LOCUS       NM_001302751            1764 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus adenosine A3 receptor (Adora3), transcript
            variant A3, mRNA.
ACCESSION   NM_001302751 NM_012896
VERSION     NM_001302751.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1764)
  AUTHORS   Bai,H., Zhang,Z., Liu,L., Wang,X., Song,X. and Gao,L.
  TITLE     Activation of adenosine A3 receptor attenuates progression of
            osteoarthritis through inhibiting the NLRP3/caspase-1/GSDMD induced
            signalling
  JOURNAL   J Cell Mol Med 26 (15), 4230-4243 (2022)
   PUBMED   35775127
  REMARK    GeneRIF: Activation of adenosine A3 receptor attenuates progression
            of osteoarthritis through inhibiting the NLRP3/caspase-1/GSDMD
            induced signalling.
REFERENCE   2  (bases 1 to 1764)
  AUTHORS   Ferreira-Silva,J., Aires,I.D., Boia,R., Ambrosio,A.F. and
            Santiago,A.R.
  TITLE     Activation of Adenosine A3 Receptor Inhibits Microglia Reactivity
            Elicited by Elevated Pressure
  JOURNAL   Int J Mol Sci 21 (19), 7218 (2020)
   PUBMED   33007835
  REMARK    GeneRIF: Activation of Adenosine A3 Receptor Inhibits Microglia
            Reactivity Elicited by Elevated Pressure.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1764)
  AUTHORS   Boia,R., Salinas-Navarro,M., Gallego-Ortega,A., Galindo-Romero,C.,
            Aires,I.D., Agudo-Barriuso,M., Ambrosio,A.F., Vidal-Sanz,M. and
            Santiago,A.R.
  TITLE     Activation of adenosine A3 receptor protects retinal ganglion cells
            from degeneration induced by ocular hypertension
  JOURNAL   Cell Death Dis 11 (5), 401 (2020)
   PUBMED   32461578
  REMARK    GeneRIF: Activation of adenosine A3 receptor protects retinal
            ganglion cells from degeneration induced by ocular hypertension.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1764)
  AUTHORS   Qu,F., Cui,Y., Zeng,J., Zhang,M., Qiu,S., Huang,X. and Chen,A.
  TITLE     Acupuncture induces adenosine in fibroblasts through energy
            metabolism and promotes proliferation by activating MAPK signaling
            pathway via adenosine3 receptor
  JOURNAL   J Cell Physiol 235 (3), 2441-2451 (2020)
   PUBMED   31556103
  REMARK    GeneRIF: Acupuncture induces adenosine in fibroblasts through
            energy metabolism and promotes proliferation by activating MAPK
            signaling pathway via adenosine3 receptor.
REFERENCE   5  (bases 1 to 1764)
  AUTHORS   Iyer,S.V., Ranjan,A., Elias,H.K., Parrales,A., Sasaki,H., Roy,B.C.,
            Umar,S., Tawfik,O.W. and Iwakuma,T.
  TITLE     Genome-wide RNAi screening identifies TMIGD3 isoform1 as a
            suppressor of NF-kappaB and osteosarcoma progression
  JOURNAL   Nat Commun 7, 13561 (2016)
   PUBMED   27886186
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1764)
  AUTHORS   Salvatore,C.A., Tilley,S.L., Latour,A.M., Fletcher,D.S.,
            Koller,B.H. and Jacobson,M.A.
  TITLE     Disruption of the A(3) adenosine receptor gene in mice and its
            effect on stimulated inflammatory cells
  JOURNAL   J Biol Chem 275 (6), 4429-4434 (2000)
   PUBMED   10660615
REFERENCE   7  (bases 1 to 1764)
  AUTHORS   Dunwiddie,T.V., Diao,L., Kim,H.O., Jiang,J.L. and Jacobson,K.A.
  TITLE     Activation of hippocampal adenosine A3 receptors produces a
            desensitization of A1 receptor-mediated responses in rat
            hippocampus
  JOURNAL   J Neurosci 17 (2), 607-614 (1997)
   PUBMED   8987783
REFERENCE   8  (bases 1 to 1764)
  AUTHORS   Sajjadi,F.G., Boyle,D.L., Domingo,R.C. and Firestein,G.S.
  TITLE     cDNA cloning and characterization of A3i, an alternatively spliced
            rat A3 adenosine receptor variant
  JOURNAL   FEBS Lett 382 (1-2), 125-129 (1996)
   PUBMED   8612733
REFERENCE   9  (bases 1 to 1764)
  AUTHORS   Zhou,Q.Y., Li,C., Olah,M.E., Johnson,R.A., Stiles,G.L. and
            Civelli,O.
  TITLE     Molecular cloning and characterization of an adenosine receptor:
            the A3 adenosine receptor
  JOURNAL   Proc Natl Acad Sci U S A 89 (16), 7432-7436 (1992)
   PUBMED   1323836
REFERENCE   10 (bases 1 to 1764)
  AUTHORS   Meyerhof,W., Muller-Brechlin,R. and Richter,D.
  TITLE     Molecular cloning of a novel putative G-protein coupled receptor
            expressed during rat spermiogenesis
  JOURNAL   FEBS Lett 284 (2), 155-160 (1991)
   PUBMED   1647979
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Feb 28, 2022 this sequence version replaced NM_012896.3.
