LOCUS       NM_016991               2515 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus adrenoceptor alpha 1B (Adra1b), mRNA.
ACCESSION   NM_016991 XM_346399
VERSION     NM_016991.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2515)
  AUTHORS   Chmielarz,P., Kusmierczyk,J., Rafa-Zablocka,K., Chorazka,K.,
            Kowalska,M., Satala,G. and Nalepa,I.
  TITLE     Antidepressants Differentially Regulate Intracellular Signaling
            from alpha1-Adrenergic Receptor Subtypes In Vitro
  JOURNAL   Int J Mol Sci 22 (9), 4817 (2021)
   PUBMED   34062902
  REMARK    GeneRIF: Antidepressants Differentially Regulate Intracellular
            Signaling from alpha1-Adrenergic Receptor Subtypes In Vitro.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2515)
  AUTHORS   Mitrano,D.A., Jackson,K., Finley,S. and Seeley,A.
  TITLE     alpha1b-Adrenergic Receptor Localization and Relationship to the
            D1-Dopamine Receptor in the Rat Nucleus Accumbens
  JOURNAL   Neuroscience 371, 126-137 (2018)
   PUBMED   29229557
  REMARK    GeneRIF: alpha1bARs were found in unmyelinated axons and axon
            terminals with some labeling in dendrites. In accordance with other
            studies of the striatum, the D1R was found mainly in dendrites and
            spines; therefore, colocalization of the D1R with the alpha1bAR was
            rare postsynaptically.
REFERENCE   3  (bases 1 to 2515)
  AUTHORS   Ahmad,A., Sattar,M., Khan,S.A., Abdullah,N.A., Johns,E.J. and
            Afzal,S.
  TITLE     INCREASED OXIDATIVE STRESS AND DOWN REGULATION OF ENDOTHELIAL
            NITRIC OXIDE SYNTHASE (ENOS) IN THE KIDNEY ATTEN- UATE THE
            RESPONSIVENESS OF (XlB ADRENERGIC RECEPTORS IN THE KIDNEY OF RATS
            WITH LEFT VENTRICULAR HYPERTROPHY
  JOURNAL   Acta Pol Pharm 74 (2), 413-423 (2017)
   PUBMED   29624247
  REMARK    GeneRIF: The renal vasoconstrictor responses to adrenergic agonist
            are blunted in left ventricular hypertrophy and adrenergic alpha 1b
            receptor is functional subtype in renal vasculature in LVH.
REFERENCE   4  (bases 1 to 2515)
  AUTHORS   Sanguesa,G., Shaligram,S., Akther,F., Roglans,N., Laguna,J.C.,
            Rahimian,R. and Alegret,M.
  TITLE     Type of supplemented simple sugar, not merely calorie intake,
            determines adverse effects on metabolism and aortic function in
            female rats
  JOURNAL   Am J Physiol Heart Circ Physiol 312 (2), H289-H304 (2017)
   PUBMED   27923787
REFERENCE   5  (bases 1 to 2515)
  AUTHORS   Tripathi,A., Vana,P.G., Chavan,T.S., Brueggemann,L.I., Byron,K.L.,
            Tarasova,N.I., Volkman,B.F., Gaponenko,V. and Majetschak,M.
  TITLE     Heteromerization of chemokine (C-X-C motif) receptor 4 with
            alpha1A/B-adrenergic receptors controls alpha1-adrenergic receptor
            function
  JOURNAL   Proc Natl Acad Sci U S A 112 (13), E1659-E1668 (2015)
   PUBMED   25775528
  REMARK    GeneRIF: heteromeric receptor complexes between alpha1A-AR and
            CXCR4 and between alpha1B-AR and CXCR4 are constitutively expressed
            in rat and human vascular smooth muscle cells; the quaternary
            structure of the receptor complex is important for signaling and
            contraction
REFERENCE   6  (bases 1 to 2515)
  AUTHORS   Kanasaki,M., Matsubara,H., Murasawa,S., Masaki,H., Nio,Y. and
            Inada,M.
