LOCUS       NM_138506               1963 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus adrenoceptor alpha 2C (Adra2c), mRNA.
ACCESSION   NM_138506
VERSION     NM_138506.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1963)
  AUTHORS   Altamirano-Espinoza,A.H., Manrique-Maldonado,G.,
            Marichal-Cancino,B.A. and Villalon,C.M.
  TITLE     Specific role of alpha2A - and alpha2B -, but not alpha2C -,
            adrenoceptor subtypes in the inhibition of the vasopressor
            sympathetic out-flow in diabetic pithed rats
  JOURNAL   Basic Clin Pharmacol Toxicol 117 (1), 31-38 (2015)
   PUBMED   25407049
  REMARK    GeneRIF: Report specific roles of alpha2A - and alpha2B -, but not
            alpha2C -, adrenoceptor subtypes in the inhibition of the
            vasopressor sympathetic out-flow in diabetic pithed rats.
REFERENCE   2  (bases 1 to 1963)
  AUTHORS   Snoeren,E.M.
  TITLE     The role of adrenoceptors in the central nervous system in male and
            female rat sexual behavior
  JOURNAL   Eur J Pharmacol 753, 229-245 (2015)
   PUBMED   25218984
  REMARK    GeneRIF: new data suggest that alpha2-adrenoceptors play no major
            role on any indices of female sexual behavior.
            Review article
REFERENCE   3  (bases 1 to 1963)
  AUTHORS   Barra,R., Soto-Moyano,R., Valladares,L., Morgan,C., Perez,H.,
            Burgos,H., Olivares,R., Saez-Briones,P., Laurido,C. and
            Hernandez,A.
  TITLE     Knockdown of alpha2C-adrenoceptors in the occipital cortex rescued
            long-term potentiation in hidden prenatally malnourished rats
  JOURNAL   Neurobiol Learn Mem 98 (3), 228-234 (2012)
   PUBMED   22892388
  REMARK    GeneRIF: the deleterious effect of prenatal malnutrition on
            neocortical plasticity in the adult progeny is in part consequence
            of increased neocortical alpha(2C)-adrenoceptor expression
REFERENCE   4  (bases 1 to 1963)
  AUTHORS   Alachkar,A., Brotchie,J.M. and Jones,O.T.
  TITLE     Changes in the mRNA levels of alpha2A and alpha2C adrenergic
            receptors in rat models of Parkinson's disease and L-DOPA-induced
            dyskinesia
  JOURNAL   J Mol Neurosci 46 (1), 145-152 (2012)
   PUBMED   21562737
  REMARK    GeneRIF: In 6-OHDA-lesioned rats, there was no change in alpha2C
            adrenoceptor expression in the rostral or caudal striatum in which
            the highest density of alpha2C mRNA is present.
REFERENCE   5  (bases 1 to 1963)
  AUTHORS   Moura,E., Pinto,C.E., Calo,A., Serrao,M.P., Afonso,J. and
            Vieira-Coelho,M.A.
  TITLE     alpha-Adrenoceptor-mediated inhibition of catecholamine release
            from the adrenal medulla of spontaneously hypertensive rats is
            preserved in the early stages of hypertension
  JOURNAL   Basic Clin Pharmacol Toxicol 109 (4), 253-260 (2011)
   PUBMED   21518261
  REMARK    GeneRIF: During the development of hypertension, adrenal alpha(2)
            -adrenoceptor inhibitory function is conserved, accompanied by
            reduced noradrenaline release and unchanged adrenaline release in
            spontaneously hypertensive rats.
REFERENCE   6  (bases 1 to 1963)
  AUTHORS   Philipp,M., Brede,M. and Hein,L.
  TITLE     Physiological significance of alpha(2)-adrenergic receptor subtype
            diversity: one receptor is not enough
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 283 (2), R287-R295 (2002)
   PUBMED   12121839
  REMARK    Review article
REFERENCE   7  (bases 1 to 1963)
  AUTHORS   Lee,A., Rosin,D.L. and Van Bockstaele,E.J.
  TITLE     Ultrastructural evidence for prominent postsynaptic localization of
            alpha2C-adrenergic receptors in catecholaminergic dendrites in the
            rat nucleus locus coeruleus
  JOURNAL   J Comp Neurol 394 (2), 218-229 (1998)
   PUBMED   9552127
REFERENCE   8  (bases 1 to 1963)
  AUTHORS   Lanier,S.M., Downing,S., Duzic,E. and Homcy,C.J.
  TITLE     Isolation of rat genomic clones encoding subtypes of the alpha
            2-adrenergic receptor. Identification of a unique receptor subtype
  JOURNAL   J Biol Chem 266 (16), 10470-10478 (1991)
   PUBMED   1645350
REFERENCE   9  (bases 1 to 1963)
  AUTHORS   Flordellis,C.S., Handy,D.E., Bresnahan,M.R., Zannis,V.I. and
            Gavras,H.
  TITLE     Cloning and expression of a rat brain alpha 2B-adrenergic receptor
  JOURNAL   Proc Natl Acad Sci U S A 88 (3), 1019-1023 (1991)
   PUBMED   1704126
REFERENCE   10 (bases 1 to 1963)
  AUTHORS   Voigt,M.M., McCune,S.K., Kanterman,R.Y. and Felder,C.C.
