LOCUS       NM_001108680            1666 bp    mRNA    linear   ROD 12-JUN-2023
DEFINITION  Rattus norvegicus ADP-ribosylserine hydrolase (Adprs), mRNA.
ACCESSION   NM_001108680 XM_001057958 XM_342918
VERSION     NM_001108680.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1666)
  AUTHORS   Danhauser K, Alhaddad B, Makowski C, Piekutowska-Abramczuk D, Syrbe
            S, Gomez-Ospina N, Manning MA, Kostera-Pruszczyk A, Krahn-Peper C,
            Berutti R, Kovacs-Nagy R, Gusic M, Graf E, Laugwitz L, Roblitz M,
            Wroblewski A, Hartmann H, Das AM, Bultmann E, Fang F, Xu M, Schatz
            UA, Karall D, Zellner H, Haberlandt E, Feichtinger RG, Mayr JA,
            Meitinger T, Prokisch H, Strom TM, Ploski R, Hoffmann GF, Pronicki
            M, Bonnen PE, Morlot S and Haack TB.
  TITLE     Bi-allelic ADPRHL2 Mutations Cause Neurodegeneration with
            Developmental Delay, Ataxia, and Axonal Neuropathy
  JOURNAL   Am J Hum Genet 103 (5), 817-825 (2018)
   PUBMED   30401461
REFERENCE   2  (bases 1 to 1666)
  AUTHORS   Wang M, Yuan Z, Xie R, Ma Y, Liu X and Yu X.
  TITLE     Structure-function analyses reveal the mechanism of the
            ARH3-dependent hydrolysis of ADP-ribosylation
  JOURNAL   J Biol Chem 293 (37), 14470-14480 (2018)
   PUBMED   30045870
  REMARK    Erratum:[J Biol Chem. 2019 Jan 18;294(3):874. PMID: 30659162]
REFERENCE   3  (bases 1 to 1666)
  AUTHORS   Abplanalp J, Leutert M, Frugier E, Nowak K, Feurer R, Kato J,
            Kistemaker HVA, Filippov DV, Moss J, Caflisch A and Hottiger MO.
  TITLE     Proteomic analyses identify ARH3 as a serine
            mono-ADP-ribosylhydrolase
  JOURNAL   Nat Commun 8 (1), 2055 (2017)
   PUBMED   29234005
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1666)
  AUTHORS   Fontana P, Bonfiglio JJ, Palazzo L, Bartlett E, Matic I and Ahel I.
  TITLE     Serine ADP-ribosylation reversal by the hydrolase ARH3
  JOURNAL   Elife 6, e28533 (2017)
   PUBMED   28650317
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1666)
  AUTHORS   Mashimo M, Kato J and Moss J.
  TITLE     ADP-ribosyl-acceptor hydrolase 3 regulates poly (ADP-ribose)
            degradation and cell death during oxidative stress
  JOURNAL   Proc Natl Acad Sci U S A 110 (47), 18964-18969 (2013)
   PUBMED   24191052
REFERENCE   6  (bases 1 to 1666)
  AUTHORS   Kasamatsu A, Nakao M, Smith BC, Comstock LR, Ono T, Kato J, Denu JM
            and Moss J.
  TITLE     Hydrolysis of O-acetyl-ADP-ribose isomers by ADP-ribosylhydrolase 3
  JOURNAL   J Biol Chem 286 (24), 21110-21117 (2011)
   PUBMED   21498885
REFERENCE   7  (bases 1 to 1666)
  AUTHORS   Ono T, Kasamatsu A, Oka S and Moss J.
