LOCUS       NM_183325               1546 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ADP-ribosylarginine hydrolase (Adprh), mRNA.
ACCESSION   NM_183325 XM_340989
VERSION     NM_183325.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1546)
  AUTHORS   Rack,J.G.M., Ariza,A., Drown,B.S., Henfrey,C., Bartlett,E.,
            Shirai,T., Hergenrother,P.J. and Ahel,I.
  TITLE     (ADP-ribosyl)hydrolases: Structural Basis for Differential
            Substrate Recognition and Inhibition
  JOURNAL   Cell Chem Biol 25 (12), 1533-1546 (2018)
   PUBMED   30472116
REFERENCE   2  (bases 1 to 1546)
  AUTHORS   Kato,J., Zhu,J., Liu,C., Stylianou,M., Hoffmann,V., Lizak,M.J.,
            Glasgow,C.G. and Moss,J.
  TITLE     ADP-ribosylarginine hydrolase regulates cell proliferation and
            tumorigenesis
  JOURNAL   Cancer Res 71 (15), 5327-5335 (2011)
   PUBMED   21697277
REFERENCE   3  (bases 1 to 1546)
  AUTHORS   Kernstock,S., Koch-Nolte,F., Mueller-Dieckmann,J., Weiss,M.S. and
            Mueller-Dieckmann,C.
  TITLE     Cloning, expression, purification and crystallization as well as
            X-ray fluorescence and preliminary X-ray diffraction analyses of
            human ADP-ribosylhydrolase 1
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 65 (Pt 5), 529-532
            (2009)
   PUBMED   19407395
REFERENCE   4  (bases 1 to 1546)
  AUTHORS   Miyaoka,T., Tsuchiya,M., Yamada,K., Badruzzaman,M., Yamamori,C.,
            Ishino,H. and Shimoyama,M.
  TITLE     Immunohistochemical localization of ADP-ribosylarginine hydrolase
            in rodent CNS
  JOURNAL   Brain Res 746 (1-2), 1-9 (1997)
   PUBMED   9037477
REFERENCE   5  (bases 1 to 1546)
  AUTHORS   Takada,T., Iida,K. and Moss,J.
  TITLE     Cloning and site-directed mutagenesis of human ADP-ribosylarginine
            hydrolase
  JOURNAL   J Biol Chem 268 (24), 17837-17843 (1993)
   PUBMED   8349667
REFERENCE   6  (bases 1 to 1546)
  AUTHORS   Moss,J., Stanley,S.J., Nightingale,M.S., Murtagh,J.J. Jr.,
            Monaco,L., Mishima,K., Chen,H.C., Williamson,K.C. and Tsai,S.C.
  TITLE     Molecular and immunological characterization of ADP-ribosylarginine
            hydrolases
  JOURNAL   J Biol Chem 267 (15), 10481-10488 (1992)
   PUBMED   1375222
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC082065.1.
