LOCUS       NM_017191               1428 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus adrenoceptor alpha 1A (Adra1a), mRNA.
ACCESSION   NM_017191
VERSION     NM_017191.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1428)
  AUTHORS   Gaynullina,D.K., Kudryashova,T.V., Vorotnikov,A.V., Schubert,R. and
            Tarasova,O.S.
  TITLE     MAPKs Are Highly Abundant but Do Not Contribute to
            alpha1-Adrenergic Contraction of Rat Saphenous Arteries in the
            Early Postnatal Period
  JOURNAL   Int J Mol Sci 22 (11), 6037 (2021)
   PUBMED   34204888
  REMARK    GeneRIF: MAPKs Are Highly Abundant but Do Not Contribute to
            alpha1-Adrenergic Contraction of Rat Saphenous Arteries in the
            Early Postnatal Period.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1428)
  AUTHORS   Chmielarz,P., Kusmierczyk,J., Rafa-Zablocka,K., Chorazka,K.,
            Kowalska,M., Satala,G. and Nalepa,I.
  TITLE     Antidepressants Differentially Regulate Intracellular Signaling
            from alpha1-Adrenergic Receptor Subtypes In Vitro
  JOURNAL   Int J Mol Sci 22 (9), 4817 (2021)
   PUBMED   34062902
  REMARK    GeneRIF: Antidepressants Differentially Regulate Intracellular
            Signaling from alpha1-Adrenergic Receptor Subtypes In Vitro.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1428)
  AUTHORS   Deji,C., Li,Y., Chen,Y., Lai,J. and Wei,S.
  TITLE     Association study of Catechol-o-methyltransferase and
            Alpha-1-adrenergic receptor gene polymorphisms with multiple
            phenotypes of heroin use disorder
  JOURNAL   Neurosci Lett 748, 135677 (2021)
   PUBMED   33577997
REFERENCE   4  (bases 1 to 1428)
  AUTHORS   Romero-Imbachi,M.R., Cupitra,N., Angel,K., Gonzalez,B., Estrada,O.,
            Calderon,J.C., Guerrero-Vargas,J., Beltran,J. and
            Narvaez-Sanchez,R.
  TITLE     Centruroides margaritatus scorpion complete venom exerts
            cardiovascular effects through alpha-1 adrenergic receptors
  JOURNAL   Comp Biochem Physiol C Toxicol Pharmacol 240, 108939 (2021)
   PUBMED   33166680
  REMARK    GeneRIF: Centruroides margaritatus scorpion complete venom exerts
            cardiovascular effects through alpha-1 adrenergic receptors.
REFERENCE   5  (bases 1 to 1428)
  AUTHORS   Mahmoodkhani,M., Amini,M., Derafshpour,L., Ghasemi,M. and
            Mehranfard,N.
  TITLE     Negative relationship between brain alpha1A-AR neurotransmission
            and betaArr2 levels in anxious adolescent rats subjected to early
            life stress
  JOURNAL   Exp Brain Res 238 (12), 2833-2844 (2020)
   PUBMED   33025031
  REMARK    GeneRIF: Negative relationship between brain alpha1A-AR
            neurotransmission and betaArr2 levels in anxious adolescent rats
            subjected to early life stress.
REFERENCE   6  (bases 1 to 1428)
  AUTHORS   Stewart,A.F., Rokosh,D.G., Bailey,B.A., Karns,L.R., Chang,K.C.,
            Long,C.S., Kariya,K. and Simpson,P.C.
  TITLE     Cloning of the rat alpha 1C-adrenergic receptor from cardiac
            myocytes. alpha 1C, alpha 1B, and alpha 1D mRNAs are present in
            cardiac myocytes but not in cardiac fibroblasts
  JOURNAL   Circ Res 75 (4), 796-802 (1994)
   PUBMED   7923624
REFERENCE   7  (bases 1 to 1428)
  AUTHORS   Laz,T.M., Forray,C., Smith,K.E., Bard,J.A., Vaysse,P.J.,
            Branchek,T.A. and Weinshank,R.L.
  TITLE     The rat homologue of the bovine alpha 1c-adrenergic receptor shows
            the pharmacological properties of the classical alpha 1A subtype
  JOURNAL   Mol Pharmacol 46 (3), 414-422 (1994)
   PUBMED   7935320
REFERENCE   8  (bases 1 to 1428)
  AUTHORS   Rokosh,D.G., Bailey,B.A., Stewart,A.F., Karns,L.R., Long,C.S. and
            Simpson,P.C.
  TITLE     Distribution of alpha 1C-adrenergic receptor mRNA in adult rat
            tissues by RNase protection assay and comparison with alpha 1B and
            alpha 1D
  JOURNAL   Biochem Biophys Res Commun 200 (3), 1177-1184 (1994)
   PUBMED   8185565
REFERENCE   9  (bases 1 to 1428)
  AUTHORS   Alonso-Llamazares,A., Zamanillo,D., Fernandez,A., Chinchetru,M.A.
            and Calvo,P.
