LOCUS       NM_144744               1487 bp    mRNA    linear   ROD 17-JUN-2024
DEFINITION  Rattus norvegicus adiponectin, C1Q and collagen domain containing
            (Adipoq), mRNA.
ACCESSION   NM_144744
VERSION     NM_144744.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1487)
  AUTHORS   Zhou,Y., Zhang,S., Jia,Y., Wang,X., Liu,Y., Zhang,H., Yuan,Z.,
            Han,Y. and Weng,Q.
  TITLE     Regulation and Role of Adiponectin Secretion in Rat Ovarian
            Granulosa Cells
  JOURNAL   Int J Mol Sci 25 (10), 5155 (2024)
   PUBMED   38791193
  REMARK    GeneRIF: Regulation and Role of Adiponectin Secretion in Rat
            Ovarian Granulosa Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1487)
  AUTHORS   Khoramipour,K., Bejeshk,M.A., Rajizadeh,M.A., Najafipour,H.,
            Dehghan,P. and Farahmand,F.
  TITLE     High-Intensity Interval Training Ameliorates Molecular Changes in
            the Hippocampus of Male Rats with the Diabetic Brain: the Role of
            Adiponectin
  JOURNAL   Mol Neurobiol 60 (6), 3486-3495 (2023)
   PUBMED   36877358
  REMARK    GeneRIF: High-Intensity Interval Training Ameliorates Molecular
            Changes in the Hippocampus of Male Rats with the Diabetic Brain:
            the Role of Adiponectin.
REFERENCE   3  (bases 1 to 1487)
  AUTHORS   Cheng,R., Xu,X., Yang,S., Mi,Z., Zhao,Y., Wang,C., Shi,X., Gao,J.,
            Yu,F. and Ren,X.
  TITLE     The effect of APN, hs-CRP and APN/hs-CRP in periodontitis with DAA
  JOURNAL   BMC Oral Health 23 (1), 85 (2023)
   PUBMED   36765308
  REMARK    GeneRIF: The effect of APN, hs-CRP and APN/hs-CRP in periodontitis
            with DAA.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1487)
  AUTHORS   Marine-Casado,R., Domenech-Coca,C., Crescenti,A., Rodriguez
            Gomez,M.A., Del Bas,J.M., Arola,L., Boque,N. and Caimari,A.
  TITLE     Maternal Supplementation with a Cocoa Extract during Lactation
            Deeply Modulates Dams' Metabolism, Increases Adiponectin
            Circulating Levels and Improves the Inflammatory Profile in Obese
            Rat Offspring
  JOURNAL   Nutrients 14 (23), 5134 (2022)
   PUBMED   36501173
  REMARK    GeneRIF: Maternal Supplementation with a Cocoa Extract during
            Lactation Deeply Modulates Dams' Metabolism, Increases Adiponectin
            Circulating Levels and Improves the Inflammatory Profile in Obese
            Rat Offspring.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1487)
  AUTHORS   Qiao,N., Zhang,J., Zhang,Y. and Liu,X.
  TITLE     Crosstalk between CD93, C1q and GIPC in the Regulation of
            Pneumococcal Meningitis Inflammation
  JOURNAL   Ann Clin Lab Sci 52 (4), 634-641 (2022)
   PUBMED   36197773
  REMARK    GeneRIF: Crosstalk between CD93, C1q and GIPC in the Regulation of
            Pneumococcal Meningitis Inflammation.
REFERENCE   6  (bases 1 to 1487)
  AUTHORS   Yokota,T., Oritani,K., Takahashi,I., Ishikawa,J., Matsuyama,A.,
            Ouchi,N., Kihara,S., Funahashi,T., Tenner,A.J., Tomiyama,Y. and
            Matsuzawa,Y.
  TITLE     Adiponectin, a new member of the family of soluble defense
            collagens, negatively regulates the growth of myelomonocytic
            progenitors and the functions of macrophages
  JOURNAL   Blood 96 (5), 1723-1732 (2000)
   PUBMED   10961870
REFERENCE   7  (bases 1 to 1487)
  AUTHORS   Ouchi,N., Kihara,S., Arita,Y., Maeda,K., Kuriyama,H., Okamoto,Y.,
            Hotta,K., Nishida,M., Takahashi,M., Nakamura,T., Yamashita,S.,
            Funahashi,T. and Matsuzawa,Y.
  TITLE     Novel modulator for endothelial adhesion molecules:
            adipocyte-derived plasma protein adiponectin
  JOURNAL   Circulation 100 (25), 2473-2476 (1999)
   PUBMED   10604883
REFERENCE   8  (bases 1 to 1487)
  AUTHORS   Bogan,J.S. and Lodish,H.F.
  TITLE     Two compartments for insulin-stimulated exocytosis in 3T3-L1
            adipocytes defined by endogenous ACRP30 and GLUT4
  JOURNAL   J Cell Biol 146 (3), 609-620 (1999)
   PUBMED   10444069
REFERENCE   9  (bases 1 to 1487)
  AUTHORS   Schaffler,A., Orso,E., Palitzsch,K.D., Buchler,C., Drobnik,W.,
            Furst,A., Scholmerich,J. and Schmitz,G.
