LOCUS       NM_152242               3569 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Rattus norvegicus adhesion G protein-coupled receptor G1 (Adgrg1),
            mRNA.
ACCESSION   NM_152242 XM_001081945
VERSION     NM_152242.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3569)
  AUTHORS   Al Hasan,M., Roy,P., Dolan,S., Martin,P.E., Patterson,S. and
            Bartholomew,C.
  TITLE     Adhesion G-protein coupled receptor 56 is required for 3T3-L1
            adipogenesis
  JOURNAL   J Cell Physiol 235 (2), 1601-1614 (2020)
   PUBMED   31304602
  REMARK    GeneRIF: Adhesion G-protein coupled receptor 56 is required for
            3T3-L1 adipogenesis.
REFERENCE   2  (bases 1 to 3569)
  AUTHORS   Chiang,N.Y., Chang,G.W., Huang,Y.S., Peng,Y.M., Hsiao,C.C.,
            Kuo,M.L. and Lin,H.H.
  TITLE     Heparin interacts with the adhesion GPCR GPR56, reduces receptor
            shedding, and promotes cell adhesion and motility
  JOURNAL   J Cell Sci 129 (11), 2156-2169 (2016)
   PUBMED   27068534
REFERENCE   3  (bases 1 to 3569)
  AUTHORS   Bae,B.I., Tietjen,I., Atabay,K.D., Evrony,G.D., Johnson,M.B.,
            Asare,E., Wang,P.P., Murayama,A.Y., Im,K., Lisgo,S.N., Overman,L.,
            Sestan,N., Chang,B.S., Barkovich,A.J., Grant,P.E., Topcu,M.,
            Politsky,J., Okano,H., Piao,X. and Walsh,C.A.
  TITLE     Evolutionarily dynamic alternative splicing of GPR56 regulates
            regional cerebral cortical patterning
  JOURNAL   Science 343 (6172), 764-768 (2014)
   PUBMED   24531968
REFERENCE   4  (bases 1 to 3569)
  AUTHORS   Yang,L., Chen,G., Mohanty,S., Scott,G., Fazal,F., Rahman,A.,
            Begum,S., Hynes,R.O. and Xu,L.
  TITLE     GPR56 Regulates VEGF production and angiogenesis during melanoma
            progression
  JOURNAL   Cancer Res 71 (16), 5558-5568 (2011)
   PUBMED   21724588
REFERENCE   5  (bases 1 to 3569)
  AUTHORS   Luo,R., Jeong,S.J., Jin,Z., Strokes,N., Li,S. and Piao,X.
  TITLE     G protein-coupled receptor 56 and collagen III, a receptor-ligand
            pair, regulates cortical development and lamination
  JOURNAL   Proc Natl Acad Sci U S A 108 (31), 12925-12930 (2011)
   PUBMED   21768377
REFERENCE   6  (bases 1 to 3569)
  AUTHORS   Li,S., Jin,Z., Koirala,S., Bu,L., Xu,L., Hynes,R.O., Walsh,C.A.,
            Corfas,G. and Piao,X.
  TITLE     GPR56 regulates pial basement membrane integrity and cortical
            lamination
  JOURNAL   J Neurosci 28 (22), 5817-5826 (2008)
   PUBMED   18509043
REFERENCE   7  (bases 1 to 3569)
  AUTHORS   Suzuki,G., Kanda,Y., Nibuya,M., Hiramoto,T., Tanaka,T., Shimizu,K.,
            Watanabe,Y. and Nomura,S.
  TITLE     Stress and electroconvulsive seizure differentially alter GPR56
            expression in the adult rat brain
  JOURNAL   Brain Res 1183, 21-31 (2007)
   PUBMED   17945200
  REMARK    GeneRIF: GPR56 is expressed in the ependymal cell layer and in
            immature progenitor cells and that its expression is regulated by
            functional stimulation
REFERENCE   8  (bases 1 to 3569)
  AUTHORS   Xu,L., Begum,S., Hearn,J.D. and Hynes,R.O.
