LOCUS       NM_024483               2937 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus adrenoceptor alpha 1D (Adra1d), mRNA.
ACCESSION   NM_024483
VERSION     NM_024483.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2937)
  AUTHORS   Chmielarz,P., Kusmierczyk,J., Rafa-Zablocka,K., Chorazka,K.,
            Kowalska,M., Satala,G. and Nalepa,I.
  TITLE     Antidepressants Differentially Regulate Intracellular Signaling
            from alpha1-Adrenergic Receptor Subtypes In Vitro
  JOURNAL   Int J Mol Sci 22 (9), 4817 (2021)
   PUBMED   34062902
  REMARK    GeneRIF: Antidepressants Differentially Regulate Intracellular
            Signaling from alpha1-Adrenergic Receptor Subtypes In Vitro.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2937)
  AUTHORS   Ishida,H., Yamauchi,H., Ito,H., Akino,H. and Yokoyama,O.
  TITLE     alpha1D-Adrenoceptor blockade increases voiding efficiency by
            improving external urethral sphincter activity in rats with spinal
            cord injury
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 311 (5), R971-R978 (2016)
   PUBMED   27605559
  REMARK    GeneRIF: These results suggest that alpha-blockade reduces the
            urethral resistance associated with detrusor-sphincter dyssynergia,
            thus improving voiding efficiency in SCI rats.
REFERENCE   3  (bases 1 to 2937)
  AUTHORS   Kountz,T.S., Lee,K.S., Aggarwal-Howarth,S., Curran,E., Park,J.M.,
            Harris,D.A., Stewart,A., Hendrickson,J., Camp,N.D., Wolf-Yadlin,A.,
            Wang,E.H., Scott,J.D. and Hague,C.
  TITLE     Endogenous N-terminal Domain Cleavage Modulates alpha1D-Adrenergic
            Receptor Pharmacodynamics
  JOURNAL   J Biol Chem 291 (35), 18210-18221 (2016)
   PUBMED   27382054
REFERENCE   4  (bases 1 to 2937)
  AUTHORS   Bota,J., Hajagos-Toth,J., Ducza,E., Samavati,R., Borsodi,A.,
            Benyhe,S. and Gaspar,R.
  TITLE     The effects of female sexual hormones on the expression and
            function of alpha1A- and alpha1D-adrenoceptor subtypes in the
            late-pregnant rat myometrium
  JOURNAL   Eur J Pharmacol 769, 177-184 (2015)
   PUBMED   26593425
  REMARK    GeneRIF: effects of female sexual hormones on the expression and
            function of alpha1A- and alpha1D-adrenoceptor subtypes in the
            late-pregnant rat myometrium
REFERENCE   5  (bases 1 to 2937)
  AUTHORS   Camp,N.D., Lee,K.S., Wacker-Mhyre,J.L., Kountz,T.S., Park,J.M.,
            Harris,D.A., Estrada,M., Stewart,A., Wolf-Yadlin,A. and Hague,C.
  TITLE     Individual protomers of a G protein-coupled receptor dimer
            integrate distinct functional modules
  JOURNAL   Cell Discov 1, 15011-15011 (2015)
   PUBMED   26617989
REFERENCE   6  (bases 1 to 2937)
  AUTHORS   Xin,X., Yang,N. and Faber,J.E.
  TITLE     Platelet-derived growth factor-BB inhibits rat alpha1D-adrenergic
            receptor gene expression in vascular smooth muscle cells by
            inducing AP-2-like protein binding to alpha1D proximal promoter
            region
  JOURNAL   Mol Pharmacol 56 (6), 1152-1161 (1999)
   PUBMED   10570042
REFERENCE   7  (bases 1 to 2937)
  AUTHORS   Kulik,A., Haentzsch,A., Luckermann,M., Reichelt,W. and Ballanyi,K.
  TITLE     Neuron-glia signaling via alpha(1) adrenoceptor-mediated Ca(2+)
            release in Bergmann glial cells in situ
  JOURNAL   J Neurosci 19 (19), 8401-8408 (1999)
   PUBMED   10493741
REFERENCE   8  (bases 1 to 2937)
  AUTHORS   Schwinn,D.A., Johnston,G.I., Page,S.O., Mosley,M.J., Wilson,K.H.,
            Worman,N.P., Campbell,S., Fidock,M.D., Furness,L.M.,
            Parry-Smith,D.J. et al.
