LOCUS       NM_138505               4047 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus adrenoceptor alpha 2B (Adra2b), mRNA.
ACCESSION   NM_138505 XM_346668
VERSION     NM_138505.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4047)
  AUTHORS   Torres,A., Munoz,K., Nahuelpan,Y., R Saez,A.P., Mendoza,P.,
            Jara,C., Cappelli,C., Suarez,R., Oyarzun,C., Quezada,C. and San
            Martin,R.
  TITLE     Intraglomerular Monocyte/Macrophage Infiltration and
            Macrophage-Myofibroblast Transition during Diabetic Nephropathy Is
            Regulated by the A2B Adenosine Receptor
  JOURNAL   Cells 9 (4), 1051 (2020)
   PUBMED   32340145
  REMARK    GeneRIF: Intraglomerular Monocyte/Macrophage Infiltration and
            Macrophage-Myofibroblast Transition during Diabetic Nephropathy Is
            Regulated by the A2B Adenosine Receptor.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4047)
  AUTHORS   Maltsev,A.V., Evdokimovskii,E.V. and Kokoz,Y.M.
  TITLE     alpha2-Adrenoceptor signaling in cardiomyocytes of spontaneously
            hypertensive rats starts to impair already at early age
  JOURNAL   Biochem Biophys Res Commun 512 (4), 908-913 (2019)
   PUBMED   30929926
  REMARK    GeneRIF: Adra2b signaling is impaired in the cardiomyocytes of
            spontaneously hypertensive rats starting from 2 months old.
REFERENCE   3  (bases 1 to 4047)
  AUTHORS   Zhang,M., Huang,W., Gao,J., Terry,A.V. and Wu,G.
  TITLE     Regulation of alpha2B-Adrenergic Receptor Cell Surface Transport by
            GGA1 and GGA2
  JOURNAL   Sci Rep 6, 37921 (2016)
   PUBMED   27901063
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4047)
  AUTHORS   Altamirano-Espinoza,A.H., Manrique-Maldonado,G.,
            Marichal-Cancino,B.A. and Villalon,C.M.
  TITLE     Specific role of alpha2A - and alpha2B -, but not alpha2C -,
            adrenoceptor subtypes in the inhibition of the vasopressor
            sympathetic out-flow in diabetic pithed rats
  JOURNAL   Basic Clin Pharmacol Toxicol 117 (1), 31-38 (2015)
   PUBMED   25407049
  REMARK    GeneRIF: Report specific roles of alpha2A - and alpha2B -, but not
            alpha2C -, adrenoceptor subtypes in the inhibition of the
            vasopressor sympathetic out-flow in diabetic pithed rats.
REFERENCE   5  (bases 1 to 4047)
  AUTHORS   Duvernay,M.T., Wang,H., Dong,C., Guidry,J.J., Sackett,D.L. and
            Wu,G.
  TITLE     Alpha2B-adrenergic receptor interaction with tubulin controls its
            transport from the endoplasmic reticulum to the cell surface
  JOURNAL   J Biol Chem 286 (16), 14080-14089 (2011)
   PUBMED   21357695
  REMARK    GeneRIF: Alpha2B-adrenergic receptor interaction with tubulin
            controls its transport from the endoplasmic reticulum to the cell
            surface
REFERENCE   6  (bases 1 to 4047)
  AUTHORS   Cussac,D., Schaak,S., Denis,C. and Paris,H.
  TITLE     alpha 2B-adrenergic receptor activates MAPK via a pathway involving
            arachidonic acid metabolism, matrix metalloproteinases, and
            epidermal growth factor receptor transactivation
  JOURNAL   J Biol Chem 277 (22), 19882-19888 (2002)
   PUBMED   11891218
  REMARK    GeneRIF: alpha 2B-adrenergic receptor activates MAPK via a pathway
            involving arachidonic acid metabolism, matrix metalloproteinases,
            and epidermal growth factor receptor transactivation.
REFERENCE   7  (bases 1 to 4047)
  AUTHORS   Zou,A.P. and Cowley,A.W. Jr.
  TITLE     alpha(2)-adrenergic receptor-mediated increase in NO production
            buffers renal medullary vasoconstriction
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 279 (3), R769-R777 (2000)
   PUBMED   10956233
REFERENCE   8  (bases 1 to 4047)
  AUTHORS   Heinonen,P., Koulu,M., Pesonen,U., Karvonen,M.K., Rissanen,A.,
            Laakso,M., Valve,R., Uusitupa,M. and Scheinin,M.
  TITLE     Identification of a three-amino acid deletion in the
            alpha2B-adrenergic receptor that is associated with reduced basal
            metabolic rate in obese subjects
  JOURNAL   J Clin Endocrinol Metab 84 (7), 2429-2433 (1999)
   PUBMED   10404816
REFERENCE   9  (bases 1 to 4047)
  AUTHORS   Le Jossec,M., Cloix,J.F., Pecquery,R., Giudicelli,Y. and
            Dausse,J.P.
