LOCUS       NM_001105975            2539 bp    mRNA    linear   ROD 17-OCT-2023
DEFINITION  Rattus norvegicus adenylosuccinate synthase 2 (Adss2), mRNA.
ACCESSION   NM_001105975 XM_001059694 XM_222946
VERSION     NM_001105975.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2539)
  AUTHORS   Li X, Zhu Z, Mo D, Wang H, Yang S, Zhao S and Li K.
  TITLE     Comparative molecular characterization of ADSS1 and ADSS2 genes in
            pig (Sus scrofa)
  JOURNAL   Comp Biochem Physiol B Biochem Mol Biol 147 (2), 271-277 (2007)
   PUBMED   17347008
REFERENCE   2  (bases 1 to 2539)
  AUTHORS   Sun H, Li N, Wang X, Chen T, Shi L, Zhang L, Wang J, Wan T and Cao
            X.
  TITLE     Molecular cloning and characterization of a novel muscle
            adenylosuccinate synthetase, AdSSL1, from human bone marrow stromal
            cells
  JOURNAL   Mol Cell Biochem 269 (1-2), 85-94 (2005)
   PUBMED   15786719
REFERENCE   3  (bases 1 to 2539)
  AUTHORS   Borza T, Iancu CV, Pike E, Honzatko RB and Fromm HJ.
  TITLE     Variations in the response of mouse isozymes of adenylosuccinate
            synthetase to inhibitors of physiological relevance
  JOURNAL   J Biol Chem 278 (9), 6673-6679 (2003)
   PUBMED   12482871
REFERENCE   4  (bases 1 to 2539)
  AUTHORS   Xia Y, McMillin JB, Lewis A, Moore M, Zhu WG, Williams RS and
            Kellems RE.
  TITLE     Electrical stimulation of neonatal cardiac myocytes activates the
            NFAT3 and GATA4 pathways and up-regulates the adenylosuccinate
            synthetase 1 gene
  JOURNAL   J Biol Chem 275 (3), 1855-1863 (2000)
   PUBMED   10636885
REFERENCE   5  (bases 1 to 2539)
  AUTHORS   Honzatko RB, Stayton MM and Fromm HJ.
  TITLE     Adenylosuccinate synthetase: recent developments
  JOURNAL   Adv Enzymol Relat Areas Mol Biol 73, 57-102 (1999)
   PUBMED   10218106
  REMARK    Review article
REFERENCE   6  (bases 1 to 2539)
  AUTHORS   Powell SM, Zalkin H and Dixon JE.
  TITLE     Cloning and characterization of the cDNA encoding human
            adenylosuccinate synthetase
  JOURNAL   FEBS Lett 303 (1), 4-10 (1992)
   PUBMED   1592113
REFERENCE   7  (bases 1 to 2539)
  AUTHORS   Lai LW, Hart IM and Patterson D.
  TITLE     A gene correcting the defect in the CHO mutant Ade -H, deficient in
            a branch point enzyme (adenylosuccinate synthetase) of de novo
            purine biosynthesis, is located on the long arm of chromosome 1
  JOURNAL   Genomics 9 (2), 322-328 (1991)
   PUBMED   2004783
REFERENCE   8  (bases 1 to 2539)
  AUTHORS   Ikegami T, Natsumeda Y and Weber G.
  TITLE     Isozyme shift of adenylosuccinate synthase in rat and human
            neoplasms
  JOURNAL   Adv Exp Med Biol 253A, 417-421 (1989)
   PUBMED   2560335
REFERENCE   9  (bases 1 to 2539)
  AUTHORS   Jenkins RL, McDaniel HG, Digerness S, Parrish SW and Ong RL.
  TITLE     Adenine nucleotide metabolism in hearts of diabetic rats.
            Comparison to diaphragm, liver, and kidney
  JOURNAL   Diabetes 37 (5), 629-636 (1988)
   PUBMED   3360219
REFERENCE   10 (bases 1 to 2539)
  AUTHORS   Matsuda,Y., Ogawa,H., Fukutome,S., Shiraki,H. and Nakagawa,H.
