LOCUS       NM_001126120            1413 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus alcohol dehydrogenase 5 (class III), chi
            polypeptide (Adh5), mRNA.
ACCESSION   NM_001126120
VERSION     NM_001126120.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1413)
  AUTHORS   Jiang,H., Polhemus,D.J., Islam,K.N., Torregrossa,A.C., Li,Z.,
            Potts,A., Lefer,D.J. and Bryan,N.S.
  TITLE     Nebivolol Acts as a S-Nitrosoglutathione Reductase Inhibitor: A New
            Mechanism of Action
  JOURNAL   J Cardiovasc Pharmacol Ther 21 (5), 478-485 (2016)
   PUBMED   26746429
  REMARK    GeneRIF: Report inhibition of GSNOR activity by nebivolol leading
            to accumulation of nitrosothiols in cells, and this is associated
            with an enhanced vasodilation by S-nitrosoglutathione.
REFERENCE   2  (bases 1 to 1413)
  AUTHORS   Wu,K., Zhang,Y., Wang,P., Zhang,L., Wang,T. and Chen,C.
  TITLE     Activation of GSNOR transcription by NF-kappaB negatively regulates
            NGF-induced PC12 differentiation
  JOURNAL   Free Radic Res 48 (9), 1011-1017 (2014)
   PUBMED   24654711
  REMARK    GeneRIF: We have defined a novel role of GSNOR in neurite
            development and provide molecular insights into the control of
            neurite growth.
REFERENCE   3  (bases 1 to 1413)
  AUTHORS   Ostberg,L.J., Stromberg,P., Hedberg,J.J., Persson,B. and Hoog,J.O.
  TITLE     Analysis of mammalian alcohol dehydrogenase 5 (ADH5):
            characterisation of rat ADH5 with comparisons to the corresponding
            human variant
  JOURNAL   Chem Biol Interact 202 (1-3), 97-103 (2013)
   PUBMED   23159888
  REMARK    GeneRIF: ADH5, while readily expressed at the mRNA level, does not
            behave similarly to other mammalian ADHs investigated.
REFERENCE   4  (bases 1 to 1413)
  AUTHORS   Lopez-Sanchez,L.M., Corrales,F.J., Barcos,M., Espejo,I.,
            Munoz-Castaneda,J.R. and Rodriguez-Ariza,A.
  TITLE     Inhibition of nitric oxide synthesis during induced cholestasis
            ameliorates hepatocellular injury by facilitating S-nitrosothiol
            homeostasis
  JOURNAL   Lab Invest 90 (1), 116-127 (2010)
   PUBMED   19806079
REFERENCE   5  (bases 1 to 1413)
  AUTHORS   Wu,X., Du,L., Xu,X., Tan,L. and Li,R.
  TITLE     Increased nitrosoglutathione reductase activity in hypoxic
            pulmonary hypertension in mice
  JOURNAL   J Pharmacol Sci 113 (1), 32-40 (2010)
   PUBMED   20431245
REFERENCE   6  (bases 1 to 1413)
  AUTHORS   Iborra,F.J., Renau-Piqueras,J., Portoles,M., Boleda,M.D., Guerri,C.
            and Pares,X.
  TITLE     Immunocytochemical and biochemical demonstration of formaldhyde
            dehydrogenase (class III alcohol dehydrogenase) in the nucleus
  JOURNAL   J Histochem Cytochem 40 (12), 1865-1878 (1992)
   PUBMED   1453005
REFERENCE   7  (bases 1 to 1413)
  AUTHORS   Lapatto,R.
  TITLE     Model for the structure of formaldehyde dehydrogenase based on
            alcohol dehydrogenase
  JOURNAL   Int J Biol Macromol 13 (2), 73-76 (1991)
   PUBMED   1888714
REFERENCE   8  (bases 1 to 1413)
  AUTHORS   Julia,P., Pares,X. and Jornvall,H.
  TITLE     Rat liver alcohol dehydrogenase of class III. Primary structure,
            functional consequences and relationships to other alcohol
            dehydrogenases
  JOURNAL   Eur J Biochem 172 (1), 73-83 (1988)
   PUBMED   3278908
REFERENCE   9  (bases 1 to 1413)
  AUTHORS   Fairwell,T., Julia,P., Kaiser,R., Holmquist,B., Pares,X.,
            Vallee,B.L. and Jornvall,H.
  TITLE     Acetylated N-terminal structures of class III alcohol
            dehydrogenases. Differences among the three enzyme classes
  JOURNAL   FEBS Lett 222 (1), 99-103 (1987)
   PUBMED   3653405
REFERENCE   10 (bases 1 to 1413)
  AUTHORS   Algar,E.M. and Holmes,R.S.