  TITLE     Differential sodium regulation between salt-sensitive and
            salt-resistant Sabra rats is not due to any mutation in the renal
            alpha 2B-adrenoceptor gene
  JOURNAL   Am J Hypertens 8 (2), 177-182 (1995)
   PUBMED   7755946
REFERENCE   10 (bases 1 to 4047)
  AUTHORS   Zeng,D.W., Harrison,J.K., D'Angelo,D.D., Barber,C.M., Tucker,A.L.,
            Lu,Z.H. and Lynch,K.R.
  TITLE     Molecular characterization of a rat alpha 2B-adrenergic receptor
  JOURNAL   Proc Natl Acad Sci U S A 87 (8), 3102-3106 (1990)
   PUBMED   2158103
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Aug 25, 2010 this sequence version replaced NM_138505.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: M32061.1, SRR26643298.18411.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4047              JAXUCZ010000003.1  135038481-135042527
FEATURES             Location/Qualifiers
     source          1..4047
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..4047
                     /gene="Adra2b"
                     /note="adrenoceptor alpha 2B"
                     /db_xref="GeneID:24174"
                     /db_xref="RGD:2057"
     exon            1..4047
                     /gene="Adra2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             369..1730
                     /gene="Adra2b"
                     /note="alpha-2B adrenoceptor; alpha-2B adrenoreceptor;
                     alpha-2BAR; Adrenergic, alpha2B-, receptor class III;
                     Adrenergic alpha2B- receptor class III; adrenergic
                     receptor, alpha 2b; adrenergic, alpha-2B-, receptor"
                     /codon_start=1
                     /product="alpha-2B adrenergic receptor"
                     /protein_id="NP_612514.2"
                     /db_xref="GeneID:24174"
                     /db_xref="RGD:2057"
                     /translation="MSGPTMDHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLT
                     SRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCT
                     SSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQR
                     PEPRGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSHCRGLGAKRGS
                     GEGESKKPQPVAGGVPTSAKVPTLVSPLSSVGEANGHPKPPREKEEGETPEDPEARAL
                     PPTWSALPRSGQGQKKGTSGATAEEGDEEDEEEVEECEPQTLPASPASVCNPPLQQPQ
                     TSRVLATLRGQVLLGKNVGVASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFF
                     SYSLGAICPQHCKVPHGLFQFFFWIGYCNSSLNPVIYTVFNQDFRRAFRRILCRPWTQ
                     TGW"
ORIGIN      
        1 ctgcaggcgc ggctccggga gagagagcgc cttttcggag cgcaggctgc gcttccccag
       61 tcagttctgt gcgtcctgca gctgtgcggt gcgacggcgc aacttccctc tagtcccggg
      121 acagcagtgg gacaacttgg aaaacttctc tgggacagac tgtagggacg ctgggcaccg
      181 gtggaagagg atataagaga ccgatggctg gtcctgggta tccccggacc tcctaggccg
      241 ctttccgtca ggctacggtg cttcagagcc atctgcacct cctgggggac gacccccaac
      301 agtagcggag ccagagtggc gctatctcct gcgtaccgtg agtttggcca gcatcgttcc
      361 ctctggacat gtccggcccc accatggacc atcaggagcc ctactcggtg caggccaccg
      421 ccgccatcgc gtcggccatc acctttctca tccttttcac cattttcggc aatgcgctgg
      481 tcattctggc tgtgttgacc agccgctcac tccgtgcacc acaaaacctg ttcctggtgt
      541 cactggcagc agccgacatc ctagtggcta ctctcatcat ccctttctct ctggccaacg
      601 agctgctggg ctactggtac ttctggcgtg cgtggtgcga ggtctacctg gcgctagacg
      661 tgctcttctg tacctcctcc atcgtgcacc tgtgtgccat cagcctggac aggtactggg
      721 cagtgagccg agcattggag tacaactcca agcgcactcc gcgccgcatc aagtgcatca
      781 tcctcactgt gtggctcatt gcagctgtca tttctctacc gcccctcatc tacaagggcg
      841 accaacgccc cgagccccgc gggctccccc agtgtgagct caaccaggag gcctggtaca
      901 tcttggcttc cagcatcgga tctttttttg ctccctgcct catcatgatc ctcgtctacc
      961 tgcgaatcta cgtgattgcc aaacgcagcc actgcagagg tctcggagcc aagaggggct
