LOCUS       NM_199097               1318 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus acireductone dioxygenase 1 (Adi1), mRNA.
ACCESSION   NM_199097 XM_216669
VERSION     NM_199097.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1318)
  AUTHORS   Hirano,W., Gotoh,I., Uekita,T. and Seiki,M.
  TITLE     Membrane-type 1 matrix metalloproteinase cytoplasmic tail binding
            protein-1 (MTCBP-1) acts as an eukaryotic aci-reductone dioxygenase
            (ARD) in the methionine salvage pathway
  JOURNAL   Genes Cells 10 (6), 565-574 (2005)
   PUBMED   15938715
REFERENCE   2  (bases 1 to 1318)
  AUTHORS   Oram,S., Jiang,F., Cai,X., Haleem,R., Dincer,Z. and Wang,Z.
  TITLE     Identification and characterization of an androgen-responsive gene
            encoding an aci-reductone dioxygenase-like protein in the rat
            prostate
  JOURNAL   Endocrinology 145 (4), 1933-1942 (2004)
   PUBMED   14684610
  REMARK    GeneRIF: May have an important role in androgen regulated prostate
            homeostasis as well as in prostate cancer progression by regulating
            cell death of prostate cancer cells.
REFERENCE   3  (bases 1 to 1318)
  AUTHORS   Uekita,T., Gotoh,I., Kinoshita,T., Itoh,Y., Sato,H., Shiomi,T.,
            Okada,Y. and Seiki,M.
  TITLE     Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding
            protein-1 is a new member of the Cupin superfamily. A possible
            multifunctional protein acting as an invasion suppressor
            down-regulated in tumors
  JOURNAL   J Biol Chem 279 (13), 12734-12743 (2004)
   PUBMED   14718544
REFERENCE   4  (bases 1 to 1318)
  AUTHORS   Yeh,C.T., Lai,H.Y., Chen,T.C., Chu,C.M. and Liaw,Y.F.
  TITLE     Identification of a hepatic factor capable of supporting hepatitis
            C virus replication in a nonpermissive cell line
  JOURNAL   J Virol 75 (22), 11017-11024 (2001)
   PUBMED   11602742
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 27, 2020 this sequence version replaced NM_199097.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY346335.1, BC092562.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               JAXUCZ010000006.1  51035267-51035401
            136-255             JAXUCZ010000006.1  51038017-51038136
            256-435             JAXUCZ010000006.1  51039402-51039581
            436-1318            JAXUCZ010000006.1  51041347-51042229
FEATURES             Location/Qualifiers
     source          1..1318
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q16"
     gene            1..1318
                     /gene="Adi1"
                     /gene_synonym="Alp1; ARD'; Fe-ARD; MTCBP-1; Ni-ARD"
                     /note="acireductone dioxygenase 1"
                     /db_xref="GeneID:298934"
                     /db_xref="RGD:727828"
     exon            1..135
                     /gene="Adi1"
                     /gene_synonym="Alp1; ARD'; Fe-ARD; MTCBP-1; Ni-ARD"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..555
                     /gene="Adi1"
                     /gene_synonym="Alp1; ARD'; Fe-ARD; MTCBP-1; Ni-ARD"
                     /EC_number="1.13.11.54"
                     /EC_number="1.13.11.53"
                     /note="androgen-responsive ARD-like protein 1;
                     acireductone dioxygenase (Ni(2+)-requiring); aci-reductone
                     dioxygenase (ARD)-like protein 1; androgen-responsive gene
                     encoding an ARD-like protein; acireductone dioxygenase
                     (Fe(2+)-requiring); membrane-type 1 matrix
                     metalloproteinase cytoplasmic tail-binding protein 1;
                     1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"
                     /codon_start=1
                     /product="acireductone dioxygenase"
                     /protein_id="NP_954528.2"
                     /db_xref="GeneID:298934"
                     /db_xref="RGD:727828"
                     /translation="MVQAWYMDESTADPRMPHRAQPDRPVGLEQLRTLGVLYWKLDAD
                     KYENDPELEQIRKTRNYSWMDIITICKDSLPNYEEKIKMFFEEHLHLDEEIRYILEGS
                     GYFDVRDKEDKWIRISMEKGDMITLPAGIYHRFTLDEKNYVKAMRLFVGEPVWTPYNR
                     PADHFDARVQYVKFLEGTA"
     exon            136..255
                     /gene="Adi1"
                     /gene_synonym="Alp1; ARD'; Fe-ARD; MTCBP-1; Ni-ARD"
                     /inference="alignment:Splign:2.1.0"
     exon            256..435
                     /gene="Adi1"
                     /gene_synonym="Alp1; ARD'; Fe-ARD; MTCBP-1; Ni-ARD"
                     /inference="alignment:Splign:2.1.0"
     exon            436..1318
                     /gene="Adi1"
                     /gene_synonym="Alp1; ARD'; Fe-ARD; MTCBP-1; Ni-ARD"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagccgtcg ccgccatggt gcaggcctgg tatatggacg agtccacggc cgacccgcgg
       61 atgccccacc gcgcacagcc cgaccgccct gtgggactgg agcagctgcg cacgctcgga
      121 gtgctctatt ggaagctaga tgcggacaag tatgagaatg atccagaact ggaacagatt
      181 cggaaaacaa ggaactactc atggatggat atcatcacca tatgcaaaga ttcacttccc
      241 aattatgagg agaagatcaa gatgttcttt gaggaacatc tgcatctgga tgaggagatc
      301 cgctacatcc tggagggcag cgggtacttc gatgtcaggg acaaggagga caagtggatc
      361 cggatttcta tggagaaggg ggacatgatc acgcttcctg ccggcattta tcaccgcttc
      421 acgctggacg agaagaacta cgtgaaggcc atgcggctgt ttgttggaga acctgtatgg
      481 acaccataca accggccagc tgaccatttt gatgcccggg tacagtacgt gaagtttttg
      541 gaaggaacag catagcagtg ctcctcaaag tgaaagccgc actgtgtgaa tctcctgctg
      601 tggtaaccga ttggaaaatt ctcacctctc tgctcttata tggactggag gctaggctag
      661 ctgtctttgg taagattgtt agatcagagt cttttaaata aaagcacctg taaaagtgat
      721 ttttacatgg aagccacgag aatgtgaata agtgatatta attttctctg tcaagtctta
      781 gaggtatggc agccctgggt atatgtatat tcatgcatag ccaatcttca tcttccagaa
      841 ggtccttctg taggtgtcag ttgggggggg gggttgaaac tgctctctgg aagagggcag
      901 ttatacccag aacaactaac cagatgatgt tttcctccct ctctgatatt tgggtgggga
      961 agtggggttg ttgttcctct ttcttcaaac taaattactt taattgtatg ctcacagcta
     1021 agctgtattg tacttatgtg tacatacagt atttttcttg gttcattaaa gcctccaatt
     1081 tagattttta catgatttta tatgtatgta catgattaat ttctatatca aggtagatat
     1141 tttcagtgta gctttgggtc cttttacaat caagattcaa aagaagtaat aataaaataa
     1201 tgatttttct acattagcac tttggggtac ctagtgtaga tgtagagatc taacctagca
     1261 aatgcaaggc ctcaggcatg agccccagca caacaaataa agaataataa ccctgaaa
//