  TITLE     Differential expression of the alpha 1c adrenergic receptor subtype
            in rat tissues
  JOURNAL   Neuroreport 4 (11), 1266-1268 (1993)
   PUBMED   7693016
REFERENCE   10 (bases 1 to 1428)
  AUTHORS   Padlan,E.A.
  TITLE     Evaluation of the structural variation among light chain variable
            domains
  JOURNAL   Mol Immunol 16 (5), 287-296 (1979)
   PUBMED   114750
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U07126.1.
            
            On Jun 10, 2007 this sequence version replaced NM_017191.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U07126.1, U13368.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1428
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..1428
                     /gene="Adra1a"
                     /gene_synonym="Adra1c"
                     /note="adrenoceptor alpha 1A"
                     /db_xref="GeneID:29412"
                     /db_xref="RGD:2055"
     exon            1..898
                     /gene="Adra1a"
                     /gene_synonym="Adra1c"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1416
                     /gene="Adra1a"
                     /gene_synonym="Adra1c"
                     /note="adrenergic receptor, alpha 1a; adrenergic receptor,
                     alpha 1c; adrenergic receptor alpha 1c subtype; alpha-1C
                     adrenergic receptor; alpha-1A adrenoceptor; alpha-1A
                     adrenoreceptor; adrenergic alpha 1c receptor; adrenergic,
                     alpha-1A-, receptor"
                     /codon_start=1
                     /product="alpha-1A adrenergic receptor"
                     /protein_id="NP_058887.2"
                     /db_xref="GeneID:29412"
                     /db_xref="RGD:2055"
                     /translation="MVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGN
                     ILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIW
                     AAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVISIG
                     PLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGL
                     KSGLKTDKSDSEQVTLRIHRKNVPAEGGGVSSAKNKTHFSVRLLKFSREKKAAKTLGI
                     VVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFK
                     KAFQNVLRIQCLRRRQSSKHALGYTLHPPSQALEGQHRDMVRIPVGSGETFYKISKTD
                     GVCEWKFFSSMPQGSARITVPKDQSACTTARVRSKSFLQVCCCVGSSAPRPEENHQVP
                     TIKIHTISLGENGEEV"
     exon            899..1428
                     /gene="Adra1a"
                     /gene_synonym="Adra1c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccctccctg agaccatggt gcttctctct gaaaatgctt cggaaggctc caactgcacc
       61 cacccaccag ctccggtgaa catttctaag gccattctgc ttggggtgat cttggggggc
      121 ctcatcattt tcggagtcct ggggaacatt ttagtgatcc tctcagtggc ctgtcatcgg
      181 catctgcact ccgtgactca ctactacatt gtcaacctgg ctgtggcaga cctcctcctc
      241 acctccactg tgctgccctt ctctgccatc tttgagatcc tgggctactg ggcctttggc
      301 agggtgttct gcaatatctg ggcggccgtg gacgtcttat gctgcacagc gtccatcatg
      361 ggcctctgca tcatctccat cgaccgatac attggtgtga gctacccgct gcgctatccc
      421 accattgtca cccagaggag gggcgtcagg gctctgctct gcgtctgggt gctttctttg
      481 gtcatctcca tcggacccct gttcggctgg aggcagccgg ctccagagga tgagaccatc
      541 tgccagatca atgaggagcc gggctacgtg ctgttctcag cgctgggctc tttctacgtg
      601 ccactggcca tcattctggt tatgtactgt cgagtctacg tagtagccaa gagagaaagc
      661 cggggcctca agtccggcct caagacggac aagtcagact cagagcaagt gacgctccgc
      721 atccaccgta aaaatgtccc tgcagaaggc ggcggagtca gcagtgccaa gaataagact
      781 cacttctcag tgaggctgct caagttttct cgagagaaga aagctgccaa gacgctgggc
      841 atcgtggtgg gttgcttcgt cctctgctgg ctgccgttct tcctagtgat gcccattggg
      901 tctttcttcc cggatttcaa gccttcggaa accgttttta aaatagtatt ttggctcggg
      961 tatctaaata gttgcatcaa ccctatcata tacccatgct ccagccagga gttcaagaaa
     1021 gcctttcaga atgtcctgcg aatccagtgt cttcgcagaa ggcagtcttc caagcatgcc
     1081 ctgggctata ccctgcaccc gcccagccag gctctagagg gacagcacag agacatggtg
     1141 cgtatcccgg tgggctcggg agagactttc tataagatct ccaagacaga tggagtctgt
     1201 gaatggaagt ttttctcttc catgccccag ggatcggcca ggattacagt gccaaaggac
     1261 caatctgcct gtaccacagc ccgggtgaga agtaaaagct ttttgcaggt ctgctgctgt
     1321 gtggggtcct cggccccgcg ccctgaagaa aatcaccaag ttccaaccat taagatccac
     1381 accatctccc tcggtgaaaa cggggaggaa gtctagagga tgggaaag
//
