LOCUS       NM_012715               1387 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Rattus norvegicus adrenomedullin (Adm), mRNA.
ACCESSION   NM_012715 NM_173716
VERSION     NM_012715.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1387)
  AUTHORS   Dai,H.B., Wang,H.Y., Wang,F.Z., Qian,P., Gao,Q., Zhou,H. and
            Zhou,Y.B.
  TITLE     Adrenomedullin ameliorates palmitic acid-induced insulin resistance
            through PI3K/Akt pathway in adipocytes
  JOURNAL   Acta Diabetol 59 (5), 661-673 (2022)
   PUBMED   34978596
  REMARK    GeneRIF: Adrenomedullin ameliorates palmitic acid-induced insulin
            resistance through PI3K/Akt pathway in adipocytes.
REFERENCE   2  (bases 1 to 1387)
  AUTHORS   Cheng,L., Wang,C., Yao,F., Li,Z., Liu,W. and Jing,J.
  TITLE     MicroRNA-26b inhibits oligodendrocyte precursor cell
            differentiation by targeting adrenomedullin in spinal cord injury
  JOURNAL   J Cell Physiol 235 (3), 2429-2440 (2020)
   PUBMED   31489964
  REMARK    GeneRIF: MicroRNA-26b inhibits oligodendrocyte precursor cell
            differentiation by targeting adrenomedullin in spinal cord injury.
REFERENCE   3  (bases 1 to 1387)
  AUTHORS   Huang,H., Wang,M. and Hong,Y.
  TITLE     Intrathecal administration of adrenomedullin induces mechanical
            allodynia and neurochemical changes in spinal cord and DRG
  JOURNAL   Neurosci Lett 690, 196-201 (2019)
   PUBMED   30366012
  REMARK    GeneRIF: results suggest that the increased Adrenomedullin
            bioactivity induced mechanical allodynia.
REFERENCE   4  (bases 1 to 1387)
  AUTHORS   Soultanova,A., Mikulski,Z., Pfeil,U., Grau,V. and Kummer,W.
  TITLE     Calcitonin Peptide Family Members Are Differentially Regulated by
            LPS and Inhibit Functions of Rat Alveolar NR8383 Macrophages
  JOURNAL   PLoS One 11 (10), e0163483 (2016)
   PUBMED   27737007
  REMARK    GeneRIF: Rat Alveolar NR8383 Macrophage cell line NR8383 is both a
            source and a target of the calcitonin peptide family members, ADM,
            ADM2, and CGRP.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1387)
  AUTHORS   Chen,Y., Zhang,Y., Huo,Y., Wang,D. and Hong,Y.
  TITLE     Adrenomedullin mediates tumor necrosis factor-alpha-induced
            responses in dorsal root ganglia in rats
  JOURNAL   Brain Res 1644, 183-191 (2016)
   PUBMED   27184601
  REMARK    GeneRIF: Study suggests that the increased adrenomedullin receptor
            signaling mediated the many, but not all, tumor necrosis
            factor-alpha-induced activities, contributing to peripheral
            sensitization in neuropathic pain.
REFERENCE   6  (bases 1 to 1387)
  AUTHORS   Allaker,R.P., Zihni,C. and Kapas,S.
  TITLE     An investigation into the antimicrobial effects of adrenomedullin
            on members of the skin, oral, respiratory tract and gut microflora
  JOURNAL   FEMS Immunol Med Microbiol 23 (4), 289-293 (1999)
   PUBMED   10225288
REFERENCE   7  (bases 1 to 1387)
  AUTHORS   McLatchie,L.M., Fraser,N.J., Main,M.J., Wise,A., Brown,J.,
            Thompson,N., Solari,R., Lee,M.G. and Foord,S.M.
  TITLE     RAMPs regulate the transport and ligand specificity of the
            calcitonin-receptor-like receptor
  JOURNAL   Nature 393 (6683), 333-339 (1998)
   PUBMED   9620797
REFERENCE   8  (bases 1 to 1387)
  AUTHORS   Wang,X., Yue,T.L., Barone,F.C., White,R.F., Clark,R.K.,
            Willette,R.N., Sulpizio,A.C., Aiyar,N.V., Ruffolo,R.R. Jr. and
            Feuerstein,G.Z.
  TITLE     Discovery of adrenomedullin in rat ischemic cortex and evidence for
            its role in exacerbating focal brain ischemic damage
  JOURNAL   Proc Natl Acad Sci U S A 92 (25), 11480-11484 (1995)
   PUBMED   8524787
REFERENCE   9  (bases 1 to 1387)
  AUTHORS   Kapas,S., Catt,K.J. and Clark,A.J.
  TITLE     Cloning and expression of cDNA encoding a rat adrenomedullin
            receptor
  JOURNAL   J Biol Chem 270 (43), 25344-25347 (1995)
   PUBMED   7592696
REFERENCE   10 (bases 1 to 1387)
  AUTHORS   Sakata,J., Shimokubo,T., Kitamura,K., Nakamura,S., Kangawa,K.,
            Matsuo,H. and Eto,T.