  TITLE     The 39-kDa poly(ADP-ribose) glycohydrolase ARH3 hydrolyzes
            O-acetyl-ADP-ribose, a product of the Sir2 family of acetyl-histone
            deacetylases
  JOURNAL   Proc Natl Acad Sci U S A 103 (45), 16687-16691 (2006)
   PUBMED   17075046
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473968.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001057958.1, XM_342918.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC159416.1, SRR8487227.281727.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1666
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1666
                     /gene="Adprs"
                     /gene_synonym="Adprhl2"
                     /note="ADP-ribosylserine hydrolase"
                     /db_xref="GeneID:362600"
                     /db_xref="RGD:1309068"
     exon            1..262
                     /gene="Adprs"
                     /gene_synonym="Adprhl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1146
                     /gene="Adprs"
                     /gene_synonym="Adprhl2"
                     /EC_number="3.2.1.143"
                     /note="poly(ADP-ribose) glycohydrolase ARH3;
                     ADP-ribosylhydrolase like 2; ADP-ribose glycohydrolase
                     ARH3"
                     /codon_start=1
                     /product="ADP-ribosylhydrolase ARH3"
                     /protein_id="NP_001102150.1"
                     /db_xref="GeneID:362600"
                     /db_xref="RGD:1309068"
                     /translation="MAAAAAAAAAAMTAAGGGGAGAARSLSRFRGCLAGALLGDCVGA
                     VFEAHDTVSLTSVLSHVQSLEPDPGTPGSARTETLYYTDDTAMTRAMVQSLLAKEAFD
                     EVDMAHRFAQEYKKDPDRGYGAGVITVFKKLLNPKCRDVYEPARAQFNGKGSYGNGGA
                     MRVAGIPLAYHSVQDVQKFARLSAQLTHASSLGYNGAILQALAVHLALQGVSSSEHFL
                     EQLLGHMEELEGDAQSVLDAKELGMEERPYSSRLKKVGELLDQDAVSREEVVSELGNG
                     IAAFESVPTAIYCFLRCMEPDPEIPSTFNSLQRTLIYSISLGGDTDTIATMAGAIAGA
                     YYGVEQVPESWQQSCEGYEETDVLAQSLHRVFQESP"
     exon            263..359
                     /gene="Adprs"
                     /gene_synonym="Adprhl2"
                     /inference="alignment:Splign:2.1.0"
     exon            360..567
                     /gene="Adprs"
                     /gene_synonym="Adprhl2"
                     /inference="alignment:Splign:2.1.0"
     exon            568..752
                     /gene="Adprs"
                     /gene_synonym="Adprhl2"
                     /inference="alignment:Splign:2.1.0"
     exon            753..853
                     /gene="Adprs"
                     /gene_synonym="Adprhl2"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1666
                     /gene="Adprs"
                     /gene_synonym="Adprhl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcgccgga agtggcgatt agtccgcgcg cggatggcgg cggcggcggc tgcggcagcg
       61 gcagcgatga cggcggcggg cggcggcgga gctggtgcgg cccgctccct ctcgcgcttc
      121 cgaggctgcc tggcgggcgc gctgctggga gactgcgtgg gcgctgtctt cgaggcacac
      181 gataccgtca gcctgacgtc tgtcctgagt cacgttcaga gcctggagcc agacccgggc
      241 acgccgggca gcgcgcggac agaaacattg tactacacag atgacaccgc catgaccagg
      301 gccatggtgc agtccctgct ggccaaggag gctttcgacg aggtggacat ggctcacagg
      361 tttgcccaag aatacaagaa ggaccctgac agagggtatg gggccggagt catcactgtc
      421 ttcaagaaac tcctgaatcc aaagtgccgt gatgtgtatg aacctgcccg ggcccagttc
      481 aatggaaagg gctcctatgg caatggggga gccatgcggg tagctggcat cccgctggcc
      541 tatcacagtg tccaagatgt gcagaagttt gcccggctct cagctcagct gacccatgcc
      601 tcttccctgg gttacaacgg tgccatcttg caggccctgg ctgtgcacct agcgctgcag
      661 ggtgtatcat ccagtgagca cttcctcgag cagcttctgg gccacatgga ggagctggaa
      721 ggtgatgccc agtcagtctt ggatgccaag gagttgggta tggaggagcg cccgtactcc
      781 agcaggctga agaaggtggg agagctgctg gaccaggacg cggtgagccg agaggaagtg
      841 gtgtctgagc tagggaatgg aatcgctgcc tttgagtctg tgcccaccgc catctactgc
      901 ttcctgcgct gcatggagcc tgatcctgag atcccctcca ccttcaacag tctccagagg
      961 actctcatct actccatctc tcttggtggg gacacagaca ccatagccac catggctggg
     1021 gccattgctg gagcttacta tggggtggaa caggtgccgg agagctggca gcagagctgt
     1081 gagggctatg aggagacaga tgtcctggcc cagagcctac accgagtctt ccaagagagt
     1141 ccctgagggc cacagcttca gtggtactga cagaaccatc aggacccaag gacgactcag
     1201 attgcaaacc atagttccct taggttgact cgcccgccct gcattcctag agggcaggct
     1261 gaattacctt ggggctggag tcttgggaca gcctgtggaa cagagaggag ctggtacctc
     1321 cttggggctg caactctggc ttgctgcagg gctgtatgac accccaggat cctcagaaat
     1381 atgagggacc agggcaggtc ttattttgga ggggtatttg gggcactctt cttcgtctag
     1441 gtcatgagac ctaggaaggt gaacctatgg gggtttccta tctcctggtt gggttttaat
     1501 cagtgtgaca gcctattgct gggtgggcgg ggccagcagc aggttggttg actcgtgaga
     1561 ctggcgttca gcccatccac tggctgcctg gcccctcaca gcaatgggct ccttgacagc
     1621 ttctggtggc tgtcacagca ataaacagtt ttttgtaagt cccagc
//
