LOCUS       NM_012701               3012 bp    mRNA    linear   ROD 08-AUG-2024
DEFINITION  Rattus norvegicus adrenoceptor beta 1 (Adrb1), mRNA.
ACCESSION   NM_012701 XM_001063787
VERSION     NM_012701.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3012)
  AUTHORS   Al Katat,A., Zhao,J., Calderone,A. and Parent,L.
  TITLE     Sympathetic Stimulation Upregulates the Ca2+ Channel Subunit,
            CaValpha2delta1, via the beta1 and ERK 1/2 Pathway in Neonatal
            Ventricular Cardiomyocytes
  JOURNAL   Cells 11 (2), 188 (2022)
   PUBMED   35053304
  REMARK    GeneRIF: Sympathetic Stimulation Upregulates the Ca(2+) Channel
            Subunit, CaValpha2delta1, via the beta1 and ERK 1/2 Pathway in
            Neonatal Ventricular Cardiomyocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3012)
  AUTHORS   Alves Barreto,A.E., Balera Brito,V.G., Patrocinio,M.S.,
            Ballassoni,B.B., Tfaile Frasnelli,S.C. and Penha Oliveira,S.H.
  TITLE     beta1-adrenergic receptor but not beta2 mediates osteogenic
            differentiation of bone marrow mesenchymal stem cells in
            normotensive and hypertensive rats
  JOURNAL   Eur J Pharmacol 911, 174515 (2021)
   PUBMED   34555397
  REMARK    GeneRIF: beta1-adrenergic receptor but not beta2 mediates
            osteogenic differentiation of bone marrow mesenchymal stem cells in
            normotensive and hypertensive rats.
REFERENCE   3  (bases 1 to 3012)
  AUTHORS   Cao,H., Hu,Y., Zhu,X., Yao,N., Gu,J., Wang,Y. and Zhu,W.
  TITLE     O-GlcNAc transferase affects the signal transduction of beta1
            adrenoceptor in adult rat cardiomyocytes by increasing the
            O-GlcNAcylation of beta1 adrenoceptor
  JOURNAL   Biochem Biophys Res Commun 528 (1), 71-77 (2020)
   PUBMED   32471715
  REMARK    GeneRIF: O-GlcNAc transferase affects the signal transduction of
            beta1 adrenoceptor in adult rat cardiomyocytes by increasing the
            O-GlcNAcylation of beta1 adrenoceptor.
REFERENCE   4  (bases 1 to 3012)
  AUTHORS   Wang,L., Ning,N., Wang,C., Hou,X., Yuan,Y., Ren,Y., Sun,C., Yan,Z.,
            Wang,X. and Liu,H.
  TITLE     Endoplasmic reticulum stress contributed to beta1-adrenoceptor
            autoantibody-induced reduction of autophagy in cardiomyocytes
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 51 (10), 1016-1025 (2019)
   PUBMED   31553425
  REMARK    GeneRIF: These results showed that prolonged action of adrenoceptor
            beta 1- autoantibodys significantly reduced the autophagy of
            myocardial tissues and H9c2 cardiomyocytes, and endoplasmic
            reticulum stress and its related apoptotic pathways were
            significantly activated.
REFERENCE   5  (bases 1 to 3012)
  AUTHORS   Nash,C.A., Wei,W., Irannejad,R. and Smrcka,A.V.
  TITLE     Golgi localized beta1-adrenergic receptors stimulate Golgi PI4P
            hydrolysis by PLCepsilon to regulate cardiac hypertrophy
  JOURNAL   Elife 8, e48167 (2019)
   PUBMED   31433293
  REMARK    GeneRIF: The authors demonstrate that endogenous beta1-adrenergic
            receptors at the Golgi apparatus in cardiac myocytes are required
            to stimulate hypertrophic Epac/PLCe-dependent phosphatidylinositol
            4-phosphate hydrolysis at the Golgi, and that these intracellular
            beta1-adrenergic receptors can be accessed by physiological
            neurotransmitters, and synthetic b-blockers and agonists.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3012)
  AUTHORS   Sala,R., Moriggi,E., Della Bella,D. and Carenzi,A.
  TITLE     The specific binding of broxaterol, a new beta 2-selective agonist,
            to beta-adrenoceptors
  JOURNAL   Eur J Pharmacol 203 (1), 17-23 (1991)
   PUBMED   1686765
REFERENCE   7  (bases 1 to 3012)
  AUTHORS   Steinfath,M., Geertz,B., Schmitz,W., Scholz,H., Haverich,A.,
            Breil,I., Hanrath,P., Reupcke,C., Sigmund,M. and Lo,H.B.
