LOCUS       NM_130822               6637 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus adhesion G protein-coupled receptor L3 (Adgrl3),
            mRNA.
ACCESSION   NM_130822
VERSION     NM_130822.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6637)
  AUTHORS   Regan,S.L., Sugimoto,C., Dawson,H.E., Williams,M.T. and
            Vorhees,C.V.
  TITLE     Latrophilin-3 heterozygous versus homozygous mutations in Sprague
            Dawley rats: Effects on egocentric and allocentric memory and
            locomotor activity
  JOURNAL   Genes Brain Behav 21 (7), e12817 (2022)
   PUBMED   35985692
  REMARK    GeneRIF: Latrophilin-3 heterozygous versus homozygous mutations in
            Sprague Dawley rats: Effects on egocentric and allocentric memory
            and locomotor activity.
REFERENCE   2  (bases 1 to 6637)
  AUTHORS   Regan,S.L., Pitzer,E.M., Hufgard,J.R., Sugimoto,C., Williams,M.T.
            and Vorhees,C.V.
  TITLE     A novel role for the ADHD risk gene latrophilin-3 in learning and
            memory in Lphn3 knockout rats
  JOURNAL   Neurobiol Dis 158, 105456 (2021)
   PUBMED   34352385
  REMARK    GeneRIF: A novel role for the ADHD risk gene latrophilin-3 in
            learning and memory in Lphn3 knockout rats.
REFERENCE   3  (bases 1 to 6637)
  AUTHORS   Regan,S.L., Cryan,M.T., Williams,M.T., Vorhees,C.V. and Ross,A.E.
  TITLE     Enhanced Transient Striatal Dopamine Release and Reuptake in Lphn3
            Knockout Rats
  JOURNAL   ACS Chem Neurosci 11 (8), 1171-1177 (2020)
   PUBMED   32203648
  REMARK    GeneRIF: Enhanced Transient Striatal Dopamine Release and Reuptake
            in Lphn3 Knockout Rats.
REFERENCE   4  (bases 1 to 6637)
  AUTHORS   Regan,S.L., Hufgard,J.R., Pitzer,E.M., Sugimoto,C., Hu,Y.C.,
            Williams,M.T. and Vorhees,C.V.
  TITLE     Knockout of latrophilin-3 in Sprague-Dawley rats causes
            hyperactivity, hyper-reactivity, under-response to amphetamine, and
            disrupted dopamine markers
  JOURNAL   Neurobiol Dis 130, 104494 (2019)
   PUBMED   31176715
  REMARK    GeneRIF: new Lphn3 knockout-out rat data collectively show that its
            disruption is significantly correlated with hyperactivity and
            associated striatal changes in dopamine markers.
REFERENCE   5  (bases 1 to 6637)
  AUTHORS   Ranaivoson,F.M., Liu,Q., Martini,F., Bergami,F., von Daake,S.,
            Li,S., Lee,D., Demeler,B., Hendrickson,W.A. and Comoletti,D.
  TITLE     Structural and Mechanistic Insights into the Latrophilin3-FLRT3
            Complex that Mediates Glutamatergic Synapse Development
  JOURNAL   Structure 23 (9), 1665-1677 (2015)
   PUBMED   26235031
REFERENCE   6  (bases 1 to 6637)
  AUTHORS   O'Sullivan,M.L., de Wit,J., Savas,J.N., Comoletti,D., Otto-Hitt,S.,
            Yates,J.R. 3rd and Ghosh,A.
  TITLE     FLRT proteins are endogenous latrophilin ligands and regulate
            excitatory synapse development
  JOURNAL   Neuron 73 (5), 903-910 (2012)
   PUBMED   22405201
REFERENCE   7  (bases 1 to 6637)
  AUTHORS   Bin Sun,H., Ruan,Y., Xu,Z.C. and Yokota,H.
  TITLE     Involvement of the calcium-independent receptor for
            alpha-latrotoxin in brain ischemia
  JOURNAL   Brain Res Mol Brain Res 104 (2), 246-249 (2002)
   PUBMED   12225880
REFERENCE   8  (bases 1 to 6637)
  AUTHORS   Kreienkamp,H.J., Zitzer,H., Gundelfinger,E.D., Richter,D. and
            Bockers,T.M.
