LOCUS       NM_053294               2491 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Rattus norvegicus adenosine A2a receptor (Adora2a), mRNA.
ACCESSION   NM_053294
VERSION     NM_053294.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2491)
  AUTHORS   Liu,W., Li,Q., Fang,W., Cai,L., Wang,Z., Kou,B., Zhou,C., Zhou,Y.,
            Yao,Z., Wei,M. and Zhang,S.
  TITLE     A2AR regulate inflammation through PKA/NF-kappaB signaling pathways
            in intervertebral disc degeneration
  JOURNAL   Eur J Med Res 29 (1), 433 (2024)
   PUBMED   39192377
  REMARK    GeneRIF: A2AR regulate inflammation through PKA/NF-kappaB signaling
            pathways in intervertebral disc degeneration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2491)
  AUTHORS   Dias,L., Madeira,D., Dias,R., Tome,A.R., Cunha,R.A. and
            Agostinho,P.
  TITLE     Abeta1-42 peptides blunt the adenosine A2A receptor-mediated
            control of the interplay between P2X7 and P2Y1 receptors mediated
            calcium responses in astrocytes
  JOURNAL   Cell Mol Life Sci 79 (8), 457 (2022)
   PUBMED   35907034
  REMARK    GeneRIF: Abeta1-42 peptides blunt the adenosine A2A
            receptor-mediated control of the interplay between P2X7 and P2Y1
            receptors mediated calcium responses in astrocytes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2491)
  AUTHORS   Jhuo,C.F., Hsu,Y.Y., Chen,W.Y. and Tzen,J.T.C.
  TITLE     Attenuation of Tumor Development in Mammary Carcinoma Rats by
            Theacrine, an Antagonist of Adenosine 2A Receptor
  JOURNAL   Molecules 26 (24), 7455 (2021)
   PUBMED   34946538
  REMARK    GeneRIF: Attenuation of Tumor Development in Mammary Carcinoma Rats
            by Theacrine, an Antagonist of Adenosine 2A Receptor.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2491)
  AUTHORS   Ribeiro,F.F., Ferreira,F., Rodrigues,R.S., Soares,R., Pedro,D.M.,
            Duarte-Samartinho,M., Aroeira,R.I., Ferreiro,E., Valero,J.,
            Sola,S., Mira,H., Sebastiao,A.M. and Xapelli,S.
  TITLE     Regulation of hippocampal postnatal and adult neurogenesis by
            adenosine A2A receptor: Interaction with brain-derived neurotrophic
            factor
  JOURNAL   Stem Cells 39 (10), 1362-1381 (2021)
   PUBMED   34043863
  REMARK    GeneRIF: Regulation of hippocampal postnatal and adult neurogenesis
            by adenosine A2A receptor: Interaction with brain-derived
            neurotrophic factor.
REFERENCE   5  (bases 1 to 2491)
  AUTHORS   Lee,C.F., Lai,H.L., Lee,Y.C., Chien,C.L. and Chern,Y.
  TITLE     The A2A adenosine receptor is a dual coding gene: a novel mechanism
            of gene usage and signal transduction
  JOURNAL   J Biol Chem 289 (3), 1257-1270 (2014)
   PUBMED   24293369
  REMARK    GeneRIF: rat A2AR gene encodes two distinct proteins (A2AR and
            uORF5) in an A2AR-dependent manner. Our study reveals a new example
            of the complexity of the mammalian genome and provides novel
            insights into the function of A2AR.
REFERENCE   6  (bases 1 to 2491)
  AUTHORS   Lee,Y.C., Chang,C.W., Su,C.W., Lin,T.N., Sun,S.H., Lai,H.L. and
            Chern,Y.
  TITLE     The 5' untranslated regions of the rat A2A adenosine receptor gene
            function as negative translational regulators
  JOURNAL   J Neurochem 73 (5), 1790-1798 (1999)
   PUBMED   10537036
REFERENCE   7  (bases 1 to 2491)
  AUTHORS   Noble,F. and Cox,B.M.
