LOCUS       NM_207587               2028 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Rattus norvegicus adiponectin receptor 1 (Adipor1), mRNA.
ACCESSION   NM_207587 XM_237893
VERSION     NM_207587.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2028)
  AUTHORS   Rajizadeh,M.A., Moslemizadeh,A., Hosseini,M.S., Rafiei,F.,
            Soltani,Z. and Khoramipour,K.
  TITLE     Adiponectin receptor 1 could explain the sex differences in
            molecular basis of cognitive improvements induced by exercise
            training in type 2 diabetic rats
  JOURNAL   Sci Rep 13 (1), 16267 (2023)
   PUBMED   37758935
  REMARK    GeneRIF: Adiponectin receptor 1 could explain the sex differences
            in molecular basis of cognitive improvements induced by exercise
            training in type 2 diabetic rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2028)
  AUTHORS   Schaffer,A., Ducza,E., Bodi,N., Bagyanszki,M., Szalai,Z.,
            Mirdamadi,M., Barna,T., Szucs,K.F. and Gaspar,R.
  TITLE     The ontogenies of endometrial and myometrial leptin and adiponectin
            receptors in pregnant rats: Their putative impact on uterine
            contractility
  JOURNAL   Life Sci 297, 120465 (2022)
   PUBMED   35271883
  REMARK    GeneRIF: The ontogenies of endometrial and myometrial leptin and
            adiponectin receptors in pregnant rats: Their putative impact on
            uterine contractility.
REFERENCE   3  (bases 1 to 2028)
  AUTHORS   Syed,A.A., Reza,M.I., Singh,P., Husain,A., Dadge,S. and Gayen,J.R.
  TITLE     Polyphenolic-rich Cissus quadrangularis extract ameliorates insulin
            resistance by activating AdipoR1 in peri-/post-menopausal rats
  JOURNAL   Exp Gerontol 159, 111681 (2022)
   PUBMED   34973346
  REMARK    GeneRIF: Polyphenolic-rich Cissus quadrangularis extract
            ameliorates insulin resistance by activating AdipoR1 in
            peri-/post-menopausal rats.
REFERENCE   4  (bases 1 to 2028)
  AUTHORS   Afzal,S., Sattar,M.A., Eseyin,O.A., Attiq,A. and Johns,E.J.
  TITLE     Crosstalk relationship between adiponectin receptors, PPAR-gamma
            and alpha-adrenoceptors in renal vasculature of diabetic WKYs
  JOURNAL   Eur J Pharmacol 917, 174703 (2022)
   PUBMED   34973951
  REMARK    GeneRIF: Crosstalk relationship between adiponectin receptors,
            PPAR-gamma and alpha-adrenoceptors in renal vasculature of diabetic
            WKYs.
REFERENCE   5  (bases 1 to 2028)
  AUTHORS   Zhang,Y., Wang,S., Huang,H., Zeng,A., Han,Y., Zeng,C., Zheng,S.,
            Ren,H., Wang,Y., Huang,Y., Jose,P.A., Ma,X.L., Zeng,C. and Chen,K.
  TITLE     GRK4-mediated adiponectin receptor-1 phosphorylative
            desensitization as a novel mechanism of reduced renal sodium
            excretion in hypertension
  JOURNAL   Clin Sci (Lond) 134 (18), 2453-2467 (2020)
   PUBMED   32940654
  REMARK    GeneRIF: GRK4-mediated adiponectin receptor-1 phosphorylative
            desensitization as a novel mechanism of reduced renal sodium
            excretion in hypertension.
REFERENCE   6  (bases 1 to 2028)
  AUTHORS   Kadowaki,T., Yamauchi,T., Kubota,N., Hara,K., Ueki,K. and Tobe,K.
  TITLE     Adiponectin and adiponectin receptors in insulin resistance,
            diabetes, and the metabolic syndrome
  JOURNAL   J Clin Invest 116 (7), 1784-1792 (2006)
   PUBMED   16823476
  REMARK    Review article
REFERENCE   7  (bases 1 to 2028)
  AUTHORS   Fujioka,D., Kawabata,K., Saito,Y., Kobayashi,T., Nakamura,T.,
            Kodama,Y., Takano,H., Obata,J.E., Kitta,Y., Umetani,K. and
            Kugiyama,K.
