LOCUS       NM_019286               1806 bp    mRNA    linear   ROD 13-AUG-2024
DEFINITION  Rattus norvegicus alcohol dehydrogenase 1C (class I), gamma
            polypeptide (Adh1c), mRNA.
ACCESSION   NM_019286 NM_130780 XM_001053019 XM_001078334
VERSION     NM_019286.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1806)
  AUTHORS   Chen,G., Zhang,F., Xue,W., Wu,R., Xu,H., Wang,K. and Zhu,J.
  TITLE     An association study revealed substantial effects of dominance,
            epistasis and substance dependence co-morbidity on alcohol
            dependence symptom count
  JOURNAL   Addict Biol 22 (6), 1475-1485 (2017)
   PUBMED   27151647
REFERENCE   2  (bases 1 to 1806)
  AUTHORS   Sarkar,S. and Chang,S.L.
  TITLE     Ethanol concentration-dependent alterations in gene expression
            during acute binge drinking in the HIV-1 transgenic rat
  JOURNAL   Alcohol Clin Exp Res 37 (7), 1082-1090 (2013)
   PUBMED   23413777
REFERENCE   3  (bases 1 to 1806)
  AUTHORS   Rivera-Meza,M., Quintanilla,M.E. and Tampier,L.
  TITLE     Reduction of ethanol consumption in alcohol-preferring rats by dual
            expression gene transfer
  JOURNAL   Alcohol Alcohol 47 (2), 102-108 (2012)
   PUBMED   22214999
  REMARK    GeneRIF: study provides evidence that the simultaneous increase of
            liver ADH and a reduction of ALDH activity by gene transfer could
            constitute a potential therapeutic strategy for the treatment of
            alcoholism.
REFERENCE   4  (bases 1 to 1806)
  AUTHORS   Kanda,J., Matsuo,K., Suzuki,T., Kawase,T., Hiraki,A., Watanabe,M.,
            Mizuno,N., Sawaki,A., Yamao,K., Tajima,K. and Tanaka,H.
  TITLE     Impact of alcohol consumption with polymorphisms in
            alcohol-metabolizing enzymes on pancreatic cancer risk in Japanese
  JOURNAL   Cancer Sci 100 (2), 296-302 (2009)
   PUBMED   19068087
REFERENCE   5  (bases 1 to 1806)
  AUTHORS   Ohno,T., Hiroi,H., Momoeda,M., Hosokawa,Y., Tsutsumi,R.,
            Koizumi,M., Nakazawa,F., Yano,T., Tsutsumi,O. and Taketani,Y.
  TITLE     Evidence for the expression of alcohol dehydrogenase class I gene
            in rat uterus and its up-regulation by progesterone
  JOURNAL   Endocr J 55 (1), 83-90 (2008)
   PUBMED   18219182
  REMARK    GeneRIF: ADH class I gene is progesterone-responsive in the uterus.
REFERENCE   6  (bases 1 to 1806)
  AUTHORS   Chen,L., Sidner,R.A. and Lumeng,L.
  TITLE     Distribution of alcohol dehydrogenase and the low Km form of
            aldehyde dehydrogenase in isolated perivenous and periportal
            hepatocytes in rats
  JOURNAL   Alcohol Clin Exp Res 16 (1), 23-29 (1992)
   PUBMED   1558299
REFERENCE   7  (bases 1 to 1806)
  AUTHORS   Crabb,D.W., Stein,P.M., Dipple,K.M., Hittle,J.B., Sidhu,R.,
            Qulali,M., Zhang,K. and Edenberg,H.J.
  TITLE     Structure and expression of the rat class I alcohol dehydrogenase
            gene
  JOURNAL   Genomics 5 (4), 906-914 (1989)
   PUBMED   2591969
REFERENCE   8  (bases 1 to 1806)
  AUTHORS   Crabb,D.W. and Edenberg,H.J.
  TITLE     Complete amino acid sequence of rat liver alcohol dehydrogenase
            deduced from the cDNA sequence
  JOURNAL   Gene 48 (2-3), 287-291 (1986)
   PUBMED   2881847
REFERENCE   9  (bases 1 to 1806)
  AUTHORS   Holmes,R.S.