  TITLE     cAMP responsive element-mediated regulation of the gene
            transcription of the alpha 1B adrenergic receptor by thyrotropin
  JOURNAL   J Clin Invest 94 (6), 2245-2254 (1994)
   PUBMED   7989580
REFERENCE   7  (bases 1 to 2515)
  AUTHORS   Garcia-Sainz,J.A., Casas-Gonzalez,P., Romero-Avila,M.T. and
            Gonzalez-Espinosa,C.
  TITLE     Characterization of the hepatic alpha 1B-adrenoceptors of rats,
            mice and hamsters
  JOURNAL   Life Sci 54 (25), 1995-2003 (1994)
   PUBMED   7911220
REFERENCE   8  (bases 1 to 2515)
  AUTHORS   Gao,B. and Kunos,G.
  TITLE     Isolation and characterization of the gene encoding the rat alpha
            1B adrenergic receptor
  JOURNAL   Gene 131 (2), 243-247 (1993)
   PUBMED   8406017
REFERENCE   9  (bases 1 to 2515)
  AUTHORS   Lomasney,J.W., Cotecchia,S., Lorenz,W., Leung,W.Y., Schwinn,D.A.,
            Yang-Feng,T.L., Brownstein,M., Lefkowitz,R.J. and Caron,M.G.
  TITLE     Molecular cloning and expression of the cDNA for the alpha
            1A-adrenergic receptor. The gene for which is located on human
            chromosome 5
  JOURNAL   J Biol Chem 266 (10), 6365-6369 (1991)
   PUBMED   1706716
REFERENCE   10 (bases 1 to 2515)
  AUTHORS   Voigt,M.M., Kispert,J. and Chin,H.M.
  TITLE     Sequence of a rat brain cDNA encoding an alpha-1B adrenergic
            receptor
  JOURNAL   Nucleic Acids Res 18 (4), 1053 (1990)
   PUBMED   2156222
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC070920.1.
            
            [WARNING] On Apr 30, 2024 this sequence was replaced by
            NM_016991.3.
            
            On May 24, 2004 this sequence version replaced NM_016991.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070920.1, X51585.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2515
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q21"
     gene            1..2515
                     /gene="Adra1b"
                     /note="adrenoceptor alpha 1B"
                     /db_xref="GeneID:24173"
                     /db_xref="RGD:2054"
     exon            1..1338
                     /gene="Adra1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             390..1937
                     /gene="Adra1b"
                     /note="alpha-1B adrenoceptor; alpha-1B adrenoreceptor;
                     adrenergic receptor, alpha 1b; Adrenergic alpha 1B-
                     receptor; adrenergic, alpha-1B-, receptor"
                     /codon_start=1
                     /product="alpha-1B adrenergic receptor"
                     /protein_id="NP_058687.2"
                     /db_xref="GeneID:24173"
                     /db_xref="RGD:2054"
                     /translation="MNPDLDTGHNTSAPAHWGELKDDNFTGPNQTSSNSTLPQLDVTR
                     AISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFS
                     ATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRR
                     KAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAV
                     ILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPR
                     SSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVF
                     WLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRGGRRRRRRRRLGGCAYTYRPWTRG
                     GSLERSQSRKDSLDDSGSCMSGSQRTLPSASPSPGYLGRGTQPPVELCAFPEWKPGAL
