LOCUS       NM_013108               2185 bp    mRNA    linear   ROD 11-JUN-2024
DEFINITION  Rattus norvegicus adrenoceptor beta 3 (Adrb3), mRNA.
ACCESSION   NM_013108
VERSION     NM_013108.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2185)
  AUTHORS   Xing,Y., Tian,T., Zhang,X., Yang,D., Zhang,C., Wang,M., Wang,Y.,
            Luo,T., Wang,Z., Wang,H. and Li,H.
  TITLE     ENDOGENOUS beta 3 -ADRENERGIC RECEPTOR ACTIVATION ALLEVIATES
            SEPSIS-INDUCED CARDIOMYOCYTE APOPTOSIS VIA PI3K/AKT SIGNALING
            PATHWAY
  JOURNAL   Shock 61 (6), 915-923 (2024)
   PUBMED   38662592
  REMARK    GeneRIF: ENDOGENOUS beta 3 -ADRENERGIC RECEPTOR ACTIVATION
            ALLEVIATES SEPSIS-INDUCED CARDIOMYOCYTE APOPTOSIS VIA PI3K/AKT
            SIGNALING PATHWAY.
REFERENCE   2  (bases 1 to 2185)
  AUTHORS   Zhu,J., Hou,B., Rong,H., Xu,K., Jiang,L., Yang,S., Zhu,H., Yang,H.,
            Jiao,Y., Liu,Y., Ni,K. and Ma,Z.
  TITLE     Blocking brown adipocyte beta3-adrenoceptor attenuates blood-spinal
            cord barrier impairment and chronic postsurgical pain in a rat
            model of preoperative stress
  JOURNAL   Int Immunopharmacol 128, 111530 (2024)
   PUBMED   38278068
  REMARK    GeneRIF: Blocking brown adipocyte beta3-adrenoceptor attenuates
            blood-spinal cord barrier impairment and chronic postsurgical pain
            in a rat model of preoperative stress.
REFERENCE   3  (bases 1 to 2185)
  AUTHORS   Cannavo,A., Jun,S., Rengo,G., Marzano,F., Agrimi,J., Liccardo,D.,
            Elia,A., Keceli,G., Altobelli,G.G., Marcucci,L., Megighian,A.,
            Gao,E., Feng,N., Kammers,K., Ferrara,N., Finos,L., Koch,W.J. and
            Paolocci,N.
  TITLE     beta3AR-Dependent Brain-Derived Neurotrophic Factor (BDNF)
            Generation Limits Chronic Postischemic Heart Failure
  JOURNAL   Circ Res 132 (7), 867-881 (2023)
   PUBMED   36884028
  REMARK    GeneRIF: beta3AR-Dependent Brain-Derived Neurotrophic Factor (BDNF)
            Generation Limits Chronic Postischemic Heart Failure.
REFERENCE   4  (bases 1 to 2185)
  AUTHORS   Balagova,L., Graban,J., Puhova,A. and Jezova,D.
  TITLE     Opposite Effects of Voluntary Physical Exercise on beta3-Adrenergic
            Receptors in the White and Brown Adipose Tissue
  JOURNAL   Horm Metab Res 51 (9), 608-617 (2019)
   PUBMED   31295748
  REMARK    GeneRIF: Voluntary exercise induced opposite changes in the gene
            expression of beta3-adrenergic receptors in the white and in the
            brown adipose tissue.
REFERENCE   5  (bases 1 to 2185)
  AUTHORS   Tuncay,E., Olgar,Y., Durak,A., Degirmenci,S., Bitirim,C.V. and
            Turan,B.
  TITLE     beta3 -adrenergic receptor activation plays an important role in
            the depressed myocardial contractility via both elevated levels of
            cellular free Zn2+ and reactive nitrogen species
  JOURNAL   J Cell Physiol 234 (8), 13370-13386 (2019)
   PUBMED   30613975
  REMARK    GeneRIF: Present data can emphasize the important deleterious
            effect of beta3 -AR activation in cardiac remodeling under
            pathological condition, at least, through a cross-link between
            beta3 -AR activation, NO-signaling, and [Zn(2+) ]i pathways.
REFERENCE   6  (bases 1 to 2185)
  AUTHORS   Susulic,V.S., Frederich,R.C., Lawitts,J., Tozzo,E., Kahn,B.B.,
            Harper,M.E., Himms-Hagen,J., Flier,J.S. and Lowell,B.B.
