LOCUS       NM_001100723            2579 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus ADP-dependent glucokinase (Adpgk), mRNA.
ACCESSION   NM_001100723 XM_001072870 XM_236306
VERSION     NM_001100723.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2579)
  AUTHORS   Richter,J.P., Goroncy,A.K., Ronimus,R.S. and Sutherland-Smith,A.J.
  TITLE     The Structural and Functional Characterization of Mammalian
            ADP-dependent Glucokinase
  JOURNAL   J Biol Chem 291 (8), 3694-3704 (2016)
   PUBMED   26555263
REFERENCE   2  (bases 1 to 2579)
  AUTHORS   Kaminski,M.M., Sauer,S.W., Kaminski,M., Opp,S., Ruppert,T.,
            Grigaravicius,P., Grudnik,P., Grone,H.J., Krammer,P.H. and Gulow,K.
  TITLE     T cell activation is driven by an ADP-dependent glucokinase linking
            enhanced glycolysis with mitochondrial reactive oxygen species
            generation
  JOURNAL   Cell Rep 2 (5), 1300-1315 (2012)
   PUBMED   23168256
REFERENCE   3  (bases 1 to 2579)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Jun 1, 2008 this sequence version replaced
            XM_001072870.1, XM_236306.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.1258832.1,
                                           SRR26360194.476718.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-271               JAXUCZ010000008.1  68595272-68595542
            272-497             JAXUCZ010000008.1  68601869-68602094
            498-560             JAXUCZ010000008.1  68608282-68608344
            561-681             JAXUCZ010000008.1  68615511-68615631
            682-878             JAXUCZ010000008.1  68619688-68619884
            879-977             JAXUCZ010000008.1  68620418-68620516
            978-2579            JAXUCZ010000008.1  68621578-68623179
FEATURES             Location/Qualifiers
     source          1..2579
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2579
                     /gene="Adpgk"
                     /gene_synonym="RGD1306103"
                     /note="ADP-dependent glucokinase"
                     /db_xref="GeneID:315722"
                     /db_xref="RGD:1306103"
     exon            1..271
                     /gene="Adpgk"
                     /gene_synonym="RGD1306103"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1529
                     /gene="Adpgk"
                     /gene_synonym="RGD1306103"
                     /EC_number="2.7.1.147"
                     /codon_start=1
                     /product="ADP-dependent glucokinase precursor"
                     /protein_id="NP_001094193.1"
                     /db_xref="GeneID:315722"
                     /db_xref="RGD:1306103"
                     /translation="MALWRGSACAGFLALAVGCVFLLEPELPGTALRSLWSSLRLGPA
                     PVPPGSLSPESRLAAAWDALIVQPARRWRRVAVGVNACVDVVISGVKLLQALGLSPGS
                     GRDHAVLHSRSDLEEAFVHFMGKGAAAERFFSDRETFHDIAQAASEFPGAQHYVGGNA
                     ALIGQKFAANPDLKVLLCGPIGPKLHELLDDNVFVPPESLQEEDEFHLILEYLAGEEW
                     GPFKAPQANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKELQRK
                     RLLEVVTSISDIPTGIPVHLELASMTNRELMSSIVHQQVFPAVASLGLNEQELLFLSQ
                     SASGPHASLSSWDGVPDVGMVSDILFWILKEHGRSKSRSSDLTRIHFHTLVYHILATV
                     DGHWANQLAAVAAGARVAGTQACATETIDTNRVSLRAPQEFMTSRLEPGSRIVLNPNK
                     PVVEWHREGVTFHFTPVLVCKDPVRTVGLGDAISAEGLFYSEAYPD"
     exon            272..497
                     /gene="Adpgk"
                     /gene_synonym="RGD1306103"
                     /inference="alignment:Splign:2.1.0"
     exon            498..560
                     /gene="Adpgk"
                     /gene_synonym="RGD1306103"
                     /inference="alignment:Splign:2.1.0"
     exon            561..681
                     /gene="Adpgk"
                     /gene_synonym="RGD1306103"