  TITLE     Differences among mouse strains in the regulation by mu, delta 1
            and delta 2 opioid receptors of striatal adenylyl cyclases
            activated by dopamine D1 or adenosine A2a receptors
  JOURNAL   Brain Res 716 (1-2), 107-117 (1996)
   PUBMED   8738226
REFERENCE   8  (bases 1 to 2491)
  AUTHORS   Chu,Y.Y., Tu,K.H., Lee,Y.C., Kuo,Z.J., Lai,H.L. and Chern,Y.
  TITLE     Characterization of the rat A2a adenosine receptor gene
  JOURNAL   DNA Cell Biol 15 (4), 329-337 (1996)
   PUBMED   8639269
REFERENCE   9  (bases 1 to 2491)
  AUTHORS   Fink,J.S., Weaver,D.R., Rivkees,S.A., Peterfreund,R.A.,
            Pollack,A.E., Adler,E.M. and Reppert,S.M.
  TITLE     Molecular cloning of the rat A2 adenosine receptor: selective
            co-expression with D2 dopamine receptors in rat striatum
  JOURNAL   Brain Res Mol Brain Res 14 (3), 186-195 (1992)
   PUBMED   1279342
REFERENCE   10 (bases 1 to 2491)
  AUTHORS   Chern,Y., King,K., Lai,H.L. and Lai,H.T.
  TITLE     Molecular cloning of a novel adenosine receptor gene from rat brain
  JOURNAL   Biochem Biophys Res Commun 185 (1), 304-309 (1992)
   PUBMED   1599465
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC081727.1 and CR477522.1.
            
            On Nov 10, 2017 this sequence version replaced NM_053294.4.
            
            Transcript Variant: This transcript includes two overlapping open
            reading frames encoding different proteins, with distinct amino
            acid compositions (A2AR and uORF5, PMID:24293369). Both proteins
            are upregulated under hypoxic conditions. This RefSeq represents
            the longer protein, A2AR, which is conserved across species.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081727.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2482              BC081727.1         1-2482
            2483-2491           CR477522.1         1-9                 c
FEATURES             Location/Qualifiers
     source          1..2491
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..2491
                     /gene="Adora2a"
                     /gene_synonym="A2ar; ADENO; Adora2l1"
                     /note="adenosine A2a receptor"
                     /db_xref="GeneID:25369"
                     /db_xref="RGD:2049"
     exon            1..185
                     /gene="Adora2a"
                     /gene_synonym="A2ar; ADENO; Adora2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            186..751
                     /gene="Adora2a"
                     /gene_synonym="A2ar; ADENO; Adora2l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             429..1661
                     /gene="Adora2a"
                     /gene_synonym="A2ar; ADENO; Adora2l1"
                     /note="adenosine receptor A2a; Adenosine A2a-receptor"
                     /codon_start=1
                     /product="adenosine receptor A2a A2AR"
                     /protein_id="NP_445746.3"
                     /db_xref="GeneID:25369"
                     /db_xref="RGD:2049"
                     /translation="MGSSVYITVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVS
                     LAAADIAVGVLAIPFAITISTGFCAACHGCLFFACFVLVLTQSSIFSLLAIAIDRYIA
                     IRIPLRYNGLVTGVRAKGIIAICWVLSFAIGLTPMLGWNNCSQKDGNSTKTCGEGRVT
                     CLFEDVVPMNYMVYYNFFAFVLLPLLLMLAIYLRIFLAARRQLKQMESQPLPGERTRS
                     TLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCSTCRHAPPWLMYLAIILSHSNS
