LOCUS       NM_001130503            1952 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus adenylosuccinate lyase (Adsl), mRNA.
ACCESSION   NM_001130503 XM_001076341 XM_235496
VERSION     NM_001130503.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1952)
  AUTHORS   Camici M, Micheli V, Ipata PL and Tozzi MG.
  TITLE     Pediatric neurological syndromes and inborn errors of purine
            metabolism
  JOURNAL   Neurochem Int 56 (3), 367-378 (2010)
   PUBMED   20005278
  REMARK    Review article
REFERENCE   2  (bases 1 to 1952)
  AUTHORS   Lee P and Colman RF.
  TITLE     Expression, purification, and characterization of stable,
            recombinant human adenylosuccinate lyase
  JOURNAL   Protein Expr Purif 51 (2), 227-234 (2007)
   PUBMED   16973378
REFERENCE   3  (bases 1 to 1952)
  AUTHORS   Tabucchi A, Carlucci F, Rosi F, Guerranti R and Marinello E.
  TITLE     Determination, activity and biological role of adenylosuccinate
            lyase in blood cells
  JOURNAL   Biomed Pharmacother 55 (5), 277-283 (2001)
   PUBMED   11428554
REFERENCE   4  (bases 1 to 1952)
  AUTHORS   Kmoch S, Hartmannova H, Stiburkova B, Krijt J, Zikanova M and
            Sebesta I.
  TITLE     Human adenylosuccinate lyase (ADSL), cloning and characterization
            of full-length cDNA and its isoform, gene structure and molecular
            basis for ADSL deficiency in six patients
  JOURNAL   Hum Mol Genet 9 (10), 1501-1513 (2000)
   PUBMED   10888601
REFERENCE   5  (bases 1 to 1952)
  AUTHORS   Stepinski J, Pawelczyk T, Bizon D and Angielski S.
  TITLE     Purine nucleotide cycle in rat renal cortex and medulla under
            conditions that mimic normal and low oxygen supply
  JOURNAL   Kidney Int 50 (4), 1195-1201 (1996)
   PUBMED   8887278
REFERENCE   6  (bases 1 to 1952)
  AUTHORS   Jenkins RL, McDaniel HG, Digerness S, Parrish SW and Ong RL.
  TITLE     Adenine nucleotide metabolism in hearts of diabetic rats.
            Comparison to diaphragm, liver, and kidney
  JOURNAL   Diabetes 37 (5), 629-636 (1988)
   PUBMED   3360219
REFERENCE   7  (bases 1 to 1952)
  AUTHORS   Reed VL, Mack DO and Smith LD.
  TITLE     Adenylosuccinate lyase as an indicator of breast and prostate
            malignancies: a preliminary report
  JOURNAL   Clin Biochem 20 (5), 349-351 (1987)
   PUBMED   3690833
REFERENCE   8  (bases 1 to 1952)
  AUTHORS   Casey PJ and Lowenstein JM.
  TITLE     Purification of adenylosuccinate lyase from rat skeletal muscle by
            a novel affinity column. Stabilization of the enzyme, and effects
            of anions and fluoro analogues of the substrate
  JOURNAL   Biochem J 246 (2), 263-269 (1987)
   PUBMED   3689310
REFERENCE   9  (bases 1 to 1952)
  AUTHORS   Mack,D.O., Lewis,E.M., Butler,E.M., Archer,W.H. and Smith,L.D.
  TITLE     A comparison of succinyladenylate lyase activity and serum sialic
            acid as markers of malignancy
  JOURNAL   Biochem Med 34 (3), 327-334 (1985)
   PUBMED   2937404
REFERENCE   10 (bases 1 to 1952)
  AUTHORS   Brand,L.M. and Lowenstein,J.M.
  TITLE     Effect of diet on adenylosuccinase activity in various organs of
            rat and chicken
  JOURNAL   J Biol Chem 253 (19), 6872-6878 (1978)
   PUBMED   690130
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473950.2.
