LOCUS       NM_017270               1372 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus alcohol dehydrogenase 4 (class II), pi
            polypeptide (Adh4), mRNA.
ACCESSION   NM_017270
VERSION     NM_017270.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1372)
  AUTHORS   Zarrilli,F., Tomaiuolo,R., Ceglia,C., Lombardo,B., Izzo,B.,
            Castaldo,G., Pastore,L. and De Simone,R.
  TITLE     Molecular analysis of cluster headache
  JOURNAL   Clin J Pain 31 (1), 52-57 (2015)
   PUBMED   24469609
REFERENCE   2  (bases 1 to 1372)
  AUTHORS   Sarkar,S. and Chang,S.L.
  TITLE     Ethanol concentration-dependent alterations in gene expression
            during acute binge drinking in the HIV-1 transgenic rat
  JOURNAL   Alcohol Clin Exp Res 37 (7), 1082-1090 (2013)
   PUBMED   23413777
REFERENCE   3  (bases 1 to 1372)
  AUTHORS   Probyn,M.E., Zanini,S., Ward,L.C., Bertram,J.F. and Moritz,K.M.
  TITLE     A rodent model of low- to moderate-dose ethanol consumption during
            pregnancy: patterns of ethanol consumption and effects on fetal and
            offspring growth
  JOURNAL   Reprod Fertil Dev 24 (6), 859-870 (2012)
   PUBMED   22781937
REFERENCE   4  (bases 1 to 1372)
  AUTHORS   Kim,S.G.
  TITLE     Gender differences in the genetic risk for alcohol dependence--the
            results of a pharmacogenetic study in Korean alcoholics
  JOURNAL   Nihon Arukoru Yakubutsu Igakkai Zasshi 44 (6), 680-685 (2009)
   PUBMED   20077761
REFERENCE   5  (bases 1 to 1372)
  AUTHORS   Chung,C.S., Wang,J., Wehman,M. and Rhoads,D.E.
  TITLE     Severity of alcohol withdrawal symptoms depends on developmental
            stage of Long-Evans rats
  JOURNAL   Pharmacol Biochem Behav 89 (2), 137-144 (2008)
   PUBMED   18207224
REFERENCE   6  (bases 1 to 1372)
  AUTHORS   Boleda,M.D., Julia,P., Moreno,A. and Pares,X.
  TITLE     Role of extrahepatic alcohol dehydrogenase in rat ethanol
            metabolism
  JOURNAL   Arch Biochem Biophys 274 (1), 74-81 (1989)
   PUBMED   2774584
REFERENCE   7  (bases 1 to 1372)
  AUTHORS   Julia,P., Farres,J. and Pares,X.
  TITLE     Characterization of three isoenzymes of rat alcohol dehydrogenase.
            Tissue distribution and physical and enzymatic properties
  JOURNAL   Eur J Biochem 162 (1), 179-189 (1987)
   PUBMED   3816781
REFERENCE   8  (bases 1 to 1372)
  AUTHORS   Mardh,G., Dingley,A.L., Auld,D.S. and Vallee,B.L.
  TITLE     Human class II (pi) alcohol dehydrogenase has a redox-specific
            function in norepinephrine metabolism
  JOURNAL   Proc Natl Acad Sci U S A 83 (23), 8908-8912 (1986)
   PUBMED   3466164
REFERENCE   9  (bases 1 to 1372)
  AUTHORS   Holmes,R.S.
  TITLE     Genetics and ontogeny of alcohol dehydrogenase isozymes in the
            mouse: evidence for a cis-acting regulator gene (Adt-i) controlling
            C2 isozyme expression in reproductive tissues and close linkage of
            Adh-3 and Adt-i on chromosome 3
  JOURNAL   Biochem Genet 17 (5-6), 461-472 (1979)
   PUBMED   518534
REFERENCE   10 (bases 1 to 1372)
  AUTHORS   Lange,L.G., Sytkowski,A.J. and Vallee,B.L.
  TITLE     Human liver alcohol dehydrogenase: purification, composition, and
            catalytic features
  JOURNAL   Biochemistry 15 (21), 4687-4693 (1976)
   PUBMED   9982
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC127504.1.
