LOCUS       NM_139110               4945 bp    mRNA    linear   ROD 07-DEC-2024
DEFINITION  Rattus norvegicus adhesion G protein-coupled receptor F5 (Adgrf5),
            mRNA.
ACCESSION   NM_139110
VERSION     NM_139110.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4945)
  AUTHORS   Lu,S., Liu,S., Wietelmann,A., Kojonazarov,B., Atzberger,A.,
            Tang,C., Schermuly,R.T., Grone,H.J. and Offermanns,S.
  TITLE     Developmental vascular remodeling defects and postnatal kidney
            failure in mice lacking Gpr116 (Adgrf5) and Eltd1 (Adgrl4)
  JOURNAL   PLoS One 12 (8), e0183166 (2017)
   PUBMED   28806758
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4945)
  AUTHORS   Ariestanti,D.M., Ando,H., Hirose,S. and Nakamura,N.
  TITLE     Targeted Disruption of Ig-Hepta/Gpr116 Causes Emphysema-like
            Symptoms That Are Associated with Alveolar Macrophage Activation
  JOURNAL   J Biol Chem 290 (17), 11032-11040 (2015)
   PUBMED   25778400
REFERENCE   3  (bases 1 to 4945)
  AUTHORS   Bridges,J.P., Ludwig,M.G., Mueller,M., Kinzel,B., Sato,A., Xu,Y.,
            Whitsett,J.A. and Ikegami,M.
  TITLE     Orphan G protein-coupled receptor GPR116 regulates pulmonary
            surfactant pool size
  JOURNAL   Am J Respir Cell Mol Biol 49 (3), 348-357 (2013)
   PUBMED   23590306
REFERENCE   4  (bases 1 to 4945)
  AUTHORS   Yang,M.Y., Hilton,M.B., Seaman,S., Haines,D.C., Nagashima,K.,
            Burks,C.M., Tessarollo,L., Ivanova,P.T., Brown,H.A., Umstead,T.M.,
            Floros,J., Chroneos,Z.C. and St Croix,B.
  TITLE     Essential regulation of lung surfactant homeostasis by the orphan G
            protein-coupled receptor GPR116
  JOURNAL   Cell Rep 3 (5), 1457-1464 (2013)
   PUBMED   23684610
REFERENCE   5  (bases 1 to 4945)
  AUTHORS   Nie,T., Hui,X., Gao,X., Li,K., Lin,W., Xiang,X., Ding,M., Kuang,Y.,
            Xu,A., Fei,J., Wang,Z. and Wu,D.
  TITLE     Adipose tissue deletion of Gpr116 impairs insulin sensitivity
            through modulation of adipose function
  JOURNAL   FEBS Lett 586 (20), 3618-3625 (2012)
   PUBMED   22971422
REFERENCE   6  (bases 1 to 4945)
  AUTHORS   Abe,J., Fukuzawa,T. and Hirose,S.
  TITLE     Cleavage of Ig-Hepta at a 'SEA' module and at a conserved G
            protein-coupled receptor proteolytic site
  JOURNAL   J Biol Chem 277 (26), 23391-23398 (2002)
   PUBMED   11973329
REFERENCE   7  (bases 1 to 4945)
  AUTHORS   Abe,J., Suzuki,H., Notoya,M., Yamamoto,T. and Hirose,S.