                     VVNPFIYAYRIREFRQTFRKIIRTHVLRRQEPFQAGGSSAWALAAHSTEGEQVSLRLN
                     GHPLGVWANGSATHSGRRPNGYTLGLGGGGSAQGSPRDVELPTQERQEGQEHPGLRGH
                     LVQARVGASSWSSEFAPS"
     exon            752..2486
                     /gene="Adora2a"
                     /gene_synonym="A2ar; ADENO; Adora2l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccacctagtt agccctccca gggacatttc ctccagttcc cgcctcaggg cctcggtttc
       61 ccccagcagc ggggcggggc gggagcagcg ctagtttcga agtcgcctgc agggtgcgcc
      121 catgagcggc gcggccggag ctggagcctg agcggcagct gagacggtgg gagccagagc
      181 aagaggtatc tcagaaccct gaagccgaga ggagccaggc cagatcccct ggagaagtca
      241 tgattttggg agatgcagag tcgtctgtga gaacgtcttc ggggagctct ctctgggaac
      301 gctcgtggct cttgtgagga aagggctgcg gggcttgggt gggtggacgg ctgggctgca
      361 gctatggacc gagagctggc ccaggcctgc atccctgctg agcctgccca agtgtggctg
      421 ctcccaccat gggctcctcg gtgtacatca cggtggagct ggccatcgct gtgctggcca
      481 tcctgggcaa cgtgctcgtg tgctgggccg tgtggatcaa cagtaacctg cagaacgtca
      541 ccaacttctt tgtggtatcg ctggcggcgg ctgacattgc agtgggtgtg ctcgccatcc
      601 ccttcgctat caccatcagc accggcttct gcgccgcctg ccacggctgc ctcttcttcg
      661 cctgttttgt cctggtcctc acgcagagtt ccatctttag cctcttggct atcgccatcg
      721 accgctacat cgccatccga attccactcc ggtacaatgg cttggtgaca ggtgtgaggg
      781 cgaagggcat cattgcaatt tgctgggtgc tgtcgtttgc cattggcctg acccccatgc
      841 tgggctggaa caactgcagt cagaaagacg ggaactccac gaagacctgc ggcgagggcc
      901 gggtgacctg tctgttcgag gacgtggtgc ccatgaatta catggtttac tacaacttct
      961 ttgcgttcgt gttactgccc cttctgctca tgctggccat ctacctacgg atttttctgg
     1021 cggcccggag acagctgaag cagatggaga gccagcccct gccaggggag cggactcggt
     1081 ccacgctgca gaaggaggtc cacgctgcca agtccctggc catcatcgtc gggctctttg
     1141 ctctgtgctg gttgccgctg cacatcatca actgtttcac cttcttctgc tccacgtgcc
     1201 ggcacgcccc tccgtggctc atgtacctgg ccatcatcct ctcccacagc aactccgtcg
     1261 tcaacccctt catctacgcc tacaggatcc gggagttccg ccagaccttc cggaagatca
     1321 tccgaaccca cgtcctgagg cggcaggaac ccttccaggc agggggttcc agtgcctggg
     1381 ccctggcagc tcacagcact gagggagagc aggttagcct ccgccttaat ggccaccccc
     1441 tgggggtatg ggccaacggc agtgccaccc attccggacg gcggcccaat ggctacactc
     1501 tggggctggg gggtggaggg agtgcccaag gctctcctcg ggatgtggag cttcctaccc
     1561 aggagcgcca ggaaggccaa gagcaccctg gcctaagggg tcatctggtc caggctagag
     1621 taggagcttc ctcatggtct tcagagtttg ccccttcctg agggaaagac attttaatat
     1681 ttttggttgg ctggaccaat ctcactaagg gaagagaaac ccaatgggcg cgtggctccc
     1741 actttgaact acaaagaggg ggcatgaagt tggagcagca tgaagcccag taagaaaggc
     1801 ctggggtgga ggaagcgatg cttctgcttc gtgctacggg gccctgtgtt aggtcagggc
     1861 tgcagtagca tctgcaaagg cagggcccag ttcccctgct ccagaagcgt ccaaaaagct
     1921 gtcttgtctc tctagagcgg ttgtggctta gaggactggc ctggcccgat gctagaatat
     1981 aggagcttca gacctcctgc tgtagtacac tactctcccc agactgtcta gggctcaggg
     2041 agctgctggc ctagaagtgg cacttggcta tttctttttc aagaagataa aaatgtgagg
     2101 aaacccattc tattttattg acttcccccc tcccctgcct gctgggtctg tggtcgatcc
     2161 tgctgggaac ccccccaacc aaggaattga aggtggtctt cttgggctag cccaagctac
     2221 catgcactta gtcacagggc tatctctgac caacaaagct ggcctggaag acagcaacta
     2281 tgaagggaag gattccagag catgggctca ggtcccatga gagagattag agatgtcaag
     2341 ccatggacct gaacctgggt agttcagcgc taccctgtct gaggccctga ctactgcctt
     2401 tccttccaga gggacttgtt tgtttgtttg tggttttttt tttccctgag gtaaaataaa
     2461 atgagccaca ctgtgtttta aatttgaaaa a
//