  TITLE     The calcium-independent receptor for alpha-latrotoxin from human
            and rodent brains interacts with members of the ProSAP/SSTRIP/Shank
            family of multidomain proteins
  JOURNAL   J Biol Chem 275 (42), 32387-32390 (2000)
   PUBMED   10964907
REFERENCE   9  (bases 1 to 6637)
  AUTHORS   Ichtchenko,K., Bittner,M.A., Krasnoperov,V., Little,A.R.,
            Chepurny,O., Holz,R.W. and Petrenko,A.G.
  TITLE     A novel ubiquitously expressed alpha-latrotoxin receptor is a
            member of the CIRL family of G-protein-coupled receptors
  JOURNAL   J Biol Chem 274 (9), 5491-5498 (1999)
   PUBMED   10026162
REFERENCE   10 (bases 1 to 6637)
  AUTHORS   Sugita,S., Ichtchenko,K., Khvotchev,M. and Sudhof,T.C.
  TITLE     alpha-Latrotoxin receptor CIRL/latrophilin 1 (CL1) defines an
            unusual family of ubiquitous G-protein-linked receptors. G-protein
            coupling not required for triggering exocytosis
  JOURNAL   J Biol Chem 273 (49), 32715-32724 (1998)
   PUBMED   9830014
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Jun 3, 2021 this sequence version replaced NM_130822.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF063103.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA5760383,
                                    SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               JAXUCZ010000014.1  27457991-27458104   c
            115-145             JAXUCZ010000014.1  27411675-27411705   c
            146-211             JAXUCZ010000014.1  27280353-27280418   c
            212-445             JAXUCZ010000014.1  27178818-27179051   c
            446-649             JAXUCZ010000014.1  27158932-27159135   c
            650-863             JAXUCZ010000014.1  27109442-27109655   c
            864-973             JAXUCZ010000014.1  27037398-27037507   c
            974-988             JAXUCZ010000014.1  26989333-26989347   c
            989-1789            JAXUCZ010000014.1  26986243-26987043   c
            1790-1870           JAXUCZ010000014.1  26939105-26939185   c
            1871-2170           JAXUCZ010000014.1  26865841-26866140   c
            2171-2274           JAXUCZ010000014.1  26862732-26862835   c
            2275-2460           JAXUCZ010000014.1  26852743-26852928   c
            2461-2499           JAXUCZ010000014.1  26849845-26849883   c
            2500-2683           JAXUCZ010000014.1  26825658-26825841   c
            2684-2806           JAXUCZ010000014.1  26824634-26824756   c
            2807-3015           JAXUCZ010000014.1  26820244-26820452   c
            3016-3192           JAXUCZ010000014.1  26819319-26819495   c
            3193-3402           JAXUCZ010000014.1  26795645-26795854   c
            3403-3623           JAXUCZ010000014.1  26792913-26793133   c
            3624-3690           JAXUCZ010000014.1  26780746-26780812   c
            3691-3782           JAXUCZ010000014.1  26778219-26778310   c
            3783-3809           JAXUCZ010000014.1  26762983-26763009   c
            3810-3978           JAXUCZ010000014.1  26760174-26760342   c
            3979-4104           JAXUCZ010000014.1  26752551-26752676   c
            4105-4201           JAXUCZ010000014.1  26748351-26748447   c
            4202-4243           JAXUCZ010000014.1  26745594-26745635   c
