LOCUS       NM_012739               2814 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus adrenoceptor alpha 2A (Adra2a), mRNA.
ACCESSION   NM_012739
VERSION     NM_012739.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2814)
  AUTHORS   Tian,C., Yang,Y., Li,Y., Sun,F., Qu,J. and Zha,D.
  TITLE     Expression and localization of &#945;2A-adrenergic receptor in the
            rat post-natal developing cochlea
  JOURNAL   Eur J Histochem 67 (3), 3748 (2023)
   PUBMED   37548252
  REMARK    GeneRIF: Expression and localization of alpha2A-adrenergic receptor
            in the rat post-natal developing cochlea.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2814)
  AUTHORS   Wu,Z., Wang,T., Li,L., Hui,Y., Zhang,Q. and Yuan,H.
  TITLE     Activation and blockade of alpha2-adrenoceptors in the prelimbic
            cortex regulate anxiety-like behaviors in hemiparkinsonian rats
  JOURNAL   Biochem Biophys Res Commun 519 (4), 697-704 (2019)
   PUBMED   31542234
  REMARK    GeneRIF: Results suggest that alpha-2A adrenergic receptor
            (alpha2-adrenoceptors) in the prelimbic cortex (PrL) are involved
            in the regulation of anxiety-like behaviors.
REFERENCE   3  (bases 1 to 2814)
  AUTHORS   Agrawal,J., Ludwig,B., Roy,B. and Dwivedi,Y.
  TITLE     Chronic Testosterone Increases Impulsivity and Influences the
            Transcriptional Activity of the Alpha-2A Adrenergic Receptor
            Signaling Pathway in Rat Brain
  JOURNAL   Mol Neurobiol 56 (6), 4061-4071 (2019)
   PUBMED   30264294
  REMARK    GeneRIF: chronic testosterone influences impulsivity possibly via
            hyperactive alpha-2A adrenergic receptor-PKA signaling axis.
REFERENCE   4  (bases 1 to 2814)
  AUTHORS   Maltsev,A.V., Evdokimovskii,E.V. and Kokoz,Y.M.
  TITLE     alpha2-Adrenoceptor signaling in cardiomyocytes of spontaneously
            hypertensive rats starts to impair already at early age
  JOURNAL   Biochem Biophys Res Commun 512 (4), 908-913 (2019)
   PUBMED   30929926
  REMARK    GeneRIF: Adra2a signaling is impaired in the cardiomyocytes of
            spontaneously hypertensive rats starting from 2 months old.
REFERENCE   5  (bases 1 to 2814)
  AUTHORS   Jia,Y., French,B., Tillman,B. and French,S.
  TITLE     Different roles of FAT10, FOXO1, and ADRA2A in hepatocellular
            carcinoma tumorigenesis in patients with alcoholic steatohepatitis
            (ASH) vs non-alcoholic steatohepatitis (NASH)
  JOURNAL   Exp Mol Pathol 105 (1), 144-149 (2018)
   PUBMED   30009772
REFERENCE   6  (bases 1 to 2814)
  AUTHORS   Surprenant,A., Horstman,D.A., Akbarali,H. and Limbird,L.E.
  TITLE     A point mutation of the alpha 2-adrenoceptor that blocks coupling
            to potassium but not calcium currents
  JOURNAL   Science 257 (5072), 977-980 (1992)
   PUBMED   1354394
REFERENCE   7  (bases 1 to 2814)
  AUTHORS   Lanier,S.M., Downing,S., Duzic,E. and Homcy,C.J.
  TITLE     Isolation of rat genomic clones encoding subtypes of the alpha
            2-adrenergic receptor. Identification of a unique receptor subtype
  JOURNAL   J Biol Chem 266 (16), 10470-10478 (1991)
   PUBMED   1645350
REFERENCE   8  (bases 1 to 2814)
  AUTHORS   Horstman,D.A., Brandon,S., Wilson,A.L., Guyer,C.A., Cragoe,E.J. Jr.
            and Limbird,L.E.