            
            On Sep 16, 2004 this sequence version replaced NM_183325.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082065.1, EV769937.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1546
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..1546
                     /gene="Adprh"
                     /gene_synonym="ADPRHA"
                     /note="ADP-ribosylarginine hydrolase"
                     /db_xref="GeneID:25371"
                     /db_xref="RGD:2052"
     exon            1..103
                     /gene="Adprh"
                     /gene_synonym="ADPRHA"
                     /inference="alignment:Splign:2.1.0"
     exon            104..458
                     /gene="Adprh"
                     /gene_synonym="ADPRHA"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..1234
                     /gene="Adprh"
                     /gene_synonym="ADPRHA"
                     /EC_number="3.2.2.19"
                     /note="[Protein ADP-ribosylarginine] hydrolase;
                     ADP-ribose-L-arginine cleaving enzyme"
                     /codon_start=1
                     /product="ADP-ribosylhydrolase ARH1"
                     /protein_id="NP_899154.2"
                     /db_xref="GeneID:25371"
                     /db_xref="RGD:2052"
                     /translation="MGGGLIERYVAAMVLSAAGDTLGYFNGKWEFLRDGEKIHRQLAQ
                     MGDLEAIDVAQWRVSDDTIMHLATAEALMEAGSSPDLPQLYSLLAKHYRDCMGDMDGR
                     APGGACMQNAMQLDPDRADGWRIPFNSHEGGCGAAMRAMCIGLRFPHPSQLDTLIQVS
                     IESGRMTHHHPTGYLGSLASALFTAYAVNGKSPRQWGKGLMEVLPEAKAYVTQSGYFV
                     KENLQHWSYFEKEWEKYLELRGILDGKSAPVFPKPFGVKERDQFYIEVSYSGWGGSSG
                     HDAPMIAYDALLAAGDSWKELAHRAFFHGGDSDSTATIAGCWWGVMHGFKGVNPSNYE
                     KLEYRQRLEEAGRALYSLGSKEDTILGP"
     exon            459..819
                     /gene="Adprh"
                     /gene_synonym="ADPRHA"
                     /inference="alignment:Splign:2.1.0"
     exon            820..1520
                     /gene="Adprh"
                     /gene_synonym="ADPRHA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgggactcc agcgcgggct accccgcctc cagctccggc cagccagccc tcggctctgg
       61 acaaccccga tcccgcccca cgctctcagc tccgcctcag caggagtctc agttgcccca
      121 taagaccgcc tgtgccaagc tcagcatggg tgggggcctg attgagaggt atgtggctgc
      181 catggtgctg agtgcggctg gtgataccct gggctacttc aacgggaagt gggaattcct
      241 tcgggatggg gagaagatac accggcagtt ggcccagatg ggtgacttgg aagccataga
      301 tgtggcccag tggagagtca gcgatgacac catcatgcac ctggctacag cagaagccct
      361 catggaagcc ggcagttccc cggatttgcc tcagctgtat tccctactag ctaaacatta
      421 ccgggactgc atgggagaca tggatggccg ggcaccaggt ggtgcttgca tgcagaatgc
      481 catgcagctg gaccccgaca gggctgacgg ctggaggatt cccttcaaca gtcacgaggg
      541 cggctgtgga gccgccatgc gcgccatgtg catcgggctg aggtttcctc accccagcca
      601 gctggatact ctgatccaag tgagcatcga gagcggccgg atgacccacc accaccccac
      661 aggctacctc ggaagcctag cgtcagctct ttttaccgca tatgccgtga acggcaaatc
      721 accacggcag tgggggaagg ggctgatgga ggtgctgcca gaggccaaag cgtatgtcac
      781 ccagtcaggc tactttgtga aggaaaatct ccaacactgg tcctacttcg agaaagaatg
      841 ggaaaagtac ctggaactta gaggaatttt ggatggcaag tccgctcccg tcttcccgaa
      901 accctttggt gtgaaggaaa gggatcagtt ctatatcgaa gtgagctact caggctgggg
      961 tggcagcagt ggacacgatg cccccatgat tgcctatgat gccctcctgg ctgcagggga
     1021 ttcctggaag gagctcgcac acagagcctt tttccatggt ggagacagtg attccacggc
     1081 caccattgct ggatgctggt ggggagttat gcacggtttc aaaggggtaa acccttctaa
     1141 ctatgagaag ctcgaatacc gacagcggct agaagaggcc ggaagagctt tgtattctct
     1201 ggggtcaaaa gaagacacta tactaggtcc ctagggaaag ggtggtttgt tttggcggtt
     1261 ttttcccctg tatccccgac actcattctc ttcagctttt ccagcgtcaa gaatcctaat
     1321 tttgtgtttg aagaattctg agtaaacaag tcccttgggc ggcttcagcc ccgccttccc
     1381 acgcttaccc tgccctcccc gagttcctct tttgtgtgta agagtctttt tatttcagtt
     1441 gatgtgctca gtgtttctca ttccagaaac ctcataacct tgtattcacg tctccatttt
     1501 tatcatggaa ttgttctaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