  TITLE     Targeted disruption of the beta 3-adrenergic receptor gene
  JOURNAL   J Biol Chem 270 (49), 29483-29492 (1995)
   PUBMED   7493988
REFERENCE   7  (bases 1 to 2185)
  AUTHORS   Clement,K., Vaisse,C., Manning,B.S., Basdevant,A., Guy-Grand,B.,
            Ruiz,J., Silver,K.D., Shuldiner,A.R., Froguel,P. and Strosberg,A.D.
  TITLE     Genetic variation in the beta 3-adrenergic receptor and an
            increased capacity to gain weight in patients with morbid obesity
  JOURNAL   N Engl J Med 333 (6), 352-354 (1995)
   PUBMED   7609752
REFERENCE   8  (bases 1 to 2185)
  AUTHORS   Rohlfs,E.M., Daniel,K.W., Premont,R.T., Kozak,L.P. and Collins,S.
  TITLE     Regulation of the uncoupling protein gene (Ucp) by beta 1, beta 2,
            and beta 3-adrenergic receptor subtypes in immortalized brown
            adipose cell lines
  JOURNAL   J Biol Chem 270 (18), 10723-10732 (1995)
   PUBMED   7738011
REFERENCE   9  (bases 1 to 2185)
  AUTHORS   Muzzin,P., Revelli,J.P., Kuhne,F., Gocayne,J.D., McCombie,W.R.,
            Venter,J.C., Giacobino,J.P. and Fraser,C.M.
  TITLE     An adipose tissue-specific beta-adrenergic receptor. Molecular
            cloning and down-regulation in obesity
  JOURNAL   J Biol Chem 266 (35), 24053-24058 (1991)
   PUBMED   1721063
REFERENCE   10 (bases 1 to 2185)
  AUTHORS   Granneman,J.G., Lahners,K.N. and Chaudhry,A.
  TITLE     Molecular cloning and expression of the rat beta 3-adrenergic
            receptor
  JOURNAL   Mol Pharmacol 40 (6), 895-899 (1991)
   PUBMED   1684635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1, M74716.1 and BQ189922.1.
            
            On Jul 31, 2012 this sequence version replaced NM_013108.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M74716.1, SRR26643285.50912.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680413
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream ORF predicted to
                                                inhibit translation from
                                                upstream AUG
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-923               JAXUCZ010000016.1  71544646-71545568
            924-1615            M74716.1           923-1614
            1616-2185           BQ189922.1         1-570               c
FEATURES             Location/Qualifiers
     source          1..2185
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.3"
     gene            1..2185
                     /gene="Adrb3"
                     /gene_synonym="ADRB"
                     /note="adrenoceptor beta 3"
                     /db_xref="GeneID:25645"
                     /db_xref="RGD:2061"
     exon            1..1383
                     /gene="Adrb3"
                     /gene_synonym="ADRB"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..1423
                     /gene="Adrb3"
                     /gene_synonym="ADRB"
                     /note="beta-3 adrenoceptor; adrenergic, beta-3-, receptor;
                     beta-3 adrenoreceptor; adrenergic receptor, beta 3"
                     /codon_start=1
                     /product="beta-3 adrenergic receptor"
                     /protein_id="NP_037240.2"
                     /db_xref="GeneID:25645"
                     /db_xref="RGD:2061"
                     /translation="MAPWPHKNGSLAFWSDAPTLDPSAANTSGLPGVPWAAALAGALL
                     ALATVGGNLLVITAIARTPRLQTITNVFVTSLATADLVVGLLVMPPGATLALTGHWPL