  TITLE     An aspartate conserved among G-protein receptors confers allosteric
            regulation of alpha 2-adrenergic receptors by sodium
  JOURNAL   J Biol Chem 265 (35), 21590-21595 (1990)
   PUBMED   2174879
REFERENCE   9  (bases 1 to 2814)
  AUTHORS   Chalberg,S.C., Duda,T., Rhine,J.A. and Sharma,R.K.
  TITLE     Molecular cloning, sequencing and expression of an alpha
            2-adrenergic receptor complementary DNA from rat brain
  JOURNAL   Mol Cell Biochem 97 (2), 161-172 (1990)
   PUBMED   2177834
REFERENCE   10 (bases 1 to 2814)
  AUTHORS   Kobilka,B.K., Matsui,H., Kobilka,T.S., Yang-Feng,T.L., Francke,U.,
            Caron,M.G., Lefkowitz,R.J. and Regan,J.W.
  TITLE     Cloning, sequencing, and expression of the gene coding for the
            human platelet alpha 2-adrenergic receptor
  JOURNAL   Science 238 (4827), 650-656 (1987)
   PUBMED   2823383
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U49747.1, U79031.1, CO574013.1, AW915790.1, AW919837.1, CB584098.1
            and CB763650.1.
            
            On Jul 22, 2011 this sequence version replaced NM_012739.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                U49747.1           2786-2830
            46-1597             U79031.1           1-1552
            1598-2042           CO574013.1         134-578
            2043-2302           AW915790.1         268-527
            2303-2354           AW919837.1         335-386
            2355-2698           CB584098.1         252-595
            2699-2814           CB763650.1         289-404
FEATURES             Location/Qualifiers
     source          1..2814
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..2814
                     /gene="Adra2a"
                     /gene_synonym="CA2-47; RATRG20; RG20"
                     /note="adrenoceptor alpha 2A"
                     /db_xref="GeneID:25083"
                     /db_xref="RGD:2056"
     exon            1..2801
                     /gene="Adra2a"
                     /gene_synonym="CA2-47; RATRG20; RG20"
                     /inference="alignment:Splign:2.1.0"
     CDS             1..1398
                     /gene="Adra2a"
                     /gene_synonym="CA2-47; RATRG20; RG20"
                     /note="alpha-2AAR; alpha-2A adrenoceptor; alpha-2A
                     adrenoreceptor; alpha-2D adrenergic receptor; adrenergic
                     receptor, alpha 2a; adrenergic, alpha-2A-, receptor"
                     /codon_start=1
                     /product="alpha-2A adrenergic receptor"
                     /protein_id="NP_036871.3"
                     /db_xref="GeneID:25083"
                     /db_xref="RGD:2056"
                     /translation="MFRQEQPLAEGSFAPMGSLQPDAGNSSWNGTEAPGGGTRATPYS
                     LQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVI
                     PFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKR
                     TPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIG
                     SFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGT
                     AGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKG
                     KTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLA
                     VVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRR
                     AFKKILCRGDRKRIV"
ORIGIN      
        1 atgttccgcc aggagcagcc gctggccgag ggcagctttg cgcccatggg ctccctgcag