            4244-6637           JAXUCZ010000014.1  26722194-26724587   c
FEATURES             Location/Qualifiers
     source          1..6637
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p21"
     gene            1..6637
                     /gene="Adgrl3"
                     /gene_synonym="CIRL-3; Cirl3; Lec3; Lphn3"
                     /note="adhesion G protein-coupled receptor L3"
                     /db_xref="GeneID:170641"
                     /db_xref="RGD:620836"
     exon            1..114
                     /gene="Adgrl3"
                     /gene_synonym="CIRL-3; Cirl3; Lec3; Lphn3"
                     /inference="alignment:Splign:2.1.0"
     exon            115..145
                     /gene="Adgrl3"
                     /gene_synonym="CIRL-3; Cirl3; Lec3; Lphn3"
                     /inference="alignment:Splign:2.1.0"
     exon            146..211
                     /gene="Adgrl3"
                     /gene_synonym="CIRL-3; Cirl3; Lec3; Lphn3"
                     /inference="alignment:Splign:2.1.0"
     exon            212..445
                     /gene="Adgrl3"
                     /gene_synonym="CIRL-3; Cirl3; Lec3; Lphn3"
                     /inference="alignment:Splign:2.1.0"
     CDS             391..5043
                     /gene="Adgrl3"
                     /gene_synonym="CIRL-3; Cirl3; Lec3; Lphn3"
                     /note="latrophilin-3; calcium-independent alpha-latrotoxin
                     receptor homolog 3; lectomedin-3; calcium-independent
                     alpha-latrotoxin receptor 3"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor L3
                     precursor"
                     /protein_id="NP_570835.2"
                     /db_xref="GeneID:170641"
                     /db_xref="RGD:620836"
                     /translation="MCPPQLFILMMLLAPVVHGGKHNERHPALAAPLRHAEHSPGGPL
                     PPRHLLQQPAAERSTAHRGQGPRGTARGVRGPGAPGAQIAAQAFSRAPIPMAVVRREL
                     SCESYPIELRCPGTDVIMIESANYGRTDDKICDSDPAQMENIRCYLPDAYKIMSQRCN
                     NRTQCAVVAGPDVFPDPCPGTYKYLEVQYECVPYKVEQKVFLCPGLLKGVYQSEHLFE
                     SDHQSGAWCKDPLQASDKIYYMPWTPYRTDTLTEYSSKDDFIAGRPTTTYKLPHRVDG
                     TGFVVYDGALFFNKERTRNIVKFDLRTRIKSGEAIIANANYHDTSPYRWGGKSDIDLA
                     VDENGLWVIYATEQNNGKIVISQLNPYTLRIEGTWDTAYDKRSASNAFMICGILYVVK
                     SVYEDDDNEATGNKIDYIYNTDQSKDSLVDVPFPNSYQYIAAVDYNPRDNLLYVWNNY
                     HVVKYSLDFGPLDSRSGPVHHGQVSYISPPIHLDSDLERPPVRGISTTGPLGMGSTTT
                     STTLRTTTWNLGRSTTPSLPGRRNRSTSTPSPAIEVLDVTTHLPSAASQIPAMEESCE
                     AVEAREIMWFKTRQGQVAKQPCPAGTIGVSTYLCLAPDGIWDPQGPDLSNCSSPWVNH
                     ITQKLKSGETAANIARELAEQTRNHLNAGDITYSVRAMDQLVGLLDVQLRNLTPGGKD
                     SAARSLNKLQKRERSCRAYVQAMVETVNNLLQPQALNAWRDLTTSDQLRAATMLLDTV
                     EESAFVLADNLLKTDIVRENTDNIQLEVARLSTEGNLEDLKFPENTGHGSTIQLSANT
                     LKQNGRNGEIRVAFVLYNNLGPYLSTENASMKLGTEAMSTNHSVIVNSPVITAAINKE
                     FSNKVYLADPVVFTVKHIKQSEENFNPNCSFWSYSKRTMTGYWSTQGCRLLTTNKTHT
                     TCSCNHLTNFAVLMAHVEVKHSDAVHDLLLDVITWVGILLSLVCLLICIFTFCFFRGL
                     QSDRNTIHKNLCISLFVAELLFLIGINRTDQPIACAVFAALLHFFFLAAFTWMFLEGV
                     QLYIMLVEVFESEHSRRKYFYLVGYGMPALIVAVSAAVDYRSYGTDKVCWLRLDTYFI