  TITLE     Ig-hepta, a novel member of the G protein-coupled hepta-helical
            receptor (GPCR) family that has immunoglobulin-like repeats in a
            long N-terminal extracellular domain and defines a new subfamily of
            GPCRs
  JOURNAL   J Biol Chem 274 (28), 19957-19964 (1999)
   PUBMED   10391944
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 27, 2020 this sequence version replaced NM_139110.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB019120.1, SRR26643429.33229.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760433,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               JAXUCZ010000009.1  25121084-25121237   c
            155-280             JAXUCZ010000009.1  25079208-25079333   c
            281-335             JAXUCZ010000009.1  25072158-25072212   c
            336-494             JAXUCZ010000009.1  25053326-25053484   c
            495-671             JAXUCZ010000009.1  25051352-25051528   c
            672-781             JAXUCZ010000009.1  25051126-25051235   c
            782-840             JAXUCZ010000009.1  25049138-25049196   c
            841-986             JAXUCZ010000009.1  25048378-25048523   c
            987-1208            JAXUCZ010000009.1  25046817-25047038   c
            1209-1412           JAXUCZ010000009.1  25044747-25044950   c
            1413-1583           JAXUCZ010000009.1  25037897-25038067   c
            1584-1793           JAXUCZ010000009.1  25035513-25035722   c
            1794-2012           JAXUCZ010000009.1  25033703-25033921   c
            2013-2168           JAXUCZ010000009.1  25031012-25031167   c
            2169-2377           JAXUCZ010000009.1  25029935-25030143   c
            2378-2557           JAXUCZ010000009.1  25027252-25027431   c
            2558-3961           JAXUCZ010000009.1  25022991-25024394   c
            3962-4003           JAXUCZ010000009.1  25021889-25021930   c
            4004-4063           JAXUCZ010000009.1  25021738-25021797   c
            4064-4148           JAXUCZ010000009.1  25021137-25021221   c
            4149-4945           JAXUCZ010000009.1  25018277-25019073   c
FEATURES             Location/Qualifiers
     source          1..4945
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q13"
     gene            1..4945
                     /gene="Adgrf5"
                     /gene_synonym="Gpr116; Gprhep; Ig-Hepta"
                     /note="adhesion G protein-coupled receptor F5"
                     /db_xref="GeneID:245977"
                     /db_xref="RGD:621679"
     exon            1..154
                     /gene="Adgrf5"
                     /gene_synonym="Gpr116; Gprhep; Ig-Hepta"
                     /inference="alignment:Splign:2.1.0"
     exon            155..280
                     /gene="Adgrf5"
                     /gene_synonym="Gpr116; Gprhep; Ig-Hepta"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..4228
                     /gene="Adgrf5"
                     /gene_synonym="Gpr116; Gprhep; Ig-Hepta"
                     /note="probable G-protein coupled receptor 116; G-protein
                     coupled hepta-helical receptor Ig-hepta; G protein-coupled
                     hepta-helical receptor Ig-Hepta"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor F5
                     precursor"
                     /protein_id="NP_620810.1"
                     /db_xref="GeneID:245977"
                     /db_xref="RGD:621679"
                     /translation="MKSSRTVTLYFVLIVICSSEATWSRPAEPIVHPLILQEHELAGE
                     ELLRPKRAVAVGGPVAEEYTVDVEISFENVSFLESIRAHLNSLRFPVQGNGTDILSMA
                     MTTVCTPTGNDLLCFCEKGYQWPEERCLSSLTCQEHDSALPGRYCNCLKGLPPQGPFC
                     QLPETYITLKIKVRLNIGFQEDLENTSSALYRSYKTDLERAFRAGYRTLPGFRSVTVT
                     QFTKGSVVVDYIVEVASAPLPGSIHKANEQVIQNLNQTYKMDYNSFQGTPSNETKFTV
                     TPEFIFEGDNVTLECESEFVSSNTSWFYGEKRSDIQNSDKFSIHTSIINNISLVTRLT
                     IFNFTQHDAGLYGCNVTLDIFEYGTVRKLDVTPIRILAKEERKVVCDNNPISLNCCSE
                     NIANWSRIEWKQEGKINIEGTPETDLESSCSTYTLKADGTQCPSGSSGTTVIYTCEFV
                     SVYGAKGSKNIAVTFTSVANLTITPDPISVSEGQSFSITCLSDVSSFDEVYWNTSAGI
                     KIHPRFYTMRRYRDGAESVLTVKTSTREWNGTYHCIFRYKNSYSIATKDVTVHPLPLE
                     SDIMMDPLEASGLCTSSHQFKCCIEENDGEEYIVTFHVDSSSFPAEREVIGKQACYTY
