LOCUS       NM_001347532            7070 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus activity-dependent neuroprotector homeobox
            (Adnp), mRNA.
ACCESSION   NM_001347532
VERSION     NM_001347532.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7070)
  AUTHORS   Chu,Y., Morfini,G.A. and Kordower,J.H.
  TITLE     Alterations in Activity-Dependent Neuroprotective Protein in
            Sporadic and Experimental Parkinson's Disease
  JOURNAL   J Parkinsons Dis 6 (1), 77-97 (2016)
   PUBMED   27003787
  REMARK    GeneRIF: These findings demonstrate that the down-regulation of
            protein ADNP is an early pathological alteration and may contribute
            to dopaminergic neurodegeneration in Parkinson's disease
REFERENCE   2  (bases 1 to 7070)
  AUTHORS   Oz,S., Kapitansky,O., Ivashco-Pachima,Y., Malishkevich,A.,
            Giladi,E., Skalka,N., Rosin-Arbesfeld,R., Mittelman,L., Segev,O.,
            Hirsch,J.A. and Gozes,I.
  TITLE     The NAP motif of activity-dependent neuroprotective protein (ADNP)
            regulates dendritic spines through microtubule end binding proteins
  JOURNAL   Mol Psychiatry 19 (10), 1115-1124 (2014)
   PUBMED   25178163
  REMARK    GeneRIF: the newly identified shared microtubule target of NAP/ADNP
            is directly implicated in synaptic plasticity, explaining the
            breadth and efficiency of neuroprotective/neurotrophic capacities
REFERENCE   3  (bases 1 to 7070)
  AUTHORS   Castorina,A., Giunta,S., Scuderi,S. and D'Agata,V.
  TITLE     Involvement of PACAP/ADNP signaling in the resistance to cell death
            in malignant peripheral nerve sheath tumor (MPNST) cells
  JOURNAL   J Mol Neurosci 48 (3), 674-683 (2012)
   PUBMED   22454142
  REMARK    GeneRIF: An endogenous PACAP-mediated ADNP signaling system
            increases malignant peripheral nerve sheath tumor cell resistance
            to hydrogen-peroxide-induced death upon serum starvation.
REFERENCE   4  (bases 1 to 7070)
  AUTHORS   Oz,S., Ivashko-Pachima,Y. and Gozes,I.
  TITLE     The ADNP derived peptide, NAP modulates the tubulin pool:
            implication for neurotrophic and neuroprotective activities
  JOURNAL   PLoS One 7 (12), e51458 (2012)
   PUBMED   23272107
  REMARK    GeneRIF: NAP is an ADNP derived peptide that modulates the tubulin
            pool in mice and rats
REFERENCE   5  (bases 1 to 7070)
  AUTHORS   Cosgrave,A.S., McKay,J.S., Morris,R., Quinn,J.P. and Thippeswamy,T.
  TITLE     Nitric oxide regulates activity-dependent neuroprotective protein
            (ADNP) in the dentate gyrus of the rodent model of kainic
            acid-induced seizure
  JOURNAL   J Mol Neurosci 39 (1-2), 9-21 (2009)
   PUBMED   19130308
  REMARK    GeneRIF: Results suggest that nitric oxide regulates
            activity-dependent neuroprotective protein in the dentate gyrus
            under both basal and pathophysiological conditions.
REFERENCE   6  (bases 1 to 7070)
  AUTHORS   Zusev,M. and Gozes,I.
  TITLE     Differential regulation of activity-dependent neuroprotective
            protein in rat astrocytes by VIP and PACAP
  JOURNAL   Regul Pept 123 (1-3), 33-41 (2004)
   PUBMED   15518891
REFERENCE   7  (bases 1 to 7070)
  AUTHORS   Zamostiano,R., Pinhasov,A., Gelber,E., Steingart,R.A., Seroussi,E.,
            Giladi,E., Bassan,M., Wollman,Y., Eyre,H.J., Mulley,J.C.,
            Brenneman,D.E. and Gozes,I.