  TITLE     Adenylosuccinate synthetase in rat liver: the existence of two
            types and their regulatory roles
  JOURNAL   Biochem Biophys Res Commun 78 (2), 766-771 (1977)
   PUBMED   71897
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473985.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_222946.4, XM_001059694.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760389,
                              SAMEA5760400 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2539
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q25"
     gene            1..2539
                     /gene="Adss2"
                     /gene_synonym="Adss"
                     /note="adenylosuccinate synthase 2"
                     /db_xref="GeneID:289276"
                     /db_xref="RGD:1310508"
     exon            1..298
                     /gene="Adss2"
                     /gene_synonym="Adss"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1486
                     /gene="Adss2"
                     /gene_synonym="Adss"
                     /EC_number="6.3.4.4"
                     /note="adenylosuccinate synthetase 2, non muscle;
                     adenylosuccinate synthetase, non muscle"
                     /codon_start=1
                     /product="adenylosuccinate synthetase isozyme 2"
                     /protein_id="NP_001099445.1"
                     /db_xref="GeneID:289276"
                     /db_xref="RGD:1310508"
                     /translation="MSISESSPAATSLPNGDCGRPRARPGGNRVTVVLGAQWGDEGKG
                     KVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIH
                     LPGLFEEAEKNVQKGKGLDGWEKRLIISDRAHIVFDFHQAADGIQEQQRQEQAGKNLG
                     TTKKGIGPVYSSKAARSGLRMCDLVSDFDGFSERFKVLANQYKSIYPTLEIDIEGELQ
                     QLKGYMERIKPMVRDGVYFLYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTV
                     GGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGR
                     KRRCGWLDLVLLKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGETIPHFPANQ
                     EVLNKVEVQYKTLPGWNTDISNARTFKELPVNAQNYVRFIEDELQIPVKWIGVGKSRE
                     SMIQLF"
     exon            299..401
                     /gene="Adss2"
                     /gene_synonym="Adss"
                     /inference="alignment:Splign:2.1.0"
     exon            402..470
                     /gene="Adss2"
                     /gene_synonym="Adss"
                     /inference="alignment:Splign:2.1.0"
     exon            471..521
                     /gene="Adss2"
                     /gene_synonym="Adss"
                     /inference="alignment:Splign:2.1.0"
     exon            522..588
                     /gene="Adss2"
                     /gene_synonym="Adss"
                     /inference="alignment:Splign:2.1.0"
     exon            589..696
                     /gene="Adss2"
                     /gene_synonym="Adss"
                     /inference="alignment:Splign:2.1.0"
     exon            697..778
                     /gene="Adss2"
                     /gene_synonym="Adss"
                     /inference="alignment:Splign:2.1.0"
     exon            779..905
                     /gene="Adss2"
                     /gene_synonym="Adss"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1060
                     /gene="Adss2"
                     /gene_synonym="Adss"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1185
                     /gene="Adss2"
                     /gene_synonym="Adss"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1283
