LOCUS       NM_001025423            1884 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Rattus norvegicus alcohol dehydrogenase, iron containing, 1
            (Adhfe1), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001025423 XM_342794
VERSION     NM_001025423.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1884)
  AUTHORS   Kim,J.Y., Tillison,K.S., Zhou,S., Lee,J.H. and Smas,C.M.
  TITLE     Differentiation-dependent expression of Adhfe1 in adipogenesis
  JOURNAL   Arch Biochem Biophys 464 (1), 100-111 (2007)
   PUBMED   17559793
REFERENCE   2  (bases 1 to 1884)
  AUTHORS   Struys,E.A., Verhoeven,N.M., Ten Brink,H.J., Wickenhagen,W.V.,
            Gibson,K.M. and Jakobs,C.
  TITLE     Kinetic characterization of human hydroxyacid-oxoacid
            transhydrogenase: relevance to D-2-hydroxyglutaric and
            gamma-hydroxybutyric acidurias
  JOURNAL   J Inherit Metab Dis 28 (6), 921-930 (2005)
   PUBMED   16435184
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097945.1.
            
            On Jul 15, 2005 this sequence version replaced XM_342794.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097945.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1884
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q11"
     gene            1..1884
                     /gene="Adhfe1"
                     /note="alcohol dehydrogenase, iron containing, 1"
                     /db_xref="GeneID:362474"
                     /db_xref="RGD:1308863"
     exon            1..85
                     /gene="Adhfe1"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1430
                     /gene="Adhfe1"
                     /EC_number="1.1.99.24"
                     /note="HOT; alcohol dehydrogenase iron-containing protein
                     1"
                     /codon_start=1
                     /product="hydroxyacid-oxoacid transhydrogenase,
                     mitochondrial"
                     /protein_id="NP_001020594.1"
                     /db_xref="GeneID:362474"
                     /db_xref="RGD:1308863"
                     /translation="MAAAARARVTHLLRHLQSTACQCPTHSHTYSQVPGLSPSGKTTD
                     YAFEMAVSNIRYGAGVTKEVGMDLQNMGAKNVCLMTDKNLSQLPPVQIVMDSLSKNGI
                     SFQVYDNVRVEPTDGSFMDAIEFAKKGAFDAYVAVGGGSTMDTCKAANLYACSPHSEF
                     LDYVNAPIGKGKPVTVPLKPLIAVPTTSGTGSETTGVAIFDYEHLKVKTGIASRAIKP
                     TLGLVDPLHTLHMPCQVVANSGFDVLCHALESYTAIPYSMRSPCPSNPIQRPAYQGSN
                     PISDIWAVHALRIVAKYLKRAVRNPDDLEARSSMHLASAFAGIGFGNAGVHLCHGMSY
                     PISGLVKTYKAKEYNVDHPLVPHGLSVVLTSPAVFTFTAQMFPERHLETAEILGANIR
                     TAKIQDAGPVLADALRKFLFDLNVDDGLAALGYSKDDIPSLVKGTLPQERVTKLAPRA
                     QSEEDLSALFEASMKLY"
     exon            86..123
                     /gene="Adhfe1"
                     /inference="alignment:Splign:2.1.0"
     exon            124..170
                     /gene="Adhfe1"
                     /inference="alignment:Splign:2.1.0"
     exon            171..224
                     /gene="Adhfe1"
                     /inference="alignment:Splign:2.1.0"
     exon            225..379
                     /gene="Adhfe1"
                     /inference="alignment:Splign:2.1.0"
     exon            380..576
                     /gene="Adhfe1"
                     /inference="alignment:Splign:2.1.0"
     exon            577..654
                     /gene="Adhfe1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..760
                     /gene="Adhfe1"
                     /inference="alignment:Splign:2.1.0"
     exon            761..913
                     /gene="Adhfe1"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1012
                     /gene="Adhfe1"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1091
                     /gene="Adhfe1"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1188
                     /gene="Adhfe1"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1346
                     /gene="Adhfe1"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1858
                     /gene="Adhfe1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtagcgggtg gacaaggagg actgccatgg ccgcagctgc acgcgctcga gtgacacatt
       61 tgctgaggca cctgcaaagc acagcatgcc agtgtccaac tcattctcat acctactccc
      121 aagtccctgg actctcacct tcaggaaaaa caacggatta tgcatttgag atggcggtct
      181 cgaacattag atatggagca ggggttacaa aggaagtggg catggatcta cagaatatgg
      241 gagctaagaa tgtctgcctg atgacagaca agaacctctc ccagctccct cctgtccaaa
      301 tagttatgga ttccctatcg aagaatggca ttagttttca ggtttatgac aacgtgaggg
      361 tggagcctac agacggaagc ttcatggatg cgattgaatt tgctaaaaag ggagcctttg
      421 atgcctatgt tgctgtgggt gggggctcca ccatggacac ctgtaaagcc gctaatctgt
      481 acgcatgcag ccctcactct gagttccttg attatgtcaa tgcccccatt gggaagggga
      541 agccagtaac tgtgcctctt aaacctctga tcgcagttcc aactacctcg gggactggca
      601 gtgagactac cggggtcgcc atttttgact atgaacattt gaaagtaaaa actggaattg
      661 cttcacgggc catcaaaccc accctggggc tggttgatcc cctgcatact ctccacatgc
      721 cttgccaggt ggttgccaac agtggcttcg atgtcctttg ccatgctctg gagtcataca
      781 ccgccattcc ctacagcatg aggagcccct gcccttccaa tcccatccaa cgaccagcat
      841 accagggtag caacccaatc agtgacatct gggcagtcca tgcactgcgc atcgttgcca
      901 aatatctgaa gagggctgtc agaaaccctg acgatctgga agcaaggtct agcatgcact
      961 tggcaagcgc cttcgctggc attggcttcg gaaacgccgg tgttcatctg tgccatggca
     1021 tgtcttaccc aatttcaggt ttagtgaaga catacaaagc caaggaatac aatgtggatc
     1081 accctctggt gccccatggc ctctctgtgg tgctcacctc tcccgcagtg ttcaccttca
     1141 cagcccagat gtttccagag cggcacctgg agacggcaga aatattagga gccaacattc
     1201 gcaccgccaa gatccaagat gccgggcctg tgttggcaga tgctctccga aaattcctat
     1261 ttgacctaaa tgttgatgac ggtctcgctg cccttggtta ttctaaagat gacattcctt
     1321 cactggtgaa aggaacactg ccccaggaaa gggtcacgaa gcttgcgccg cgtgcccagt
     1381 cagaggaaga tttgtctgct ttgttcgaag catcaatgaa actgtactaa ttaacagatt
     1441 aatgaaaaga atcgccatcg gcccttacaa cggaagctac gagagcagaa gttggtcagg
     1501 gctggccttt gccgtcttat ctccacactt aattccactg ttactggctt gaatgtgacg
     1561 tgattttatc ctttggggga ttcctttgtg ctcattatgt aagaccccag gagtcagtgt
     1621 ccctgcacca aaccccatca aatacagaaa tatgcctctg tccagacact gcatgtctag
     1681 aaattcaccc tgaagaaata ctagcattag tatacaaaaa acatgacaag ggtgtatctg
     1741 acagtatggg tagcaaaaat taaaacaatc taaatcttcc ttcctaaatg aatcctaata
     1801 tagtcagtaa tagaatactg tggtgttgtt aataaagatg aagccaaact cttgaaaaaa
     1861 aaaaaaaaaa aaaaaaaaaa aaaa
//
