LOCUS       NM_001012084            1854 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus alcohol dehydrogenase 6 (class V) (Adh6), mRNA.
ACCESSION   NM_001012084 XM_227746
VERSION     NM_001012084.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1854)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   2  (bases 1 to 1854)
  AUTHORS   Chen,C.S. and Yoshida,A.
  TITLE     Enzymatic properties of the protein encoded by newly cloned human
            alcohol dehydrogenase ADH6 gene
  JOURNAL   Biochem Biophys Res Commun 181 (2), 743-747 (1991)
   PUBMED   1755855
REFERENCE   3  (bases 1 to 1854)
  AUTHORS   Lange,L.G., Sytkowski,A.J. and Vallee,B.L.
  TITLE     Human liver alcohol dehydrogenase: purification, composition, and
            catalytic features
  JOURNAL   Biochemistry 15 (21), 4687-4693 (1976)
   PUBMED   9982
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083792.1.
            
            On Feb 11, 2005 this sequence version replaced XM_227746.2.
            
            Sequence Note: This sequence has been modified as follows: removed
            38 bp suspected to be vector contamination from the 3' end.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083792.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1854              BC083792.1         1-1854
FEATURES             Location/Qualifiers
     source          1..1854
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q44"
     gene            1..1854
                     /gene="Adh6"
                     /note="alcohol dehydrogenase 6 (class V)"
                     /db_xref="GeneID:310903"
                     /db_xref="RGD:1306313"
     exon            1..69
                     /gene="Adh6"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1182
                     /gene="Adh6"
                     /EC_number="1.1.1.1"
                     /note="class V alcohol dehydrogenase"
                     /codon_start=1
                     /product="alcohol dehydrogenase 6"
                     /protein_id="NP_001012084.1"
                     /db_xref="GeneID:310903"
                     /db_xref="RGD:1306313"
                     /translation="MGTQGKVIRCKATVLWKPGAPLAIEEIEVAPPKAKEVRIKMVAT
                     GVCGTDIKHLDTQELSKFCPMIMGHEGVGIVESVGEGVSSVRTGDKVILLCIPQCGEC
                     KTCLNSKNNICTEIRLSKTHLASEGTSRITCKGKLVHQYIALGSFSEYTVLKEISVAK
                     IDEGAPLEKVCIIGCGFATGYGAAINSAKVTPGSTCAVFGLGGVGLSVIIGCKAAGAA
                     RIIAVDINKDRFAKAKTVGATDCVDPRDFEKPIEEVLSDMIDGGVDFCFEVTGNTEAV
                     GAALGSCHKDHGVCVTVGALASFTSTLSIRSHLFFSGRILKGSILGGWKTKEEIPKLV
                     SDYMAKKFNIDPLITHTLTLSEANEAVQLMKSGQCIRCVLLL"
     exon            70..171
                     /gene="Adh6"
                     /inference="alignment:Splign:2.1.0"
     exon            172..313
                     /gene="Adh6"
                     /inference="alignment:Splign:2.1.0"
     exon            314..401
                     /gene="Adh6"
                     /inference="alignment:Splign:2.1.0"
     exon            402..618
                     /gene="Adh6"
                     /inference="alignment:Splign:2.1.0"
     exon            619..879
                     /gene="Adh6"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1018
                     /gene="Adh6"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1157
                     /gene="Adh6"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1854
                     /gene="Adh6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaaaggcc agagtcagaa ggacacttcc aaagcgagct tcccaaggaa aatgggcacc
       61 cagggaaagg tgatcagatg caaagccact gtgctctgga agcctggagc cccacttgcc
      121 attgaggaga tcgaagtggc cccacctaaa gcaaaggagg ttcgaataaa gatggtggcc
      181 acaggagtct gtggcacaga cataaaacat ctggacacac aagaactttc taagttttgc
      241 cccatgatta tgggccatga aggagttggg atagtcgaga gtgtggggga aggagtaagc
      301 agcgtaagaa caggtgataa agttatccta ttatgtatcc ctcagtgtgg ggaatgcaaa
      361 acttgcctga attccaagaa caatatttgt acagaaatta gactgtcaaa gacacacctg
      421 gcatctgaag gcaccagcag aattacctgc aagggaaagt tagtgcatca gtatatcgct
      481 ctcggcagct tctcggaata cacagtccta aaggaaatct cagtcgccaa gattgacgaa
      541 ggtgcacctc tggagaaggt gtgcataatt ggctgtgggt ttgccactgg gtacggcgct
      601 gccatcaact ctgccaaggt gaccccaggc tccacctgtg cggtgtttgg cctcggaggt
      661 gtcggtctgt ctgtcatcat tggctgtaaa gcagcaggag cagccaggat cattgccgtg
      721 gacatcaaca aagacaggtt tgcgaaggcc aagacagtgg gtgccactga ctgcgtcgac
      781 ccacgggact tcgagaaacc cattgaggaa gttttatccg atatgataga tggtggcgtg
      841 gacttctgct ttgaggtcac tgggaacaca gaagcagtgg gagctgccct gggctcctgt
      901 cacaaggacc acggggtctg cgtgactgtt ggagccctag catctttcac cagtacactc
      961 agcattagaa gccacttgtt cttctcagga cgcattctga aagggtctat tttgggaggc
     1021 tggaaaacga aagaagaaat ccctaagctg gtttctgact atatggcaaa gaagtttaac
     1081 atagatcctc tgatcaccca caccctgact ctcagcgagg ccaatgaggc agttcagctc
     1141 atgaaaagtg ggcaatgtat ccgctgtgtc ctgctcctat aactacgaga tctacatatg
     1201 tcaccacgtg tcaagattta gaagaatcca ccacgcaatg cttttctatt ttcttgcctt
     1261 tcattcactc ggcaacaatc ttttatcaag ttctcacctg ttcacaccat cgaaatcttc
     1321 ccctgtgacc cagtaccgtt ggaatacagt ctccctttta cagctgtgag ggtcgatttg
     1381 agtcgcccag tggcagagtc cgcagaggag ggcacaccaa gatgctccaa tggcacggag
     1441 gtccctacgt agggatgcac atttcctcac tcactgaatc tttcccacgc tgtatggatc
     1501 ccaccagaga agttactgga actgataaac aaatgggcga atgtttaggt cacaaaacca
     1561 ccacccccag aacccacggt gtggttgtat ggcaacagca agttatctca tatggagtca
     1621 aggagacaat ctcacaactg ctgtgagatt gatctcgcaa ataaattaac aacatagaaa
     1681 tcaatttaat caaaggtgaa atatccctac aataaaaagt ataaaacaag agagaagctg
     1741 tggcaggaca atggaggctc acattaagat tccgcttgag gggctgggga tgtagctcag
     1801 tggtagagcg cttacctagg aagcgcaagg ccctgggttc ggtccccagc tccg
//
