LOCUS       NM_001108487            2402 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus apoptosis enhancing nuclease (Aen), mRNA.
ACCESSION   NM_001108487 XM_001064302 XM_341874
VERSION     NM_001108487.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2402)
  AUTHORS   Kawase,T., Ichikawa,H., Ohta,T., Nozaki,N., Tashiro,F., Ohki,R. and
            Taya,Y.
  TITLE     p53 target gene AEN is a nuclear exonuclease required for
            p53-dependent apoptosis
  JOURNAL   Oncogene 27 (27), 3797-3810 (2008)
   PUBMED   18264133
REFERENCE   2  (bases 1 to 2402)
  AUTHORS   Lee,J.H., Koh,Y.A., Cho,C.K., Lee,S.J., Lee,Y.S. and Bae,S.
  TITLE     Identification of a novel ionizing radiation-induced nuclease, AEN,
            and its functional characterization in apoptosis
  JOURNAL   Biochem Biophys Res Commun 337 (1), 39-47 (2005)
   PUBMED   16171785
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166435.1.
            
            On Apr 29, 2008 this sequence version replaced NM_001108487.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166435.1, SRR8487226.50006.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2402
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..2402
                     /gene="Aen"
                     /gene_synonym="Isg20l1; RGD1305051"
                     /note="apoptosis enhancing nuclease"
                     /db_xref="GeneID:361594"
                     /db_xref="RGD:1305051"
     exon            1..293
                     /gene="Aen"
                     /gene_synonym="Isg20l1; RGD1305051"
                     /inference="alignment:Splign:2.1.0"
     exon            294..881
                     /gene="Aen"
                     /gene_synonym="Isg20l1; RGD1305051"
                     /inference="alignment:Splign:2.1.0"
     CDS             357..1355
                     /gene="Aen"
                     /gene_synonym="Isg20l1; RGD1305051"
                     /EC_number="3.1.-.-"
                     /note="interferon stimulated exonuclease gene 20-like 1;
                     interferon-stimulated 20 kDa exonuclease-like 1"
                     /codon_start=1
                     /product="apoptosis-enhancing nuclease"
                     /protein_id="NP_001101957.1"
                     /db_xref="GeneID:361594"
                     /db_xref="RGD:1305051"
                     /translation="MVPREVPESSLTSLKTKDVARRRHKRRSRQHQRFMARKALLQEQ
                     ESLSMVPGPGLCPLPSPTQTPAGTEASGNRKQRTKARSGSKGLCSKRPVPREAPSSGP
                     SKYVAIDCEMVGTGPQGRVSELARCSVVSYSGDVLYDKYIRPEMPIVDYRTRWSGITR
                     QHMHKAIPFQVAQKEILKLLKGKVVVGHALHNDFQALKYVHPGSQIRDTTYVPNLLSQ
                     PSSLTRARVSLKDLALNLLHKKIQVGHHGHSSVEDAMTAMELYQLVEVQWEQQVASTA
                     KAHPEDRGPDSSTDVEQYMDDQYWPEDLAQSTRGDTREAQDRQEGEEGQGARSAPP"
     exon            882..1082
                     /gene="Aen"
                     /gene_synonym="Isg20l1; RGD1305051"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..2377
                     /gene="Aen"