  TITLE     Cloning and characterization of the human activity-dependent
            neuroprotective protein
  JOURNAL   J Biol Chem 276 (1), 708-714 (2001)
   PUBMED   11013255
REFERENCE   8  (bases 1 to 7070)
  AUTHORS   Gozes,I., Giladi,E., Pinhasov,A., Bardea,A. and Brenneman,D.E.
  TITLE     Activity-dependent neurotrophic factor: intranasal administration
            of femtomolar-acting peptides improve performance in a water maze
  JOURNAL   J Pharmacol Exp Ther 293 (3), 1091-1098 (2000)
   PUBMED   10869414
REFERENCE   9  (bases 1 to 7070)
  AUTHORS   Offen,D., Sherki,Y., Melamed,E., Fridkin,M., Brenneman,D.E. and
            Gozes,I.
  TITLE     Vasoactive intestinal peptide (VIP) prevents neurotoxicity in
            neuronal cultures: relevance to neuroprotection in Parkinson's
            disease
  JOURNAL   Brain Res 854 (1-2), 257-262 (2000)
   PUBMED   10784133
REFERENCE   10 (bases 1 to 7070)
  AUTHORS   Bassan,M., Zamostiano,R., Davidson,A., Pinhasov,A., Giladi,E.,
            Perl,O., Bassan,H., Blat,C., Gibney,G., Glazner,G., Brenneman,D.E.
            and Gozes,I.
  TITLE     Complete sequence of a novel protein containing a
            femtomolar-activity-dependent neuroprotective peptide
  JOURNAL   J Neurochem 72 (3), 1283-1293 (1999)
   PUBMED   10037502
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000120.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001347532.3.
            
            On Feb 10, 2021 this sequence version replaced NM_001347532.1.
            
            Summary: This gene encodes a member of a protein family
            characterized by nine zinc finger motifs followed by a homeobox
            domain. In vitro studies demonstrate that the encoded protein
            interacts with the brahma-related gene1-associated or hBRM factors
            (BAF) gene expression regulating complex, components of the protein
            translation machinery, and microtubule-associated proteins. This
            gene has been implicated in neuroprotection through various
            processes that include chromatin remodeling, splicing, cytoskeletal
            reorganization, and autophagy. Homozygous mutant knockout mice
            display embryonic lethality with defects in neural tube closure.
            [provided by RefSeq, Nov 2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BF523190.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840131, SAMN13663604
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1596              JACYVU010000120.1  11487952-11489547   c
            1597-1709           JACYVU010000120.1  11473292-11473404   c
            1710-1802           JACYVU010000120.1  11471663-11471755   c
            1803-7070           JACYVU010000120.1  11463616-11468883   c
FEATURES             Location/Qualifiers
     source          1..7070
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..7070
