LOCUS       NM_134329               2024 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus alcohol dehydrogenase 7 (class IV), mu or sigma
            polypeptide (Adh7), mRNA.
ACCESSION   NM_134329
VERSION     NM_134329.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2024)
  AUTHORS   Li,H., Cui,H., Kundu,T.K., Alzawahra,W. and Zweier,J.L.
  TITLE     Nitric oxide production from nitrite occurs primarily in tissues
            not in the blood: critical role of xanthine oxidase and aldehyde
            oxidase
  JOURNAL   J Biol Chem 283 (26), 17855-17863 (2008)
   PUBMED   18424432
  REMARK    GeneRIF: NO generation from nitrite mainly occurs in tissues not in
            the blood, with XO and AO playing critical roles in nitrite
            reduction, and this process is regulated by pH, oxygen tension,
            nitrite, and reducing substrate concentrations
REFERENCE   2  (bases 1 to 2024)
  AUTHORS   Gallego,O., Belyaeva,O.V., Porte,S., Ruiz,F.X., Stetsenko,A.V.,
            Shabrova,E.V., Kostereva,N.V., Farres,J., Pares,X. and
            Kedishvili,N.Y.
  TITLE     Comparative functional analysis of human medium-chain
            dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto
            reductases with retinoids
  JOURNAL   Biochem J 399 (1), 101-109 (2006)
   PUBMED   16787387
REFERENCE   3  (bases 1 to 2024)
  AUTHORS   Martras,S., Alvarez,R., Gallego,O., Dominguez,M., de Lera,A.R.,
            Farres,J. and Pares,X.
  TITLE     Kinetics of human alcohol dehydrogenase with ring-oxidized
            retinoids: effect of Tween 80
  JOURNAL   Arch Biochem Biophys 430 (2), 210-217 (2004)
   PUBMED   15369820
REFERENCE   4  (bases 1 to 2024)
  AUTHORS   Galter,D., Carmine,A., Buervenich,S., Duester,G. and Olson,L.
  TITLE     Distribution of class I, III and IV alcohol dehydrogenase mRNAs in
            the adult rat, mouse and human brain
  JOURNAL   Eur J Biochem 270 (6), 1316-1326 (2003)
   PUBMED   12631290
REFERENCE   5  (bases 1 to 2024)
  AUTHORS   Chou,C.F., Lai,C.L., Chang,Y.C., Duester,G. and Yin,S.J.
  TITLE     Kinetic mechanism of human class IV alcohol dehydrogenase
            functioning as retinol dehydrogenase
  JOURNAL   J Biol Chem 277 (28), 25209-25216 (2002)
   PUBMED   11997393
  REMARK    Erratum:[J Biol Chem 2002 Oct 25;277(43):41294]
REFERENCE   6  (bases 1 to 2024)
  AUTHORS   Pares,X., Moreno,A., Cederlund,E., Hoog,J.O. and Jornvall,J.
  TITLE     Class IV mammalian alcohol dehydrogenase. Structural data of the
            rat stomach enzyme reveal a new class well separated from those
            already characterized
  JOURNAL   FEBS Lett 277 (1-2), 115-118 (1990)
   PUBMED   2269340
REFERENCE   7  (bases 1 to 2024)
  AUTHORS   Connor,M.J. and Smit,M.H.
  TITLE     Terminal-group oxidation of retinol by mouse epidermis. Inhibition
            in vitro and in vivo
  JOURNAL   Biochem J 244 (2), 489-492 (1987)
   PUBMED   3663136
REFERENCE   8  (bases 1 to 2024)
  AUTHORS   Mather,P.B., Duley,J.A. and Holmes,R.S.
  TITLE     Aldehyde oxidase and alcohol dehydrogenase genetics in the mouse.
            New alleles for the Aox-2 and Adh-3 loci
  JOURNAL   Anim Blood Groups Biochem Genet 14 (4), 279-286 (1983)
   PUBMED   6372555
REFERENCE   9  (bases 1 to 2024)
  AUTHORS   Holmes,R.S.