                     WSFIGPATLIIMLNVIFLGIALYKMFHHTAILKPESGCLDNINYEDNRPFIKSWVIGA
                     IALLCLLGLTWAFGLMYINESTVIMAYLFTIFNSLQGMFIFIFHCVLQKKVRKEYGKC
                     LRTHCCSGKSTESSIGSGKTSGSRTPGRYSTGSQSRIRRMWNDTVRKQSESSFITGDI
                     NSSASLNRGSYLPCIQACVTYLEGLLNNARDTSVMDTLPLNGNHGNSYSIAGGEYLSN
                     CVQIIDRGYNHNETALEKKILKELTSNYIPSYLNNHERSSEQNRNMMNKLVDNLGSGS
                     EDDAIVLDDAASFNHEESLGLELIHEESDAPLLPPRVYSTDNHQPHHYSRRRLPQDHS
                     ESFFPLLTDEHTEDPQSPHRDSLYTSMPALAGVPAADSVTTSTQTEAAAAKGGDAEDV
                     YYKSMPNLGSRNHVHPLHAYYQLGRGSSDGFIVPPNKDGASPEGTSKGPAHLVTSL"
     exon            446..649
                     /gene="Adgrl3"
                     /gene_synonym="CIRL-3; Cirl3; Lec3; Lphn3"
                     /inference="alignment:Splign:2.1.0"
     exon            650..863
                     /gene="Adgrl3"
                     /gene_synonym="CIRL-3; Cirl3; Lec3; Lphn3"
                     /inference="alignment:Splign:2.1.0"
     exon            864..973
                     /gene="Adgrl3"
                     /gene_synonym="CIRL-3; Cirl3; Lec3; Lphn3"
                     /inference="alignment:Splign:2.1.0"
     exon            974..988
                     /gene="Adgrl3"
                     /gene_synonym="CIRL-3; Cirl3; Lec3; Lphn3"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1789
                     /gene="Adgrl3"
                     /gene_synonym="CIRL-3; Cirl3; Lec3; Lphn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1870
                     /gene="Adgrl3"
                     /gene_synonym="CIRL-3; Cirl3; Lec3; Lphn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..2170
                     /gene="Adgrl3"
                     /gene_synonym="CIRL-3; Cirl3; Lec3; Lphn3"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2274
                     /gene="Adgrl3"
                     /gene_synonym="CIRL-3; Cirl3; Lec3; Lphn3"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2460
                     /gene="Adgrl3"
                     /gene_synonym="CIRL-3; Cirl3; Lec3; Lphn3"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..2499
                     /gene="Adgrl3"
                     /gene_synonym="CIRL-3; Cirl3; Lec3; Lphn3"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2683
                     /gene="Adgrl3"
                     /gene_synonym="CIRL-3; Cirl3; Lec3; Lphn3"
                     /inference="alignment:Splign:2.1.0"
     exon            2684..2806
                     /gene="Adgrl3"
                     /gene_synonym="CIRL-3; Cirl3; Lec3; Lphn3"
                     /inference="alignment:Splign:2.1.0"
     exon            2807..3015
                     /gene="Adgrl3"
                     /gene_synonym="CIRL-3; Cirl3; Lec3; Lphn3"
                     /inference="alignment:Splign:2.1.0"
     exon            3016..3192
                     /gene="Adgrl3"
                     /gene_synonym="CIRL-3; Cirl3; Lec3; Lphn3"
                     /inference="alignment:Splign:2.1.0"
     exon            3193..3402
                     /gene="Adgrl3"
                     /gene_synonym="CIRL-3; Cirl3; Lec3; Lphn3"
                     /inference="alignment:Splign:2.1.0"
     exon            3403..3623
                     /gene="Adgrl3"
                     /gene_synonym="CIRL-3; Cirl3; Lec3; Lphn3"