                     /gene="Adnp"
                     /note="activity-dependent neuroprotector homeobox"
                     /db_xref="GeneID:64622"
                     /db_xref="RGD:71030"
     exon            1..1596
                     /gene="Adnp"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1709
                     /gene="Adnp"
                     /inference="alignment:Splign:2.1.0"
     CDS             1602..4913
                     /gene="Adnp"
                     /note="activity-dependent neuroprotective protein; NAP
                     peptide"
                     /codon_start=1
                     /product="activity-dependent neuroprotector homeobox
                     protein"
                     /protein_id="NP_001334461.1"
                     /db_xref="GeneID:64622"
                     /db_xref="RGD:71030"
                     /translation="MFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPN
                     DFYLKNTTWEDVGLWDPSLTKNQDYRTKPFCCSACPFSSKFFSAYKSHFRNVHSEDFE
                     NRILLNCPYCTFNADKKTLETHIKIFHAPNSSAPSSSLSTFKDKNKNDGLKPKQADNV
                     EQAVYYCKKCTYRDPLYEIVRKHIYREHFQHVAAPYIAKAGEKSLNGAVSLGTNAREE
                     CNIHCKRCLFMPKSYEALVQHVIEDHERIGYQVTAMIGHTNVVVPRAKPLMLIAPKPQ
                     EKKSMGLPPRISSLASGNVRSLPSQQMVNRLSIPKPNLNSTGVNMMSNVHLQQNNYGV
                     KSVGQSYGVGQSVRLGLGGNAPVSIPQQSQSVKQLLPSGNGRSYGLGAEQRPPAAARY
                     SLQTANTSSLPPGQVKSPSVSQSQASRVLGQSSSKPPPAATGPPPSNHCATQKWKICT
                     ICNELFPENVYSVHFEKEHKAEKVPAVANYIMKIHNFTSKCLYCNRYLPTDTLLNHML
                     IHGLSCPYCRSTFNDVEKMAAHMRMVHIDEEMGPKTDSTLSFDLTLQQGSHTNIHLLV
                     TTYNLRDAPAESVAYHAQNNAPVPPKPQPKVQEKADVPVKSSPQAAVPYKKDVGKTLC
                     PLCFSILKGPISDALAHHLRERHQVIQTVHPVEKKLTYKCIHCLGVYTSNMTASTITL
                     HLVHCRGVGKTQNGQDKTNAPSRLNQSPGLAPVKRTYEQMEFPLLKKRKLEDENDSPG
                     CFEEKPEEPVVLALDPKGHEDDSYEARKSFLTKYFNKQPYPTRREIEKLAASLWLWKS
                     DIASHFSNKRKKCVRDCEKYKPGVLLGFNMKELNKVKHEMDFDAEWLFENHDEKASRV
                     NASKTVDKKLNLGKEDDSFSDSFEHLEEESNGSGGPFDPVFEVEPKIPSDNAEEPVPK
                     VIPEGALESEKLDQKEEEDGSKYETIHLTEERAKLMHDASDSEVDQDDVVEWKDGASP
                     SESGPGSRQVSDFEDNTCEMKPGTWSDESSQSEDARSSKPAAKKKATVQDDTEQLKWK
                     NSSYGKVEGFWSKDQSQWENASENAERLPNPQIEWQNSTIDSEDGEQFDSMTDGVADP
                     MHGSLTGVKLSSQQA"
     exon            1710..1802
                     /gene="Adnp"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..7070
                     /gene="Adnp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caccacagcc cttcaccagt cccgctctca atctgggcta cctggtcagc attccctctt
       61 tagagctttc tcataaactt tgcagttaga aaatggaaat ccagaaagcc ttagagagat
      121 tttttttttt caaatgcaat gaatggggag tagttctttg agcaccctct tattcacctc
