LOCUS       NP_001388474             495 aa            linear   ROD 30-MAR-2024
DEFINITION  zinc finger protein AEBP2 [Rattus norvegicus].
ACCESSION   NP_001388474
VERSION     NP_001388474.1
DBSOURCE    REFSEQ: accession NM_001401545.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 495)
  AUTHORS   Ragazzini,R., Perez-Palacios,R., Baymaz,I.H., Diop,S., Ancelin,K.,
            Zielinski,D., Michaud,A., Givelet,M., Borsos,M., Aflaki,S.,
            Legoix,P., Jansen,P.W.T.C., Servant,N., Torres-Padilla,M.E.,
            Bourc'his,D., Fouchet,P., Vermeulen,M. and Margueron,R.
  TITLE     EZHIP constrains Polycomb Repressive Complex 2 activity in germ
            cells
  JOURNAL   Nat Commun 10 (1), 3858 (2019)
   PUBMED   31451685
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 495)
  AUTHORS   Herz,H.M., Garruss,A. and Shilatifard,A.
  TITLE     SET for life: biochemical activities and biological functions of
            SET domain-containing proteins
  JOURNAL   Trends Biochem Sci 38 (12), 621-639 (2013)
   PUBMED   24148750
  REMARK    Review article
REFERENCE   3  (residues 1 to 495)
  AUTHORS   Pasini,D., Cloos,P.A., Walfridsson,J., Olsson,L., Bukowski,J.P.,
            Johansen,J.V., Bak,M., Tommerup,N., Rappsilber,J. and Helin,K.
  TITLE     JARID2 regulates binding of the Polycomb repressive complex 2 to
            target genes in ES cells
  JOURNAL   Nature 464 (7286), 306-310 (2010)
   PUBMED   20075857
REFERENCE   4  (residues 1 to 495)
  AUTHORS   Shen,X., Kim,W., Fujiwara,Y., Simon,M.D., Liu,Y., Mysliwiec,M.R.,
            Yuan,G.C., Lee,Y. and Orkin,S.H.
  TITLE     Jumonji modulates polycomb activity and self-renewal versus
            differentiation of stem cells
  JOURNAL   Cell 139 (7), 1303-1314 (2009)
   PUBMED   20064376
REFERENCE   5  (residues 1 to 495)
  AUTHORS   Peng,J.C., Valouev,A., Swigut,T., Zhang,J., Zhao,Y., Sidow,A. and
            Wysocka,J.
  TITLE     Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and
            target gene occupancy in pluripotent cells
  JOURNAL   Cell 139 (7), 1290-1302 (2009)
   PUBMED   20064375
REFERENCE   6  (residues 1 to 495)
  AUTHORS   He,G.P., Kim,S. and Ro,H.S.
  TITLE     Cloning and characterization of a novel zinc finger transcriptional
            repressor. A direct role of the zinc finger motif in repression
  JOURNAL   J Biol Chem 274 (21), 14678-14684 (1999)
   PUBMED   10329662
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.18341.1,
                                           SRR22582424.1431195.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q44"
     Protein         1..495
                     /product="zinc finger protein AEBP2"
                     /calculated_mol_wt=51783
     Region          <209..356
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          258..278
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(262,264,266,268..269,272..273,277,295,297,301..302,
                     309..310,313,329,331,333,335..336,339..340,343)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          289..314
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          322..344
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..495
                     /gene="Aebp2"
                     /coded_by="NM_001401545.1:183..1670"
                     /db_xref="GeneID:297705"
                     /db_xref="RGD:1307233"
ORIGIN      
        1 maaaltdmad leelsrlspl spgspgpaar graeppeeee eeeddeaeae avaalllngg
       61 agggagggea etmsepspes asqaggdede ddeddedegs ssggaeeess aeslvgsssg
      121 gcsgdetrsl spgaassssg dgdgkeglee pkgprggpgg pgngggssss svvssggdeg
      181 ygtggggssa tsggrrgsle mssdgeplsr mdsedsisst lmdidstiss grstpammng
      241 qgstaasskh iaynccwdqc qacfnsspdl adhirsihvd gqrggvfvcl wkgckvyntp
      301 stsqswlqrh mlthsgdkpf kcvvggcnas fasqgglarh vpthfsqqns skvssqpkak
      361 eespskagmn krrklknkrr rslprphdff daqtldairh raicfnlsah ieslgkghsv
      421 vfhstviakr keesgkikll lhwmpedilp dvwvneserh qlrtkvvhls klpkdtalll
      481 dpniyrtmpq krlkr
//
