LOCUS       NM_012895               1763 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus adenosine kinase (Adk), mRNA.
ACCESSION   NM_012895
VERSION     NM_012895.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1763)
  AUTHORS   Jin,W., Xu,W., Chen,J., Zhang,X., Shi,L. and Ren,C.
  TITLE     Adenosine kinase facilitated astrogliosis-induced cortical neuronal
            death in traumatic brain injury
  JOURNAL   J Mol Histol 47 (3), 259-271 (2016)
   PUBMED   26983602
  REMARK    GeneRIF: ADK was associated with astrogliosis after TBI, its
            inhibition in reactive astrocytes ameliorated astrogliosis-induced
            neuronal death. Our findings extended the current knowledge on the
            role of ADK in astrogliosis, and also provided new evidence for the
            TBI treatment.
REFERENCE   2  (bases 1 to 1763)
  AUTHORS   Pimentel,V.C., Moretto,M.B., Oliveira,M.C., Zanini,D.,
            Sebastiao,A.M. and Schetinger,M.R.
  TITLE     Neuroinflammation after neonatal hypoxia-ischemia is associated
            with alterations in the purinergic system: adenosine deaminase 1
            isoenzyme is the most predominant after insult
  JOURNAL   Mol Cell Biochem 403 (1-2), 169-177 (2015)
   PUBMED   25720338
REFERENCE   3  (bases 1 to 1763)
  AUTHORS   Singer,P., McGarrity,S., Shen,H.Y., Boison,D. and Yee,B.K.
  TITLE     Working memory and the homeostatic control of brain adenosine by
            adenosine kinase
  JOURNAL   Neuroscience 213, 81-92 (2012)
   PUBMED   22521820
REFERENCE   4  (bases 1 to 1763)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 1763)
  AUTHORS   Annes,J.P., Ryu,J.H., Lam,K., Carolan,P.J., Utz,K.,
            Hollister-Lock,J., Arvanites,A.C., Rubin,L.L., Weir,G. and
            Melton,D.A.
  TITLE     Adenosine kinase inhibition selectively promotes rodent and porcine
            islet beta-cell replication
  JOURNAL   Proc Natl Acad Sci U S A 109 (10), 3915-3920 (2012)
   PUBMED   22345561
  REMARK    GeneRIF: Adenosine kinase inhibition selectively promotes rodent
            and porcine islet beta-cell replication
REFERENCE   6  (bases 1 to 1763)
  AUTHORS   Snyder,F.F., Jenuth,J.P., Dilay,J.E., Fung,E., Lightfoot,T. and
            Mably,E.R.
  TITLE     Secondary loss of deoxyguanosine kinase activity in purine
            nucleoside phosphorylase deficient mice
  JOURNAL   Biochim Biophys Acta 1227 (1-2), 33-40 (1994)
   PUBMED   7918681
REFERENCE   7  (bases 1 to 1763)
  AUTHORS   Hurley,M.C., Lin,B. and Fox,I.H.
  TITLE     Regulation of deoxyadenosine and nucleoside analog phosphorylation
            by human placental adenosine kinase
  JOURNAL   J Biol Chem 260 (29), 15675-15681 (1985)
   PUBMED   2999129
REFERENCE   8  (bases 1 to 1763)
  AUTHORS   Snyder,F.F., Biddle,F.G., Lukey,T. and Sparling,M.J.
  TITLE     Genetic variability of purine nucleoside phosphorylase activity in
            the mouse: relationship to Np-1 and Np-2
  JOURNAL   Biochem Genet 21 (3-4), 323-332 (1983)
   PUBMED   6407470
REFERENCE   9  (bases 1 to 1763)
  AUTHORS   Stallings,R.L. and Siciliano,M.J.
  TITLE     Confirmational, provisional, and/or regional assignment of 15
            enzyme loci onto Chinese hamster autosomes 1, 2, and 7
  JOURNAL   Somatic Cell Genet 7 (6), 683-698 (1981)
   PUBMED   7323947
REFERENCE   10 (bases 1 to 1763)
  AUTHORS   Andres,C.M. and Fox,I.H.
  TITLE     Purification and properties of human placental adenosine kinase
  JOURNAL   J Biol Chem 254 (22), 11388-11393 (1979)
   PUBMED   227870
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081712.1.
