LOCUS       NM_001100970            3817 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus AE binding protein 1 (Aebp1), mRNA.
ACCESSION   NM_001100970 XM_001069152 XM_223583
VERSION     NM_001100970.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3817)
  AUTHORS   Blackburn,P.R., Xu,Z., Tumelty,K.E., Zhao,R.W., Monis,W.J.,
            Harris,K.G., Gass,J.M., Cousin,M.A., Boczek,N.J., Mitkov,M.V.,
            Cappel,M.A., Francomano,C.A., Parisi,J.E., Klee,E.W., Faqeih,E.,
            Alkuraya,F.S., Layne,M.D., McDonnell,N.B. and Atwal,P.S.
  TITLE     Bi-allelic Alterations in AEBP1 Lead to Defective Collagen Assembly
            and Connective Tissue Structure Resulting in a Variant of
            Ehlers-Danlos Syndrome
  JOURNAL   Am J Hum Genet 102 (4), 696-705 (2018)
   PUBMED   29606302
REFERENCE   2  (bases 1 to 3817)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   3  (bases 1 to 3817)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   4  (bases 1 to 3817)
  AUTHORS   Didangelos,A., Yin,X., Mandal,K., Baumert,M., Jahangiri,M. and
            Mayr,M.
  TITLE     Proteomics characterization of extracellular space components in
            the human aorta
  JOURNAL   Mol Cell Proteomics 9 (9), 2048-2062 (2010)
   PUBMED   20551380
REFERENCE   5  (bases 1 to 3817)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   6  (bases 1 to 3817)
  AUTHORS   Lyons,P.J., Muise,A.M. and Ro,H.S.
  TITLE     MAPK modulates the DNA binding of adipocyte enhancer-binding
            protein 1
  JOURNAL   Biochemistry 44 (3), 926-931 (2005)
   PUBMED   15654748
REFERENCE   7  (bases 1 to 3817)
  AUTHORS   He,G.P., Muise,A., Li,A.W. and Ro,H.S.
  TITLE     A eukaryotic transcriptional repressor with carboxypeptidase
            activity
  JOURNAL   Nature 378 (6552), 92-96 (1995)
   PUBMED   7477299
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC133065.1.
            
            On or before Aug 12, 2007 this sequence version replaced
            XM_223583.4, XM_001069152.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC133065.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132268
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3817
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..3817
                     /gene="Aebp1"
                     /note="AE binding protein 1"
                     /db_xref="GeneID:305494"
                     /db_xref="RGD:1306922"
     exon            1..438
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..3578
                     /gene="Aebp1"
                     /note="adipocyte enhancer-binding protein 1; aortic
                     carboxypeptidase-like protein"
                     /codon_start=1
                     /product="adipocyte enhancer-binding protein 1 precursor"
                     /protein_id="NP_001094440.1"
                     /db_xref="GeneID:305494"
                     /db_xref="RGD:1306922"
                     /translation="MAAVRTASLLCGLLALLALCPEGSPQTVLTDDEIQEFLEGFLSE
                     FETQSPPREDDVEAQPLPEPTQRARKSKAGGKPRADAEAPPEKNKDKEKKGKKDKGPK
                     AAKHLEGSTRPTKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKR
                     PSAGKRFSTVAPLETPERSLTSPSNPGTRELPEERGRTSLNTWQGQGEETQVEARQHR
                     PEPEEETEMPTLDYNDQIEREDYEDFEYIRRQKQPRPTPSRKRIWPEPPEEKTQEPEE
                     RKEVDPPLKPLLPPDYGDGYLIPNYDDLDYYFPHPPPQKPDVGQEVDEEKEELKKPKK
                     EGSSPKEDTEDKWAAEKNKDHKAGPRKGEELEEEWGPVEKIKCPPIGMESHRIEDNQI
                     RASSMLRHGLGAQRGRLNMQAGANEDDYYDGAWCAEDESQTQWIEVDTRRTTRFTGVI