  TITLE     GPR56, an atypical G protein-coupled receptor, binds tissue
            transglutaminase, TG2, and inhibits melanoma tumor growth and
            metastasis
  JOURNAL   Proc Natl Acad Sci U S A 103 (24), 9023-9028 (2006)
   PUBMED   16757564
REFERENCE   9  (bases 1 to 3569)
  AUTHORS   Piao,X., Hill,R.S., Bodell,A., Chang,B.S., Basel-Vanagaite,L.,
            Straussberg,R., Dobyns,W.B., Qasrawi,B., Winter,R.M., Innes,A.M.,
            Voit,T., Ross,M.E., Michaud,J.L., Descarie,J.C., Barkovich,A.J. and
            Walsh,C.A.
  TITLE     G protein-coupled receptor-dependent development of human frontal
            cortex
  JOURNAL   Science 303 (5666), 2033-2036 (2004)
   PUBMED   15044805
REFERENCE   10 (bases 1 to 3569)
  AUTHORS   Liu,M., Parker,R.M., Darby,K., Eyre,H.J., Copeland,N.G.,
            Crawford,J., Gilbert,D.J., Sutherland,G.R., Jenkins,N.A. and
            Herzog,H.
  TITLE     GPR56, a novel secretin-like human G-protein-coupled receptor gene
  JOURNAL   Genomics 55 (3), 296-305 (1999)
   PUBMED   10049584
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CO557428.1, CV116515.1, EX488169.1, CB766806.1, CK482497.1 and
            JAXUCZ010000019.1.
            
            On Oct 26, 2007 this sequence version replaced NM_152242.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.202703.1,
                                           SRR26643291.41191.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840105,
                                           SAMN12840106 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-724               CO557428.1         15-738
            725-1287            CV116515.1         181-743
            1288-1601           EX488169.1         399-712
            1602-1980           CB766806.1         39-417
            1981-2482           CK482497.1         177-678
            2483-3569           JAXUCZ010000019.1  10009983-10011069   c
FEATURES             Location/Qualifiers
     source          1..3569
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p13"
     gene            1..3569
                     /gene="Adgrg1"
                     /gene_synonym="Gpr56"
                     /note="adhesion G protein-coupled receptor G1"
                     /db_xref="GeneID:260326"
                     /db_xref="RGD:628617"
     exon            1..283
                     /gene="Adgrg1"
                     /gene_synonym="Gpr56"
                     /inference="alignment:Splign:2.1.0"
     exon            284..352
                     /gene="Adgrg1"
                     /gene_synonym="Gpr56"
                     /inference="alignment:Splign:2.1.0"
     CDS             289..2352
                     /gene="Adgrg1"
                     /gene_synonym="Gpr56"
                     /EC_number="2.7.11.25"
                     /note="G-protein coupled receptor 56"
                     /codon_start=1
                     /product="adhesion G-protein coupled receptor G1
                     precursor"
                     /protein_id="NP_689448.2"
                     /db_xref="GeneID:260326"
                     /db_xref="RGD:628617"
                     /translation="MAVQVLLQMVYFLLTLLFLVQGAHGASPREDFRFCGQRNQTRQS
                     NLHYDQTSEPHIFVWNTDESLTIRAPFPAAPDIPYFFPEPRGLYHFCLYWSRHTGRLH
                     LRYGKNDYLLSSRASNLLCYRKQEESLKQGAPLVATSVSSWQSPQNTSLPGAPSFIFS
                     FHNAPHKVSHNASVNMCDLKKELQLLSKFLQHPHKASKRPSAAFISQQLQNLESKLTS