            
            On Sep 19, 2004 this sequence version replaced NM_012895.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081712.1, U90340.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1763
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..1763
                     /gene="Adk"
                     /gene_synonym="AK"
                     /note="adenosine kinase"
                     /db_xref="GeneID:25368"
                     /db_xref="RGD:2046"
     exon            1..74
                     /gene="Adk"
                     /gene_synonym="AK"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1098
                     /gene="Adk"
                     /gene_synonym="AK"
                     /EC_number="2.7.1.20"
                     /note="adenosine 5'-phosphotransferase"
                     /codon_start=1
                     /product="adenosine kinase"
                     /protein_id="NP_037027.2"
                     /db_xref="GeneID:25368"
                     /db_xref="RGD:2046"
                     /translation="MAAADEPKPKKLKVEAPEALSENVLFGMGNPLLDISAVVDKDFL
                     DKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSMKVAQWMIQEPHRAATF
                     FGCIGIDKFGEILKSKAADAHVDAHYYEQNEQPTGTCAACITGGNRSLVANLAAANCY
                     KKEKHLDLENNWMLVEKARVYYIAGFFLTVSPESVLKVARYAAENNRTFTLNLSAPFI
                     SQFFKEALMEVMPYVDILFGNETEAATFAREQGFETKDIKEIARKTQALPKVNSKRQR
                     TVIFTQGRDDTIVATGNDVTAFPVLDQNQEEIVDTNGAGDAFVGGFLSQLVSNKPLTE
                     CIRAGHYAASVIIRRTGCTFPEKPNFH"
     exon            75..149
                     /gene="Adk"
                     /gene_synonym="AK"
                     /inference="alignment:Splign:2.1.0"
     exon            150..203
                     /gene="Adk"
                     /gene_synonym="AK"
                     /inference="alignment:Splign:2.1.0"
     exon            204..282
                     /gene="Adk"
                     /gene_synonym="AK"
                     /inference="alignment:Splign:2.1.0"
     exon            283..455
                     /gene="Adk"
                     /gene_synonym="AK"
                     /inference="alignment:Splign:2.1.0"
     exon            456..564
                     /gene="Adk"
                     /gene_synonym="AK"
                     /inference="alignment:Splign:2.1.0"
     exon            565..735
                     /gene="Adk"
                     /gene_synonym="AK"
                     /inference="alignment:Splign:2.1.0"
     exon            736..771
                     /gene="Adk"
                     /gene_synonym="AK"
                     /inference="alignment:Splign:2.1.0"
     exon            772..886
                     /gene="Adk"
                     /gene_synonym="AK"
                     /inference="alignment:Splign:2.1.0"
     exon            887..973
                     /gene="Adk"
                     /gene_synonym="AK"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1737
                     /gene="Adk"
                     /gene_synonym="AK"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagagtgcga agatggcagc tgcggacgag ccgaagccca agaagctcaa ggtggaagcg
       61 ccagaagcgc tgagtgaaaa tgtgctgttt ggaatgggga atcctcttct tgacatctct
      121 gctgtggtag acaaagattt ccttgataag tattctctga aaccaaacga ccagatcttg
      181 gccgaagaca agcacaagga attgtttgat gaacttgtaa aaaaattcaa agttgaatat
      241 catgccggtg ggtccacgca gaattcaatg aaagtggctc agtggatgat tcaggagcca
      301 cacagagcag caacgttctt cggatgcatt gggatagata agttcgggga gatcctgaag
      361 agcaaagccg cagatgcaca cgtggacgcc cattactatg agcagaacga gcagcccaca
      421 ggaacgtgcg ctgcatgcat caccggtggc aaccggtctc ttgttgctaa ccttgctgcc
      481 gccaattgtt ataagaaaga aaagcacctt gatctggaga acaactggat gttggtagag
      541 aaagccagag tttactacat agctggcttc tttctcaccg tctccccaga gtcagtgttg
      601 aaagtggctc gctatgctgc cgagaacaac aggaccttca ctctgaacct gtccgcaccg
      661 ttcattagcc agttcttcaa ggaagccttg atggaagtca tgccttatgt tgacatcctc
      721 tttggaaatg agacggaggc tgccactttt gctagagagc aaggctttga gactaaagac
      781 attaaagaaa tagccagaaa gacgcaggct cttccaaagg tgaactcgaa gaggcagagg
      841 accgtgatct tcacccaagg gagagatgac actatagtgg ctacaggaaa tgatgtcact
      901 gctttccctg tcttggatca aaaccaggaa gagatcgttg acaccaatgg agctggagat
      961 gcatttgtag gagggtttct gtctcagctg gtctccaaca agcctctgac tgaatgcatc
     1021 cgggccgggc actatgcagc gagcgtcatc attaggcgaa ctggctgtac ttttcctgag
     1081 aagccaaact tccactgacg gaagaaaagc aactcaggct gtggagtgga gactgcagag
     1141 accacgtcct gagcgttcct gccttgagaa agaataacat tatcttctgt ctttgcccac
     1201 catgattctc attattaccg tagagggctc agtgctactc ctagaacctt tagtctctca
     1261 aaatctgggg aaaaatgttt atttccatag tctgttagtg cctcttaaat gtcacacagg
     1321 aatccaacat ttcagtagaa acttttaagt tccttttcaa ttgtttataa attcatcagt
     1381 atttagtaag ttgatttttt tttatatttc tgcttctaat gcgggtgcaa tttaatatga
     1441 tagacttttt aaagagatta atgctaacgt cattcttgag ctttttatat aaatgtgttt
     1501 aatttggaag cgtgtgtgca cacatgtcat atatattcct gataattgtc aaataaggta
     1561 cagaaacgtt gacgcacacc acattgcccc gcataagctc ttccatgtgc tgcggacacc
     1621 cggtggactt ggggggacag ctgactaatc ccagctttgc gctgtgctca gattgtaacc
     1681 tctgcctact catggtactc tgtaatttga tacaaataaa aaactgccac atagggaaaa
     1741 aaaaaaaaaa aaaaaaaaaa aaa
//