  TITLE     Molecular cloning and biological activities of rat adrenomedullin,
            a hypotensive peptide
  JOURNAL   Biochem Biophys Res Commun 195 (2), 921-927 (1993)
   PUBMED   7690563
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012715.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U15419.1, D15069.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               JAXUCZ010000001.1  174180200-174180348
            150-269             JAXUCZ010000001.1  174180780-174180899
            270-416             JAXUCZ010000001.1  174181058-174181204
            417-1387            JAXUCZ010000001.1  174181401-174182371
FEATURES             Location/Qualifiers
     source          1..1387
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q33"
     gene            1..1387
                     /gene="Adm"
                     /gene_synonym="Ap; H39316; RATAP"
                     /note="adrenomedullin"
                     /db_xref="GeneID:25026"
                     /db_xref="RGD:2047"
     exon            1..149
                     /gene="Adm"
                     /gene_synonym="Ap; H39316; RATAP"
                     /inference="alignment:Splign:2.1.0"
     exon            150..269
                     /gene="Adm"
                     /gene_synonym="Ap; H39316; RATAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..729
                     /gene="Adm"
                     /gene_synonym="Ap; H39316; RATAP"
                     /note="pro-adrenomedullin"
                     /codon_start=1
                     /product="pro-adrenomedullin precursor"
                     /protein_id="NP_036847.1"
                     /db_xref="GeneID:25026"
                     /db_xref="RGD:2047"
                     /translation="MKLVSIALMLLGSLAVLGADTARLDTSSQFRKKWNKWALSRGKR
                     ELQASSSYPTGLVDEKTVPTQTLGLQDKQSTSSTPQASTQSTAHIRVKRYRQSMNQGS
                     RSTGCRFGTCTMQKLAHQIYQFTDKDKDGMAPRNKISPQGYGRRRRRSLPEVLRARTV
                     ESSQEQTHSAPASPAHQDISRVSRL"
     exon            270..416
                     /gene="Adm"
                     /gene_synonym="Ap; H39316; RATAP"
                     /inference="alignment:Splign:2.1.0"
     exon            417..1387
                     /gene="Adm"
                     /gene_synonym="Ap; H39316; RATAP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacactaggc agaacaactc cagcctttac cgctcctggt ttctcggctt ctcatcgcag
       61 tcagtcttgg actttgcggg ttttgccgct gtcagaagga cgtctcggac tttctgcttc
      121 aagtgcttga caactcaccc tttcagcagg gtatcggagc atcgctacag aatgaagctg
      181 gtttccatcg ccctgatgtt attgggttcg ctcgccgttc tcggcgcgga caccgcacgg
      241 ctcgacactt cctcgcagtt ccgaaagaag tggaataagt gggcgctaag tcgtgggaag
      301 agggaactac aagcgtccag cagctaccct acggggctcg ttgatgagaa gacagtcccg
      361 acccagactc ttgggctcca ggacaagcag agcacgtcta gcaccccaca agccagcact
      421 cagagcacag cccacattcg agtcaaacgc taccgccaga gcatgaacca ggggtcccgc
      481 agcactggat gccgctttgg gacctgcaca atgcagaaac tggctcacca gatctaccag
      541 tttacagaca aagacaagga cggcatggcc cccagaaaca agatcagccc tcaaggctat
      601 ggccgccggc gccggcgttc cctgccagag gtcctccgag cccggactgt ggagtcctcc
      661 caggagcaga cacactcagc tccagcctcc ccggcgcacc aagacatctc cagagtctct
      721 aggttatagg tgcgggtggc agcattgaac agtcgggcga gtatcccatt ggcgcctgcg
      781 gaatcagaga gcttcgcacc ctgagcggac tgagacaatc ttgcagagat ctgcctggct
      841 gcccctaggg gaggcagagg aacccaagat caagccaggc tcacgtcaga aaccgagaat
      901 tacaggctga tactctctcc gggcaggggt ctgagccact gccttgcccg ctcataaact
      961 ggttttctca cggggcatac gcctcattac tacttgaact ttccaaaacc tagcgaggaa
     1021 aagtgcaatg cttgttatac agccaaaggt aactatcata tttaagtttg ttgatgtcaa
     1081 gaggtttttt tttttgtaac ttcaaatata tagaaatatt tttgtacgtt atatattgta
     1141 ttaagggcat tttaaagcga ttatattgtc accttcccct attttaagaa gtgaatgtct
     1201 cagcaaggtg taaggttgtt tggttccgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     1261 tgtgtgtaag gtggagagcg cctgattacc gcctgtggat gaagaaaaaa cattgtgtct
     1321 tctataatct atttacataa aatatgtgat ctgggaaaaa gcaaaccaat aaactgtctc
     1381 aatgctg
//