                     TQGRDSSIHDDFVTTFFVGFSNDSQTWVMYTNGYEEMTFHGNVDKDTPVLSELPEPVV
                     ARFIRIYPLTWNGSLCMRLEVLGCPVTPVYSYYAQNEVVTTDSLDFRHHSYKDMRQLM
                     KVVNEECPTITRTYSLGKSSRGLKIYAMEISDNPGEHELGEPEFRYTAGMHGNEVLGR
                     ELLLLLMQYLCHEYRDGNPRVRNLVQDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGL
                     WTEEGFDIFEDFPDLNSVLWAAEEKKWVPYRVPNNNLPIPERYLSPDATVSTEVRAII
                     SWMEKNPFVLGANLNGGERLVSYPYDMARTPSQEQLLAAALAAARGEDEDEVSEAQET
                     PDHAIFRWLAISFASAHLTMTEPYRGGCQAQDYTSGMGIVNGAKWNPRSGTFNDFSYL
                     HTNCLELSIYLGCDKFPHESELPREWENNKEALLTFMEQVHRGIKGVVTDEQGIPIAN
                     ATISVSGINHGVKTASGGDYWRILNPGEYRVTAHAEGYTSSAKICNVDYDIGATQCNF
                     ILARSNWKRIREILAMNGNRPILRVDPSRPMTPQQRRLQQRRLRYRLRMREQMRLRRL
                     NSTTGPATSPTPALTLPPSPTPGSTSRLWEILPTTAAGWEESETETYTEVVTEFETEY
                     GPDLEVEELEEEEEEEEEMDTGLTFPVTTVETYTVNFGDF"
     exon            439..777
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            778..849
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            850..921
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1032
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1101
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1179
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1260
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1317
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1427
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1567
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1652
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1797
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1883
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2007
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2204
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2384
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2736
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2737..2876
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2877..2976
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2977..3793
                     /gene="Aebp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggagctggg ctcgccagaa cctctctcgg aatccccttg aatctctctc ccccacccct
       61 ttctggatac cctcgacgtc cacgttgctc cccagggttc ctcacgccct ttcccgcccc
      121 cacgcggggc gccgcccctg ccacccaagt ccctgctcaa gcccacccga ctcccacgcg
      181 tgcccagagc catggctgcg gtacgcaccg catccctgct ctgcggcctc ttggcactcc
      241 tggcgctgtg cccggagggg agcccacaga cggtgctgac ggacgacgag atccaggagt
      301 tcctcgaagg cttcctttcg gagtttgaga cccagtcccc gccccgggag gacgacgtgg
      361 aagcccagcc acttcccgaa cccacccagc gtgcccgcaa atccaaggca gggggcaagc
      421 cgcgggcaga tgcagaagcc cctccagaaa agaacaaaga caaagagaag aaaggaaaga
      481 aggacaaagg ccccaaggct gcaaaacacc tggaaggttc caccaggccc accaagaaac
      541 caaaggagaa gccacccaag gccaccaaga agcccaaaga gaagccaccc aaggccacca
      601 agaagcctaa agagaagcca cccaaggcca ccaagaagcc caaggagaag ccacccaagg
      661 ccactaagag gccctcggca ggaaagagat tctcaactgt agccccctta gaaacgccgg
      721 agcgttcact cacctcaccc tccaaccccg gcaccaggga gctaccagag gagagaggaa
      781 gaacctccct gaatacctgg cagggccaag gagaagagac ccaagtggag gccaggcagc
      841 accggccaga gccagaggag gagaccgaga tgcccacact ggactacaat gaccagatag
      901 agcgggaaga ttatgaagac tttgagtaca tcaggcgcca gaagcagccc agacccacac
      961 ccagcaggaa gaggatctgg ccagagcccc ctgaggagaa gacccaagag ccggaggaaa