                     /inference="alignment:Splign:2.1.0"
     exon            682..878
                     /gene="Adpgk"
                     /gene_synonym="RGD1306103"
                     /inference="alignment:Splign:2.1.0"
     exon            879..977
                     /gene="Adpgk"
                     /gene_synonym="RGD1306103"
                     /inference="alignment:Splign:2.1.0"
     exon            978..2579
                     /gene="Adpgk"
                     /gene_synonym="RGD1306103"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaggatctc gtagtctcca gtgcggcagt gtgtccacat ggcgctgtgg cgcggctctg
       61 cgtgcgccgg cttcctggcg ctggccgtgg gctgcgtgtt tctgctggag ccggagctgc
      121 cgggcacagc gctacgctcg ctctggagct cgctgaggct ggggcccgcg ccagtgcccc
      181 cgggatctct gtccccagag agccggctgg cggccgcttg ggatgccctc atcgtgcagc
      241 ccgcccggcg ctggcgccgc gtggctgtgg gagtcaatgc ctgtgtggat gtggtcatct
      301 ctggcgtgaa gctcctgcag gcactcggcc taagtcctgg gagtggaaga gaccatgctg
      361 ttctacactc aagaagtgat ctggaagaag cctttgtcca cttcatgggg aagggagctg
      421 ctgctgaacg cttcttcagt gatagagaga cctttcatga cattgcccag gctgcatctg
      481 agttcccagg agcccagcac tatgtaggag gaaatgccgc tttaattgga cagaagtttg
      541 ctgccaaccc agacttaaag gttcttcttt gtggtccaat tggcccaaag ctacatgaac
      601 ttcttgatga caatgtgttt gttccgccag agtcactgca ggaagaggat gagttccacc
      661 ttattttaga gtacctggca ggggaggagt ggggcccgtt taaagctccc caggccaacc
      721 ggttcatctt ctctcacgac ctctccaacg gggccatgaa tatgctggag gtgtttgtgt
      781 ctagcctgga ggagttccag cctgacctgg tggtcctttc tggattgcac atgatggagg
      841 gacaaagcaa ggagctccag aggaagaggc tcttggaggt tgtgacctcc atctctgaca
      901 tccccactgg tattccagtt cacctagagc tggccagtat gaccaacagg gagctcatga
      961 gcagtattgt gcatcagcag gtctttcccg cagtggcttc tcttgggctg aatgaacagg
     1021 agctgctgtt tctcagccag tcagcatctg gaccccatgc ttctctctcc tcttgggatg
     1081 gcgttcctga tgtgggcatg gtcagtgata tcctcttctg gatcttgaaa gaacatggaa
     1141 ggagcaaaag cagatcgtca gatctcacca ggatccattt ccacacgctg gtctaccaca
     1201 ttctggcaac tgtggacgga cactgggcca accagctcgc agctgtagct gcaggagctc
     1261 gtgtagctgg gacacaagcc tgtgccacgg aaaccataga caccaaccga gtatctctga
     1321 gagcacctca ggagtttatg acatcccgtt tggagcccgg ctccaggatt gtattaaacc
     1381 caaataagcc agtggtggag tggcacaggg agggggtcac tttccacttc acacccgtgt
     1441 tggtgtgtaa agaccctgtt cgaactgtag gccttggtga tgccatttct gctgaaggcc
     1501 tcttctattc agaagcatac cctgattagg aatgctgtag acagttatat gaggaatgaa
     1561 agccacccat cttaagaatt ccaggacgaa catagcttgg gaaataggct tgtgggtgtc
     1621 agaacagttc ctagatctaa ttggaaggca gccaaagaaa tcacagcaga ttaaactgca
     1681 cagatacatt ccagcctgtt ggcagcataa aatcacttca ggtataatcg aaacgtagct
     1741 atctactaac gagactggat ttttgttttt tgtgtgtgct acaaaggtta agaacacctc
     1801 cctgggggat tggggtttag ctcagtggta gagcgattgc ctagcaaggg taaggccctg
     1861 ggttcggtcc tcagctaaaa aaaaaaaaaa gaacacctct ctgaatcccc agttgatgta
     1921 ccatgactct ggagagtctc ctccggccgc agaaagcact tccctccttg ccctctagag
     1981 aaggcagtcc tcccccacaa gactgaccac tcgtgaaacc tgctgaaggc agtcatgaca
     2041 ccttatgctc ctggcagaat cagcttgtcc attcagtgtt agagtgacaa tatttgacat
     2101 gtgtaccttc tcagcctcct gttctcagac ataggtcaga gccgcaagag aggacaaaac
     2161 agtcctgtgc tttatgggct aggattggag attcttggga gagccttgag ccacctaatc
     2221 attctgcacc tgcttgggag catcatgcct tcctgcctca gcttcagaga ttggggctga
     2281 ctgagaaaag gccctatggc ttgttctcag cctcagtgcc gagcctggaa atgctttctg
     2341 cagcaggaga ctggttctcg tttcttctga gccttgaaga gatgtgtctt acaactggaa
     2401 agtgcttcag tatagaacac atcatgtgtt ttgtgttttt gttttgacac atccattagt
     2461 ttgacctctt aagagcccca ggatcatgaa taaatgtgtc gtgttgtata tttatttttt
     2521 taataaatca agatttctgt gtgcttttaa aaatattaaa acaatttaca tttccagga
//