       61 ccggatgccg gcaatagcag ctggaacggc accgaggcgc ccggaggcgg cacccgggcc
      121 accccttact ccctgcaggt gacgctgacg ctggtgtgcc tggctggcct gctcatgctg
      181 ttcaccgtgt ttggcaacgt gctggttatt atcgcagtgt tcaccagccg cgcgctcaaa
      241 gcgccccaga acctcttcct ggtgtctctg gcctcagcgg acatcctggt ggccacgctg
      301 gtcattccct tttctttggc caacgaggtt atgggctact ggtactttgg taaggtgtgg
      361 tgcgagatct acttggccct cgacgtgctc ttttgcacgt cgtccatagt gcacctgtgc
      421 gccatcagcc ttgaccgcta ctggtccatc acgcaggcca tcgagtacaa cctgaagcgc
      481 acgccgcggc gcatcaaggc catcattgtc actgtgtggg tcatctcggc cgtcatctcc
      541 ttcccgccac tcatctccat agagaagaag ggcgctggcg gcgggcagca gccggccgag
      601 ccgagctgca agattaacga ccagaagtgg tatgtcatct cgtcgtccat cggctccttc
      661 ttcgcgcctt gcctcatcat gatcctggtc tacgtgcgta tctaccagat cgccaagcgt
      721 cgcacccgcg tgccgcccag tcgccggggt ccggacgcct gttccgcgcc gccggggggc
      781 gccgatcgca ggcccaacgg gctgggcccg gagcgcggcg ctggtaccgc gggcgcggag
      841 gccgagccgc tgcccaccca gcttaacggc gccccggggg agcccgcgcc cacccggccg
      901 cgcgacgggg atgcgctgga cctagaggag agttcgtcgt ccgagcacgc cgagcggccc
      961 caggggcccg gcaaacccga gcgcggtccc cgggccaagg gcaagaccaa ggcgagccag
     1021 gtgaaaccgg gggacagtct gccgcggcgc gggcccgggg ctgcggggcc gggggcttcg
     1081 gggtccgggc agggagagga gcgtgccggg ggcgccaaag cgtcgcgctg gcgcgggagg
     1141 cagaaccgcg agaaacgctt cacgttcgtg ctggcggtgg tgatcggcgt gttcgtggtg
     1201 tgttggttcc cgttcttttt cacctacacg ctcatagcgg tcggctgccc ggtgccctac
     1261 cagctcttca acttcttctt ctggttcggc tactgcaaca gctcgctgaa ccctgttatc
     1321 tacaccattt tcaaccacga cttccgccgc gccttcaaga agatcctctg ccgtggggac
     1381 agaaagcgca tcgtgtgagc gctcgggctg tgccctgctt acagaccctg gtcagatgca
     1441 ggccctgggc ttcgaggggg cgcgtctacg catgcagccc ctagcactct gaaaccctgg
     1501 accttcctgc tctgtgtaat acccagtttg gaggggactt ggtggctttt gagacctttt
     1561 gttaccatgt gtaaagttct ggctgagagg gacatatgcg cctttttgct ggttgttgtg
     1621 gttgttccca gcccacagcc agtttcctgg tgggctaccc ccgatcagta ttgtttcctg
     1681 acgatattgc catcttctcc ccgagtctga ctctcccaag ctcttcagag caagcacagt
     1741 actagagagg gcatgactgc caaagggtta atgaaccaag gtttcctagc cctggctaat
     1801 tgtcacttcc ctccttcccc ccctttaaaa atatcattca gggcagccct gcctgccctc
     1861 cgtaccctcc actgtaaata tacattattt ttgatagcac actttgtgtt cctcagaatt
     1921 ggccttgtcg cgatattgga atcccggctg tggggatgcc ctccagtcac agacagtggg
     1981 ctatctggtc cagaccaacg tcctttgcaa tgcaagtccc tttctagtgt tattacatcg
     2041 tcgctctcag tacttttcag cagtaactgg taactgtccc ctggacacgg acctgctttg
     2101 acatttcctg agagggaagg gatttctgtt cattttcccc ctgtgcctaa cagcataatt
     2161 gccttttcct atgtaaatat tacagcgatg gaccaagaca gaaggaaatg aaccttctgc
     2221 ctggccccag ccctgtgtat aaagccatta ttcgctgagg caccacttgc cccagtaact
     2281 cactttagaa ctgacgctgc ggttctcctc tcctctgggg ccaaggcttg aagaagaacg
     2341 ggtgggtgtg cttgtttctg tcttgtgtgt gtgccgcccc tcatccagaa agtgctgagt
     2401 aaggggaatc ttttagcagc tgtttttaga cacacaggag gggaaattat gtggaagaaa
     2461 cctacccgat acaatttgcc aaggtaaaca gtgtgaggag acaaacagtc cgccacactg
     2521 ttcagcgcca gccccaagag ctcttgggta tcaaagtgtt acctcccctt gcttttctgg
     2581 ctgagatcac gtcaccagtg aattgccaaa gtcagggagt aggcggagaa ttggtgttta
     2641 caacctggtt tctacttagt ttaggcggac tgtggaaggc ctgcgatctg tttttcctga
     2701 gagaaaaacc taaatgtcag cacttgttgc tcatgatggt ggattttttt ttaaaataaa
     2761 agtttacaga tcaaatgtga aataaacatg aattaagtga taaaaaaaaa aaaa
//