  TITLE     Distinct down-regulation of cardiac beta 1- and beta
            2-adrenoceptors in different human heart diseases
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 343 (2), 217-220 (1991)
   PUBMED   1648674
REFERENCE   8  (bases 1 to 3012)
  AUTHORS   Shimomura,H. and Terada,A.
  TITLE     Primary structure of the rat beta-1 adrenergic receptor gene
  JOURNAL   Nucleic Acids Res 18 (15), 4591 (1990)
   PUBMED   2167473
REFERENCE   9  (bases 1 to 3012)
  AUTHORS   Machida,C.A., Bunzow,J.R., Searles,R.P., Van Tol,H., Tester,B.,
            Neve,K.A., Teal,P., Nipper,V. and Civelli,O.
  TITLE     Molecular cloning and expression of the rat beta 1-adrenergic
            receptor gene
  JOURNAL   J Biol Chem 265 (22), 12960-12965 (1990)
   PUBMED   1695899
REFERENCE   10 (bases 1 to 3012)
  AUTHORS   Rothwell,N.J., Stock,M.J. and Sudera,D.K.
  TITLE     Beta-adrenoreceptors in rat brown adipose tissue: proportions of
            beta 1- and beta 2-subtypes
  JOURNAL   Am J Physiol 248 (4 Pt 1), E397-E402 (1985)
   PUBMED   2858976
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Sep 13, 2022 this sequence version replaced NM_012701.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR26643289.4869.1, SRR26643299.7816.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3012              JAXUCZ010000001.1  265777103-265780114
FEATURES             Location/Qualifiers
     source          1..3012
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..3012
                     /gene="Adrb1"
                     /gene_synonym="B1AR; RATB1AR"
                     /note="adrenoceptor beta 1"
                     /db_xref="GeneID:24925"
                     /db_xref="RGD:2059"
     exon            1..3012
                     /gene="Adrb1"
                     /gene_synonym="B1AR; RATB1AR"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..1656
                     /gene="Adrb1"
                     /gene_synonym="B1AR; RATB1AR"
                     /note="beta-1 adrenoceptor; beta-1 adrenoreceptor; beta
                     1-adrenergic receptor beta 1-AR; adrenergic receptor, beta
                     1; adrenergic, beta-1-, receptor"
                     /codon_start=1
                     /product="beta-1 adrenergic receptor"
                     /protein_id="NP_036833.2"
                     /db_xref="GeneID:24925"
                     /db_xref="RGD:2059"
                     /translation="MGAGALALGASEPCNLSSAAPLPDGAATAARLLVLASPPASLLP
                     PASEGSAPLSQQWTAGMGLLLALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLAS
                     ADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAI
                     TSPFRYQSLLTRARARALVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDF
                     VTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLSGPPRPPSPA
                     PSPSPGPPRPADSLANGRSSKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANV
                     VKAFHRDLVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAACRRRA
                     AHGDRPRASGCLARAGPPPSPGAPSDDDDDDAGATPPARLLEPWAGCNGGTTTVDSDS
                     SLDEPGRQGFSSESKV"
ORIGIN      
        1 agaaacatgc tgaggtcccg gcggctcttc cagcagcgac agcggctcca gcagcagcgg
       61 cggcggcggc ggcggcgaca gcgcttggct acggaggaga aggcgcccgg cgtccatgcc
      121 tccggcccca agccgcggct gccctgacct ggccgcgacc tccccgcgcg ggccccgcag
      181 ccccggctcc tggggtgctt cccaggcgcg gcccagtccc gccacacccc ccgcccccgg