      181 ttctttcctc tggctgcctg tcctcccacc ccacccccca acctggatgc ctatctacta
      241 gaaaaggcgc gatagcttct cttctctcca agatcgagct ctgaagtcta atattcattt
      301 actctcactc cctgccacac accccaagtg tcttctcagt gttcttacag tcaccaggtc
      361 ctctggacaa ttcttgtcat aaccccattt cacagacaaa ggcttaggag ggaaaaagaa
      421 tcaaactgtt tcctgtgtta gccattttaa tgctgtccag ccccaaacgc ccagttccca
      481 tccctgatgc ttcttgtgcc tgtgtcttga accttcacaa taggatgtgt gcgatatggg
      541 gtgtctcttg gatagctttg tgcagtttct ttataaatct gcattgttgc ttctggtttg
      601 tggccatgaa gaaaatacca gcccccaccc aaaaggcact gcagccaagt cggttaaagg
      661 cattgagtgt tggagtcagt agggggcgca ttctctgcac tgggtaaggc tgcagagggg
      721 ggaagggccc cagaactaga acaggatgtg cttaacagcg ccttctacag accatgggaa
      781 aatgggccca gcaagacttg cagtgggtga gctgacagca acatggcgaa ggattaagtg
      841 agtctagaga gagattttat ttaagaaagc cacttctccg tttggaaagt tgtctttttt
      901 actttttcaa atatgttcac cctcagactt cgattgctga tcagtcacct tggtgtacat
      961 ccttgggtca taggttccct ttctcaagaa ttccttggcc ttaaggtctg atgtgttgac
     1021 atctcttttc taggccaggt gtaaaggggg ttgtttaaaa cctgaaagtc ataggcttgg
     1081 gggatgatca ctggtcaatc caaatctttc caactctttg gagagtgaaa agtcattctt
     1141 gagaggtttt tgtggggtaa tgattttgat agccatgcaa gatgggtgtc gggatttgca
     1201 aggctttgtt ggtaaacacc aggtccctat tgagttcttc attgtcaaac ttaatagagt
     1261 taattgcaga agtgtgttgc cttccacctt cagcagcctt ccagcagtac actgtcaata
     1321 gccaacgcct ttgcaagtgt tgacaccagt cttcagtgcg cacccacctt ttcagggtgt
     1381 gtggatttct gtagatttta ttcctgttgt tatttccata ggtgtgagat gcacagtacg
     1441 aaacctaggc cccaactttt acaccgcgat gcacagggtt gcactttttg tactgaactg
     1501 ataggtggcc tagtggttat tccctgtact gccattttga ggatctggac tccgttccct
     1561 gccttgctct ttggactaca ttgtcaattc acaccgaaac tatgttccaa cttcctgtca
     1621 acaatcttgg cagtttaaga aaagcccgga aaactgtgaa aaaaatactt agtgacattg
     1681 ggttggaata ctgtaaagaa catatagaag attttaaaca gtttgaacct aatgactttt
     1741 atttgaaaaa cactacatgg gaggatgtag gactgtggga cccttctctt acaaaaaatc
     1801 aggactatcg gacaaaacct ttctgctgca gtgcttgtcc gttttcctca aaattcttct
     1861 ctgcctacaa aagtcatttc cggaatgtcc atagtgaaga ctttgaaaat aggattctcc
     1921 ttaactgccc ttactgtacc ttcaatgcag ataaaaagac tttggaaaca cacattaaaa
     1981 tatttcatgc tccaaactcc agcgcaccaa gtagcagcct cagcactttc aaagataaaa
     2041 acaaaaacga tggccttaaa cctaagcagg ctgacaatgt agagcaagcc gtgtattact
     2101 gcaagaagtg cacttaccga gaccctctct atgagatcgt caggaagcac atctacaggg
     2161 aacattttca acacgtggca gcaccctaca tagcaaaggc aggagaaaaa tcactcaatg
     2221 gtgcagtctc tctgggcaca aatgcccgag aagagtgtaa catccactgc aagcgatgcc
     2281 ttttcatgcc caaatcctat gaagctttgg tacagcatgt cattgaagac catgaacgga
     2341 taggctatca ggtcactgcc atgattggac acacaaatgt tgtagttccc cgagccaaac
     2401 ccttaatgct aattgctccc aaacctcaag aaaaaaagag catgggactc ccaccaagaa
     2461 tcagttctct tgcttctgga aatgtccggt ctttgccatc acagcagatg gtgaaccgat