     1021 ggaaggaagt tgatccgcct ctgaagcccc tgttgccccc tgactatggg gatggctact
     1081 tgatccccaa ctacgatgac ttggactact acttccccca ccccccacca cagaagcccg
     1141 atgttggaca agaggtggat gaagaaaagg aggagttgaa gaagcccaaa aaggagggca
     1201 gtagccccaa ggaggacaca gaagacaagt gggcggcaga gaaaaacaag gaccacaaag
     1261 caggaccccg gaagggcgag gagctggagg aggagtgggg tccagtggag aaaatcaagt
     1321 gcccacctat cgggatggag tcacaccgca ttgaggacaa ccagatccgc gcctcctcca
     1381 tgctgcgcca tggcctcgga gcccagcggg gccggctcaa catgcaggct ggtgccaatg
     1441 aagatgacta ctatgatggg gcatggtgtg ctgaggacga gtctcagacc cagtggattg
     1501 aggtggacac ccggaggacg actcggttca caggcgtgat tacacagggt cgggactcca
     1561 gcatccatga cgactttgtg actaccttct tcgtgggctt cagcaatgac agccagacct
     1621 gggtgatgta caccaatggc tatgaggaaa tgaccttcca tgggaatgtg gataaggaca
     1681 cacctgtgct gagtgaactc cccgagccag ttgtggcccg tttcatccgc atctatccac
     1741 tcacctggaa cggtagcctg tgcatgcgcc tggaggtgct aggctgccct gtgacccctg
     1801 tctacagcta ctacgcacag aacgaggtgg tgaccactga cagcctggac ttccggcacc
     1861 acagctacaa ggacatgcgc cagctgatga aggttgtgaa tgaggagtgt cctaccatta
     1921 cccgcacgta cagcttgggc aagagttcac gagggctcaa gatctatgcg atggagatct
     1981 cagacaaccc cggggagcat gagctggggg agcctgagtt ccgctacaca gccggcatgc
     2041 acggcaatga ggtgctgggc cgagagctgc tgttactgct catgcagtac ctgtgtcacg
     2101 agtaccggga tgggaacccc agagtgcgta acctggtgca ggacacgcgc atccacctgg
     2161 tgccttcgct gaaccctgac ggctacgagg tggcagcgca gatgggctca gagtttggga
     2221 actgggcact ggggctgtgg actgaggagg gctttgacat cttcgaggat ttcccagatc
     2281 tcaactctgt gctctgggca gctgaggaga agaaatgggt cccctacagg gtcccgaaca
     2341 ataacttgcc aatccctgaa cgttacctgt ccccagatgc cacggtatcc acagaagtcc
     2401 gggccatcat ttcctggatg gagaagaacc cctttgtgct gggtgcaaat ctgaatggtg
     2461 gcgagcggct tgtgtcttac ccctatgaca tggcccggac acctagccag gagcagctgt
     2521 tggccgcggc actggcagct gcccgtggag aagacgagga tgaggtgtct gaggcccagg
     2581 agactccaga tcacgccatt ttccgctggc tggctatctc ctttgcctct gcccatctca
     2641 ccatgactga gccctaccgg ggagggtgcc aggcccagga ctacaccagc ggcatgggta
     2701 tcgtcaacgg ggccaagtgg aatcctcggt ctgggacttt caatgacttc agctacctgc
     2761 ataccaactg cctggagctc tctatatacc tgggctgcga caagttcccc cacgagagcg
     2821 agctgccccg agagtgggag aacaacaaag aagccttgct aaccttcatg gagcaggtgc
     2881 accgtggcat caagggtgtg gtgacggatg agcaagggat ccccattgcc aatgctacca
     2941 tctctgtgag tggcatcaac cacggagtaa agacagcgag tggaggtgac tactggcgca
     3001 ttctgaaccc gggtgagtac cgtgtgacag ctcacgcaga gggctacacc tcgagtgcca
     3061 agatttgcaa cgtggactac gatatcgggg ccacccagtg caacttcatc ctggcgcgct
     3121 ccaactggaa gcgcattcgg gagatcttgg ctatgaacgg gaaccgtccc attctccgag
     3181 ttgacccctc acgaccaatg acaccccagc agcggcgcct gcagcagcgc cggctacggt
     3241 accggctcag gatgagggaa cagatgaggc tgcggcgcct caattctacc acaggccctg
     3301 ccacgagccc cactcctgcc cttacgctgc ctccttcccc tacaccaggc agtacctcga
     3361 ggctctggga aattctaccc actaccgctg cgggctggga ggagtcagag actgagacct
     3421 atacagaggt agtgacagag tttgagacag agtatgggcc tgacctggag gtggaggaac
     3481 tggaggagga ggaggaggag gaggaggaga tggacacagg cctcacgttt ccagtcacaa
     3541 cagtggagac ctacacagtc aactttgggg acttctgaga ctggggtccc aaagccctag
     3601 cccaattcaa actaaagcag catttcccca gcctgtgctg gcaggcgcat agccatcaga
     3661 tgctcctggg tgggccctgt taccaccagg cctccaaaag cagagtctct gcagaagccc
     3721 ccggttctac ctgccagcct ttggggaggc aaggaagcca acgtcacacc aataaaacaa
     3781 gctcacggca ccaaaaaaaa aaaaaaaaaa aaaaaaa
//
