LOCUS       NM_017161               1842 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Rattus norvegicus adenosine A2B receptor (Adora2b), mRNA.
ACCESSION   NM_017161
VERSION     NM_017161.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1842)
  AUTHORS   Xiong,Y., Qin,F., Wei,S., Yang,X., Li,J., Wu,C., Zhang,F. and
            Yuan,J.
  TITLE     Targeting Adenosine A2b Receptor Promotes Penile Rehabilitation of
            Refractory Erectile Dysfunction
  JOURNAL   Adv Sci (Weinh) 11 (30), e2306514 (2024)
   PUBMED   38874549
  REMARK    GeneRIF: Targeting Adenosine A2b Receptor Promotes Penile
            Rehabilitation of Refractory Erectile Dysfunction.
REFERENCE   2  (bases 1 to 1842)
  AUTHORS   Bessa-Goncalves,M., Braganca,B., Martins-Dias,E., Vinhas,A.,
            Certal,M., Rodrigues,T., Ferreirinha,F., Costa,M.A.,
            Correia-de-Sa,P. and Fontes-Sousa,A.P.
  TITLE     Blockage of the adenosine A2B receptor prevents cardiac fibroblasts
            overgrowth in rats with pulmonary arterial hypertension
  JOURNAL   Purinergic Signal 20 (2), 163-179 (2024)
   PUBMED   37402944
  REMARK    GeneRIF: Blockage of the adenosine A2B receptor prevents cardiac
            fibroblasts overgrowth in rats with pulmonary arterial
            hypertension.
REFERENCE   3  (bases 1 to 1842)
  AUTHORS   Ishioh,M., Nozu,T., Miyagishi,S., Igarashi,S., Funayama,T.,
            Ohhira,M. and Okumura,T.
  TITLE     Activation of basal forebrain cholinergic neurons improves colonic
            hyperpermeability through the vagus nerve and adenosine A2B
            receptors in rats
  JOURNAL   Biochem Pharmacol 206, 115331 (2022)
   PUBMED   36330948
  REMARK    GeneRIF: Activation of basal forebrain cholinergic neurons improves
            colonic hyperpermeability through the vagus nerve and adenosine A2B
            receptors in rats.
REFERENCE   4  (bases 1 to 1842)
  AUTHORS   Zhang,W., Qiao,W. and Zuo,L.
  TITLE     A1 and A2b adenosine receptors regulate GPX4 against ferroptosis of
            cardiomyocytes in myocardial infarction rat model and in vitro
  JOURNAL   Tissue Cell 77, 101828 (2022)
   PUBMED   35653908
  REMARK    GeneRIF: A1 and A2b adenosine receptors regulate GPX4 against
            ferroptosis of cardiomyocytes in myocardial infarction rat model
            and in vitro.
REFERENCE   5  (bases 1 to 1842)
  AUTHORS   Zhang,X., Du,P., Luo,K., Li,Y., Liu,Z., Wang,W., Zeng,C., Ye,Q. and
            Xiao,Q.
  TITLE     Hypoxia-inducible factor-1alpha protects the liver against
            ischemia-reperfusion injury by regulating the A2B adenosine
            receptor
  JOURNAL   Bioengineered 12 (1), 3737-3752 (2021)
   PUBMED   34288817
  REMARK    GeneRIF: Hypoxia-inducible factor-1alpha protects the liver against
            ischemia-reperfusion injury by regulating the A2B adenosine
            receptor.
REFERENCE   6  (bases 1 to 1842)
  AUTHORS   Dubey,R.K., Gillespie,D.G. and Jackson,E.K.
  TITLE     Adenosine inhibits collagen and protein synthesis in cardiac
            fibroblasts: role of A2B receptors
  JOURNAL   Hypertension 31 (4), 943-948 (1998)
   PUBMED   9535419
REFERENCE   7  (bases 1 to 1842)
  AUTHORS   Marquardt,D.L., Walker,L.L. and Heinemann,S.
  TITLE     Cloning of two adenosine receptor subtypes from mouse bone
            marrow-derived mast cells
  JOURNAL   J Immunol 152 (9), 4508-4515 (1994)
   PUBMED   8157966
REFERENCE   8  (bases 1 to 1842)
  AUTHORS   Peakman,M.C. and Hill,S.J.
  TITLE     Adenosine A2B-receptor-mediated cyclic AMP accumulation in primary
            rat astrocytes
  JOURNAL   Br J Pharmacol 111 (1), 191-198 (1994)
   PUBMED   8012696
REFERENCE   9  (bases 1 to 1842)
  AUTHORS   Rivkees,S.A. and Reppert,S.M.
  TITLE     RFL9 encodes an A2b-adenosine receptor
  JOURNAL   Mol Endocrinol 6 (10), 1598-1604 (1992)
   PUBMED   1333049
REFERENCE   10 (bases 1 to 1842)
  AUTHORS   Stehle,J.H., Rivkees,S.A., Lee,J.J., Weaver,D.R., Deeds,J.D. and
            Reppert,S.M.