                     /inference="alignment:Splign:2.1.0"
     exon            3624..3690
                     /gene="Adgrl3"
                     /gene_synonym="CIRL-3; Cirl3; Lec3; Lphn3"
                     /inference="alignment:Splign:2.1.0"
     exon            3691..3782
                     /gene="Adgrl3"
                     /gene_synonym="CIRL-3; Cirl3; Lec3; Lphn3"
                     /inference="alignment:Splign:2.1.0"
     exon            3783..3809
                     /gene="Adgrl3"
                     /gene_synonym="CIRL-3; Cirl3; Lec3; Lphn3"
                     /inference="alignment:Splign:2.1.0"
     exon            3810..3978
                     /gene="Adgrl3"
                     /gene_synonym="CIRL-3; Cirl3; Lec3; Lphn3"
                     /inference="alignment:Splign:2.1.0"
     exon            3979..4104
                     /gene="Adgrl3"
                     /gene_synonym="CIRL-3; Cirl3; Lec3; Lphn3"
                     /inference="alignment:Splign:2.1.0"
     exon            4105..4201
                     /gene="Adgrl3"
                     /gene_synonym="CIRL-3; Cirl3; Lec3; Lphn3"
                     /inference="alignment:Splign:2.1.0"
     exon            4202..4243
                     /gene="Adgrl3"
                     /gene_synonym="CIRL-3; Cirl3; Lec3; Lphn3"
                     /inference="alignment:Splign:2.1.0"
     exon            4244..6637
                     /gene="Adgrl3"
                     /gene_synonym="CIRL-3; Cirl3; Lec3; Lphn3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttttttttt tttttttgcc ccggggctca atggatggat tgtggaaaac tgcaccgggt
       61 tgcaggttgt tgagcaactg atgggaccat ctcagggacc agcggttacg aaagatgctg
      121 atttgaagaa ctgccctgaa aactgaaatg attaatgcag aaagtcagaa gacagaacta
      181 tggattttta gcaatcacag aacaaattaa ggtgtctgac ttgggaaatc agtgtttatt
      241 tttgaggaat ttttctttct ttcctttttt ttttttgctt ttggttttta atcattgata
      301 ttggaataca gaagaggagc cagaagtata ctgatttggc ttcacctcag aacagccatt
      361 cttgaggcat tctcctccga gaacacagcc atgtgtccac ctcagctgtt catcctcatg
      421 atgcttttag cacctgtagt tcatggtggc aagcacaatg agagacatcc agccctcgct
      481 gctccactgc gacatgctga gcacagccca ggaggccctc tccctcccag acatcttctt
      541 cagcagccag ctgcagagcg ctctacagct catcgaggac aagggccacg tggaactgcc
      601 agaggagttc gcggacccgg tgccccagga gcacagattg cagcccaagc tttcagccgc
      661 gccccaattc ccatggcagt ggtccgcaga gagctctcct gtgagagcta ccccattgag
      721 ctacgctgtc caggcacaga cgtcatcatg atcgagagcg ccaactacgg gaggacagat
      781 gacaagatct gtgactcgga ccctgctcag atggagaata ttcggtgtta tctgccagat
      841 gcctataaga ttatgtctca aagatgcaat aacagaaccc agtgtgcagt ggtggcaggt
      901 cctgatgtat ttccagaccc atgtccggga acatataaat accttgaagt gcagtatgaa
      961 tgtgtccctt acaaagtgga acaaaaagtt tttctttgtc ccggactgct caaaggagtg
     1021 taccagagcg aacacttgtt tgaatctgac caccaatctg gggcatggtg caaagaccct
     1081 ctacaggctt ctgacaagat ttactatatg ccctggactc cctacagaac cgataccctg
     1141 acagagtatt catccaaaga tgacttcatt gctggaaggc cgacaactac atacaagctc
     1201 cctcacagag tggatggtac tggatttgta gtatatgatg gtgccctgtt cttcaacaag
     1261 gagcgtacaa ggaacatagt aaagtttgat ttgaggacta ggataaagag tggagaggca
     1321 atcatagcaa atgctaacta ccatgatacc tccccatacc gatggggtgg caagtccgac
