacttgt gttgatacat ttcatctgtt acctgcccca tctctgagca gttggagcca
     3841 gttacctcac actggtttct gaaggctaaa tgtttttaca cgtatattat tgtctttcta
     3901 atcccagggc attttatttt ctgtatcata aacacttggt gacctttatc aagtggcgag
     3961 ttagactttt tttttttttt taaataaaat gttcattgta
//