     2521 tgtcaatacc aaagcccaat ttaaattcaa cgggagtcaa catgatgtcc aatgttcacc
     2581 tgcagcaaaa caactatgga gtgaaatctg tgggccagag ctatggtgtt ggccagtcag
     2641 tgaggctggg gctaggtggc aatgctccag tttccatccc tcaacagtct cagtctgtca
     2701 aacagttact tccaagtgga aatgggaggt cctacgggct aggtgctgag cagaggcccc
     2761 cggcagctgc caggtattcc ctgcagactg ccaacacgtc ctctctaccc ccaggccagg
     2821 taaagtctcc ctctgtgtct cagtcacagg catctagagt attaggtcag tccagttcta
     2881 aacctccacc agcagccaca ggccctcctc caagcaacca ttgtgccact cagaagtgga
     2941 aaatatgtac aatctgtaat gagctttttc ctgagaatgt ctacagtgtt cacttcgaaa
     3001 aggaacataa agcggagaaa gttccagcag tagctaacta cattatgaaa atacacaatt
     3061 ttactagcaa atgcctctat tgtaatcgct atctgcccac agataccctg ctcaaccata
     3121 tgttaattca tggtctgtct tgtccatatt gccgttccac cttcaatgat gtggagaaga
     3181 tggcagcaca catgcgaatg gttcatattg atgaggagat ggggcctaaa acggattcta
     3241 ccttgagctt tgatttgaca ttgcaacagg gcagtcacac caacattcat ctcctggtga
     3301 ccacatacaa cctgagagat gccccggctg aatcagttgc ttaccatgcc caaaataatg
     3361 ccccagttcc tccaaagcca caaccaaaag ttcaggaaaa agctgatgtc cctgttaaaa
     3421 gttcacctca agctgcagtg ccctataaaa aagatgtggg gaagaccctc tgccctctct
     3481 gcttttcaat cctaaaagga cccatatctg atgcacttgc acatcattta cgagaaagac
     3541 accaagttat tcagacagtt catccggttg agaaaaagct aacttacaaa tgtatccatt
     3601 gccttggtgt gtatactagc aacatgacag cctcaaccat cactctgcat ctagtccact
     3661 gcaggggtgt tggaaagacc cagaatggcc aggacaagac aaacgcacct tctcggctca
     3721 atcagtctcc aggcctggcc cctgtgaagc gcacatatga gcaaatggag tttccactgc
     3781 taaagaagcg aaagctggag gatgagaatg actccccagg ctgctttgaa gagaagccgg
     3841 aagagcctgt tgttttagct ttagacccca agggtcatga agatgattca tatgaagcta
     3901 ggaaaagctt tctcacaaag tacttcaaca aacagcccta tcccactagg agagaaattg
     3961 agaagttagc tgccagtctg tggctgtgga agagcgacat tgcctcccat ttcagtaaca
     4021 agaggaagaa gtgtgtccgt gactgtgaga agtataagcc tggtgtgctg ctaggtttta
     4081 acatgaaaga attaaataaa gtcaaacatg agatggattt tgatgctgag tggctatttg
     4141 aaaatcatga cgagaaagcc tcaagagtca atgctagcaa gactgttgac aaaaagctta
     4201 accttgggaa agaagatgac agcttctcag atagttttga acatttggaa gaagaatcca
     4261 atggaagcgg cggccctttt gaccctgtct ttgaagttga gcctaaaatt cccagtgata
     4321 atgcagagga gcctgtgccg aaggtaattc ctgaaggtgc tttggagtct gagaagctag
     4381 accaaaaaga ggaggaggat ggttcaaaat atgaaaccat ccatttgact gaggaacgag
     4441 ccaaactgat gcatgatgcc tctgatagtg aggtagacca agatgatgtg gttgagtgga
     4501 aagatggtgc ttcgccatct gagagtgggc ctggttcccg acaggtctca gactttgagg
     4561 ataatacatg tgaaatgaaa ccaggaacct ggtctgatga gtcttcccag agtgaagacg
     4621 caaggagcag taagccggct gccaaaaaaa aggctacagt gcaagatgac acagagcagt
     4681 tgaaatggaa gaatagttcc tatggaaaag ttgaagggtt ttggtccaag gaccagtcac
     4741 agtgggaaaa tgcatctgag aatgcagagc gcttaccaaa cccacagatt gagtggcaga