      241 cctccgaagc tcggcatggg cgcgggggcg ctcgccctgg gcgcctccga accctgcaac
      301 ctgtcgtcgg ccgcgccgct gcccgacggc gcggccaccg cggcacgact gctggtgctc
      361 gcgtcgcctc ccgcctcgct gctgcctcca gccagcgagg gctcagcgcc gctgtcgcag
      421 cagtggaccg cgggtatggg cctactcctg gcgctcatcg tgctgctcat cgtagtgggc
      481 aacgtgttgg tgatcgtggc catcgccaag accccgcggc tgcagacgct caccaacctc
      541 ttcatcatgt ccctggccag cgccgatctg gtcatgggac tgctggtggt gcctttcggg
      601 gccaccattg tggtgtgggg ccgctgggag tacggctcct tcttctgtga gctctggact
      661 tcggtagacg tgctatgtgt gacggccagc atcgagaccc tgtgtgtcat cgccctggac
      721 cgctacctcg ccatcacgtc gccctttcgc taccagagcc tgctgacgcg cgcgcgagcg
      781 cgggccctcg tgtgcacagt gtgggccatc tccgcgctgg tgtccttcct gcccatcctc
      841 atgcactggt ggcgggccga gagcgacgaa gcgcgccgct gctacaacga ccccaagtgc
      901 tgcgatttcg tcaccaaccg ggcctacgcc atcgcctcgt ccgtcgtctc cttctacgtg
      961 cccctgtgca tcatggcctt cgtgtacctc cgggtgttcc gcgaggccca gaaacaggtg
     1021 aagaagatcg acagctgcga gcgccgcttc ctcagcggcc cgccccggcc gccctcgccc
     1081 gcgccctcgc catcaccagg gccaccgcgc cccgcagact cgctggccaa cgggcgctcc
     1141 agcaagcggc ggccgtcgcg cctcgtggct ctgcgagagc agaaggcgct caagacactg
     1201 ggcatcatca tgggtgtgtt cacgctctgc tggctgccct tcttcctggc caacgtggtg
     1261 aaagctttcc accgcgacct ggtgccggat cgcctcttcg tcttcttcaa ctggctgggc
     1321 tacgccaact cggccttcaa ccccatcatc tactgccgca gccccgactt ccgcaaggct
     1381 ttccagcgcc tgctttgctg cgcgcgccgg gccgcctgca gacgccgcgc agcccacggg
     1441 gaccggccgc gcgcctcggg ctgcctggcg agagctgggc cgccgccgtc ccccggggct
     1501 ccttcggacg acgacgacga tgacgccggg gccaccccac ccgcgcgcct gttggagccc
     1561 tgggccggct gcaacggcgg gacgaccact gtggacagcg attcgagcct ggacgagccg
     1621 ggacgccagg gcttctcctc cgagtccaag gtgtagaggg ccaggctctc cgggcgcacg
     1681 gacgccgctc cccatagtcc cgggctggac acgggctctg catccctaga ggaagagagc
     1741 ccgcctgggc gcccctgagc cgctccccag gggagagagg aggtttctgt ttactcaaga
     1801 ccgaaagcag gtgaatgcga agcccacaga tcttttgaat catccgagac gtacagaaaa
     1861 gcccgggacc gagcgttgcg caaaaaggaa agtttgggag tagttgggag agtgtggctt
     1921 agtgtggctt actggcttgt cttgagttcc tttctctctg aggttcggcc tttcgtgtgt
     1981 ttaatgcacc tttaggcacc ccccccccgt gggttttgac actttctgca aggacccgag
     2041 tggaaactag gaggggaggg gaagggggag ggtggagtct atcacctggc cttctgactt
     2101 cacacctagg aacctaagtg ttcagctctg gtttggggtg ggggcaggag cggtgataat
     2161 tagccaggaa gtgtttcctt ttgctttcta aagaaattgc atattaattc cggagtattg
     2221 gtgtctcctt aaagcaaagg ggggaaaggt ggctgagaaa cagaccaatc tggtttcgag
     2281 aaactatttg tggagcacgg ttcaccttgc tttctcctgg agggcaaacc ctgtcccctg
     2341 cgcgcctcgg tggtcctgct gtgggtcctc tacctcactc tgtgcatatt gcacagcaag
     2401 atagaaagac ttgtttatat taaacagctt atttatgtat caatattagt tggaaggacc
     2461 aggcgctgag tctctctctg tgacatgtga ttctgtcaac taaagatagg acagaacaaa
     2521 aggaaacagt tgggattatt gcacatgtgg ctaaaaacaa agatgacaaa aaaaaaaaag
     2581 gcagtggttg aaaggccatt ttgcacagtg ttagacattg taaaatccat agaagttgtt
     2641 aacttgcaca aaaaattaaa tatttttaat gggacgggga ggtgggcaga tctttaaaat
     2701 gctaaaaaat aaaattcaaa ctcagtttct cttgtctatt atgttattga gttgatgatt
     2761 tattgggaaa tcacttttta tactcttatc atggtactgt aactgtatcc atattataaa
     2821 tattattatc ttacgtattt ttattataat tttttaatgt ccaagtgccc acgtgaatct
     2881 gctggtaaaa tttagcattc gtgtgtatat tctatctctt cttgtgtgtg tgaccaagta
     2941 tttatactct ggtgcgacta agtaccatgt ggggaattgg tccatgtgca ataaagcagc
     3001 agtgcagcgc aa
//