  TITLE     Cloning and pharmacological characterization of human alpha-1
            adrenergic receptors: sequence corrections and direct comparison
            with other species homologues
  JOURNAL   J Pharmacol Exp Ther 272 (1), 134-142 (1995)
   PUBMED   7815325
REFERENCE   9  (bases 1 to 2937)
  AUTHORS   Perez,D.M., Piascik,M.T. and Graham,R.M.
  TITLE     Solution-phase library screening for the identification of rare
            clones: isolation of an alpha 1D-adrenergic receptor cDNA
  JOURNAL   Mol Pharmacol 40 (6), 876-883 (1991)
   PUBMED   1661838
REFERENCE   10 (bases 1 to 2937)
  AUTHORS   Lomasney,J.W., Cotecchia,S., Lorenz,W., Leung,W.Y., Schwinn,D.A.,
            Yang-Feng,T.L., Brownstein,M., Lefkowitz,R.J. and Caron,M.G.
  TITLE     Molecular cloning and expression of the cDNA for the alpha
            1A-adrenergic receptor. The gene for which is located on human
            chromosome 5
  JOURNAL   J Biol Chem 266 (10), 6365-6369 (1991)
   PUBMED   1706716
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Dec 5, 2020 this sequence version replaced NM_024483.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L31771.1, M60654.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1574              JAXUCZ010000003.1  139260758-139262331 c
            1575-2937           JAXUCZ010000003.1  139246333-139247695 c
FEATURES             Location/Qualifiers
     source          1..2937
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..2937
                     /gene="Adra1d"
                     /gene_synonym="Adrd1"
                     /note="adrenoceptor alpha 1D"
                     /db_xref="GeneID:29413"
                     /db_xref="RGD:62064"
     exon            1..1574
                     /gene="Adra1d"
                     /gene_synonym="Adrd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             482..2170
                     /gene="Adra1d"
                     /gene_synonym="Adrd1"
                     /note="adrenergic receptor, alpha 1d; RA42; alpha-1A
                     adrenergic receptor; alpha-1D adrenoceptor; alpha-1D
                     adrenoreceptor; adrenergic receptor delta1; adrenergic,
                     alpha-1D-, receptor"
                     /codon_start=1
                     /product="alpha-1D adrenergic receptor"
                     /protein_id="NP_077809.2"
                     /db_xref="GeneID:29413"
                     /db_xref="RGD:62064"
                     /translation="MTFRDILSVTFEGPRSSSSTGGSGAGGGAGTVGPEGPAVGGVPG
                     ATGGGAVVGTGSGEDNQSSTGEPGAAASGEVNGSAAVGGLVVSAQGVGVGVFLAAFIL
                     TAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWAFGR
                     TFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWAVA
                     LVVSVGPLLGWKEPVPPDERFCGITEEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVAR
                     STTRSLEAGIKREPGKASEVVLRIHCRGAATSAKGYPGTQSSKGHTLRSSLSVRLLKF
                     SREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVN
                     PLIYPCSSREFKRAFLRLLRCQCRRRRRRLWRVYGHHWRASTGDARSDCAPSPRIAPP
                     GAPLALTAHPGAGSADTPETQDSVSSSRKPASALREWRLLGPLQRPTTQLRAKVSSLS
                     HKIRSGGARRAETACALRSEVEAVSLNVPQDGAEAVICQAYEPGDYSNLRETDI"
     exon            1575..2937
                     /gene="Adra1d"
                     /gene_synonym="Adrd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggatccccgc agccgctgga cgcacggagc cccttcgctg gccggtagct tacgctcgcg
       61 ccggccgccc cctcctccct ctcgaccgcc cctcctccgt cccgcccccg cgcggagtcc