  TITLE     Genetics and ontogeny of alcohol dehydrogenase isozymes in the
            mouse: evidence for a cis-acting regulator gene (Adt-i) controlling
            C2 isozyme expression in reproductive tissues and close linkage of
            Adh-3 and Adt-i on chromosome 3
  JOURNAL   Biochem Genet 17 (5-6), 461-472 (1979)
   PUBMED   518534
REFERENCE   10 (bases 1 to 2024)
  AUTHORS   Lange,L.G., Sytkowski,A.J. and Vallee,B.L.
  TITLE     Human liver alcohol dehydrogenase: purification, composition, and
            catalytic features
  JOURNAL   Biochemistry 15 (21), 4687-4693 (1976)
   PUBMED   9982
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 26, 2020 this sequence version replaced NM_134329.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X98746.1, SRR26643294.11606.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                JAXUCZ010000002.1  229422125-229422199
            76-177              JAXUCZ010000002.1  229426649-229426750
            178-316             JAXUCZ010000002.1  229427908-229428046
            317-404             JAXUCZ010000002.1  229428465-229428552
            405-621             JAXUCZ010000002.1  229428648-229428864
            622-882             JAXUCZ010000002.1  229430684-229430944
            883-1018            JAXUCZ010000002.1  229432582-229432717
            1019-1157           JAXUCZ010000002.1  229433397-229433535
            1158-2024           JAXUCZ010000002.1  229435718-229436584
FEATURES             Location/Qualifiers
     source          1..2024
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q44"
     gene            1..2024
                     /gene="Adh7"
                     /note="alcohol dehydrogenase 7 (class IV), mu or sigma
                     polypeptide"
                     /db_xref="GeneID:171178"
                     /db_xref="RGD:621638"
     exon            1..75
                     /gene="Adh7"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1182
                     /gene="Adh7"
                     /EC_number="1.1.1.1"
                     /EC_number="1.1.1.105"
                     /EC_number="1.1.1.66"
                     /note="class IV alcohol dehydrogenase, mu or sigma
                     subunit; alcohol dehydrogenase class 4 mu/sigma chain;
                     alcohol dehydrogenase class IV mu/sigma chain;
                     omega-hydroxydecanoate dehydrogenase ADH7"
                     /codon_start=1
                     /product="all-trans-retinol dehydrogenase [NAD(+)] ADH7"
                     /protein_id="NP_599156.2"
                     /db_xref="GeneID:171178"
                     /db_xref="RGD:621638"
                     /translation="MDTAGKVIKCKAAVLWGTNQPFSIEDIEVAPPKAKEVRVKILAT
                     GICGTDDHVIKGTMVSKFPVIVGHEAVGIVESVGEEVTTVRPGDKVIPLFLPQCRECN
                     PCRNPEGNLCIRSDLTGRGVLADGTTRFTCKDKPVQHFMNTSTFTEYTVLDESSVAKI
                     DAEAPPEKACLIGCGFSTGYGAAVKTAKVSPGSTCAVFGLGGVGLSVVMGCKAAGASR
                     IIGIDINKDKFQKALDVGATECINPRDFTKPISEVLSDMTGNTVQYTFEVIGRLETMV
                     DALSSCHMNYGTSVVVGAPPSAKMLSYDPMLLFTGRTWKGCVFGGWKSRDDVPKLVTE
                     FLEKKFDLGQLITHTLPFHNISEGFELLYSGQSIRTVLTF"
     exon            76..177
                     /gene="Adh7"
                     /inference="alignment:Splign:2.1.0"
