LOCUS       NM_001037979            1185 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Rattus norvegicus adiponectin receptor 2 (Adipor2), mRNA.
ACCESSION   NM_001037979 XM_232323
VERSION     NM_001037979.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1185)
  AUTHORS   Schaffer,A., Ducza,E., Bodi,N., Bagyanszki,M., Szalai,Z.,
            Mirdamadi,M., Barna,T., Szucs,K.F. and Gaspar,R.
  TITLE     The ontogenies of endometrial and myometrial leptin and adiponectin
            receptors in pregnant rats: Their putative impact on uterine
            contractility
  JOURNAL   Life Sci 297, 120465 (2022)
   PUBMED   35271883
  REMARK    GeneRIF: The ontogenies of endometrial and myometrial leptin and
            adiponectin receptors in pregnant rats: Their putative impact on
            uterine contractility.
REFERENCE   2  (bases 1 to 1185)
  AUTHORS   Afzal,S., Sattar,M.A., Eseyin,O.A., Attiq,A. and Johns,E.J.
  TITLE     Crosstalk relationship between adiponectin receptors, PPAR-gamma
            and alpha-adrenoceptors in renal vasculature of diabetic WKYs
  JOURNAL   Eur J Pharmacol 917, 174703 (2022)
   PUBMED   34973951
  REMARK    GeneRIF: Crosstalk relationship between adiponectin receptors,
            PPAR-gamma and alpha-adrenoceptors in renal vasculature of diabetic
            WKYs.
REFERENCE   3  (bases 1 to 1185)
  AUTHORS   de Sousa,A.R., de Castro Moreira,M.E., Toledo,R.C.L., Dos Anjos
            Benjamin,L., Queiroz,V.A.V., Veloso,M.P., de Souza Reis,K. and
            Martino,H.S.D.
  TITLE     Extruded sorghum (Sorghum bicolor L.) reduces metabolic risk of
            hepatic steatosis in obese rats consuming a high fat diet
  JOURNAL   Food Res Int 112, 48-55 (2018)
   PUBMED   30131158
REFERENCE   4  (bases 1 to 1185)
  AUTHORS   Li,J., Xue,Y.M., Zhu,B., Pan,Y.H., Zhang,Y., Wang,C. and Li,Y.
  TITLE     Rosiglitazone Elicits an Adiponectin-Mediated Insulin-Sensitizing
            Action at the Adipose Tissue-Liver Axis in Otsuka Long-Evans
            Tokushima Fatty Rats
  JOURNAL   J Diabetes Res 2018, 4627842 (2018)
   PUBMED   30225267
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1185)
  AUTHORS   Lei,L., Zhou,C., Yang,X. and Li,L.
  TITLE     Down-regulation of microRNA-375 regulates adipokines and inhibits
            inflammatory cytokines by targeting AdipoR2 in non-alcoholic fatty
            liver disease
  JOURNAL   Clin Exp Pharmacol Physiol 45 (8), 819-831 (2018)
   PUBMED   29569260
REFERENCE   6  (bases 1 to 1185)
  AUTHORS   Fujioka,D., Kawabata,K., Saito,Y., Kobayashi,T., Nakamura,T.,
            Kodama,Y., Takano,H., Obata,J.E., Kitta,Y., Umetani,K. and
            Kugiyama,K.
  TITLE     Role of adiponectin receptors in endothelin-induced cellular
            hypertrophy in cultured cardiomyocytes and their expression in
            infarcted heart
  JOURNAL   Am J Physiol Heart Circ Physiol 290 (6), H2409-H2416 (2006)
   PUBMED   16415076
  REMARK    GeneRIF: AdipoR2 might play a role in the pathogenesis of
            endothelin-1-related cardiomyocyte hypertrophy after myocardial
            infarction
REFERENCE   7  (bases 1 to 1185)
  AUTHORS   Fang,X., Palanivel,R., Zhou,X., Liu,Y., Xu,A., Wang,Y. and
            Sweeney,G.
  TITLE     Hyperglycemia- and hyperinsulinemia-induced alteration of
            adiponectin receptor expression and adiponectin effects in L6
            myoblasts
  JOURNAL   J Mol Endocrinol 35 (3), 465-476 (2005)
   PUBMED   16326833
REFERENCE   8  (bases 1 to 1185)
  AUTHORS   Caminos,J.E., Nogueiras,R., Gallego,R., Bravo,S., Tovar,S.,
            Garcia-Caballero,T., Casanueva,F.F. and Dieguez,C.
  TITLE     Expression and regulation of adiponectin and receptor in human and
            rat placenta
  JOURNAL   J Clin Endocrinol Metab 90 (7), 4276-4286 (2005)
   PUBMED   15855268
REFERENCE   9  (bases 1 to 1185)
  AUTHORS   Steinmetz,M., Quentin,T., Poppe,A., Paul,T. and Jux,C.