                     VSFLGDTLSFEENRVNATVWKLPPTAGLEDLQIHSQQEEEQSEVQAYSVLLPRAVFQQ
                     TRGRRRDAAKRLLVVDFSSQALFQDKNSSQVLGEKVLGIVVQNTKVTNLSDPVVLTFQ
                     HQPQPKNVTLQCVFWVEDPTSSSPGSWSSEGCETVSRDTQTSCLCNHLTYFAVLMVSS
                     MEVEATHKHYLTLLSYVGCVISALACVFTIAAYLCTRRKSRDYTIKVHMNLLLAVFLL
                     DVSFLLSEPVALMGSEAACRTSAMFLHFSLLACLSWMGLEGYNLYRLVVEVFGTYVPG
                     YLLKLSTVGWGFPVFLVTLVALVDVNNYGPIILAVRRTPDHVIYPSMCWIRDSVVSYV
                     TNLGLFSLVILFNMAMLATMVVQILRLRPHSQKWPHVLTLLGLSLVLGLPWALVFFSF
                     ASGTFQLVIIYLFSIMTSFQGFLIFLWYWSMRFQAQGGPSPLKNNSDSAKLPISSGST
                     SSSRI"
     exon            353..775
                     /gene="Adgrg1"
                     /gene_synonym="Gpr56"
                     /inference="alignment:Splign:2.1.0"
     exon            776..908
                     /gene="Adgrg1"
                     /gene_synonym="Gpr56"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1056
                     /gene="Adgrg1"
                     /gene_synonym="Gpr56"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1188
                     /gene="Adgrg1"
                     /gene_synonym="Gpr56"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1305
                     /gene="Adgrg1"
                     /gene_synonym="Gpr56"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1351
                     /gene="Adgrg1"
                     /gene_synonym="Gpr56"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1455
                     /gene="Adgrg1"
                     /gene_synonym="Gpr56"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1574
                     /gene="Adgrg1"
                     /gene_synonym="Gpr56"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1843
                     /gene="Adgrg1"
                     /gene_synonym="Gpr56"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1952
                     /gene="Adgrg1"
                     /gene_synonym="Gpr56"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2221
                     /gene="Adgrg1"
                     /gene_synonym="Gpr56"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..3569
                     /gene="Adgrg1"
                     /gene_synonym="Gpr56"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaccgtgtg atcccagcct cccacaaggc agctcttact aaccagggaa gagatgccaa
       61 aagtccacgg aggctgaaga ccctgtaaag cttcgccaga aaacctagga gtgttcgagg
      121 gcacttggca ccggaagcta gacctgtagg cggagcctca cctgggttga gttcacagct
      181 gcctagacag gctcagacta ggtgctgggc acctggaagg aggaggcaga ggcaccagca
      241 gtaaagccta tctatcaaca gaagggcctg cctaggcttg gaggtataat ggctgtccag
      301 gtgctactgc agatggtcta cttcctactg actctgctct ttctggtgca aggtgcccat
      361 ggtgccagcc cccgagaaga cttccgcttc tgtggccagc ggaaccagac acgtcagagc
      421 aacctccatt atgatcaaac ttcagagcct cacatttttg tatggaacac agacgagagc
      481 ctcacgatcc gtgccccatt cccggcagcc ccagacattc cctacttctt cccggaacct
      541 agaggactct atcatttctg cctctactgg agccgccaca ctgggaggct ccacctgcgc
      601 tatggcaaga atgattacct gcttagtagc cgagcctcca acctcctctg ctaccggaaa
      661 caggaggaga gcctgaaaca gggggctcca ctggttgcca cctctgtcag ctcctggcag
      721 agcccacaga acaccagcct gccgggagct ccaagcttca tcttctcctt ccataatgcc
      781 ccacataagg tctcccacaa tgcatctgtg aacatgtgtg acctcaagaa ggaactgcag