  TITLE     Genetics and ontogeny of alcohol dehydrogenase isozymes in the
            mouse: evidence for a cis-acting regulator gene (Adt-i) controlling
            C2 isozyme expression in reproductive tissues and close linkage of
            Adh-3 and Adt-i on chromosome 3
  JOURNAL   Biochem Genet 17 (5-6), 461-472 (1979)
   PUBMED   518534
REFERENCE   10 (bases 1 to 1806)
  AUTHORS   Lange,L.G., Sytkowski,A.J. and Vallee,B.L.
  TITLE     Human liver alcohol dehydrogenase: purification, composition, and
            catalytic features
  JOURNAL   Biochemistry 15 (21), 4687-4693 (1976)
   PUBMED   9982
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FQ218571.1, BC062403.1 and JAXUCZ010000002.1.
            
            On Sep 16, 2014 this sequence version replaced NM_019286.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ218571.1, FQ209590.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                FQ218571.1         1-13
            14-212              BC062403.1         1-199
            213-696             JAXUCZ010000002.1  229481808-229482291
            697-1046            BC062403.1         201-550
            1047-1530           JAXUCZ010000002.1  229481808-229482291
            1531-1853           BC062403.1         552-874
            1854-2337           JAXUCZ010000002.1  229481808-229482291
            2338-2771           BC062403.1         876-1309
            2772-3255           JAXUCZ010000002.1  229481808-229482291
FEATURES             Location/Qualifiers
     source          1..1806
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q44"
     gene            1..1806
                     /gene="Adh1c"
                     /gene_synonym="Adh; Adh1; Adh1a"
                     /note="alcohol dehydrogenase 1C (class I), gamma
                     polypeptide"
                     /db_xref="GeneID:24172"
                     /db_xref="RGD:2044"
     exon            1..81
                     /gene="Adh1c"
                     /gene_synonym="Adh; Adh1; Adh1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1194
                     /gene="Adh1c"
                     /gene_synonym="Adh; Adh1; Adh1a"
                     /EC_number="1.1.1.1"
                     /note="alcohol dehydrogenase (class I), alpha polypeptide;
                     alcohol dehydrogenase A subunit; alcohol dehydrogenase 1,
                     complex; alcohol dehydrogenase 1 (class I); alcohol
                     dehydrogenase 1 (class I), gamma polypeptide"
                     /codon_start=1
                     /product="alcohol dehydrogenase 1"
                     /protein_id="NP_062159.3"
                     /db_xref="GeneID:24172"
                     /db_xref="RGD:2044"
                     /translation="MSTAGKVIKCKAAVLWEPHKPFTIEDIEVAPPKAHEVRIKMVAT
                     GVCRSDDHAVSGSLFTPLPAVLGHEGAGIVESIGEGVTCVKPGDKVIPLFSPQCGKCR
                     ICKHPESNLCCQTKNLTQPKGALLDGTSRFSCRGKPIHHFISTSTFSQYTVVDDIAVA
                     KIDAAAPLDKVCLIGCGFSTGYGSAVQVAKVTPGSTCAVFGLGGVGLSVVIGCKTAGA
                     AKIIAVDINKDKFAKAKELGATDCINPQDYTKPIQEVLQEMTDGGVDFSFEVIGRLDT
                     MTSALLSCHSACGVSVIVGVPPSAQSLSVNPMSLLLGRTWKGAIFGGFKSKDAVPKLV
                     ADFMAKKFPLEPLITHVLPFEKINEAFDLLRAGKSIRTVLTF"
     exon            82..183
                     /gene="Adh1c"
                     /gene_synonym="Adh; Adh1; Adh1a"
                     /inference="alignment:Splign:2.1.0"