            
            On Jul 11, 2009 this sequence version replaced NM_017270.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC127504.1, X90710.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1372
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q44"
     gene            1..1372
                     /gene="Adh4"
                     /gene_synonym="Ac1002; ADH-1"
                     /note="alcohol dehydrogenase 4 (class II), pi polypeptide"
                     /db_xref="GeneID:29646"
                     /db_xref="RGD:71028"
     exon            1..62
                     /gene="Adh4"
                     /gene_synonym="Ac1002; ADH-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1178
                     /gene="Adh4"
                     /gene_synonym="Ac1002; ADH-1"
                     /EC_number="1.1.1.105"
                     /note="class II alcohol dehydrogenase, pi subunit; ADH2;
                     alcohol dehydrogenase II; alcohol dehydrogenase class II;
                     alcohol dehydrogenase 4-like; alcohol dehydrogenase 2"
                     /codon_start=1
                     /product="all-trans-retinol dehydrogenase [NAD(+)] ADH4"
                     /protein_id="NP_058966.2"
                     /db_xref="GeneID:29646"
                     /db_xref="RGD:71028"
                     /translation="MGTQGKVITCKAAIAWKTDSPLCIEEIEVSPPKAHEVRIKVIAT
                     CVCPTDINATNPKKKALFPVVLGHECAGIVESVGPGVTNFKPGDKVIPFFAPQCKKCK
                     LCLSPLTNLCGKLRNFKYPTIDQELMEDRTSRFTCKGRSIYHFMGVSSFSQYTVVSEA
                     NLARVDDEANLERVCLIGCGFTSGYGAAINTAKVTPGSACAVFGLGCVGLSAVIGCKI
                     AGASRIIAIDINSEKFPKAKALGATDCLNPRDLDKPVQDVITELTGGGVDFSLDCAGT
                     AQTLKAAVDCTVVGWGSCTVVGAKVDEMNISTVDMILGRSVKGTFFGGWKSVDSVPNL
                     VTDYKNKKFDLDLLVTHALPFDKINDAIDLMNQGKSIRTILTF"
     exon            63..164
                     /gene="Adh4"
                     /gene_synonym="Ac1002; ADH-1"
                     /inference="alignment:Splign:2.1.0"
     exon            165..303
                     /gene="Adh4"
                     /gene_synonym="Ac1002; ADH-1"
                     /inference="alignment:Splign:2.1.0"
     exon            304..391
                     /gene="Adh4"
                     /gene_synonym="Ac1002; ADH-1"
                     /inference="alignment:Splign:2.1.0"
     exon            392..623
                     /gene="Adh4"
                     /gene_synonym="Ac1002; ADH-1"
                     /inference="alignment:Splign:2.1.0"
     exon            624..884
                     /gene="Adh4"
                     /gene_synonym="Ac1002; ADH-1"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1014
                     /gene="Adh4"
                     /gene_synonym="Ac1002; ADH-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1153
                     /gene="Adh4"
                     /gene_synonym="Ac1002; ADH-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1334
                     /gene="Adh4"
                     /gene_synonym="Ac1002; ADH-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccagagtca gaaggacact tccaaagcaa gcttcccaag gaaaatgggc acccagggaa
       61 aggtcattac atgcaaggca gccattgcct ggaaaactga cagccccctt tgcattgaag
      121 aaattgaagt ttctcctcct aaggctcatg aagttcgaat taaggtaatc gccacatgcg
      181 tgtgccctac tgacatcaat gccaccaatc ctaagaagaa agctctcttc ccagtagtcc
      241 tcggccatga gtgtgcagga attgtagaaa gcgttgggcc aggagtgacc aacttcaaac
      301 caggtgacaa agtaatccca ttcttcgcac cacagtgcaa aaagtgcaag ctctgtctga
      361 gtcctctcac gaacctctgt gggaagctca gaaattttaa ataccctact attgatcaag
      421 agctcatgga agacagaacc agcaggttta cctgcaaagg aagatcaatt taccacttca
      481 tgggagtcag ttccttctct cagtacactg tggtttcaga agccaatctt gcccgagtgg
      541 atgatgaggc aaatttggag agagtgtgtc tgattggatg tgggttcaca tcaggctatg
      601 gggctgcgat caacactgcc aaggtcaccc ctggttccgc ttgtgctgtc tttggcctgg
      661 ggtgtgtagg tctttctgct gtaattggat gtaaaatagc aggtgcttcc agaatcatag
      721 ctattgacat caacagtgag aagttcccaa aagccaaggc cctgggagcc actgactgcc
      781 ttaatcccag agacctagac aaacctgtcc aagatgtcat cactgaactg acgggtggag
      841 gtgtggattt ctccctggac tgtgcaggaa cagctcagac cttgaaagca gctgtagact
      901 gcaccgtcgt aggctggggg tcatgcactg tggtcggagc aaaggttgat gaaatgaata
      961 tatccaccgt ggacatgata ttgggccgtt ctgtaaaggg aacgttcttt ggtggttgga
     1021 aaagtgtaga ctctgtccca aacctggtta ctgactacaa gaataagaaa ttcgatctgg
     1081 acttactggt gacccatgcc ctaccttttg acaaaatcaa cgacgcgatt gacctgatga
     1141 accaaggaaa aagcatccga acaatcctga ccttttgaag acgccaggag gaacttggaa
     1201 tgtcatcaga ttggatccaa gcttgtccag atgacttccc acttcccacg atgagccaag
     1261 gaaagctatg agtttaagca tgtgttcaca cttcgtatca acacaaatga actataaatt
     1321 atatagtcac tcttaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