     1381 atagacttgg cagtggatga aaacggatta tgggtaatct atgcaacaga acagaacaat
     1441 ggcaaaattg ttattagcca gttgaaccct tacaccctac ggattgaggg gacatgggac
     1501 actgcctatg ataaaaggtc tgcttccaat gcatttatga tttgtgggat tctgtatgtg
     1561 gtcaagtctg tatatgagga tgacgacaat gaggccaccg gtaataagat tgactacatt
     1621 tacaatactg accaaagcaa ggatagcctg gtggatgtac cctttcccaa ctcataccag
     1681 tacatagcag ccgtggacta caatcccagg gacaatctgc tgtacgtgtg gaacaactac
     1741 catgttgtca aatactcctt ggacttcggg cctctggata gcagatcagg gccagtgcat
     1801 catggacaag tttcctacat ctctccaccg attcaccttg actctgacct ggaaaggccc
     1861 cctgtcagag ggatttctac cacaggaccc ctgggtatgg gaagcacgac caccagcacc
     1921 accctccgga ctaccacctg gaacctaggg aggagtacaa cgccatcctt gcctggcaga
     1981 agaaaccgca gtaccagtac gccgtcccca gcgattgagg tgctggatgt taccacacac
     2041 ctgccatctg cagcctccca aatcccagcg atggaagaga gctgcgaggc tgtggaagcc
     2101 cgagagatca tgtggtttaa gacccgacag gggcaagtag caaagcagcc atgcccagca
     2161 ggaaccatag gtgtatcaac ttacctgtgt cttgctcctg atggaatatg ggatccccaa
     2221 ggaccagatc tcagcaactg ctcttctcct tgggtcaatc acataacaca gaagctgaaa
     2281 tctggagaaa cagctgccaa tattgccaga gagctagcag aacagaccag aaatcatttg
     2341 aacgccgggg atatcaccta ctcagttcgt gccatggacc aactggttgg cctcctggac
     2401 gtacagctca ggaatttgac accagggggg aaagacagtg ctgcccgaag cttgaacaag
     2461 cttcagaaaa gagagcgctc ttgcagagcc tatgtccagg cgatggtgga gacagttaac
     2521 aatctccttc agccacaagc tctgaatgcg tggagggacc tgacgacaag tgatcaacta
     2581 cgcgcagcca ccatgttgct cgacactgtg gaggagagtg ctttcgtgtt agccgataac
     2641 cttttgaaga ccgacattgt cagggagaat acagacaata ttcagttgga ggttgcaagg
     2701 ctgagcacgg aaggaaacct agaagatcta aaatttccag aaaacacggg ccacggaagc
     2761 actatacagc tttccgcaaa cacgttaaag caaaatggcc ggaatggaga gattagagtg
     2821 gcctttgtcc tgtataacaa cctgggtcct tatttatcta cggagaatgc cagtatgaag
     2881 ttgggcacag aagctatgtc cacaaatcac tcagttatcg tcaattcccc tgttattaca
     2941 gcagcaataa ataaggaatt cagtaataaa gtgtatttgg ctgatcctgt ggtatttact
     3001 gttaaacata tcaagcagtc agaggaaaat ttcaacccta actgttcatt ttggagctat
     3061 tccaagcgca caatgacagg ttattggtca acacaaggct gtcgactcct gacaacgaac
     3121 aagacacaca ctacgtgctc ctgtaaccac ctcaccaact tcgcagtatt aatggcacat
     3181 gtggaagtta agcacagcga tgccgtccac gatcttcttc tggatgtgat cacgtgggtc
     3241 ggaatcctgt tgtctcttgt ttgtctcctg atctgcatct tcacattctg cttcttccgt
     3301 gggctccaga gcgaccgtaa caccattcac aagaacctgt gcatcagcct gtttgtggca
     3361 gaactgctct tcctgattgg gatcaacaga accgaccaac cgattgcctg tgcagtgttt
     3421 gcggctcttt tgcatttctt cttcttggcg gccttcacct ggatgtttct agaaggggta
     3481 cagctgtata tcatgctggt ggaggtcttt gagagtgagc attcccgtag gaagtacttc
     3541 tatctggttg gctacgggat gcccgcactc atcgtggccg tttctgctgc agtcgactac
     3601 aggagctatg gaacagacaa agtatgttgg cttcgccttg acacctactt catttggagt
     3661 tttataggac cagcgacctt gataattatg ctgaatgtaa tcttcctcgg gattgcttta
     3721 tacaaaatgt ttcaccatac tgccatactg aaacctgaat caggctgtct tgataatatc
     3781 aactatgagg ataacagacc cttcatcaag tcatgggtta taggtgcaat agcgctgctc
     3841 tgcctattag gattgacctg ggcctttgga ctcatgtata ttaatgaaag cacagtcatc
     3901 atggcgtatc tcttcaccat tttcaattct ctacagggga tgtttatatt cattttccac
     3961 tgtgtcctac agaagaaggt acggaaagag tatgggaaat gcctacggac gcattgctgt