     exon            184..322
                     /gene="Adh1c"
                     /gene_synonym="Adh; Adh1; Adh1a"
                     /inference="alignment:Splign:2.1.0"
     exon            323..410
                     /gene="Adh1c"
                     /gene_synonym="Adh; Adh1; Adh1a"
                     /inference="alignment:Splign:2.1.0"
     exon            411..633
                     /gene="Adh1c"
                     /gene_synonym="Adh; Adh1; Adh1a"
                     /inference="alignment:Splign:2.1.0"
     exon            634..894
                     /gene="Adh1c"
                     /gene_synonym="Adh; Adh1; Adh1a"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1030
                     /gene="Adh1c"
                     /gene_synonym="Adh; Adh1; Adh1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1169
                     /gene="Adh1c"
                     /gene_synonym="Adh; Adh1; Adh1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1806
                     /gene="Adh1c"
                     /gene_synonym="Adh; Adh1; Adh1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcactgcagg agggaagaag tctacgagga tccatccatt tcctgcccac agcgaaggac
       61 agcatgagca cagctggaaa agtaatcaaa tgcaaagcgg ccgtgctatg ggagcctcac
      121 aagcccttca ccatcgagga catagaagtc gcacccccca aggcccatga agttcgcatt
      181 aagatggtgg ccaccggagt ctgccgctca gatgatcacg cggttagtgg atccctgttc
      241 acgcctcttc ctgcagttct aggccacgag ggagctggca ttgttgagag cattggagaa
      301 ggggtgactt gtgtgaaacc aggtgataaa gtcatcccgc tgttctctcc ccagtgtgga
      361 aaatgcagga tctgcaagca cccggaaagc aacctctgtt gccaaactaa gaatctgaca
      421 cagcctaagg gagctttgct cgacggcacc agcaggttct cctgcagggg aaagcccatt
      481 caccacttca tcagcaccag caccttctcc cagtacactg tggtagatga catagcggtg
      541 gccaaaatcg atgcggctgc accactggac aaagtctgcc tcatcggctg tggcttctcg
      601 actggctatg gctctgccgt ccaagtcgcc aaggtgaccc caggctccac ctgtgccgtg
      661 tttggcctgg gaggtgttgg tctgtctgtc gtcattggct gtaaaacagc aggagcagcc
      721 aagatcattg ccgtggacat caacaaagac aagtttgcga aggccaaaga gttaggtgcc
      781 actgactgta tcaaccctca agactacacc aaacccatcc aggaagttct ccaggagatg
      841 actgatggag gggtggactt ttcatttgaa gtcattggcc gtcttgacac catgacttct
      901 gccctgttaa gctgccattc agcatgcggt gtaagcgtca ttgtcggggt gcctcccagt
      961 gcccaaagcc tctccgttaa ccccatgtcg ctgctgctgg gacgcacctg gaaaggagca
     1021 atattcggcg ggtttaagag taaagatgcc gtccccaaac ttgtcgctga cttcatggct
     1081 aagaagtttc cgttggagcc gctgattact catgttttac cttttgaaaa gataaatgaa
     1141 gcatttgacc tgctccgtgc tggaaagagt atccgtaccg tcctgacgtt ctgagaacac
     1201 atgaatgcct tcccggtttc tgactcctcc gcctaccgaa tcaagcgcca gccacatcac
     1261 aaccttaacc ttgctcttca gagacacaca gccaataaag cacctgtgca agctttccgt
     1321 gagaaactga gttttctatg gaacctgttc caaccgcatg tttacaatcc tatctatggc
     1381 tttcgcacct cagctgggga actgtggggt actaaaccat ccttcttttt cgattgactt
     1441 agatcatctc tcctcctgag gacagtgtgt cttgttgaca acttgcattc ttttctgttt
     1501 ggaatcgcag tggctgacac tcagtggagc agacagacct ttctctcccc catgcacaca
     1561 gaatacccca tgtgctcatt ctcccgaccc ctcccgttct actgtgtgta cctccttctt
     1621 tatgaaaggc gtgagtgtgc aaggaaccca cagcaggtca ggggacagag ctgggctgga
     1681 agctggagaa tctctgttgt aagaactaaa aggcagcacc acacatggcc gctctgcttc
     1741 tatgcccttt ggtggacaat gaatatggag ttgtttcctt caataaaaac ctgaaataat
     1801 gactga
//