                     /gene_synonym="Isg20l1; RGD1305051"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtcaaggct tccacgtgaa agccgcaaag tgcggcccgg tcttcaggtg agctagggga
       61 ccgccacagg gagccccggg ctgcgggttc ctgtcgccag cctcacgtgg ctctcgggac
      121 cgggtggtgt gcagccaggc cggaacgcgg cctcacgcgg tctttcccaa cttggagccg
      181 gtgggcatca ggggaccgcg tggacattga gcgtccactg cacgcctcag ctgtgaggat
      241 tgcggcctgc cctcatactt aaaaaacaaa caaacaaaca aaaaactggt cagcacactg
      301 cctcgtgggc agacagcctc cagagctttc ttaccgctgc ctgtgagctg gctggcatgg
      361 tgcccaggga agtccctgag tcttccctca ctagcctgaa gaccaaggat gtggctcgga
      421 ggagacacaa aaggagaagc cggcagcacc agcggttcat ggcccgcaag gccttgcttc
      481 aggagcagga gtcgttgagc atggtaccag ggccaggact ctgccctctg ccctccccaa
      541 cacagacgcc agcaggcaca gaggcttcag gcaacaggaa acaacgtacc aaggccaggt
      601 ctggcagcaa aggcctgtgt agcaaaaggc ctgtccccag agaagcccca agctctgggc
      661 ccagcaagta tgtggccatt gactgtgaga tggtgggtac cggcccccaa gggcgagtga
      721 gtgagctagc ccgctgctcc gtggtgagtt acagtggtga tgttctctat gacaagtaca
      781 tccggcctga aatgcccatt gtggactatc gaacccgctg gagcggcatt acccgtcagc
      841 acatgcacaa ggctatcccc tttcaggtgg cccagaagga gatccttaag ctgctgaagg
      901 gcaaggtggt ggtggggcat gcactgcaca atgacttcca ggccctgaag tacgtccacc
      961 ctgggagcca gatccgggat acgacttatg tcccaaacct gctcagccag cccagctccc
     1021 tcacccgagc tcgggtctct cttaaggacc tggccctgaa cctgctgcac aagaagatcc
     1081 aggtaggtca ccatggacac tcatctgtgg aggatgccat gacagccatg gagctgtacc
     1141 agctggtgga ggtgcagtgg gaacagcaag tggccagcac cgccaaggcc catcctgagg
     1201 acaggggccc tgacagcagc actgatgtgg agcagtacat ggacgaccag tactggcctg
     1261 aggacctggc ccagagcacc aggggagaca caagggaggc ccaggataga caggagggag
     1321 aggaagggca gggagccagg agtgctcctc cctagtcaca cagggtggga ggtaactgaa
     1381 gtaacctcct ggtaaccagg atcagggttc taaggcaatg tttctcaaaa cctgatggtc
     1441 aggactcctt tgtggggttg aaaaaccttt tcacaggggt cacctaagac catcagaaga
     1501 cacaggtatt tacattatga tccgtaacta gcaaaattac agttatgaag tagcaacaaa
     1561 aatgatttta ttttgggggc tctccacggc atgaggaact gtcttaaaga gttgcagcat
     1621 taggaaggtt tagaaccact ggtctgggat gactttaggg cagtagtagg caaggactca
     1681 ggtcacacca tcctctgtca gagtctcgtc attcctgcca cttagcatgg atacattagg
     1741 caagcctaat cgagcctgtt ttccctttgt aaagcgggga gtggtggcat ctacctcatg
     1801 ggtgtgtaag catgttgagt gtatcctagt gattcagtgc atgggctgta ttcaggcctg
     1861 atttccaagc agctatggct caggcaggac tttttcactt ggcttttcca tcagatgagg
     1921 tggggccagg gcaaggagtt gaaagcaggg caggggagtt cagaggtctc tgcaggtctt
     1981 gctgccagct tctgtctcca caccagcctc ttgacactgc atctgggaaa gtgacaacag
     2041 taatccaggc agagtcagga aggaagggac actactgaga ccacacttcc cactctccac
     2101 tgaggtcctg attgcagaaa gttttagatt gtttgattgc tggctcctcc ctgccaggga
     2161 aaaagggagc tggcaaaatc gtcaccacca cttatggtct ggcgccaggg gtaaactctt
     2221 gtttccttaa aaagcagcag cttgtgccag ccttggtgct gggcagtagc cattgtgggt
     2281 tgaagggtgg tggaactact agctgggaga agtgtactgt gagaaatcag cttgtttgtg
     2341 cttccagagg agtaaaggaa taagtgcaac tggaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2401 aa
//