      841 ttgcttagca agttcctgca gcatcctcac aaggcctcca agcggccctc ggcagcgttc
      901 atcagtcagc agttgcagaa cctagagtca aagctgacct ccgtgagctt cctgggagac
      961 acactgtctt ttgaggagaa ccgggtcaat gccacagtgt ggaagctgcc acccacagcc
     1021 gggctggagg atctgcaaat ccactcccag caggaggagg agcagagtga ggtccaggcc
     1081 tactccgtgt tgcttccccg ggccgtattc cagcagacca gaggccgtcg ccgggatgcc
     1141 gccaagaggc tcctggtagt cgacttcagc agccaagctt tgttccagga caagaattct
     1201 agccaagtcc tgggtgagaa ggtcttgggt atcgtcgtgc agaacaccaa agtcactaac
     1261 ctctcagatc ccgtggtact caccttccag caccagccac agccaaagaa cgtgactctg
     1321 cagtgtgtgt tctgggttga agacccgaca tcaagcagcc ctgggagctg gagcagtgag
     1381 ggctgtgaga ctgttagcag agacacacag acatcctgcc tgtgtaacca tctgacctac
     1441 tttgcagtgc tgatggtgtc atccatggag gtagaagcca ctcacaaaca ctacctcacg
     1501 ctcctgtcct acgtgggctg tgtcatctct gccctagctt gtgtcttcac catcgctgcg
     1561 tacctgtgca ccaggaggaa gtcacgtgac tacaccatca aagtgcacat gaacctgctt
     1621 ctggccgtct tcctcctgga cgtgagcttc ctgctcagtg agcccgtggc gctgatgggc
     1681 tctgaagcag cctgtcgcac cagtgccatg ttcctgcact tctccctgct tgcctgcctc
     1741 tcctggatgg gcctggaggg ctacaatctc taccgactgg tggtggaggt cttcggtacc
     1801 tatgtccctg gctatctgct caagctgagc accgtgggct ggggttttcc tgtcttcctg
     1861 gtcactctgg tggcgttggt cgacgtgaat aactatggcc ccatcatcct agctgtgcgc
     1921 cggactccgg accatgtcat ctacccctct atgtgctgga tccgggactc tgtagttagc
     1981 tatgtcacta acctgggcct cttcagcctg gtgatcctgt tcaacatggc tatgctggcc
     2041 accatggtgg tgcagatcct gcggcttcgc ccacacagcc agaagtggcc ccacgtgctg
     2101 actttgctgg gcctcagcct ggtccttggc cttccctggg ccttggtctt cttttccttt
     2161 gcttctggta ccttccagct tgtcatcatc taccttttca gcatcatgac ttccttccaa
     2221 ggcttcctca tcttcctgtg gtactggtcc atgaggttcc aggcccaagg cggtccctct
     2281 cctctgaaga acaattcaga cagcgccaag ctccccatca gctccggcag cacctcttcc
     2341 agccgcatct aggccaccgc cacacctccc ctcccctctg gggttggggg tgcacatgca
     2401 tggcgtctgc tcacattgtc tgtggcctgg tgctgtgccc agccttggtt ggttagtggc
     2461 atactagaga aggccctggt ccttgaaggg gtaggactgt tgctctggta ggtagatacc
     2521 tagcttgcct tggggatcac tctggtcccc aaaggactca gaagcacact gccattccgt
     2581 ttgtgggcct gccctatttc agcccggagc tgaggccttg tctttctggc cacctctggg
     2641 tccagctgtt gctgctgggt gttgagacct gcaggcccaa gctagggtta gatcttgaag
     2701 gaggctgaca catccagcct gagacacagc tgccttggct cttgctgctc tgtctctgtg
     2761 gtcaccacgc agatcaggag gttggcactg ggggtaaatg gactgggagg aggttaggag
     2821 ctgagcatct tccaaacctg tctgtaactc cttctcttca ttccccacct caccccctcc
     2881 tctgtggtcc cctagcactc tacctgcatc ctggggtcct agaccagtgc tgtgattagg
     2941 ggtagtagtt cccaggagtt ttcctggtgc cagctataaa cttctgtcta ttgtgtgggc
     3001 tttggcctct gactcagggc aggttcctgg gctgaaccag gccaacctgt ctgagcctct
     3061 ctccaagctg cctcatcttt gttcacacct cagaggggcc accgcctctc ctgaagactc
     3121 cctctggcaa gaactgtggg atacagccta cttttcaacc cagcattccg aagaccaaga
     3181 cggcaccctc tggtgacagt ggccaagctt gatgctctcc tgagaagtgg tcttcaaatc
     3241 cctgtgggtg tatctgaaga tactgggctt gcctgtcgtg aattctgtct tgctaacata
     3301 cagtgagggg acccccccgc cccccacgaa agctctcacg aagtcctgga gctttaggca
     3361 tggggctgag aatccaggag gacttcctgc aggaggcagc gtttcatctt gacctcagcc
     3421 ttctagttgg ggaggaggat gttctttttt aaagaccagt tcatttgtct tttgatatta
     3481 aagctctttg tagagagttt ggaaactgta ggagattgtt gagaagaaaa ataaaaatca
     3541 gctgttatct aatgccatgg taaaaagca
//
