LOCUS       NM_017155               1073 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus adenosine A1 receptor (Adora1), mRNA.
ACCESSION   NM_017155
VERSION     NM_017155.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1073)
  AUTHORS   Taketo,M.
  TITLE     Activation of adenosine A1 receptor potentiates metabotropic
            glutamate receptor 1-mediated Ca2+ mobilization in the rat
            hippocampal marginal zone
  JOURNAL   Brain Res 1821, 148581 (2023)
   PUBMED   37714421
  REMARK    GeneRIF: Activation of adenosine A1 receptor potentiates
            metabotropic glutamate receptor 1-mediated Ca[2+] mobilization in
            the rat hippocampal marginal zone.
REFERENCE   2  (bases 1 to 1073)
  AUTHORS   Zhang,L., Chen,X., Li,M., Lv,R., Gu,B. and Chen,Z.
  TITLE     Activation of the adenosine A1 receptor in the lumbosacral spinal
            cord improves bladder overactivity in rats with cystitis induced by
            cyclophosphamide
  JOURNAL   Int Urol Nephrol 55 (9), 2183-2191 (2023)
   PUBMED   37330931
  REMARK    GeneRIF: Activation of the adenosine A1 receptor in the lumbosacral
            spinal cord improves bladder overactivity in rats with cystitis
            induced by cyclophosphamide.
REFERENCE   3  (bases 1 to 1073)
  AUTHORS   Zhang,W., Qiao,W. and Zuo,L.
  TITLE     A1 and A2b adenosine receptors regulate GPX4 against ferroptosis of
            cardiomyocytes in myocardial infarction rat model and in vitro
  JOURNAL   Tissue Cell 77, 101828 (2022)
   PUBMED   35653908
  REMARK    GeneRIF: A1 and A2b adenosine receptors regulate GPX4 against
            ferroptosis of cardiomyocytes in myocardial infarction rat model
            and in vitro.
REFERENCE   4  (bases 1 to 1073)
  AUTHORS   Torregroza,C., Glashoerster,C.O., Feige,K., Stroethoff,M.,
            Raupach,A., Heinen,A., Hollmann,M.W. and Huhn,R.
  TITLE     Mediation of the Cardioprotective Effects of Mannitol Discovered,
            with Refutation of Common Protein Kinases
  JOURNAL   Int J Mol Sci 22 (22), 12471 (2021)
   PUBMED   34830353
  REMARK    GeneRIF: Mediation of the Cardioprotective Effects of Mannitol
            Discovered, with Refutation of Common Protein Kinases.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1073)
  AUTHORS   Joya,A., Ardaya,M., Montilla,A., Garbizu,M., Plaza-Garcia,S.,
            Gomez-Vallejo,V., Padro,D., Gutierrez,J.J., Rios,X.,
            Ramos-Cabrer,P., Cossio,U., Pulagam,K.R., Higuchi,M., Domercq,M.,
            Cavaliere,F., Matute,C., Llop,J. and Martin,A.
  TITLE     In vivo multimodal imaging of adenosine A1 receptors in
            neuroinflammation after experimental stroke
  JOURNAL   Theranostics 11 (1), 410-425 (2021)
   PUBMED   33391483
  REMARK    GeneRIF: In vivo multimodal imaging of adenosine A1 receptors in
            neuroinflammation after experimental stroke.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1073)
  AUTHORS   Pfaff,T. and Karschin,A.
  TITLE     Expression cloning of rat cerebellar adenosine A1 receptor by
            coupling to Kir channels
  JOURNAL   Neuroreport 8 (11), 2455-2460 (1997)
   PUBMED   9261808
REFERENCE   7  (bases 1 to 1073)
  AUTHORS   Uehara,Y., Numabe,A., Hirawa,N., Kawabata,Y., Nagoshi,H.,
            Kaneko,H., Gomi,T., Goto,A., Toyo-oka,T. and Omata,M.
  TITLE     A new adenosine subtype-1 receptor antagonist, FK-838, attenuates
            salt-induced hypertension in Dahl salt-sensitive rats
  JOURNAL   Am J Hypertens 8 (12 Pt 1), 1189-1199 (1995)
   PUBMED   8998253
REFERENCE   8  (bases 1 to 1073)
  AUTHORS   Reppert,S.M., Weaver,D.R., Stehle,J.H. and Rivkees,S.A.