     1021 ctggagaagg tgagtccaag aagccccagc cggttgctgg gggagtgcca acctcagcta
     1081 aggtgcccac cctggtctct cctctatctt ctgttggaga ggccaatgga caccccaagc
     1141 ctccaagaga gaaggaggag ggggagaccc ctgaagatcc tgaggccagg gctttgcccc
     1201 caacttggtc tgcccttccc agatcaggcc aaggccagaa gaaggggact agtggggcga
     1261 ctgcagagga gggagatgaa gaggatgagg aagaggtgga agaatgtgaa ccccaaacac
     1321 tgccagcatc tcctgcctcg gtatgcaacc cacccttgca gcagcctcag acttctcggg
     1381 tactggccac acttcgtggc caggtgcttc tgggcaagaa tgtgggagtt gccagtgggc
     1441 agtggtggcg cagacggaca cagctgagcc gggagaagag gttcaccttt gtgctggccg
     1501 tggtcattgg agttttcgtg gtctgctggt ttcctttctt cttcagctac agcctggggg
     1561 ccatctgccc acagcactgc aaggtaccgc atggcctctt ccagttcttc ttctggatcg
     1621 gctactgcaa cagctctttg aaccctgtca tctacaccgt cttcaaccag gacttccgcc
     1681 gtgcctttcg aaggatcctt tgccggccgt ggacccagac tggctggtga ggctgcctgt
     1741 tcgctgtcta tgccagggtt ggtgccagga ccacccggtg gtagtgcccc acctccacag
     1801 tctctatggc catttctctg gggcccactt gcagacctca tcctcagact ctcctgaagg
     1861 ggaaaggaca aaaatgctgt tcctagggcc catttgaaac cttcccttgc tggctgtact
     1921 gtgggatggc tcttcccttc tctctccctg gcaaggggac cttcttgaat atggccaaag
     1981 ccagactgga ttagaatacc tccctcccag ccacctgtaa gccaacaggc aggctaccct
     2041 ctcctggaga ccccctgtgc cttggcaggc cacttgtggt gtttttggtt ttcttcttct
     2101 tcttcttttt gttttttatt ttgttcattt ttattttatt ttatttttat ttttattttt
     2161 tattttttga gacagggtct caggtagccc agaccagcct cagacttgct gtgcagcccg
     2221 aggatgctct taagattctg atcatcctgc cttcacctct ccagcagtag agttaacaac
     2281 aatccctacc atacctggtt tacctgatgc tggggaatga attcagggct tcaagcatgc
     2341 tagggtagtc aaccgagtta tatccctagc cttgatcttc ctcttgcttc tcaaagagcc
     2401 ggaagcccaa cgtcgacatt tcccaggagg acctgatgct gagaaagagg acggaaggaa
     2461 gaggattcag ccatgccgag cacctgtgct tctcattggc tattgggaag gctggttatg
     2521 ggctagtatt gtggtttttt gtttgtttgt ttgtttgttt gggttttttt ttaaagcttc
     2581 ctagctcctt taagctccag aagcatgggt tggtttttct tactcagcat ccccctggga
     2641 ggcaagtgga cacatggatg cctcagtgga gaggtctgga atcctggcct cagcctcacc
     2701 atgggctcct gatcactggc attcaccctt gcaaagagcg gggtgacaat tgcctgccgc
     2761 ctacttgcgg cagggagatg aaaggctttg cagagagctt tgagctccgt ggggggaacg
     2821 agctagagag ccagcaaatg tgattatctg gtgatataaa aatccctttc ctatgtgttt
     2881 accactgtga gccttcctgt agacctttgt tctgggcttg gggtgtgtga atgcctaccc
     2941 caaactggaa gtgggttgag gtgtgcccga gccactcttt caaattccag aatttctttg
     3001 agaatgcatt cttgtgcatt ctcaaaggtt ttgagttatt gtgctgttgt cagctccccc
     3061 atctgttacc tgtaacacag acagagtttt cagtggcttg gccccaaccc cattagagga
     3121 taagttcttt gtcattgagc aggcaaatcg gtttcctaag ctaaaaatac tcacatcaag
     3181 gaagcagtct gagacgagat cctcaggtgg ggtgctgggg ctagagcagg cagcctgtgg
     3241 actcctggga gagccaccct ctgcggtggc ccagacaatt ctctgaaccc ccaagcaaca
     3301 cctttggaga tataaccagt tccaccccag ctcagaagga cgtctcattt gccgccaaga
     3361 accctcacag tgatatggct gtgcactagg gtgtctctac ctcctggttg tcttcccaac
     3421 ttgggaattg ctccccagag tgactgggga tgtgtctagg ccttccccac aagcagcctg
     3481 acttcaactt tgggcaataa acctcaacct cagggaaggt gtagtttgag ccatggaggc
     3541 tacaagcgac acaggcttgg gtgttagctt agggtggatt tatcagattt tgaaggtgct
     3601 aagggagttt tctcaggtag agacagtgat ggttcctaaa tagaattcct cctggagagg
     3661 atgagtgtcc agcttggttc tcagttggtt ggcggcagtt gtaaggccag gacattgatt
     3721 tggagtgtgg ctgaggggct gatttgattt tctgcttttg ttttgtttgt tttgagacag
     3781 ggtttccctg tgtaaccctg actgttctgg aactcacact ccatagacta ggccgcccta
     3841 gaactcacag agatctgcct gtctctgcct cctgagtgct gggaataaag gcgtacgcca
     3901 ccaccgcctg gcagaggggc agatttataa ccatttgcca gctgagactg tgtgtgctcc
     3961 gtgggaccca agccccctgt tgtgacatat aggtgtttct aagactctga gctattttat
     4021 caataaaggc tattttgtaa taagcaa
//