                     LSLPEPPGRRGRLDSGPLFTFKLLGDPESPGTEGDTSNGGCDTTTDLANGQPGFKSNM
                     PLAPGHF"
     exon            1339..2484
                     /gene="Adra1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgatcgctgg gcggagaagg caccgcggtc cgcagacccg ctgcgggccg ggcacagccg
       61 ggcacccccg gccccgcgcc tgctcctccc agcgctcccg cgccagccgg gccaggcgcg
      121 cctgacgtgg accattaaac ttggagctgc cgcctcgtcc cctctctcct cctcctcctc
      181 ctcctccttc tgacaggcga gcgagccgct gggtgcaggc aggcgacgtg ctgccgggct
      241 aggctgcccg ggggagatga cttctcgcca ggaggacgcc tctggaaaga agaccacgga
      301 gggagcaaag tttcagggta gctgaggtgc cttggtcgca gcccttccga gcccaatctc
      361 ctccctggct atggagggcg gactttaaaa tgaatcccga tctggacacc ggccacaaca
      421 catcagcacc tgcccactgg ggagagttga aagatgacaa cttcactggc cccaaccaga
      481 cctcgagcaa ctccacactg ccccagctgg acgtcaccag ggccatctct gtgggcctgg
      541 tgctgggcgc cttcatcctc tttgccatcg tgggcaacat cttggtcatc ctgtcggtgg
      601 cctgcaaccg gcacctgcgg acgcccacca actactttat cgtcaacctg gccattgctg
      661 acctgctgtt gagtttcaca gtactgccct tctccgctac cctagaagtg cttggctact
      721 gggtgctggg gcgcatcttc tgtgacatct gggcagcggt agatgtcctg tgctgtacgg
      781 cctccatcct gagcctatgt gccatctcca ttgaccgcta cattggggtg cgatactctc
      841 tgcagtaccc cacgctggtc acccgcagga aggccatctt ggcgctcctc agtgtgtggg
      901 tcttgtccac ggtcatctcc atcgggcctc tccttggatg gaaagaacct gcgcccaatg
      961 atgacaaaga atgtggggtc accgaagaac ccttctacgc cctcttttcc tccctgggct
     1021 ccttctacat cccgctcgcg gtcatcctgg tcatgtactg ccgggtctac atcgtggcca
     1081 agaggaccac caagaatctg gaggcgggag tcatgaagga aatgtccaac tccaaggagc
     1141 tgaccctgag gatccactcc aagaactttc atgaggacac cctcagcagt accaaggcca
     1201 agggccacaa ccccaggagt tccatagctg tcaaactttt taagttctcc agggaaaaga
     1261 aagcagccaa aaccttgggc attgtagtcg gaatgttcat cttatgttgg ctccccttct
     1321 tcatcgctct cccgcttggc tccctgttct ccaccctaaa gcccccggac gccgtgttca
     1381 aggtggtgtt ctggctgggc tacttcaaca gctgcctcaa tcccatcatc tacccgtgct
     1441 ccagcaagga gttcaagcgc gccttcatgc gtatccttgg gtgccagtgc cgcggtggcc
     1501 gccgccgccg ccgccgtcgc cgtctaggcg gctgcgctta cacctaccgg ccgtggaccc
     1561 gcggcggctc gctggagaga tcacagtcgc ggaaggactc tctggatgac agcggcagct
     1621 gcatgagcgg cagccagagg accctgccct cggcgtcgcc cagcccgggc tacctgggtc
     1681 gaggaacgca gccacccgtg gagctgtgcg ccttccccga gtggaaaccc ggggcgctgc
     1741 tcagcttgcc agagcctcct ggccgccgcg gccgtctcga ctctgggcca ctcttcacct
     1801 tcaagctcct gggcgatcct gagagcccgg gaaccgaagg cgacaccagc aacgggggct
     1861 gcgacaccac gaccgacctg gccaacgggc agcccggctt caagagcaac atgcccctgg
     1921 cgcccgggca cttttagggt cccttttcat cctccccctc aacacactca cacatcgggg
     1981 tgggggagaa caccatcgta ggggcgggag ggcgcgtggg gggagtgtca gccctaggta
     2041 gacacagggt cgcaagggga caagggggga ggggggcggg gagaggggca gctgcttttc
     2101 tggcaggggc atgggtgcca ggtacagcga agagctgggc tgagcatgct gagagcgtgg
     2161 ggggcccccc cgacgccggc cgggacttaa gtctctctct cttctctctc tgtatataca
     2221 taaaatgagt tcctctattc gtatttatct gtgggtacac gtgcgtgtgt ctgttcggtg
     2281 tacgtgtggg ctgcatgggt gtgagtgtga ggcctgcccg cacgcgcgtg ccggggcaga
     2341 gcgagtgcgc cccctggtga cgtccaggtg tgttgtttgt ctcttgactt tgtacctctc
     2401 aagcccctcc ctgttctcta gtcaatgctg gcactttgat aggatcggaa aacaagtcag
     2461 atattaaaga tcatttctcc tgtgaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