  TITLE     Mouse mitochondrial aldehyde dehydrogenase isozymes: purification
            and molecular properties
  JOURNAL   Int J Biochem 17 (1), 51-60 (1985)
   PUBMED   3996732
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083724.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083724.1, FQ212535.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1413
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q44"
     gene            1..1413
                     /gene="Adh5"
                     /note="alcohol dehydrogenase 5 (class III), chi
                     polypeptide"
                     /db_xref="GeneID:100145871"
                     /db_xref="RGD:2292706"
     exon            1..27
                     /gene="Adh5"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1140
                     /gene="Adh5"
                     /EC_number="1.1.1.1"
                     /EC_number="1.1.1.284"
                     /note="class III alcohol dehydrogenase, chi subunit; FDH;
                     FALDH; ADH-B2; GSH-FDH; alcohol dehydrogenase 2; alcohol
                     dehydrogenase B2; alcohol dehydrogenase class-III;
                     S-(hydroxymethyl)glutathione dehydrogenase;
                     glutathione-dependent formaldehyde dehydrogenase"
                     /codon_start=1
                     /product="alcohol dehydrogenase class-3"
                     /protein_id="NP_001119592.1"
                     /db_xref="GeneID:100145871"
                     /db_xref="RGD:2292706"
                     /translation="MANQVIRCKAAVAWEAGKPLSIEEIEVAPPQAHEVRIKIIATAV
                     CHTDAYTLSGADPEGCFPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKF
                     CLNPKTNLCQKIRVTQGKGLMPDGTSRFTCKGKPILHFMGTSTFSEYTVVADISVAKI
                     DPSAPLDKVCLLGCGISTGYGAAVNTAKVEPGSTCAVFGLGGVGLAVIMGCKVAGASR
                     IIGIDINKDKFAKAKEFGATECINPQDFSKSIQEVLIEMTDGGVDFSFECIGNVKVMR
                     SALEAAHKGWGVSVVVGVAASGEEISTRPFQLVTGRTWKGTAFGGWKSVESVPKLVSE
                     YMSKKIKVDEFVTGNLSFDQINKAFDLMHSGNSIRTVLKM"
     exon            28..129
                     /gene="Adh5"
                     /inference="alignment:Splign:2.1.0"
     exon            130..271
                     /gene="Adh5"
                     /inference="alignment:Splign:2.1.0"
     exon            272..359
                     /gene="Adh5"
                     /inference="alignment:Splign:2.1.0"
     exon            360..579
                     /gene="Adh5"
                     /inference="alignment:Splign:2.1.0"
     exon            580..840
                     /gene="Adh5"
                     /inference="alignment:Splign:2.1.0"
     exon            841..976
                     /gene="Adh5"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1115
                     /gene="Adh5"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1387
                     /gene="Adh5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgaacttg cggacatggc gaaccaggtg atcaggtgta aggctgcagt cgcctgggag
       61 gccggaaagc ctctctccat agaggagata gaggtggccc ctccacaggc tcatgaagtt
      121 cgaattaaga tcattgccac tgctgtttgc cacaccgatg cctataccct gagtggagct
      181 gatcctgagg ggtgtttccc cgtgatctta ggacatgaag gcgctggcat tgtggagagt
      241 gttggcgaag gggttactaa gctgaaggca ggtgataccg tcatcccgct gtacatccca
      301 cagtgtggag aatgcaagtt ctgtctgaat cctaaaacaa acctttgcca gaaaataaga
      361 gtcactcagg ggaaagggtt gatgcccgat gggaccagca ggtttacctg caaagggaag
      421 cctattcttc acttcatggg aaccagcacg ttttccgagt acacagtggt ggcagacatc
      481 tctgttgcta aaattgaccc ttccgcccct ttggataaag tctgccttct cggttgtggc
      541 atttcaactg gctacggggc cgctgtgaac actgccaagg tggagcctgg ttctacctgt
      601 gccgtctttg gcctgggagg agttggattg gcggtgatca tgggctgtaa agtggctggt
      661 gcgtcccgga tcattggtat tgacatcaat aaagataaat tcgcgaaggc caaagaattt
      721 ggagccactg aatgtattaa cccccaagat ttcagtaaat ccatccagga agtcctcatc
      781 gagatgacag atggcggagt ggacttctcc tttgagtgta tcggtaacgt gaaggtcatg
      841 agatcagccc tcgaggcagc ccacaaaggc tggggtgtca gtgtggtggt tggtgtggcc
      901 gcttcaggtg aagaaatctc cactcgtccg ttccaactgg tgacaggacg cacgtggaaa
      961 ggcactgcct ttggaggctg gaagagtgtg gagagtgtcc cgaagctggt gtctgaatat
     1021 atgtccaaaa agataaaagt tgacgaattt gtgactggca atctgtcctt cgaccagatt
     1081 aacaaagcct ttgatctgat gcactcggga aacagcattc gaactgttct aaagatgtaa
     1141 attctgaaga gagtactgcc catcctgcac tctttcctgt gattgaatag aaacagacag
     1201 gatttacaag cttaactgcc acttagactt caggacccac tagaaggaag gtgcaaaatc
     1261 gtggctgcaa tcatgaatga ggcaactggt cgccgtgcct ttctgagctc tccacacaaa
     1321 taattgttgc tcaccaatgc aacgttttac gtaataaaaa tacactctgt gtttgtgtga
     1381 aagccgaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