     exon            178..316
                     /gene="Adh7"
                     /inference="alignment:Splign:2.1.0"
     exon            317..404
                     /gene="Adh7"
                     /inference="alignment:Splign:2.1.0"
     exon            405..621
                     /gene="Adh7"
                     /inference="alignment:Splign:2.1.0"
     exon            622..882
                     /gene="Adh7"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1018
                     /gene="Adh7"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1157
                     /gene="Adh7"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..2024
                     /gene="Adh7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgtgcgtca gtcagaacac gttcctgttt gcagaccaca aacccaggaa agccaggatg
       61 gacactgctg gaaaagttat taagtgcaaa gcagctgtcc tatgggggac gaaccagccc
      121 ttctccattg aggacattga agtggcccca ccaaaggcta aggaagttcg tgttaagatt
      181 ttggccacgg gaatctgtgg cacagatgac cacgtgatca agggaacgat ggtgtctaag
      241 ttcccagtga ttgtgggaca cgaagcagtt gggattgtgg agagtgttgg agaagaggtc
      301 actacagtga gaccaggtga caaagtgatc cccctctttc taccacagtg tagagaatgc
      361 aacccctgcc gcaacccgga gggaaatctc tgcattagga gcgacctgac aggccgtgga
      421 gtattggctg acggcacgac caggttcaca tgcaaggaca aaccagtcca gcacttcatg
      481 aacaccagca ccttcactga gtacacggtc ctggatgaat cctccgtagc taagatcgat
      541 gccgaggctc ctcccgagaa agcctgcttg attggctgtg gattttccac tggttatggg
      601 gctgctgtta aaactgccaa ggtcagccct ggctccacct gtgctgtgtt tggcctggga
      661 ggagttggcc tgtcagtcgt catgggctgt aaagcggccg gcgcctcccg gatcatcgga
      721 attgacatca acaaggacaa atttcagaaa gccctggatg taggggccac agagtgtatc
      781 aatcccaggg acttcaccaa gcccatcagt gaggtgctgt cagacatgac aggcaacact
      841 gtccagtata cttttgaagt tatcgggcgc cttgagacca tggttgatgc cctctcatct
      901 tgccatatga actacgggac cagcgtggtg gtcggggctc ctccgtcagc caagatgctc
      961 agctatgacc caatgctgct tttcactgga cggacatgga agggctgcgt ctttggtggt
     1021 tggaagagca gagatgatgt tcccaaattg gtgactgaat tcctggaaaa gaaatttgac
     1081 ctgggccagt tgataaccca caccttgcct tttcataaca tcagtgaagg atttgaattg
     1141 ctttattcag ggcaaagcat tcggactgtc ctgacatttt gagatccaga gagctgggtg
     1201 ttctgtgctg ggcgaccgtg acctgaagcc ttgttcctga cagtgttctc tgatatcacg
     1261 agtctgtctc agaaatgcat gcagaggcag gttgggggca agagagggaa gctctataga
     1321 ggtttataaa ccttcatatg tttagtttac cgagtgccta gcattagcag agaacagtaa
     1381 gagtaaatgt tttagtctgc gttttctaag acgataattc tacacttcat aagcatatac
     1441 ttggggctct atttgttgga agagggattg ttttcagaat tttacacagt tgttgtgact
     1501 taaaaacaga caaagcatgt agagatgtag agaatgcatt tttcaagaga tacccaccaa
     1561 agccacccga gctctcattc tgtttttcaa cagaaacact tttaaaaatg ttataaatta
     1621 acttgaatta gattgtgaaa ttgcacacat aacttgatta gattaagaaa gaaagttggg
     1681 aaatttaagg gaagggcacg ttttttaatg attaactttg aaaattatcg ttatgtaact
     1741 tagtgacatg ggggaagcac atctgtgcct ggagatatcg tcagcgttta ttaatataaa
     1801 gcacttttac agtagcgatt acagatgaac catagatata accacattgg gatatttatg
     1861 atattaagtt taataaagta gaatgacaag tccttaagga catagtagta actacattta
     1921 acatgaagat tattctcaga ttgctttaac tacaccagcc tgtatctgca tctgtctgtg
     1981 gacatgtaca cacacgtaat attcattaaa ttttcattgt ggta
//