  TITLE     Role of adiponectin receptors in endothelin-induced cellular
            hypertrophy in cultured cardiomyocytes and their expression in
            infarcted heart
  JOURNAL   Am J Physiol Heart Circ Physiol 290 (6), H2409-H2416 (2006)
   PUBMED   16415076
  REMARK    GeneRIF: AdipoR1 might play a role in the pathogenesis of
            endothelin-1-related cardiomyocyte hypertrophy after myocardial
            infarction
REFERENCE   8  (bases 1 to 2028)
  AUTHORS   Beylot,M., Pinteur,C. and Peroni,O.
  TITLE     Expression of the adiponectin receptors AdipoR1 and AdipoR2 in lean
            rats and in obese Zucker rats
  JOURNAL   Metabolism 55 (3), 396-401 (2006)
   PUBMED   16483885
  REMARK    GeneRIF: results do not support an important role for the
            expression of AdipoR1 and AdipoR2 in the modulation of sensitivity
            to insulin.
REFERENCE   9  (bases 1 to 2028)
  AUTHORS   Fang,X., Palanivel,R., Zhou,X., Liu,Y., Xu,A., Wang,Y. and
            Sweeney,G.
  TITLE     Hyperglycemia- and hyperinsulinemia-induced alteration of
            adiponectin receptor expression and adiponectin effects in L6
            myoblasts
  JOURNAL   J Mol Endocrinol 35 (3), 465-476 (2005)
   PUBMED   16326833
REFERENCE   10 (bases 1 to 2028)
  AUTHORS   Yamauchi,T., Kamon,J., Ito,Y., Tsuchida,A., Yokomizo,T., Kita,S.,
            Sugiyama,T., Miyagishi,M., Hara,K., Tsunoda,M., Murakami,K.,
            Ohteki,T., Uchida,S., Takekawa,S., Waki,H., Tsuno,N.H., Shibata,Y.,
            Terauchi,Y., Froguel,P., Tobe,K., Koyasu,S., Taira,K., Kitamura,T.,
            Shimizu,T., Nagai,R. and Kadowaki,T.
  TITLE     Cloning of adiponectin receptors that mediate antidiabetic
            metabolic effects
  JOURNAL   Nature 423 (6941), 762-769 (2003)
   PUBMED   12802337
  REMARK    Erratum:[Nature. 2004 Oct 28;431(7012):1123]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Nov 27, 2020 this sequence version replaced NM_207587.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061838.1, SRR26360190.2049422.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               JAXUCZ010000013.1  48411930-48412052
            124-358             JAXUCZ010000013.1  48419436-48419670
            359-475             JAXUCZ010000013.1  48422099-48422215
            476-647             JAXUCZ010000013.1  48423520-48423691
            648-834             JAXUCZ010000013.1  48424684-48424870
            835-1022            JAXUCZ010000013.1  48426638-48426825
            1023-1216           JAXUCZ010000013.1  48429991-48430184
            1217-2028           JAXUCZ010000013.1  48430440-48431251
FEATURES             Location/Qualifiers
     source          1..2028
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..2028
                     /gene="Adipor1"
                     /note="adiponectin receptor 1"
                     /db_xref="GeneID:289036"
                     /db_xref="RGD:1303151"
     exon            1..123
                     /gene="Adipor1"
                     /inference="alignment:Splign:2.1.0"
     exon            124..358
                     /gene="Adipor1"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..1345
                     /gene="Adipor1"
                     /codon_start=1
                     /product="adiponectin receptor protein 1"
                     /protein_id="NP_997470.2"
                     /db_xref="GeneID:289036"
                     /db_xref="RGD:1303151"
                     /translation="MSSHKGSAVAQGNGAPSSNRAADTVELAELGPLLEEKGKRAATS
                     PAKAEEEQACPVPQEEEEEVRVLTLPLQAHHAMEKMEEFVYKVWEGRWRVIPYDVLPD