                     GATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGTLVTKRRARAAVVLVWI
                     VSATVSFAPIMSQWWRVGADAEAQECHSNPRCCSFASNMPYALLSSSVSFYLPLLVML
                     FVYARVFVVAKRQRRLLRRELGRFPPEESPRSPSRSPSPATVGTPTASDGVPSCGRRP
                     ARLLPLGEHRALRTLGLIMGIFSLCWLPFFLANVLRALVGPSLVPSGVFIALNWLGYA
                     NSAFNPLIYCRSPDFRDAFRRLLCSYGGRGPEEPRVVTFPASPVASRQNSPLNRFDGY
                     EGERPFPT"
     exon            1384..1451
                     /gene="Adrb3"
                     /gene_synonym="ADRB"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..2167
                     /gene="Adrb3"
                     /gene_synonym="ADRB"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctctcttgt gactattgga cgctgctcct ttaaaagcag ccactcctcc tggcttctag
       61 ggtgtggggg tgggggctga gatggaggga agctgacaga attacctcaa caattaggga
      121 agatggacca ggctggaaaa gtcgctccca agccctaatg tccccttccc taagccagcg
      181 ggtctggggg gaaaacttcc catcccagac gcgacacgag atggctccgt ggcctcacaa
      241 aaacggctct ctggctttct ggtcagacgc ccccaccttg gaccccagtg cagccaacac
      301 cagtgggttg ccaggggtgc catgggcagc ggcattggct ggagcattgc tggcgctggc
      361 cacggtggga ggcaacctgc tggtaatcac agctatcgcc cgcacgccga gactacagac
      421 cataaccaac gtgttcgtga cttcgctggc cacagctgac ttggtagtgg gactcctcgt
      481 aatgccacca ggggccacat tggcgctgac tggccactgg cccttgggcg caactggctg
      541 cgagctgtgg acgtcagtgg acgtgctctg tgtaactgcc agcatcgaga ccctgtgcgc
      601 cctggctgta gaccgctacc tagccgtcac caaccctctg cgttacggca cgctggttac
      661 caagcgccgc gcccgggcgg cagtagtcct ggtgtggatc gtgtccgcca ccgtgtcctt
      721 tgcgcccatc atgagccagt ggtggcgtgt aggggcagac gctgaggcgc aagagtgtca
      781 ctccaatccg cgctgctgtt cctttgcctc caatatgccc tacgcgctgc tctcctcctc
      841 cgtctccttc taccttcccc tccttgtgat gctcttcgtc tatgctcgag tgttcgtcgt
      901 agctaagcgc cagcggcgtt tgctgcgccg ggagctgggc cgttttccgc ccgaggagtc
      961 tccgcggtct ccgtcgcgct ctccatcccc tgccacagtc gggacaccca cggcatcgga
     1021 tggagtgccc tcctgcgggc ggcggcctgc gcgcctccta ccgctcgggg aacaccgcgc
     1081 cctgcgcacc ttgggtctca ttatgggcat cttctctctg tgctggctgc ccttctttct
     1141 ggccaacgtg ctgcgcgcac tcgtggggcc ctccctagtt cccagcggag ttttcatcgc
     1201 cctgaactgg ttgggctatg ccaactctgc cttcaacccg ctcatctact gccgcagccc
     1261 ggactttcgc gacgccttcc gtcgtcttct gtgcagctac ggtggccgtg gaccggaaga
     1321 gccacgcgtg gtcaccttcc cagctagccc tgttgcgtcc aggcagaact caccgctcaa
     1381 caggtttgat ggctatgaag gtgagcgtcc atttcccaca tgaaggacca tggagatcta
     1441 gcaaggagcc tgacttctgg agaaattttt ttttaagaca gaaagacaag caacgtccat
     1501 ggatgcaaac tttttataca gcccttgatt tctgctcaga gtgagttccc aggaaccgca
     1561 actctccaga accaatgact agaccacaga atgtaaaggg gaaatcttac caaatgggtt
     1621 ttaccatctt ctctctcttt ctgagagacg ttgtctagga tccaccttga acttcgctac
     1681 tacctcagcc gccgggatat caggccaccc gtgcttgact gccctgggag gagctgcgtt
     1741 cccaccacca ccctgcttat tatgtttgtg ctggatgctt agggctaaga aagcaccctt
     1801 acctacctcc cttcctactg ctttcctgac cccatgaatg acttttgtct ccacaaatca
     1861 ctctgtctcc aggttctgtg ttcccagtct ctgtgtctct ggttagttgg aaagcaggaa
     1921 acccggcggg ggaggcgggg gaggggggga acgaccaagt ttgaggtttt gtccctggct
     1981 cctcactaca gctctctaaa catcatcttg gaccatctct cacaataggc acaaaacagc
     2041 tctaatctac ctcactctta ggacttcaag gtttgggaga aattccaggg ttcctgggaa
     2101 gaagtcaaac cattggaatg ggtccctttt ccacttaaaa tcaaattaat aaatattatt
     2161 gaatgtgaaa aaaaaaaaaa aaaaa
//
