LOCUS       NP_653345                244 aa            linear   ROD 17-JUN-2024
DEFINITION  adiponectin precursor [Rattus norvegicus].
ACCESSION   NP_653345
VERSION     NP_653345.1
DBSOURCE    REFSEQ: accession NM_144744.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 244)
  AUTHORS   Zhou,Y., Zhang,S., Jia,Y., Wang,X., Liu,Y., Zhang,H., Yuan,Z.,
            Han,Y. and Weng,Q.
  TITLE     Regulation and Role of Adiponectin Secretion in Rat Ovarian
            Granulosa Cells
  JOURNAL   Int J Mol Sci 25 (10), 5155 (2024)
   PUBMED   38791193
  REMARK    GeneRIF: Regulation and Role of Adiponectin Secretion in Rat
            Ovarian Granulosa Cells.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 244)
  AUTHORS   Khoramipour,K., Bejeshk,M.A., Rajizadeh,M.A., Najafipour,H.,
            Dehghan,P. and Farahmand,F.
  TITLE     High-Intensity Interval Training Ameliorates Molecular Changes in
            the Hippocampus of Male Rats with the Diabetic Brain: the Role of
            Adiponectin
  JOURNAL   Mol Neurobiol 60 (6), 3486-3495 (2023)
   PUBMED   36877358
  REMARK    GeneRIF: High-Intensity Interval Training Ameliorates Molecular
            Changes in the Hippocampus of Male Rats with the Diabetic Brain:
            the Role of Adiponectin.
REFERENCE   3  (residues 1 to 244)
  AUTHORS   Cheng,R., Xu,X., Yang,S., Mi,Z., Zhao,Y., Wang,C., Shi,X., Gao,J.,
            Yu,F. and Ren,X.
  TITLE     The effect of APN, hs-CRP and APN/hs-CRP in periodontitis with DAA
  JOURNAL   BMC Oral Health 23 (1), 85 (2023)
   PUBMED   36765308
  REMARK    GeneRIF: The effect of APN, hs-CRP and APN/hs-CRP in periodontitis
            with DAA.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 244)
  AUTHORS   Marine-Casado,R., Domenech-Coca,C., Crescenti,A., Rodriguez
            Gomez,M.A., Del Bas,J.M., Arola,L., Boque,N. and Caimari,A.
  TITLE     Maternal Supplementation with a Cocoa Extract during Lactation
            Deeply Modulates Dams' Metabolism, Increases Adiponectin
            Circulating Levels and Improves the Inflammatory Profile in Obese
            Rat Offspring
  JOURNAL   Nutrients 14 (23), 5134 (2022)
   PUBMED   36501173
  REMARK    GeneRIF: Maternal Supplementation with a Cocoa Extract during
            Lactation Deeply Modulates Dams' Metabolism, Increases Adiponectin
            Circulating Levels and Improves the Inflammatory Profile in Obese
            Rat Offspring.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 244)
  AUTHORS   Qiao,N., Zhang,J., Zhang,Y. and Liu,X.
  TITLE     Crosstalk between CD93, C1q and GIPC in the Regulation of
            Pneumococcal Meningitis Inflammation
  JOURNAL   Ann Clin Lab Sci 52 (4), 634-641 (2022)
   PUBMED   36197773
  REMARK    GeneRIF: Crosstalk between CD93, C1q and GIPC in the Regulation of
            Pneumococcal Meningitis Inflammation.
REFERENCE   6  (residues 1 to 244)
  AUTHORS   Yokota,T., Oritani,K., Takahashi,I., Ishikawa,J., Matsuyama,A.,
            Ouchi,N., Kihara,S., Funahashi,T., Tenner,A.J., Tomiyama,Y. and
            Matsuzawa,Y.
  TITLE     Adiponectin, a new member of the family of soluble defense
            collagens, negatively regulates the growth of myelomonocytic
            progenitors and the functions of macrophages
  JOURNAL   Blood 96 (5), 1723-1732 (2000)
   PUBMED   10961870
REFERENCE   7  (residues 1 to 244)
  AUTHORS   Ouchi,N., Kihara,S., Arita,Y., Maeda,K., Kuriyama,H., Okamoto,Y.,
            Hotta,K., Nishida,M., Takahashi,M., Nakamura,T., Yamashita,S.,
            Funahashi,T. and Matsuzawa,Y.
  TITLE     Novel modulator for endothelial adhesion molecules:
            adipocyte-derived plasma protein adiponectin
  JOURNAL   Circulation 100 (25), 2473-2476 (1999)
   PUBMED   10604883
REFERENCE   8  (residues 1 to 244)
  AUTHORS   Bogan,J.S. and Lodish,H.F.
  TITLE     Two compartments for insulin-stimulated exocytosis in 3T3-L1
            adipocytes defined by endogenous ACRP30 and GLUT4
  JOURNAL   J Cell Biol 146 (3), 609-620 (1999)
   PUBMED   10444069
REFERENCE   9  (residues 1 to 244)
  AUTHORS   Schaffler,A., Orso,E., Palitzsch,K.D., Buchler,C., Drobnik,W.,
            Furst,A., Scholmerich,J. and Schmitz,G.
  TITLE     The human apM-1, an adipocyte-specific gene linked to the family of
            TNF's and to genes expressed in activated T cells, is mapped to
            chromosome 1q21.3-q23, a susceptibility locus identified for
            familial combined hyperlipidaemia (FCH)
  JOURNAL   Biochem Biophys Res Commun 260 (2), 416-425 (1999)
   PUBMED   10403784
REFERENCE   10 (residues 1 to 244)
  AUTHORS   Scherer,P.E., Williams,S., Fogliano,M., Baldini,G. and Lodish,H.F.
  TITLE     A novel serum protein similar to C1q, produced exclusively in
            adipocytes
  JOURNAL   J Biol Chem 270 (45), 26746-26749 (1995)
   PUBMED   7592907
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM047633.1 and JAXUCZ010000011.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078720.1, FM047633.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..244
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     Protein         1..244
                     /product="adiponectin precursor"
                     /note="adipocyte complement related protein of 30 kDa;
                     adiponectin d"
                     /calculated_mol_wt=24406
     sig_peptide     1..18
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2022
     Region          51..107
                     /region_name="Collagen"
                     /note="Collagen triple helix repeat (20 copies);
                     pfam01391"
                     /db_xref="CDD:460189"
     Region          109..242
                     /region_name="C1Q"
                     /note="Complement component C1q domain; smart00110"
                     /db_xref="CDD:128420"
     CDS             1..244
                     /gene="Adipoq"
                     /gene_synonym="Acdc; Acrp30; Adid"
                     /coded_by="NM_144744.3:86..820"
                     /db_xref="GeneID:246253"
                     /db_xref="RGD:628748"
ORIGIN      
        1 mlllqallfl lilpshegit ategpgalvp ppketcagwm agipgypghn gipgrdgrdg
       61 tpgekgekgd agvlgpkgdp gdagmtgaeg prgfpgtpgr kgepgeaaym yhsafsvgle
      121 trvtvpnvpi rftkifynqq nhydgstgkf hcnipglyyf syhitvymkd vkvslfkkdk
      181 avlftydqyq eknvdqasgs mllhlevgdq vwlqvygegd nnglyadnvn dstftgflly
      241 hdtn
//
