LOCUS       NM_022294               4274 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus adhesion G protein-coupled receptor L4 (Adgrl4),
            mRNA.
ACCESSION   NM_022294
VERSION     NM_022294.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4274)
  AUTHORS   Ziegler,J., Pody,R., Coutinho de Souza,P., Evans,B., Saunders,D.,
            Smith,N., Mallory,S., Njoku,C., Dong,Y., Chen,H., Dong,J.,
            Lerner,M., Mian,O., Tummala,S., Battiste,J., Fung,K.M., Wren,J.D.
            and Towner,R.A.
  TITLE     ELTD1, an effective anti-angiogenic target for gliomas: preclinical
            assessment in mouse GL261 and human G55 xenograft glioma models
  JOURNAL   Neuro Oncol 19 (2), 175-185 (2017)
   PUBMED   27416955
REFERENCE   2  (bases 1 to 4274)
  AUTHORS   Towner,R.A., Jensen,R.L., Colman,H., Vaillant,B., Smith,N.,
            Casteel,R., Saunders,D., Gillespie,D.L., Silasi-Mansat,R., Lupu,F.,
            Giles,C.B. and Wren,J.D.
  TITLE     ELTD1, a potential new biomarker for gliomas
  JOURNAL   Neurosurgery 72 (1), 77-90 (2013)
   PUBMED   23096411
REFERENCE   3  (bases 1 to 4274)
  AUTHORS   Xiao,J., Jiang,H., Zhang,R., Fan,G., Zhang,Y., Jiang,D. and Li,H.
  TITLE     Augmented cardiac hypertrophy in response to pressure overload in
            mice lacking ELTD1
  JOURNAL   PLoS One 7 (5), e35779 (2012)
   PUBMED   22606234
REFERENCE   4  (bases 1 to 4274)
  AUTHORS   Nechiporuk,T., Urness,L.D. and Keating,M.T.
  TITLE     ETL, a novel seven-transmembrane receptor that is developmentally
            regulated in the heart. ETL is a member of the secretin family and
            belongs to the epidermal growth factor-seven-transmembrane
            subfamily
  JOURNAL   J Biol Chem 276 (6), 4150-4157 (2001)
   PUBMED   11050079
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF192401.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF192401.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4274
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q45"
     gene            1..4274
                     /gene="Adgrl4"
                     /gene_synonym="Eltd1; Etl"
                     /note="adhesion G protein-coupled receptor L4"
                     /db_xref="GeneID:64124"
                     /db_xref="RGD:621136"
     exon            1..257
                     /gene="Adgrl4"
                     /gene_synonym="Eltd1; Etl"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..2452
                     /gene="Adgrl4"
                     /gene_synonym="Eltd1; Etl"
                     /note="EGF, latrophilin and seven transmembrane
                     domain-containing protein 1; EGF-TM7-latrophilin-related
                     protein; EGF, latrophilin seven transmembrane domain
                     containing 1; EGF, latrophilin and seven transmembrane
                     domain containing 1"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor L4
                     precursor"
                     /protein_id="NP_071630.1"
                     /db_xref="GeneID:64124"
                     /db_xref="RGD:621136"
                     /translation="MRLLLLLVGLSTLLNHSYTQNCKTPCLPNAKCEVLDEVAACFCS
                     TGYTGNGITICEDVDECNETSVCGDHAVCENTNGGFSCFCVEGYQTSTGKTQFTPNDG
                     SYCQDVDECNETSVCGDHAVCENTNGGFSCFCVEGYQTSTGKTQFTPNDGSYCQEIVN
                     SNCHLEHDCIAANINKTLKRIGPITEQLTLLHEIYKNSEAELSLVDIVTYIEILTESS
                     SLQGYIKNTTSPKDAYFGSALTEFGKTVNNFVEKNTHEMWDQLPTNRRRLHLTKLMHA
                     AEHVTLQISQNIQKNTQFDMNSTDLALKVFVFDSVHMKHTHPHMNVDGGYVKISPRRK
                     SAYDPNGNVIVAFLCYRSIGPLLSSSDDFLLGAQSDNSKGKEKVISSVISASISSNPP
                     TLYELEKITFTLSHVKLSDKHQTQCAFWNYSVDDMNNGSWSSEGCELTYSNDTHTSCR
                     CSHLTHFAILMSPSTSIEVKDYNILTRITQLGIIISLICLAICIFTFWFFSEIQSTRT
                     TIHKNLCCSLFLAQLVFLVGININTNKLVCSIIAGLLHYFFLAAFAWMCIEGIYLYLI