  TITLE     Molecular cloning and characterization of a rat A1-adenosine
            receptor that is widely expressed in brain and spinal cord
  JOURNAL   Mol Endocrinol 5 (8), 1037-1048 (1991)
   PUBMED   1658635
REFERENCE   9  (bases 1 to 1073)
  AUTHORS   Mahan,L.C., McVittie,L.D., Smyk-Randall,E.M., Nakata,H.,
            Monsma,F.J. Jr., Gerfen,C.R. and Sibley,D.R.
  TITLE     Cloning and expression of an A1 adenosine receptor from rat brain
  JOURNAL   Mol Pharmacol 40 (1), 1-7 (1991)
   PUBMED   1857334
REFERENCE   10 (bases 1 to 1073)
  AUTHORS   Schrier,D.J., Lesch,M.E., Wright,C.D. and Gilbertsen,R.B.
  TITLE     The antiinflammatory effects of adenosine receptor agonists on the
            carrageenan-induced pleural inflammatory response in rats
  JOURNAL   J Immunol 145 (6), 1874-1879 (1990)
   PUBMED   2167912
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            [WARNING] On Apr 24, 2024 this sequence was replaced by
            NM_017155.4.
            
            On Nov 27, 2020 this sequence version replaced NM_017155.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M69045.1, AF042079.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-398               JAXUCZ010000013.1  48246434-48246831   c
            399-1073            JAXUCZ010000013.1  48214523-48215197   c
FEATURES             Location/Qualifiers
     source          1..1073
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..1073
                     /gene="Adora1"
                     /note="adenosine A1 receptor"
                     /db_xref="GeneID:29290"
                     /db_xref="RGD:2048"
     exon            1..398
                     /gene="Adora1"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1038
                     /gene="Adora1"
                     /codon_start=1
                     /product="adenosine receptor A1"
                     /protein_id="NP_058851.2"
                     /db_xref="GeneID:29290"
                     /db_xref="RGD:2048"
                     /translation="MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDAT
                     FCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIA
                     VDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANG
                     SVGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSAS
                     SGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFL
                     THGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCQPKPPIDEDLPEEKAED"
     exon            399..1073
                     /gene="Adora1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgctggcct cgtgccccag ggcgcctgtc tgctgatgtg cccagctcct gcccaccatg
       61 ccgccctaca tctcggcctt ccaggctgcc tacattggca tcgaggtgct cattgccttg
      121 gtctctgtgc ccggaaatgt actggtgatt tgggctgtga aggtgaacca ggcacttcgc
      181 gatgccacct tctgcttcat cgtgtcactg gcggtagctg atgtggccgt tggcgccctg
      241 gtcatcccac tggccatcct tatcaacatt gggccacaga cctacttcca cacctgcctc
      301 atggtggcct gccctgtcct catcctcacc cagagctcca ttctggctct gctcgccatt
      361 gctgtggatc gatacctccg agtcaagatc cctctccggt acaagacagt ggtgacccag
      421 cggcgggcgg cagtggccat agctggctgc tggattctct cccttgtggt aggcctgaca
      481 cccatgtttg gctggaacaa cctgagtgtg gtagagcaag actggagagc caacggcagt
      541 gttggggagc ccgtgatcaa gtgtgagttt gagaaggtta tcagcatgga gtacatggtc
      601 tacttcaact tcttcgtctg ggtgctgccg ccactgctcc tcatggtcct catctacctg
      661 gaggtcttct acctgatccg taagcagctc aacaaaaagg tgtcagcctc ctccggtgac
      721 ccccagaagt actacgggaa ggagctgaag atcgccaagt cgctggccct catcctcttc
      781 ctctttgccc tcagctggct gccgctgcat atcttgaact gtatcaccct cttctgcccc
      841 acctgccaga aacccagcat tctgatctac atcgccatct tcctcacaca cggcaactcc
      901 gccatgaacc ccatcgtcta tgccttccgg atccacaagt tccgggtcac ctttctgaag
      961 atttggaatg accacttccg atgccagcct aagcctccca tcgatgaaga cctcccagag
     1021 gagaaagctg aggactagac tctgccttgc tccgtctagc ccatgcccag cgg
//