  TITLE     Changes in expression levels of genes involved in fatty acid
            metabolism: upregulation of all three members of the PPAR family
            (alpha, gamma, delta) and the newly described adiponectin receptor
            2, but not adiponectin receptor 1 during neonatal cardiac
            development of the rat
  JOURNAL   Basic Res Cardiol 100 (3), 263-269 (2005)
   PUBMED   15754086
REFERENCE   10 (bases 1 to 1185)
  AUTHORS   Yamauchi,T., Kamon,J., Ito,Y., Tsuchida,A., Yokomizo,T., Kita,S.,
            Sugiyama,T., Miyagishi,M., Hara,K., Tsunoda,M., Murakami,K.,
            Ohteki,T., Uchida,S., Takekawa,S., Waki,H., Tsuno,N.H., Shibata,Y.,
            Terauchi,Y., Froguel,P., Tobe,K., Koyasu,S., Taira,K., Kitamura,T.,
            Shimizu,T., Nagai,R. and Kadowaki,T.
  TITLE     Cloning of adiponectin receptors that mediate antidiabetic
            metabolic effects
  JOURNAL   Nature 423 (6941), 762-769 (2003)
   PUBMED   12802337
  REMARK    Erratum:[Nature. 2004 Oct 28;431(7012):1123]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from DQ148392.1.
            
            On Dec 23, 2005 this sequence version replaced XM_232323.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ148392.1, AY724514.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN16676787
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1185
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1185
                     /gene="Adipor2"
                     /note="adiponectin receptor 2"
                     /db_xref="GeneID:312670"
                     /db_xref="RGD:1307891"
     exon            1..182
                     /gene="Adipor2"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..1172
                     /gene="Adipor2"
                     /codon_start=1
                     /product="adiponectin receptor protein 2"
                     /protein_id="NP_001033068.1"
                     /db_xref="GeneID:312670"
                     /db_xref="RGD:1307891"
                     /translation="MNEPTEHRLGCTRTPEPDIRLRKGHQLDDTRGGNNDNHHGDLEP
                     SLETPVCSSYYENSPEELECHDDNSQEDEGFMGMSPLLQAHHAMERMEEFVCKVWEGR
                     WRVIPHDVLPDWLKDNDFLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGCVFFL
                     CLGIFYMFRPNISFVAPLQEKVVFGLFFLGAILCLSFSWLFHTVYCHSEGVSRLFSKL
                     DYSGIALLIMGSFVPWLYYSFYCNPQPCFIYLIVICVLGIAAIIVSQWDMFATPQYRG
                     VRAGVFVGLGLSGIIPTLHYVISEGFLKAATIGQIGWLMLMASLYITGAALYAARIPE
                     RFFPGKCDIWFHFHQLFHIFVVAGAFVHFHGVSNLQEFRFMIGGGCTEEDAL"
     exon            183..302
                     /gene="Adipor2"
                     /inference="alignment:Splign:2.1.0"
     exon            303..474
                     /gene="Adipor2"
                     /inference="alignment:Splign:2.1.0"
     exon            475..661
                     /gene="Adipor2"
                     /inference="alignment:Splign:2.1.0"
     exon            662..849
                     /gene="Adipor2"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1043
                     /gene="Adipor2"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1185
                     /gene="Adipor2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttggtatcg catgaacgag ccaaccgaac accgattggg gtgcaccagg actccagagc
       61 cagatataag gctcagaaaa gggcaccaac ttgatgatac aaggggaggt aacaatgaca
      121 accaccacgg agatttggag cccagtttag agacacctgt ttgttcttcc tactatgaaa
      181 atagccccga ggaactcgag tgtcatgatg acaactccca agaagatgaa gggtttatgg
      241 gcatgtcccc tctcctacaa gcccatcatg ctatggaacg aatggaagag tttgtttgta
      301 aggtgtggga aggtcgatgg cgagtgatcc ctcatgatgt gctgccagat tggcttaagg
      361 acaatgactt ccttctccat ggacaccggc ctcctatgcc ttctttccgg gcctgtttta
      421 agagcatctt tagaatacac acagagacgg gcaacatttg gacacatctc ctaggttgtg
      481 tattcttcct gtgcctgggg atcttttata tgtttcgccc aaatatatct tttgtggccc
      541 ctctgcaaga gaaagtggtc ttcgggttgt tcttcttggg agccattctc tgcctttcct
      601 tttcatggct cttccacacg gtgtactgcc actcagaagg ggtctcccga ctcttctcta
      661 aattggatta ctctggtatt gctcttctga tcatgggaag ttttgttcct tggctttatt
      721 attctttcta ctgtaaccca caaccttgct tcatctacct gattgtcatc tgtgtgctgg
      781 gcattgcagc cattatcgtc tctcagtggg acatgtttgc cacccctcag tatcgggggg
      841 tcagagcagg agtgttcgtg ggcttgggtc tgagtggaat catccctacc ttgcattatg
      901 tcatctcaga agggttcctg aaggctgcca ccatagggca gataggctgg ctaatgctca
      961 tggctagcct ctatatcaca ggagctgccc tctacgcggc ccgtatccct gagcgcttct
     1021 ttcctggcaa atgtgacatc tggtttcact ttcatcagct cttccacatc tttgtggttg
     1081 ctggtgcctt tgttcacttc catggagtct caaacctgca ggaatttcgt ttcatgattg
     1141 gtgggggctg cactgaagag gatgcgctgt gatactctcc aggaa
//