                     VVGLIYNKGFLHKNFYIFGYLSPAVVVGFSASLGYRYYGTTKVCWLSTENNFIWSFIG
                     PACLIILVNLLAFGVIIYKVFRHTAGLKPEVSCYENIRSCARGALALLFLLGTTWTFG
                     VLHVVHASVVTAYLFTVSNAFQGMFIFLFLCVLSRKIQEEYYRLFKNVPCCFECLR"
     exon            258..404
                     /gene="Adgrl4"
                     /gene_synonym="Eltd1; Etl"
                     /inference="alignment:Splign:2.1.0"
     exon            405..554
                     /gene="Adgrl4"
                     /gene_synonym="Eltd1; Etl"
                     /inference="alignment:Splign:2.1.0"
     exon            555..704
                     /gene="Adgrl4"
                     /gene_synonym="Eltd1; Etl"
                     /inference="alignment:Splign:2.1.0"
     exon            705..775
                     /gene="Adgrl4"
                     /gene_synonym="Eltd1; Etl"
                     /inference="alignment:Splign:2.1.0"
     exon            776..955
                     /gene="Adgrl4"
                     /gene_synonym="Eltd1; Etl"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1139
                     /gene="Adgrl4"
                     /gene_synonym="Eltd1; Etl"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1256
                     /gene="Adgrl4"
                     /gene_synonym="Eltd1; Etl"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1459
                     /gene="Adgrl4"
                     /gene_synonym="Eltd1; Etl"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1636
                     /gene="Adgrl4"
                     /gene_synonym="Eltd1; Etl"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1840
                     /gene="Adgrl4"
                     /gene_synonym="Eltd1; Etl"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..2061
                     /gene="Adgrl4"
                     /gene_synonym="Eltd1; Etl"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2128
                     /gene="Adgrl4"
                     /gene_synonym="Eltd1; Etl"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2220
                     /gene="Adgrl4"
                     /gene_synonym="Eltd1; Etl"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2389
                     /gene="Adgrl4"
                     /gene_synonym="Eltd1; Etl"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..4219
                     /gene="Adgrl4"
                     /gene_synonym="Eltd1; Etl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccacaggctg agactagagt ccaggctgtt tgggtgaagg ggcctggcgg ccggacgtgg
       61 cctgcagagt ctgggctgtg cacacattca cacaaaagag gccgggaagt gacaggagga
      121 agctgtgcgt cacaagggac tgagcgggac cctgccgcgc ctgcccagct ccaggacaga
      181 ccccaactct tgccttcagc gctctgcgga gccagccagc tccacccggc ttccaatgag
      241 actcctcctg cttctagtgg gtctctccac tttgctgaat cactcctaca cacaaaactg
      301 caagacaccg tgtctcccaa atgccaagtg tgaggtgttg gacgaagtgg cagcctgctt
      361 ctgcagtaca ggctacactg ggaatggcat cacgatttgt gaagatgtag acgagtgcaa
      421 cgagacctcc gtctgcggtg atcacgctgt gtgtgaaaac acgaatggag gatttagctg
      481 cttctgcgtg gaaggttatc agacctccac cgggaagacg cagttcacgc ctaatgatgg
      541 ctcttactgc caagatgtag acgagtgcaa cgagacctcc gtctgcggtg atcacgctgt
      601 gtgtgaaaac acgaacggag gatttagctg cttctgcgtg gaaggttatc agacctccac
      661 cgggaagacg cagttcacgc ctaatgatgg ctcttactgc caagaaattg tgaattcaaa
      721 ttgccactta gagcatgact gcattgctgc aaacattaat aaaactctaa aaagaattgg
      781 acccataaca gaacagctga ctttactcca tgaaatctac aagaattctg aggctgagct
      841 ttctctggtg gatatagtca catacataga gatactaaca gaatcatcct cactacaagg
      901 ctacataaag aacaccactt cgcccaagga tgcctacttc ggttcagctc ttactgaatt
      961 tggaaaaacc gtcaataatt ttgttgaaaa gaacacacat gaaatgtggg accagttacc
     1021 tacaaatcgt agaagactcc atctcacaaa actgatgcac gctgctgagc acgtcacctt
     1081 acagatctct cagaacatcc agaagaatac tcagtttgac atgaattcta ccgacttggc
     1141 tctcaaggtt ttcgtttttg attcagttca catgaagcat actcatcccc atatgaatgt