  TITLE     The human apM-1, an adipocyte-specific gene linked to the family of
            TNF's and to genes expressed in activated T cells, is mapped to
            chromosome 1q21.3-q23, a susceptibility locus identified for
            familial combined hyperlipidaemia (FCH)
  JOURNAL   Biochem Biophys Res Commun 260 (2), 416-425 (1999)
   PUBMED   10403784
REFERENCE   10 (bases 1 to 1487)
  AUTHORS   Scherer,P.E., Williams,S., Fogliano,M., Baldini,G. and Lodish,H.F.
  TITLE     A novel serum protein similar to C1q, produced exclusively in
            adipocytes
  JOURNAL   J Biol Chem 270 (45), 26746-26749 (1995)
   PUBMED   7592907
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM047633.1 and JAXUCZ010000011.1.
            
            On Mar 23, 2011 this sequence version replaced NM_144744.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078720.1, FM047633.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-568               FM047633.1         1-568
            569-1487            JAXUCZ010000011.1  91226524-91227442   c
FEATURES             Location/Qualifiers
     source          1..1487
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..1487
                     /gene="Adipoq"
                     /gene_synonym="Acdc; Acrp30; Adid"
                     /note="adiponectin, C1Q and collagen domain containing"
                     /db_xref="GeneID:246253"
                     /db_xref="RGD:628748"
     exon            1..71
                     /gene="Adipoq"
                     /gene_synonym="Acdc; Acrp30; Adid"
                     /inference="alignment:Splign:2.1.0"
     exon            72..299
                     /gene="Adipoq"
                     /gene_synonym="Acdc; Acrp30; Adid"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..820
                     /gene="Adipoq"
                     /gene_synonym="Acdc; Acrp30; Adid"
                     /note="adipocyte complement related protein of 30 kDa;
                     adiponectin d"
                     /codon_start=1
                     /product="adiponectin precursor"
                     /protein_id="NP_653345.1"
                     /db_xref="GeneID:246253"
                     /db_xref="RGD:628748"
                     /translation="MLLLQALLFLLILPSHEGITATEGPGALVPPPKETCAGWMAGIP
                     GYPGHNGIPGRDGRDGTPGEKGEKGDAGVLGPKGDPGDAGMTGAEGPRGFPGTPGRKG
                     EPGEAAYMYHSAFSVGLETRVTVPNVPIRFTKIFYNQQNHYDGSTGKFHCNIPGLYYF
                     SYHITVYMKDVKVSLFKKDKAVLFTYDQYQEKNVDQASGSMLLHLEVGDQVWLQVYGE
                     GDNNGLYADNVNDSTFTGFLLYHDTN"
     exon            300..1487
                     /gene="Adipoq"
                     /gene_synonym="Acdc; Acrp30; Adid"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcaggagac ctggcgattt tctcttcatt cctgtctgta cgagtgccag tggatctgat
       61 tacaccaaaa gttccaggac tcaggatgct actgttgcaa gcgctcctgt tcctcttaat
      121 cctgcccagt catgaaggga ttactgcaac cgaagggcca ggagctttgg tccctccacc
      181 caaggaaact tgtgcaggtt ggatggcagg catcccagga tatcctggtc acaatgggat
      241 accgggccgt gatggcagag atggcactcc tggagagaag ggagagaagg gagacgcagg
      301 tgttcttggt cctaagggtg acccaggaga tgctggaatg acaggagcgg aagggccacg
      361 gggctttccc ggaacccctg gcaggaaagg agagcccgga gaagccgctt acatgtatca
      421 ctcagcattc agcgtagggc tggagacccg cgtcactgtc cccaatgttc ccattcgctt
      481 tactaagatc ttctacaacc aacagaatca ttatgacggc agcactggca aattccactg
      541 caacattccg gggctctact acttttccta ccacatcacg gtgtacatga aggatgtgaa
      601 agtgagcctc ttcaagaagg acaaggccgt tctcttcacc tacgaccagt atcaggaaaa
      661 aaatgtggac caggcctctg gctccatgct cctccatctg gaggtgggag accaagtctg
      721 gctccaagtg tatggggaag gggacaacaa tggactctat gcagataatg tcaatgactc
      781 tacatttaca ggcttccttc tctaccatga taccaactga ctgccactaa ttcagagcag
      841 cccgtagccc cgagaatcaa agaacaggcg acaggctttc agcttagttt gagaggttga
      901 ttgtattgct tactttgagg gttctgagtg ttatccccat gagtactcat ttgttcatta
      961 aatgacttta taaaaaataa tttctgtgtt cctagttgag aaaaaaagca ctccctagtc
     1021 tccgcgcctc tttttttttt tgatcatcaa caactatttt ttattacaac tatattgcca
     1081 ctttgacatt gcagtgtaat tagaggtact caggattatt ttgtctccac agtcttttaa
     1141 ccaaagtttc atatttagtc cttttgtatt ctggttaata cttattatag aattgatatt
     1201 tagccatgtg ggaaaaagta accaatctta agaatcagca tctagccaca tctgtgagat
     1261 agcatcttca gtcaagactg atgtgagaag gcccatctca ctgtgggctg aaccaggacc
     1321 tggacgtaag tgcattgaca gtctaagaaa gcaagctgag tgttcaccag ccagctagcc
     1381 agtaagcagc atttcaccat ggcttctgcg ttagttcctg cctgatttca ctctcgattg
     1441 tctataacct ggaattataa gttgaaataa atccttccct tacctaa
//
