LOCUS       NM_201426               1066 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Rattus norvegicus adrenomedullin 2 (Adm2), mRNA.
ACCESSION   NM_201426
VERSION     NM_201426.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1066)
  AUTHORS   Zhang,Y.R., Liu,S.M., Chen,Y., Zhang,L.S., Ji,D.R., Zhao,J.,
            Yu,Y.R., Jia,M.Z., Tang,C.S., Huang,W., Zhou,Y.B., Chai,S.B. and
            Qi,Y.F.
  TITLE     Intermedin alleviates diabetic vascular calcification by inhibiting
            GLUT1 through activation of the cAMP/PKA signaling pathway
  JOURNAL   Atherosclerosis 385, 117342 (2023)
   PUBMED   37879153
  REMARK    GeneRIF: Intermedin alleviates diabetic vascular calcification by
            inhibiting GLUT1 through activation of the cAMP/PKA signaling
            pathway.
REFERENCE   2  (bases 1 to 1066)
  AUTHORS   Zhang,L.S., Zhang,J.S., Hou,Y.L., Lu,W.W., Ni,X.Q., Lin,F.,
            Liu,X.Y., Wang,X.J., Yu,Y.R., Jia,M.Z., Tang,C.S., Han,L.,
            Chai,S.B. and Qi,Y.F.
  TITLE     Intermedin1-53 Inhibits NLRP3 Inflammasome Activation by Targeting
            IRE1alpha in Cardiac Fibrosis
  JOURNAL   Inflammation 45 (4), 1568-1584 (2022)
   PUBMED   35175495
  REMARK    GeneRIF: Intermedin1-53 Inhibits NLRP3 Inflammasome Activation by
            Targeting IRE1alpha in Cardiac Fibrosis.
REFERENCE   3  (bases 1 to 1066)
  AUTHORS   Li,Z., Guo,J., Bian,Y. and Zhang,M.
  TITLE     Intermedin protects thapsigargin-induced endoplasmic reticulum
            stress in cardiomyocytes by modulating protein kinase A and
            sarco/endoplasmic reticulum Ca2+-ATPase
  JOURNAL   Mol Med Rep 23 (2) (2021)
   PUBMED   33300086
  REMARK    GeneRIF: Intermedin protects thapsigargininduced endoplasmic
            reticulum stress in cardiomyocytes by modulating protein kinase A
            and sarco/endoplasmic reticulum Ca(2+)ATPase.
REFERENCE   4  (bases 1 to 1066)
  AUTHORS   Wang,Y., Mi,Y., Tian,J., Qiao,X., Su,X., Kang,J., Wu,Z., Wang,G.,
            Zhou,X., Zhou,Y. and Li,R.
  TITLE     Intermedin Alleviates Renal Ischemia-Reperfusion Injury and
            Enhances Neovascularization in Wistar Rats
  JOURNAL   Drug Des Devel Ther 14, 4825-4834 (2020)
   PUBMED   33204068
  REMARK    GeneRIF: Intermedin Alleviates Renal Ischemia-Reperfusion Injury
            and Enhances Neovascularization in Wistar Rats.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1066)
  AUTHORS   Dong,H., Zhou,Y., Wang,Y., Zhou,Q., Zhang,Y., Gan,X., Luo,Y. and
            Li,R.
  TITLE     The protective role of intermedin in promoting angiogenesis during
            renal fibrosis
  JOURNAL   Gene 688, 34-43 (2019)
   PUBMED   30472381
  REMARK    GeneRIF: Intermedin could be a potential candidate treatment for
            renal fibrosis.
REFERENCE   6  (bases 1 to 1066)
  AUTHORS   Fujisawa,Y., Nagai,Y., Miyatake,A., Miura,K., Shokoji,T.,
            Nishiyama,A., Kimura,S. and Abe,Y.
  TITLE     Roles of adrenomedullin 2 in regulating the cardiovascular and
            sympathetic nervous systems in conscious rats
  JOURNAL   Am J Physiol Heart Circ Physiol 290 (3), H1120-H1127 (2006)
   PUBMED   16227344
  REMARK    GeneRIF: These findings indicate that the physiological roles of
            rAM2 and rAM are similar and that rAM2 also has a long-lasting
            vasodilator action on the renal vascular bed.
REFERENCE   7  (bases 1 to 1066)
  AUTHORS   Lin Chang,C., Roh,J., Park,J.I., Klein,C., Cushman,N.,
            Haberberger,R.V. and Hsu,S.Y.
  TITLE     Intermedin functions as a pituitary paracrine factor regulating
            prolactin release
  JOURNAL   Mol Endocrinol 19 (11), 2824-2838 (2005)
   PUBMED   16002435
  REMARK    GeneRIF: IMD represents a novel estrogen-dependent intermediate
            lobe-derived prolactin-releasing factor and could play important
            roles in the regulation of prolactin release during reproduction in
            females.
REFERENCE   8  (bases 1 to 1066)
  AUTHORS   Yang,J.H., Qi,Y.F., Jia,Y.X., Pan,C.S., Zhao,J., Yang,J.,
            Chang,J.K. and Tang,C.S.