     1201 ggacggaggc tatgtaaaaa tatccccgag gagaaaatct gcatatgacc caaatggcaa
     1261 cgtcattgtt gcattcctgt gctataggag cattggcccc ttgctttcct catctgacga
     1321 cttcttactg ggcgctcaga gtgacaattc caaaggaaag gagaaggtca tttcttcagt
     1381 gatttctgcc tcaattagct caaacccacc cacactgtat gaacttgaaa aaattacatt
     1441 tacactgagt catgtaaagc tctcagataa gcaccagaca cagtgcgcct tttggaacta
     1501 ctcagtcgat gacatgaaca atggcagctg gtcatctgag ggctgtgagc tgacatactc
     1561 caacgacacc catacttcct gccgatgtag tcatctgaca cactttgcga ttttgatgtc
     1621 ccccagtacc tccattgaag ttaaagatta caatatcctg acgaggatca ctcagctggg
     1681 aataatcatc tccctgatct gcctcgccat atgcattttc accttctggt tcttcagtga
     1741 gattcaaagc accaggacca caatccacaa gaatctctgc tgcagcctct ttcttgcaca
     1801 actagttttt cttgtcggca tcaacataaa cacaaacaag ctggtctgct ctatcatcgc
     1861 tggcctgctc cattacttct tcttagctgc ctttgcctgg atgtgcattg aaggcatcta
     1921 cctatacctc atcgttgttg ggctcatcta taacaagggg tttttacaca agaacttcta
     1981 tatctttggc tatcttagcc cggctgtagt tgttggattc tcggcctctt tgggatacag
     2041 atattatggt accaccaaag tatgttggtt gagcactgaa aacaacttta tctggagctt
     2101 catagggcca gcgtgtctaa tcattcttgt taatctcttg gcttttggag ttatcatata
     2161 caaagtgttc cgccacactg ctggactgaa gccagaagtt agttgctacg agaacataag
     2221 gtcttgcgcc agaggagccc tggccctcct cttccttctg ggtaccacct ggacctttgg
     2281 ggttctccac gtagtgcatg catctgttgt gacagcctac ctcttcacag tcagcaacgc
     2341 tttccaaggg atgtttattt tcttattcct atgtgtttta tctagaaaga ttcaagaaga
     2401 atattacaga ttgttcaaaa atgtcccctg ctgttttgaa tgtttaagat aaacaacgag
     2461 aagacacaat aattatagct gaaatgaaat ggaaattcca agatttcgga tagcctgtgt
     2521 gacaaaaatg agcctgcctt cattgttagt aattaatttc aaattcgctt ttctgttcgc
     2581 agtataaaag atgtagttaa tgtgagataa aattatgggc cagagagctc ctgtgtgttt
     2641 tcctacatga catagttaga tatgtcaaaa atagtactgc agatatttgg aaagtaattg
     2701 gtttctctgg agtgatatca ctgtgcccaa ggaaagattt ctttctaaca caagaaatag
     2761 atgaatgtcc tcaaggaagc gactggcttg atatctttgt gactcatgtt gcctttcaaa
     2821 cgagtcccct accaccatag taatgagttc ctttgcagaa aggagagtat aagaaacttg
     2881 gaggggcaga atatgaagca atggagaagc cttctctgac aaggaattgt cattccaata
     2941 aaattggctt tctccaaaat tgaagaggaa aaaattttca ggctaaaata acgaaaaagg
     3001 aaatgcatcc tagcactttg ggaattggtc tgaacttaaa aggcccagac ctaaatttac
     3061 tacatccatg ttcttcctta ctgttctaaa ccaaagaaaa accttaaaat ttacagatac
     3121 atggatgagt gttctcacat aacatcatat ttgaatgtaa atttttttca ttcctcacag
     3181 attaagactt cagcaacata tttggtaaaa cataaatttg tcaaactata agactgttca
     3241 tatctttagt gaaaaaatag aatgtgaagt attttgtcta taatatttta ctgttatgaa
     3301 aataatcttt tcatattaga gcagtatact tgaatacttt actgttttta atcttacaaa
     3361 tagtgtgatt catgttgcaa ccagcccttt taattgactg tatttaaaag ggcattataa
     3421 atttaaacta ttgatgaagt aaattataat ggttttctga tcagaaaata catacttaaa
     3481 gcattattta taacaaataa aaagtcactg agcactgcag gggtttcaca gtggatctga
     3541 tatttttaga ccgtttccta tcacctatca gtctatttac ttaaatgtac agctctacca
     3601 attctcttac tcaaaggaag aggcagtatt tttctcagaa gtgagtcatt gttctgtacc
     3661 ttcctggaga catgattcga tccattgaac attgtggttt taattcttgt gctgttgaat
     3721 gaagcctgac aagacacctc ctaaaaaatg aaatgtcagc tggatgaagc agccctgcta
     3781 ctgcctgact gagttgttct ctcaggaaag accactcacc tgccaagaag cacgttgcat
     3841 ctctacagat ctcagggttt ctcccatgcc aagtctgtag cccacgagca tcattgtcat
     3901 tctaagatgg gactgtagaa ataggatatc aaaacataat ccgttcaatc aatggataag
     3961 aaactatcac atgtagtaga cagaataacc cttctcaaat attcatacac tcctcttcac
     4021 aagctgtggc cgtggtggat agtgaggagc aggaggtcct gtcaggagga agagtagctg
     4081 aggtccactc agttggagaa ggctctcact gtgctggggg aagtcagcat gctgacgatg
     4141 ttactttagt ttgggtctct tgttttggac atctcatttc tagagctgta aagacaataa
     4201 aattctatta tcaaagccaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     4261 aaaaaaaaaa aaaa
//