     4021 agtgggaaaa gcacggagag ttcgattggc tcagggaaaa catctggttc tcgaactcca
     4081 ggacggtatt ccacaggctc acagagccgg attcggagaa tgtggaatga caccgtccga
     4141 aagcagtcag agtcatcctt catcactgga gacataaaca gctcagcgtc gctcaacaga
     4201 ggatcctatc ttccctgcat tcaggcgtgt gtaacatatt tagaggggct tctgaacaat
     4261 gccagggata caagtgtcat ggatactcta ccactgaatg gtaaccatgg caacagttac
     4321 agcattgctg gcggcgaata cctgagcaac tgtgtgcaaa ttatagaccg tggctataac
     4381 cacaacgaga ccgccctaga gaaaaagatc ctaaaggaac tcacttccaa ctatatccct
     4441 tcatacctga acaaccacga gcgctccagc gaacagaacc ggaacatgat gaacaaactg
     4501 gtggacaact taggcagtgg gagtgaagat gacgccatag tcctggatga cgcagcgtcc
     4561 tttaaccacg aggagagtct gggcctggaa ctcattcacg aggaatcgga tgctcccttg
     4621 ctgcccccga gggtttactc caccgataac caccagccac accattacag caggaggcgg
     4681 ctcccccagg accacagcga gagcttcttc cctctgctaa ccgacgagca cacagaagac
     4741 ccgcagtcac cgcacaggga ctctctgtac accagcatgc cggccctggc cggtgtgccc
     4801 gctgcagaca gtgtgaccac cagcacccag accgaagccg cagcggccaa gggtggtgac
     4861 gccgaagatg tttactacaa aagcatgcca aacctgggct ccagaaacca tgtgcacccg
     4921 ctgcacgcct actaccagct agggcgaggc agcagcgatg gattcatagt tcctcccaat
     4981 aaagatgggg cctctccgga ggggacttcc aaaggaccgg cgcacttggt cactagtcta
     5041 tagaaggtga cacggggatg acaaccaacg ggacagctaa cacccggtgg cccattctga
     5101 gtcgatataa gcagtggtca tcgtgtgtaa cacgtgtgtg acatctgatg ctgttctcaa
     5161 aagagagact ctgacatttg gttttttttt ttttttttta acttgaattt ttaggtcagc
     5221 gcaggggaga aagctccccc tgtgccccag tctttcccgt ctttcccctc agatggacac
     5281 ttcattatgt taatgaacga gataagatga aaatggcgct cattgtggcc ttgttgagtt
     5341 aggttgtgat taacagctct gatgctctgt tactagaatc acgaggacct gatttttctt
     5401 tctttttttt tttttaaaaa aaaaagaggc cggaactatt gtttggaatt agtaacaatg
     5461 ctgcatctag attggagtgc tgcccagccg tagaagcaga gcagaactgt atcccatagc
     5521 ggtgcgcggt cactcgcaac ctgagttcac cacagcgagc atagctgtga aaagcaaaag
     5581 caaaacaaca gaattaataa tctgacggtg gggaattcta gaattatatg ctaaatgcat
     5641 attttatgat ttgctgtatt aactgatgat aaaactaatg gcagaaaaaa aaagaattga
     5701 acaatttcta tgtcatgtac agatactagc attgcgcata tagtctgctt tttgttcctc
     5761 cagaatttga gtcctgttaa tgtagtggca aagaagaaat tttccttttc ttttgtgcta
     5821 gtcttgcaag tttgtctacc agtaaaagag caaagtttcc ttcctttctt gttttctttc
     5881 tttttatttg ttcttttgtc ccctctcccc ccaccccacc tttttatttt tcctttaaaa
     5941 attcacctgg caaaaaataa taataataaa taaataaatg aagctatcac tttataagaa
     6001 tcattttcta gtaatgcaaa caaattattt tttaacaaaa aataaaataa aataaataaa
     6061 attagacttc cttccctcca tatatatcta tctatctata tttatccagc ccgagtattt
     6121 ccaatgtcat ttttgcaaat tagagcagga caaattttac atttccaggg cacatctgtt
     6181 gtaatgcgaa gcattatttg gcaagcagtt catcaccaag gcagtagcta tgattctaga
     6241 agctaagagg tgtctataga gctagagggg gcttctgcat gtgaaatgct gtaattcgta
     6301 ggcgttaaaa gtgctgaatg ggcagtctga cccccacgtg ggcacctgca ctaccaattg
     6361 ttagaggaaa ttcactccct cctagtgaga gttgaaaggt caaattattt tgaggtaatt
     6421 cttttttttt aaagttttct gttaacagga aaatttattt atttgacagg attttaagta
     6481 atgtagagat acaaatggta aattagcagc acatataatt ttttttaaat ttatgatcca
     6541 ttttgtatgg tctcaagttg gatgacctca ttactaatat ttgttgtaaa agtgaaactt
     6601 gtttgccgac caataaacaa ctgattgaga tttagaa
//