                     WLKDNDYLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGFVLFLFLGILTMLRPN
                     MYFMAPLQEKVVFGMFFLGAVLCLSFSWLFHTVYCHSEKVSRTFSKLDYSGIALLIMG
                     SFVPWLYYSFYCSPQPRLIYLSIVCVLGISAIIVAQWDRFATPKHRQTRAGVFLGLGL
                     SGVVPTMHFTIAEGFVKATTVGQMGWFFLMAVMYITGAGLYAARIPERFFPGKFDIWF
                     QSHQIFHVLVVAAAFVHFYGVSNLQEFRYGLEGGCTDDSLL"
     exon            359..475
                     /gene="Adipor1"
                     /inference="alignment:Splign:2.1.0"
     exon            476..647
                     /gene="Adipor1"
                     /inference="alignment:Splign:2.1.0"
     exon            648..834
                     /gene="Adipor1"
                     /inference="alignment:Splign:2.1.0"
     exon            835..1022
                     /gene="Adipor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1216
                     /gene="Adipor1"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..2028
                     /gene="Adipor1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacaccggcc acccagggcc gggaacccta aggcccccac ccgcgatccg caggtcaaac
       61 gtgacggctc tccctcctgg atagggtcgg cggggaggtt gatggagagt cgacaggcct
      121 aagtgtccat catcactggg agatctctgc cctctggggc tgagagaccc caacctctcc
      181 tcaagctgaa gctgcaaggc actgaggtac cagccagatg tcttcccaca aaggatctgc
      241 cgtggcccag ggcaatgggg ctccttctag taacagagca gcggacacgg tggagctggc
      301 tgagctgggg cccctgctgg aggagaaggg taagcgggca gccaccagcc cagccaaggc
      361 tgaagaagaa caagcatgcc ccgtgcctca ggaggaggag gaggaggtgc gggtgctgac
      421 ccttcctctg caagcccacc atgccatgga gaagatggag gagttcgtat ataaggtctg
      481 ggaggggcgt tggagggtca tcccatacga tgtgcttcct gactggctga aagacaatga
      541 ctacctgcta catggccaca gaccacctat gccctccttc cgggcttgct tcaagagcat
      601 cttccgcatc cacacagaaa ctggcaacat ctggacacat ttgcttggtt ttgtgctatt
      661 tctctttctg ggaatcttga ccatgctcag accaaatatg tacttcatgg ctcccctcca
      721 ggagaaggtg gtcttcggga tgttcttcct gggtgcagtg ctctgcctca gcttctcctg
      781 gcttttccac accgtctact gtcattcaga gaaggtctct cgcacttttt ccaaactgga
      841 ctattcaggg attgctctac tgattatggg gagcttcgtc ccctggctct attactcctt
      901 ctactgctcc ccacagccac ggctcatcta cctctccatc gtctgtgtcc tgggcatctc
      961 tgccatcatt gtggcacagt gggaccggtt tgccactccc aagcaccggc agacaagagc
     1021 aggagtgttc ctgggacttg gcttgagtgg tgttgtaccc accatgcact ttactatcgc
     1081 tgagggcttt gtcaaggcca ccacagtggg ccagatgggc tggttcttcc tcatggctgt
     1141 gatgtacatc accggcgctg gcctttatgc tgctcggatt cctgagcgct tctttcctgg
     1201 aaaatttgac atatggttcc agtctcatca gattttccat gtcctggtgg tggcagcggc
     1261 tttcgtccac ttctatgggg tgtccaacct acaggaattc cgttacggcc tagagggtgg
     1321 atgtaccgat gactcccttc tctgagcctt cccacctgag ggttggtgga ggaacttccc
     1381 aagtgctttt aaaaataact tctttgctga agtacgagga agagtctgag ttgtctgttt
     1441 ctagaagaaa cctcttagag aatcgcacca gtgacccttc agcccactgg cacagcctcc
     1501 gggccgtaca cttcccatgt gcattcctag cagtcacctc agcaaggcaa ctgctggtcc
     1561 ttcacagaca ggacgtggga gctcatgttg agattttacc cattccttca gccattttgg
     1621 ggaaaaaatt atgaactggg attcttcaga aattaagtgt tgttttttct tgaagaaaat
     1681 atccctccct taccctcctc cttactttgt aacctggcgg atgacaggcc atccattttt
     1741 gtagcacact tttcagaaac aagtataacc tggtcccatc tttctaggac aaacaaagcc
     1801 acgccttgat gtagcccggc taatcatgga agtatgtcca ggcttcaagt aacttgagtt
     1861 taaatccttt tttttttttt tcttggcaga gtaatgtaaa attaaaatgg ggaagatatt
     1921 taatatttaa tactaagctt taaaaagaaa cctgctatca ctgctgtgta tcttgatgca
     1981 aagactatgg tgataataaa agaaagtaca gaccgcttgg cattcaaa
//