     4801 atagcacaat tgacagtgag gatggggagc agtttgacag catgaccgat ggagttgccg
     4861 atcccatgca cggcagctta actggagtga agctgagcag ccagcaagcc tgaggccctg
     4921 gcctgccata gcgtacgggc tgtgttctgt cctggactta tgctctcctt ccagtctgac
     4981 tgcaaagctg tcttctaagc tggaactacc ttgtaaggac tggtcagtca gcgggctgtg
     5041 gggatatgtg accactacag tccagtggtc acttccaagt ctatgacata tattggttga
     5101 tcttgcttca gactcttctc tggtagactg ggtgatgaag tgtgaaaaac caataagctg
     5161 tggctcatga atgcacacag ggaggaggag ttcagtacct atctgccttc ccagcatttc
     5221 ttcccctcag taagaagttt ggttggatgt cctgggaaag ccttaccctg attcacatag
     5281 tagtgcaggg cgggcataca cactaccagt caaatgtgtc tactagacgt gggaacatgg
     5341 actgggtttt tttttttttt tcatgtattc attctgaata gttgaaatgt atatttgtac
     5401 agtcttttag acctcaagtg atgcttatga cactgttact gtgtgcccgt catagattgg
     5461 tttttagtgt tgcccttgct gtgtgataaa tgctatatct agtttaccta gcagaagctt
     5521 gaccctgcga tagtatggac ctttggacag acttagtttt tgcacataac cttgtacaat
     5581 cttgcaacag aggccagcaa cataagatat atatctggac tctcctgtat tatagaattt
     5641 ttttcttgtt ctgagtatcc ttgacattac aattgtcaaa aatggtattt cagatctctt
     5701 tctgagacct tttaagctaa aataacatgc aagaattgat tttacagcta ctaattttga
     5761 caccttttag atctgtaaga gtgttgtgtc agagcagcaa gcacagttga gcgctgcatt
     5821 tgggatattt agttttctct ttagttgagc accaccatcg tttataccat ctaatatatg
     5881 acacactgtt gtggtctgta tgattctgcg gtctttattt ccctttgtat tcattttaag
     5941 catctaaata aattgctgta ttgtgcttaa tgtaaatatt tgcttttatt acacaccaca
     6001 gtcctgtgtg tctgttaaca tcttttgctg tttgatacca cagcaccctg ggcagagatg
     6061 gaagccactc tcacaaagta ctgtgggaaa tcacgatcta tcatttgcct aaagcatgct
     6121 ttctctccag gcacctgcta cagattgtgt tcatttgtgt atgtttcctt tttgctgcaa
     6181 aagtaaacat tcttgaggtt ttcaattccc cttttgataa ggaccagagc ctgcctgggt
     6241 ctctatgtag atcatcatag tggaggacag aactctgttg gccctggtgg gctttcttcc
     6301 ctgcgtcctg ttcattccct ccttatggca acacttgtac caagcaggca gctgctctgt
     6361 ctctggagtc ctttgactgt tttgccctga agagagaggc tggtgagcac acagttgggg
     6421 cacttggcac tgatggagct ggtacattga ctgagcaaga gagttctgag aacaggctaa
     6481 atgcagagtg cagtaaggag gcagaagtgg cagaacatac agggtgggac ttctccgtgc
     6541 tgggggaggt cagccacctc tctgctacct taccttagag aagtcagaag tggctacctt
     6601 caggactcct gagcctcttt caagaaaaga cctgttacct gacttagtac cagtaaagga
     6661 gaatgtgcag ttctagcatg agctgctata gctggcttgg agcttttcta gtcagttgcc
     6721 aggatacatt ataaatgtgt gcagcagctc tcccccgggg agggttatct ccatgtccac
     6781 atgctaaaga cacccaatca gaaacaccag ctgactttct ttttaagcca cctcccattt
     6841 gtgcaaattt aggtctgcaa ggaccagtaa tgagaccagt acaggtagaa tggaagtgag
     6901 gttgtggtcc tccctggacc tgtgcagcgt ccaggtgctt ccctgccaag tggatgggtg
     6961 tgagacctca gcaccaaaag gggtgtaact gctgtggaat ttggtgccca actggaaatc
     7021 atgctgaagc tctaaaagtg tctcaataaa agccattttg aaagaaagaa
//
