LOCUS       NP_001094440            1128 aa            linear   ROD 08-APR-2025
DEFINITION  adipocyte enhancer-binding protein 1 isoform 1 precursor [Rattus
            norvegicus].
ACCESSION   NP_001094440 XP_001069152 XP_223583
VERSION     NP_001094440.1
DBSOURCE    REFSEQ: accession NM_001100970.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1128)
  AUTHORS   Blackburn,P.R., Xu,Z., Tumelty,K.E., Zhao,R.W., Monis,W.J.,
            Harris,K.G., Gass,J.M., Cousin,M.A., Boczek,N.J., Mitkov,M.V.,
            Cappel,M.A., Francomano,C.A., Parisi,J.E., Klee,E.W., Faqeih,E.,
            Alkuraya,F.S., Layne,M.D., McDonnell,N.B. and Atwal,P.S.
  TITLE     Bi-allelic Alterations in AEBP1 Lead to Defective Collagen Assembly
            and Connective Tissue Structure Resulting in a Variant of
            Ehlers-Danlos Syndrome
  JOURNAL   Am J Hum Genet 102 (4), 696-705 (2018)
   PUBMED   29606302
REFERENCE   2  (residues 1 to 1128)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   3  (residues 1 to 1128)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   4  (residues 1 to 1128)
  AUTHORS   Didangelos,A., Yin,X., Mandal,K., Baumert,M., Jahangiri,M. and
            Mayr,M.
  TITLE     Proteomics characterization of extracellular space components in
            the human aorta
  JOURNAL   Mol Cell Proteomics 9 (9), 2048-2062 (2010)
   PUBMED   20551380
REFERENCE   5  (residues 1 to 1128)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   6  (residues 1 to 1128)
  AUTHORS   Lyons,P.J., Muise,A.M. and Ro,H.S.
  TITLE     MAPK modulates the DNA binding of adipocyte enhancer-binding
            protein 1
  JOURNAL   Biochemistry 44 (3), 926-931 (2005)
   PUBMED   15654748
REFERENCE   7  (residues 1 to 1128)
  AUTHORS   He,G.P., Muise,A., Li,A.W. and Ro,H.S.
  TITLE     A eukaryotic transcriptional repressor with carboxypeptidase
            activity
  JOURNAL   Nature 378 (6552), 92-96 (1995)
   PUBMED   7477299
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On or before Aug 12, 2007 this sequence version replaced
            XP_223583.4, XP_001069152.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC133065.1, SRR26643299.55417.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1128
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     Protein         1..1128
                     /product="adipocyte enhancer-binding protein 1 isoform 1
                     precursor"
                     /note="adipocyte enhancer-binding protein 1; aortic
                     carboxypeptidase-like protein"
                     /calculated_mol_wt=125609
     sig_peptide     1..25
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2471
     mat_peptide     26..1128
                     /product="Adipocyte enhancer-binding protein 1.
                     /id=PRO_0000333191"
                     /note="propagated from UniProtKB/Swiss-Prot (A2RUV9.1)"
                     /calculated_mol_wt=125609
     Region          40..368
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2RUV9.1)"
     Region          378..531
                     /region_name="FA58C"
                     /note="Coagulation factor 5/8 C-terminal domain, discoidin
                     domain; Cell surface-attached carbohydrate-binding domain,
                     present in eukaryotes and assumed to have horizontally
                     transferred to eubacterial genomes; cd00057"
                     /db_xref="CDD:238014"
     Region          382..547
                     /region_name="Required for DNA-binding and interaction
                     with NFKBIA. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (A2RUV9.1)"
     Region          413..616
                     /region_name="Interaction with MAPK1 and MAPK3.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (A2RUV9.1)"
     Site            order(426,454,461)
                     /site_type="other"
                     /note="sugar binding site [chemical binding]"
                     /db_xref="CDD:238014"
     Site            520
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (A2RUV9.1)"
     Region          547..977
                     /region_name="Interaction with PTEN.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (A2RUV9.1)"
     Region          556..895
                     /region_name="Peptidase_M14_like"
                     /note="M14 family of metallocarboxypeptidases and related
                     proteins; cl11393"
                     /db_xref="CDD:472171"
     Site            order(617,620,682,691..692,755..756,762,866)
                     /site_type="active"
                     /db_xref="CDD:349427"
     Region          899..974
                     /region_name="Peptidase_M14NE-CP-C_like"
                     /note="Peptidase associated domain: C-terminal domain of
                     M14 N/E carboxypeptidase; putative folding, regulation, or
                     interaction domain; cd11308"
                     /db_xref="CDD:200604"
     Region          933..1128
                     /region_name="Required for transcriptional repression.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (A2RUV9.1)"
     Region          998..1128
                     /region_name="Interaction with MAPK1 and MAPK3.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (A2RUV9.1)"
     Region          1027..1056
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2RUV9.1)"
     CDS             1..1128
                     /gene="Aebp1"
                     /coded_by="NM_001100970.2:197..3583"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="GeneID:305494"
                     /db_xref="RGD:1306922"
ORIGIN      
        1 maavrtasll cgllallalc pegspqtvlt ddeiqefleg flsefetqsp preddveaqp
       61 lpeptqrark skaggkprad aeappeknkd kekkgkkdkg pkaakhlegs trptkkpkek
      121 ppkatkkpke kppkatkkpk ekppkatkkp kekppkatkr psagkrfstv apletpersl
      181 tspsnpgtre lpeergrtsl ntwqgqgeet qvearqhrpe peeetemptl dyndqiered
      241 yedfeyirrq kqprptpsrk riwpeppeek tqepeerkev dpplkpllpp dygdgylipn
      301 yddldyyfph pppqkpdvgq evdeekeelk kpkkegsspk edtedkwaae knkdhkagpr
      361 kgeeleeewg pvekikcppi gmeshriedn qirassmlrh glgaqrgrln mqaganeddy
      421 ydgawcaede sqtqwievdt rrttrftgvi tqgrdssihd dfvttffvgf sndsqtwvmy
      481 tngyeemtfh gnvdkdtpvl selpepvvar firiypltwn gslcmrlevl gcpvtpvysy
      541 yaqnevvttd sldfrhhsyk dmrqlmkvvn eecptitrty slgkssrglk iyameisdnp
      601 gehelgepef rytagmhgne vlgrelllll mqylcheyrd gnprvrnlvq dtrihlvpsl
      661 npdgyevaaq mgsefgnwal glwteegfdi fedfpdlnsv lwaaeekkwv pyrvpnnnlp
      721 iperylspda tvstevraii swmeknpfvl ganlnggerl vsypydmart psqeqllaaa
      781 laaargeded evseaqetpd haifrwlais fasahltmte pyrggcqaqd ytsgmgivng
      841 akwnprsgtf ndfsylhtnc lelsiylgcd kfpheselpr ewennkeall tfmeqvhrgi
      901 kgvvtdeqgi pianatisvs ginhgvktas ggdywrilnp geyrvtahae gytssakicn
      961 vdydigatqc nfilarsnwk rireilamng nrpilrvdps rpmtpqqrrl qqrrlryrlr
     1021 mreqmrlrrl nsttgpatsp tpaltlppsp tpgstsrlwe ilpttaagwe esetetytev
     1081 vtefeteygp dleveeleee eeeeeemdtg ltfpvttvet ytvnfgdf
//