            
            On or before Jul 27, 2008 this sequence version replaced
            XM_001076341.1, XM_235496.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1952
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1952
                     /gene="Adsl"
                     /note="adenylosuccinate lyase"
                     /db_xref="GeneID:315150"
                     /db_xref="RGD:1307617"
     exon            1..194
                     /gene="Adsl"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1496
                     /gene="Adsl"
                     /EC_number="4.3.2.2"
                     /codon_start=1
                     /product="adenylosuccinate lyase"
                     /protein_id="NP_001123975.1"
                     /db_xref="GeneID:315150"
                     /db_xref="RGD:1307617"
                     /translation="MAASGDPACAESYRSPLAARYASHEMCFLFSDRYKFQTWRQLWL
                     WLAEAEQTLGLPITDEQIQEMRSNLSNIDFQMAAEEEKRLRHDVMAHVHTFGHCCPKA
                     AGIIHLGATSCYVGDNTDLIILRNAFDLLLPKLARVISRLADFAKERADLPTLGFTHF
                     QPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDELRFRGVKGTTGTQASFLQLFEGDHQK
                     VEQLDKMVTEKAGFKRAYIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLK
                     EMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMSLTMDPLQTASVQWFERTLDDS
                     ANRRICLAEAFLTADTILTTLQNVSEGLVLYPKVIERRIRQELPFMATENIIMAMVKA
                     GGSRQDCHEKIRVLSQQAAAVVKQEGGDNDLIERIRADAYFSPIHSQLEQLLDPSSFT
                     GRAPQQVHRFLEEEVYPLLKPYGSVMAVKAELCL"
     exon            195..398
                     /gene="Adsl"
                     /inference="alignment:Splign:2.1.0"
     exon            399..443
                     /gene="Adsl"
                     /inference="alignment:Splign:2.1.0"
     exon            444..523
                     /gene="Adsl"
                     /inference="alignment:Splign:2.1.0"
     exon            524..695
                     /gene="Adsl"
                     /inference="alignment:Splign:2.1.0"
     exon            696..742
                     /gene="Adsl"
                     /inference="alignment:Splign:2.1.0"
     exon            743..833
                     /gene="Adsl"
                     /inference="alignment:Splign:2.1.0"
     exon            834..903
                     /gene="Adsl"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1051
                     /gene="Adsl"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1142
                     /gene="Adsl"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1232
                     /gene="Adsl"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1409
                     /gene="Adsl"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1952
                     /gene="Adsl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgctactg aagtccgccg tagctgagtc gcgtgttgaa aatggctgca tccggggacc
       61 ctgcctgtgc tgaaagctac cgttctccgc tggcggctcg ctacgccagc catgaaatgt
      121 gcttcttgtt cagcgacagg tacaagttcc agacgtggcg gcagctgtgg ctgtggctgg
      181 cggaggccga acagacactg ggtttgccta tcacggatga acagatccag gagatgaggt
      241 cgaacctgag caacattgac ttccagatgg cagctgagga agagaagcgc ctgcggcacg
      301 acgtgatggc tcatgtgcac acgtttggcc actgctgtcc gaaagctgct ggcatcatcc
      361 atcttggagc cacctcctgc tatgttggag acaatacgga cttgattatt ctgagaaatg
      421 catttgacct gcttttacca aagcttgcta gagtgatctc gaggcttgcc gactttgcta
      481 aggaacgtgc tgatctgccc acattaggtt tcacacactt tcagcctgct cagctgacca
      541 cggttgggaa acgctgctgc ctttggattc aagatctctg catggatctt cagaacttga
      601 agcgtgtccg agatgagctg cgcttccgag gagtgaaggg caccactggc acgcaggcca
      661 gcttcttgca gctcttcgag ggggatcacc agaaggtgga gcagctggac aagatggtga
      721 cagaaaaggc agggtttaaa agagcttaca tcatcacagg acagacctac acacggaaag
      781 tggacatcga agtgctgtct gtgctggcca gcctaggggc gtcagtgcac aagatttgca
      841 ctgacattcg cctactggcg aacctgaagg agatggagga accctttgag aagcagcaga
      901 ttggttccag tgcgatgccg tacaagcgga accccatgcg ctccgaacgt tgctgcagct
      961 tggctcgtca cctgatgtcc cttaccatgg acccactaca gacagcttct gtgcagtggt
     1021 ttgaacgtac cctggatgat agtgccaacc gacggatctg tttggctgaa gcatttctca
     1081 ctgcagacac tatattaact actctacaga acgtctctga aggattggtg ctgtacccca
     1141 aggtaattga acggcgcatt cggcaagagc ttcctttcat ggccacagag aacattatca
     1201 tggcaatggt caaagccggg ggcagccgac aggactgtca tgagaaaatt agagtgcttt
     1261 cccagcaggc agctgctgtg gttaagcagg aagggggtga caatgacctt atagagcgca
     1321 ttcgggcaga tgcctacttc agccccattc actcacagtt ggaacaattg ttggacccct
     1381 cttctttcac tggccgagct ccccagcagg tccacagatt cctagaagag gaggtgtacc
     1441 ccctgctgaa gccctacgga agtgtgatgg cagtgaaggc ggagctgtgt ctgtagagga
     1501 gagaattatg gaagaaacct gatgagtctg ctaactacag tgttaaggaa ctagtgctgt
     1561 gttctgcagg gctcctttac ctgggtgtgg tacatactca ggaggcaggg acaaaggcag
     1621 gcagatctct gagttcaagg ccagcctggt ctacagagca agttccagga cagccagggc
     1681 tacacagaga aaccacatct ccaaaaagca aacaaacaaa aagaatgtat attaagaatg
     1741 tatacaggac tcacagcaga cagccatgca ttcttgtttt ctccagtctg ttgttgctga
     1801 gacaaaaatc tcactgtata tcacggacag acctggaaca cagaaatctg cctcatctcc
     1861 ccaatggcag gattaaaggt gttccccacc atgcctggct gttttctttt tttacagcaa
     1921 cgtaatctta gagaataatg tagctcacac tt
//