  TITLE     The rat alpha 2-C4 adrenergic receptor gene encodes a novel
            pharmacological subtype
  JOURNAL   FEBS Lett 278 (1), 45-50 (1991)
   PUBMED   1704314
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Jul 29, 2021 this sequence version replaced NM_138506.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: M58316.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1963              JAXUCZ010000014.1  79695514-79697476   c
FEATURES             Location/Qualifiers
     source          1..1963
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1963
                     /gene="Adra2c"
                     /note="adrenoceptor alpha 2C"
                     /db_xref="GeneID:24175"
                     /db_xref="RGD:2058"
     exon            1..1963
                     /gene="Adra2c"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1467
                     /gene="Adra2c"
                     /note="alpha-2C adrenoceptor; alpha-2C adrenoreceptor;
                     alpha-2 adrenergic receptor subtype C4; alpha-2CAR;
                     Adrenergic, alpha2C-, receptor class I; adrenergic,
                     alpha-2C-, receptor; Adrenergic alpha2C- receptor class I;
                     adrenergic receptor, alpha 2c"
                     /codon_start=1
                     /product="alpha-2C adrenergic receptor"
                     /protein_id="NP_612515.2"
                     /db_xref="GeneID:24175"
                     /db_xref="RGD:2058"
                     /translation="MASPALAAALAAAAAEGPNGSDAGEWGSGGGANASGTDWGPPPG
                     QYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVAT
                     LVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYN
                     LKRTPRRVKATIVAVWLISAVISFPPLVSFYRRPDGAAYPQCGLNDETWYILSSCIGS
                     FFAPCLIMGLVYARIYRVAKLRTRTLSEKRGPAGPDGASPTTENGLGKAAGENGHCAP
                     PRTEVEPDESSAAERRRRRGALRRGGRRREGAEGDTGSADGPGPGLAAEQGARTASRS
                     PGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWF
                     PFFFSYSLYGICREACQLPEPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFR
                     RRRRGFRQ"
ORIGIN      
        1 gatgcagacg ccgactctgg ctatggggcg cccgagctgc ggaggctgcg ccccggctcc
       61 tggcaggacc gcgtagctct cgggaggacc atggcgtccc cagcgctggc cgcggcgctg
      121 gcggcggcgg cggctgaggg ccccaacggg agcgacgcgg gcgaatgggg tagcggcggg
      181 ggtgccaatg cctcggggac cgactgggga ccaccgccgg gccagtactc cgcaggtgct
      241 gtggcagggc tggcagccgt ggtgggtttc ctcatcgttt tcaccgtggt gggcaacgtg
      301 ctcgtggtga tcgctgtgtt gacaagccga gcgctgcgcg ccccgcagaa cctcttcctg
      361 gtgtctctgg cctcagctga catcctggtg gccacactgg tcatgccctt ttcgctggcc
      421 aatgagctca tggcctactg gtactttggg caagtgtggt gtggtgtgta cctggcactg
      481 gacgtgctct tctgcacctc gtccatcgtg cacctgtgtg ccattagcct ggaccgctac
      541 tggtcggtga cgcaagcggt agagtacaac ctgaagcgca cgccacgccg tgtcaaggcc
      601 accatcgtgg ccgtgtggct catctcggct gtcatctcct tcccgcctct cgtctctttc
      661 taccgccggc ccgacggcgc cgcctacccg cagtgcggcc tcaacgatga gacctggtac
      721 atcttgtcct cctgcatagg ctccttcttc gcgccctgcc tcatcatggg cctggtctat
      781 gcgcgcatct accgcgtggc caagctgcgc acgcgtacgc tcagcgagaa acgcggcccc
      841 gccggccccg acggcgcgtc cccgaccaca gagaatgggt tgggcaaggc ggcgggggag
      901 aatgggcatt gcgcgccccc gcgcactgaa gtggagccgg atgagagcag cgcggcagag
      961 aggcggaggc gccggggagc gctgcgcaga ggaggacggc ggcgagaggg tgccgagggg
     1021 gacacgggca gtgcggacgg accgggacct gggttggcgg ccgaacaggg tgctcggacg
     1081 gcgtctcggt ctccaggccc cggagggcgc ctgtcgcggg ccagctcgcg ctccgtcgag
     1141 ttcttcctgt cgcgtcggcg ccgggcgcgc agcagtgtgt gccgccgcaa ggtggcccag
     1201 gcgcgcgaga aacgcttcac cttcgtgttg gcggtggtca tgggcgtgtt cgtactgtgc
     1261 tggttcccct tcttcttcag ctacagcctg tatggcatct gccgtgaggc ctgccagctg
     1321 ccagaaccgc tctttaagtt tttcttctgg atcggctact gcaacagttc gctcaacccg
     1381 gtcatctata ctgtcttcaa tcaggacttc aggcgctctt tcaagcacat cctcttccgt
     1441 aggaggagaa ggggcttcag gcagtgaccc tctggctgcc tggacttggc cccactgacc
     1501 tcctggacag ctccgaactc gggtagatag ggggaccaac cagtgtggct tctccagagt
     1561 tccagggcgg acttcagggt acagtgtgga atgtggccag caggaactgg gagagagaca
     1621 actgggcctc tgggagtggg gaggagaaag ggagaccctt tgccttccca tctcagcgag
     1681 gggctgtggc tagatccagt tcctaagaag gcttctgtgg agtgtggctg tgaacttagt
     1741 tagggtttta gagctcagac aactgcacca gaaaggagac cccccccccc aactctcggt
     1801 cttccctgtg agcaagggct gacttcctat gacctgaaaa aggtatctgt ctgggggagg
     1861 agagatagca caggcaatct ctggttactg agagtgtttg ccaaatacaa tgacagccaa
     1921 acaaaaccaa actttttttt taaaataaac ctttgtaatc taa
//