                     /gene="Adss2"
                     /gene_synonym="Adss"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1433
                     /gene="Adss2"
                     /gene_synonym="Adss"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..2539
                     /gene="Adss2"
                     /gene_synonym="Adss"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccggcctc tggctccttc ttcctccgca tgtcgcgggc ggtcccgcag cagttaagtt
       61 gaggttctgt tctcctgccg agtctcctca aggctcttct tccctgccgg gagccatgtc
      121 gatctctgag agcagcccgg cggctacttc cttgccgaac ggcgactgcg gccgccccag
      181 ggcgcggcct ggagggaacc gggtgactgt ggtgctggga gcgcagtggg gcgacgaggg
      241 caaagggaag gtggtggatc tgctggcgca ggacgccgac atcgtgtgcc gttgccaggg
      301 agggaataac gctggccaca cagttgtcgt agactcggtg gagtatgact ttcacctctt
      361 acctagtggg ataatcaacc caaatgtcac tgccttcatt ggcaatggag tggtaattca
      421 tcttcctgga ctgtttgaag aagcagagaa aaatgttcaa aaggggaaag gtctagatgg
      481 ctgggaaaaa aggcttatca tatcggacag agctcatatt gtgtttgact ttcatcaagc
      541 agctgatggt atccaggaac agcagagaca agagcaagca ggaaaaaatt tgggtaccac
      601 gaaaaagggt atcggccctg tatattcctc taaagctgct cggagtggac ttcggatgtg
      661 tgatcttgtt tctgacttcg atggcttctc tgagaggttc aaagttctag ctaaccagta
      721 taaatctata tatccgactt tggaaataga cattgaaggt gaattacaac aactcaaggg
      781 ttatatggaa aggattaaac cgatggtgag agatggagtt tatttcctat atgaggccct
      841 ccatggaccc cccaagaaaa tcttggtaga aggtgcgaac gcagcactgt tagatattga
      901 ctttggaact tacccttttg taacctcttc aaactgcact gttggaggtg tctgtacagg
      961 tctgggtatg ccccctcaaa atgttggaga agtgtatgga gttgtgaaag cttacaccac
     1021 tagagttggg attggtgcct ttcccacaga gcaagacaat gaaattggag aattattaca
     1081 aacacggggt agagaatttg gagtaactac tgggaggaaa agaagatgcg gctggttgga
     1141 ccttgtctta ctcaaatacg ctcacatgat caatggattt actgcgttgg cccttaccaa
     1201 gttggatatt ttggatatgt ttacggagat caaagtcgga gttgcttaca aattagatgg
     1261 ggaaaccata cctcatttcc cagcaaacca agaagtctta aataaagtgg aagttcagta
     1321 taagactctc ccaggatgga acacagatat atctaatgca aggacattta aggagctacc
     1381 tgtcaatgca caaaattatg ttcggtttat tgaagatgag cttcaaatac cagttaaatg
     1441 gattggtgtg ggtaaatcca gagagtccat gattcagctc ttctaaggac tgccagcaat
     1501 gcaagagaca ttccttgaga ggacttatac atttctctgt gacctacaaa ttcaagaata
     1561 aagacattga agtgcgtttt cagctggcat tggtttgcag tctctggtgg acggatggct
     1621 gtcatggctg gcctggcgct ctccccagct tccagatggc ctggctgcca catctgttgc
     1681 tctgctgctc gtggtgccgc acagtccttt ccatggttag taactatgta tccccgtttg
     1741 acatctagaa cttgcagcct tgcttttctt cattatggcc attgtgtttg agttttacaa
     1801 ctagatggta agaacaatta atgcagtttt gcacaaatat ttttacattc tgatcattca
     1861 cttctgccat tgtaatcttt gctgttaggg aaaaaatgat ggaaagataa gtgttctgtc
     1921 aacttttgta atgctacaaa ttctgtttaa attgtgaact gctttttttc tgctgagacc
     1981 attgcaaaat tgagctttgg tagggtgagg ggagtatgtt catgggactt ttaatttgta
     2041 tagaacacag aacttagttc tctctgcaat ttatttaata cattaaattg agtgttcaaa
     2101 aagagagaga gagagagaga aatgtttccc tacaataaca atcttaatgt tggaaaataa
     2161 ttaaaaaaaa atctgttgtg atatttggtg gatatttttc tttgttttgc agatatgagc
     2221 tcaatgtata tcttttcact ttctttttta agcatactgt tgtttctaag accgtgggtt
     2281 tgcttccagc attccatctg ccagtatacc tacaaaatga cccttaagta acccacacaa
     2341 gtccaagttg tcagccagaa ttttgatcat gccttcattc ctcctttctt gaaaaagcaa
     2401 agaggtatta cctgacactt aggctatatg ttgtgctgag attatccttc atgaaccatt
     2461 aaatgtttaa ttaggtatca cttgagatta ttttattata ccatcaatag ctgattaaaa
     2521 ggaaccaaat atttccagt
//