            
            Transcript Variant: This variant (A3) uses an alternate in-frame
            splice site in the 3' terminal exon, compared to variant A3i,
            resulting in an isoform (b) that is shorter than isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X59249.1, DQ075463.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-671               JAXUCZ010000002.1  196077042-196077712
            672-1458            JAXUCZ010000002.1  196079594-196080380
            1459-1764           JAXUCZ010000002.1  196080381-196080686
FEATURES             Location/Qualifiers
     source          1..1764
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1764
                     /gene="Adora3"
                     /gene_synonym="A3; TGPCR1"
                     /note="adenosine A3 receptor"
                     /db_xref="GeneID:100911796"
                     /db_xref="RGD:2051"
     exon            1..671
                     /gene="Adora3"
                     /gene_synonym="A3; TGPCR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             316..1278
                     /gene="Adora3"
                     /gene_synonym="A3; TGPCR1"
                     /note="isoform b is encoded by transcript variant A3;
                     Adenosine receptor A3; putative G-protein coupled
                     receptor; adenosine receptor A3-like"
                     /codon_start=1
                     /product="adenosine receptor A3 isoform b"
                     /protein_id="NP_001289680.1"
                     /db_xref="GeneID:100911796"
                     /db_xref="RGD:2051"
                     /translation="MKANNTTTSALWLQITYITMEAAIGLCAVVGNMLVIWVVKLNRT
                     LRTTTFYFIVSLALADIAVGVLVIPLAIAVSLEVQMHFYACLFMSCVLLVFTHASIMS
                     LLAIAVDRYLRVKLTVRYRTVTTQRRIWLFLGLCWLVSFLVGLTPMFGWNRKVTLELS
                     QNSSTLSCHFRSVVGLDYMVFFSFITWILIPLVVMCIIYLDIFYIIRNKLSQNLTGFR
                     ETRAFYGREFKTAKSLFLVLFLFALCWLPLSIINFVSYFNVKIPEIAMCLGILLSHAN
                     SMMNPIVYACKIKKFKETYFVILRACRLCQTSDSLDSNLEQTTE"
     exon            672..1764
                     /gene="Adora3"
                     /gene_synonym="A3; TGPCR1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagccctgt ctctgtctgc ccagggaagt aagaacagca gcactcttgg atttggctgc
       61 atagaactgt gtcctccagg ttatcaggag ggcagggcta agtggctgag gtctacgatc
      121 ctgtcaagga ccttttctga gaaaagtctc taaaagagca tcacaccaga aggaataagc
      181 aagtcatgaa ttctccggac tgttgctacc ttctaacttc tgggcagatg tctgtcaaga
      241 gctaggtcca ctggcccata cacatcctgc tgaagaagca acagaagttt ccagctgaag
      301 cttctctgag acagcatgaa agccaacaat accacgacga gtgccttgtg gttgcaaatc
      361 acctacatca ccatggaggc tgccattggt ctctgtgctg tagtgggcaa catgctggtc
      421 atctgggtgg tcaagctgaa ccgcactctg aggaccacca ccttctattt catcgtctcc
      481 ctagcactgg ctgacattgc tgttggggtg ctggtcatac ccttggccat tgccgtcagc
      541 ctggaggtcc agatgcactt ctatgcctgc cttttcatgt cctgtgtgct tctggtcttc
      601 acccacgctt ccatcatgtc cttgctggcc attgctgtag accgatacct gcgagtcaag
      661 ctgacagtca gatatagaac ggttaccact caaagaagaa tatggctatt cctgggcctc
      721 tgctggctag tgtcctttct ggtgggactg acccccatgt ttggctggaa tagaaaagtg
      781 accttagagc tctctcaaaa cagctccacc ctctcatgcc acttccgttc cgtggtcggc
      841 ttggattaca tggtcttctt cagcttcatc acctggatcc tcatccccct ggttgtcatg
      901 tgcatcatct atctggacat cttctacatc atccgaaaca aactcagtca aaatctgact
      961 ggcttcagag agacgcgtgc attttacggt cgggagttca agaccgctaa gtccctgttt
     1021 ctggttctct tcttgtttgc cttgtgctgg ctgcctttgt ccatcatcaa ttttgtttcc
     1081 tactttaatg tgaagatacc agagattgca atgtgcctgg gcatcctgtt gtcccatgcg
     1141 aactccatga tgaaccctat tgtctacgcc tgcaaaataa aaaagttcaa agaaacctac
     1201 tttgtgatcc tcagagcttg caggctctgt cagacctcgg attctttgga ctcaaacctt
     1261 gaacagacta ctgagtagtt accatgacag ataaagagcc agctcattta ccttcacagt
     1321 tcgcatcggt aaacactata aggacttaac agccattctt gcttacttcc actgcagtgg
     1381 gatcatcggg ctggttgcca cagagctccc ttccctcctc cctccgctcc tccctccact
     1441 cctccctcca gtcttccctc cactcctccc tcccgcttca tttattttct tgagcttctc
     1501 tcattcaatt ctgtggaggt ctgacatgaa ggcaatgcat tcctggttac cacagacttc
     1561 gcccttcctt cccagacaca agaagtaatg gagtgaacgt tgagggagtc tcctctcacc
     1621 aaagaagact ctagtggggc tggatgtaca gaacctgcgt tgaaggatcc ctaggatgtt
     1681 gggaacacag ggagtgaatt gaatttaaag agggctaaat tcacctgtgt gggtgcattt
     1741 gagcaaataa aagatggcgc ccaa
//