  TITLE     Molecular cloning and expression of the cDNA for a novel
            A2-adenosine receptor subtype
  JOURNAL   Mol Endocrinol 6 (3), 384-393 (1992)
   PUBMED   1584214
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017161.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M91466.1, BC161854.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-442               JAXUCZ010000010.1  47439712-47440153
            443-1842            JAXUCZ010000010.1  47454693-47456092
FEATURES             Location/Qualifiers
     source          1..1842
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q23"
     gene            1..1842
                     /gene="Adora2b"
                     /note="adenosine A2B receptor"
                     /db_xref="GeneID:29316"
                     /db_xref="RGD:2050"
     exon            1..442
                     /gene="Adora2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1106
                     /gene="Adora2b"
                     /codon_start=1
                     /product="adenosine receptor A2b"
                     /protein_id="NP_058857.2"
                     /db_xref="GeneID:29316"
                     /db_xref="RGD:2050"
                     /translation="MQLETQDALYVALELVIAALAVAGNVLVCAAVGASSALQTPTNY
                     FLVSLATADVAVGLFAIPFAITISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAVD
                     RYLAIRVPLRYKGLVTGTRARGIIAVLWVLAFGIGLTPFLGWNSKDRATSNCTEPGDG
                     ITNKSCCPVKCLFENVVPMSYMVYFNFFGCVLPPLLIMMVIYIKIFMVACKQLQHMEL
                     MEHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAINCITLFHPALAKDKPKWVMNVAI
                     LLSHANSVVNPVVYAYRNRDFRYSFHRIISRYVLCQTDTKGGSGQAGGQSTFSLSL"
     exon            443..1842
                     /gene="Adora2b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggacgcgcg gtctcggcgc tgtggccatg cctggcggca ccttagcggc tgtcctgagc
       61 ccgacacaac cccggtagag gactccccgg gcccggctgg cccggccatg cagctagaga
      121 cgcaggacgc gctgtacgtg gcgctggagc tggttatcgc cgcgctggca gtggcgggca
      181 acgtgctggt gtgcgctgcg gtgggagcct cgagtgcttt acagaccccc accaactact
      241 ttctggtgtc cctggcgacg gcggacgtgg ctgtgggact cttcgccatc ccctttgcca
      301 tcaccatcag cctgggcttc tgcacggact ttcacagctg cctcttcctc gcctgcttcg
      361 tgctggtgct cacacagagc tccatcttta gcctcttggc ggtggctgtc gaccggtatc
      421 tggccattcg cgtcccgctc aggtataaag gtttggtcac tggaacacga gcaagaggga
      481 tcatcgctgt cctctgggtc cttgcctttg gcattggact gactcctttc ctgggttgga
      541 acagtaaaga ccgtgccacc agcaactgca cagaacctgg ggatggcatc acgaataaga
      601 gctgctgccc tgtgaagtgt ctctttgaga acgtagttcc catgagctac atggtttatt
      661 tcaacttctt tgggtgtgtc cttcctccac tgctcatcat gatggtgatc tacatcaaaa
      721 tcttcatggt ggcctgcaag cagcttcagc acatggaact gatggagcac tccaggacca
      781 cgctgcagcg ggagatccac gcggccaagt cactggctat gattgtgggc atctttgctc
      841 tgtgttggct ccccgtgcat gccatcaact gcatcaccct cttccatcca gccctggcca
      901 aggacaagcc caaatgggtg atgaatgtgg ccatcctcct gtcacacgcc aattcagttg
      961 tcaatcccgt tgtctatgcc tacaggaacc gggacttccg ctacagtttc cacaggatca
     1021 tctccagata cgttctctgc cagacggaca ccaagggtgg gagcgggcag gccgggggac
     1081 agtcaacttt cagtctgagc ttgtgaccta ggctctggcc tttgggagaa gaaggcttaa
     1141 aataaacaat ggactggaca cagctggtga cctcactgtg gaggacaact accctctcaa
     1201 gcatgtggcc cacctgccct gaacgcttgc caggagtcac acaagtctgg ctcacacgta
     1261 catgcaacta ggaggccctg aggctaacag atacacttag gaatctattc agctgctctt
     1321 acttactgtg tggatggcgg gcggctagaa ctgattccaa aaactgtttt atttttaaga
     1381 atctgcctca ttcgtggtag aaaaatgact gaaacttacc ttactgtgaa acactgtgaa
     1441 ctattataat gtaagtattt ttcacttaca gcaatgggaa aataaaagtt ggctctatta
     1501 acatatactc attccgggga cagcaactca gaaaactgaa gtataattct tcagtcaaga
     1561 tactgtagtg ttaatttagg gaatggtact accctaagtt tgaaagtaga attatagtaa
     1621 caaaacaatt tgagttcagt atcttccttg cccacaaaac actagaggtg gaaacttgga
     1681 gagctgggtc cttcctccac tgcacccctg ctttagagct aggtactaga gtttgcttct
     1741 ctctcacatt acagtttatt ggatcccaaa gtatgaaaat tttactgagc aaaatcccct
     1801 agctgtgtat tatatccagt gaaataaaac tttgaaaggt ga
//