      121 ccagcgctgc agaggccgcc gcctgcactg ccactcctag agccgccgct ctcccggaca
      181 cgcttgcaga ggggagcagg gagccggccc cggcccttct ttccttgtga ctccgcagcc
      241 accgccggag tcggttccct cacaccaacg ttcccattgg gaccttcacg gcccggtgac
      301 ctctgtcctg ctctacctgc agcactgctc ccctgcagcc cctctgccgc gggaacttgg
      361 gcaggaccga cgggactggc acacggggct ggctcgggcg ctgcggcgat gcccgcgggc
      421 tctctcccct ccacttgctc gccctgtgcc tgggctcggg ccccgacggc tgcgccgtga
      481 gatgactttc cgcgacatcc tgagcgtcac tttcgaagga ccccggtcga gcagtagcac
      541 tgggggctcc ggcgcgggcg gcggagctgg cacggttggc cccgagggtc cggcggtggg
      601 cggcgtgccg ggcgctacag gcggcggcgc tgtggtggga accggcagcg gcgaggacaa
      661 ccagagctcc acgggagaac cgggagccgc ggcgagcggc gaagtaaatg gctcggcggc
      721 cgtcgggggg ctagtggtga gtgctcaggg cgtgggagtg ggtgtcttcc tggcggcctt
      781 catcctcacc gctgtggcgg gcaacctgct ggtcatcctt tcggtggcct gcaaccgcca
      841 cctacagacg gtcaccaact atttcatcgt gaacctggcg gtggctgacc tgcttttgag
      901 tgcagctgtg ttgcccttct cagccactat ggaggttcta ggcttctggg ccttcggccg
      961 aaccttctgc gacgtgtggg ccgcggtgga cgtgctgtgc tgcactgcct ccatccttag
     1021 cctctgcacc atctctgtgg accggtacgt gggtgtgcgc cactcgctca agtacccagc
     1081 cattatgaca gagcgcaagg ccgctgccat tctggctctg ctttgggcgg tggccctggt
     1141 ggtatctgtg ggaccgctac taggttggaa ggagccagtg cccccggatg agcgtttctg
     1201 cggcatcacc gaggaggtgg gctatgcaat cttctcttcc gtgtgctcct tctacctacc
     1261 catggcagtg atcgtggtca tgtactgccg cgtgtacgtg gtcgcacgca gcactacgcg
     1321 cagcctcgag gcaggcatca agagggagcc cggcaaggcc tccgaggtgg ttctgaggat
     1381 ccactgtcgc ggcgcagcga ccagcgccaa aggatatccc ggaacacaga gtagcaaggg
     1441 ccacaccttg cgcagctcgc tttccgtgag gctgctcaag ttttcccgcg agaaaaaggc
     1501 tgccaagacg ttggccatcg tcgtgggtgt cttcgtcctg tgctggttcc ccttcttctt
     1561 cgtcctgcct ctgggctctc tgttcccgca gctgaaaccg tcagagggtg tcttcaaggt
     1621 catcttctgg ctgggctact tcaatagctg tgtgaacccg ctcatctacc cctgctccag
     1681 tcgcgagttc aagcgcgcct tcctccgcct cctgcgctgc cagtgtcgcc gccgccgccg
     1741 ccgcctctgg cgagtctacg gccaccactg gcgagcctcg accggcgacg cgcgttccga
     1801 ctgcgccccc agccctcgca tcgctccccc cggggcccct ctagccctca ctgcacaccc
     1861 gggtgcgggc tcggcagaca cgccggagac gcaggattcg gtctccagca gtcgaaagcc
     1921 agcctccgcc ctccgggagt ggagactgct cgggccgcta cagagaccca cgacccagct
     1981 gcgtgcgaag gtgtccagcc tgtcccataa gattcgctct gggggcgcgc ggcgcgcgga
     2041 gactgcgtgt gccctgcgct ccgaggtaga agcagtgtcc ctaaatgttc cccaagatgg
     2101 ggcagaagct gtcatctgcc aggcttatga gccgggcgac tacagcaacc tccgagagac
     2161 tgacatttaa ggaccgaaac tcaggctggg gaaggtgctg gggaaagtgc gggggccagg
     2221 ggtggggtgc tttatgggat actgccttcg gatccaagac tgcccagggt ggctgctcca
     2281 tctcacccag agcaaccgga gctggacctg ggggtcggag cacttcgaag gtgatgggtt
     2341 atggtgccgc ctgctggaca tagttgtcca gagctcttcc tgaaagggaa aggctacagg
     2401 attcgccctt ctcatccagt ctaagaaact acttagtcaa ctcctagtgt ctaagcagaa
     2461 ggcttcagct atggcttctc cccttgggga ggaagaggaa gaggtacaaa ttcttgtttt
     2521 gctgctccca gggaaaagat ccgtggacag tttctactcc ttactgccac ctggaggaag
     2581 tcaatggacc taccatagga cctgccatcc ggcaagtttt ggtggcgtat tggatgcccg
     2641 ccgaacaaat ctgttgctct tccgctctgg gcccactgcc ctcttcccca cactcctaac
     2701 tgtatgttcc cctcaccata ccccccgccc cggggcctta ctgtttacac tgtgtacata
     2761 gttcattgtg cctgtctgtg cccatcactt ctcactggga ttccaggctg ccaaagggga
     2821 gagccttatt tatcattttg aaacctattt attggtaaga gtacttatat tttgttcaga
     2881 ctgtgcaaac tgtccatctt tggcttgtaa tgcatataga gcctccttct tctgaaa
//