  TITLE     Protective effects of intermedin/adrenomedullin2 on
            ischemia/reperfusion injury in isolated rat hearts
  JOURNAL   Peptides 26 (3), 501-507 (2005)
   PUBMED   15652657
  REMARK    GeneRIF: IMD, like adrenomedullin, exerts cardio-protective effects
            against myocardial ischemia/reperfusion injury
REFERENCE   9  (bases 1 to 1066)
  AUTHORS   Roh,J., Chang,C.L., Bhalla,A., Klein,C. and Hsu,S.Y.
  TITLE     Intermedin is a calcitonin/calcitonin gene-related peptide family
            peptide acting through the calcitonin receptor-like
            receptor/receptor activity-modifying protein receptor complexes
  JOURNAL   J Biol Chem 279 (8), 7264-7274 (2004)
   PUBMED   14615490
  REMARK    GeneRIF: Intermedin is a calcitonin/calcitonin gene-related peptide
            family peptide acting through the calcitonin receptor-like
            receptor/receptor activity-modifying protein receptor complexes
REFERENCE   10 (bases 1 to 1066)
  AUTHORS   Takei,Y., Inoue,K., Ogoshi,M., Kawahara,T., Bannai,H. and Miyano,S.
  TITLE     Identification of novel adrenomedullin in mammals: a potent
            cardiovascular and renal regulator
  JOURNAL   FEBS Lett 556 (1-3), 53-58 (2004)
   PUBMED   14706825
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Mar 19, 2021 this sequence version replaced NM_201426.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB121036.1, AB181297.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               JAXUCZ010000007.1  122272808-122273008
            202-316             JAXUCZ010000007.1  122273148-122273262
            317-1066            JAXUCZ010000007.1  122273845-122274594
FEATURES             Location/Qualifiers
     source          1..1066
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1066
                     /gene="Adm2"
                     /gene_synonym="Imd"
                     /note="adrenomedullin 2"
                     /db_xref="GeneID:399475"
                     /db_xref="RGD:1302971"
     exon            1..201
                     /gene="Adm2"
                     /gene_synonym="Imd"
                     /inference="alignment:Splign:2.1.0"
     exon            202..316
                     /gene="Adm2"
                     /gene_synonym="Imd"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..653
                     /gene="Adm2"
                     /gene_synonym="Imd"
                     /note="intermedin; protein ADM2"
                     /codon_start=1
                     /product="protein ADM2 preproprotein"
                     /protein_id="NP_958829.1"
                     /db_xref="GeneID:399475"
                     /db_xref="RGD:1302971"
                     /translation="MAQLLMVTVTFGCISLLYLLPGTLSGSLGKGLRPREPPAKIPSS
                     GPQPGHPSLRPVVWKPPHALQPQGRGNPALATVHLPQGGGSRHPGPQRHVGSRRPHAQ
                     LLRVGCVLGTCQVQNLSHRLWQLVRPSGRRDSAPVDPSSPHSYG"
     exon            317..1066
                     /gene="Adm2"
                     /gene_synonym="Imd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccttcagct ccaaagacta cttagtgctg gaagtgcttc ccaaactagt tttccgctga
       61 accctagaag gctatctctc ctaggagacc acgacctgac ccacaagttc cgctgtgtgc
      121 tctgggaact gccagcaaat ccaagtcttg ccagctgtct ccagatcctg agacctgtgc
      181 cccgacagac aacagacgca gcccagcccg ccatggccca gttgctgatg gtcacggtaa
      241 ccttcggttg catcagcctc ctctacctgc tcccgggcac gctgtctggc agcctgggta
      301 agggactgag acccagagaa cccccagcca agattccttc cagcggccca cagcctggac
      361 acccctcact tcggcctgta gtctggaagc ctccacatgc tctccagcca cagggaaggg
      421 gcaacccggc ccttgctacg gttcatctgc ctcagggtgg tggctcacga cacccaggtc
      481 cccagcgtca cgtgggatcc cgaagacccc atgcccagct ccttcgggtt ggctgtgtcc
      541 tgggaacgtg tcaagtccag aatctcagcc atcgcctgtg gcaacttgtc cggccaagtg
      601 gccggcggga ctcagctcct gtggatccca gcagccccca cagttatggc tgaggtgggt
      661 cctaggtatc ccgcctagag tgctgtactc tgagcccaga gattgcagct gagctccaca
      721 ccctggccca atcctctgga gctcctgctt acagcaattc ctcatggctt tggatatcat
      781 aaacctatga ggatatgagg atctaggctg tagattcagc accaacaggg gcctgtgcat
      841 cccagaactg tgtacacaca gggtacaggt gctcggaaga agtgttctca gcatcacaga
      901 ccacagagta ctcgaggagg cctgtgccta aagaaaatcg gcaaaagcct gagtcttaaa
      961 cagggctcca cttgtgagca agcaggagaa aggctggagt ggcccctgtg accccaccct
     1021 accccgaccc cactaggaat taaagcctga ctgtggtcaa aagctg
//