                     SLPGKLPSRCPKDIDVFCHFTNAANSSVRSPSMKLTLVPGKNITCQDPIIGIGEPGKV
                     IQKLCQFAGVSRSPGQTIGGTVTYKCVGSQWKEETRACISAPINGLLQLAKALIKSPS
                     QDQKLPKYLRDLSVSTGKEEQDIRSSPGSLGAIISILDLLSTVPTQVNSEMMRDILAT
                     INVILDKSTLNSWEKLLQQQSNQSSQFLQSVERFSKALELGDSTPPFLFHPNVQMKSM
                     VIKRGHAQMYQQKFVFTDSDLWGDVAIDECQLGSLQPDSSIVTVAFPTLKAILAQDGQ
                     RKTPSNSLVMTTTVSHNIVKPFRISMTFKNNHRSGGKPQCVFWNFSLANNTGGWDSSG
                     CTVEDDGRDNRDRVFCKCNHLTSFSILMSPDSPDPGSLLKILLDIISYIGLGFSIVSL
                     AACLVVEAMVWKSVTKNRTSYMRHICIVNIALCLLIADIWFIVAGAIHDGHYPLNETA
                     CVAATFFIHFFYLSVFFWMLTLGLMLFYRLIFILHDASKSTQKAIAFSLGYGCPLIIS
                     SITVGVTQPQEVYMRKNACWLNWEDTRALLAFAIPALIIVVVNVSITVVVITKILRPS
                     VGDKPGKQEKSSLFQISKSIGVLTPLLGLTWGFGLATVIQGSNAVFHIIFTLLNAFQG
                     LFILLFGCLWDQKVQEALLHKFSLSRWSSQHSKSTSLGSSTPVFSMSSPISRRFNNLF
                     GKTGTYNVSTPETTSSSVENSSSAYSLLN"
     exon            281..335
                     /gene="Adgrf5"
                     /gene_synonym="Gpr116; Gprhep; Ig-Hepta"
                     /inference="alignment:Splign:2.1.0"
     exon            336..494
                     /gene="Adgrf5"
                     /gene_synonym="Gpr116; Gprhep; Ig-Hepta"
                     /inference="alignment:Splign:2.1.0"
     exon            495..671
                     /gene="Adgrf5"
                     /gene_synonym="Gpr116; Gprhep; Ig-Hepta"
                     /inference="alignment:Splign:2.1.0"
     exon            672..781
                     /gene="Adgrf5"
                     /gene_synonym="Gpr116; Gprhep; Ig-Hepta"
                     /inference="alignment:Splign:2.1.0"
     exon            782..840
                     /gene="Adgrf5"
                     /gene_synonym="Gpr116; Gprhep; Ig-Hepta"
                     /inference="alignment:Splign:2.1.0"
     exon            841..986
                     /gene="Adgrf5"
                     /gene_synonym="Gpr116; Gprhep; Ig-Hepta"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1208
                     /gene="Adgrf5"
                     /gene_synonym="Gpr116; Gprhep; Ig-Hepta"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1412
                     /gene="Adgrf5"
                     /gene_synonym="Gpr116; Gprhep; Ig-Hepta"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1583
                     /gene="Adgrf5"
                     /gene_synonym="Gpr116; Gprhep; Ig-Hepta"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1793
                     /gene="Adgrf5"
                     /gene_synonym="Gpr116; Gprhep; Ig-Hepta"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..2012
                     /gene="Adgrf5"
                     /gene_synonym="Gpr116; Gprhep; Ig-Hepta"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2168
                     /gene="Adgrf5"
                     /gene_synonym="Gpr116; Gprhep; Ig-Hepta"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2377
                     /gene="Adgrf5"
                     /gene_synonym="Gpr116; Gprhep; Ig-Hepta"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2557
                     /gene="Adgrf5"
                     /gene_synonym="Gpr116; Gprhep; Ig-Hepta"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..3961
                     /gene="Adgrf5"
                     /gene_synonym="Gpr116; Gprhep; Ig-Hepta"
                     /inference="alignment:Splign:2.1.0"
     exon            3962..4003
                     /gene="Adgrf5"
                     /gene_synonym="Gpr116; Gprhep; Ig-Hepta"
                     /inference="alignment:Splign:2.1.0"
     exon            4004..4063
                     /gene="Adgrf5"
                     /gene_synonym="Gpr116; Gprhep; Ig-Hepta"
                     /inference="alignment:Splign:2.1.0"
     exon            4064..4148
                     /gene="Adgrf5"
                     /gene_synonym="Gpr116; Gprhep; Ig-Hepta"
                     /inference="alignment:Splign:2.1.0"
     exon            4149..4945
                     /gene="Adgrf5"
                     /gene_synonym="Gpr116; Gprhep; Ig-Hepta"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 taaagtctga tctactgaaa ctctaccctc ctcaggctgc ctgaatgaat gggacacctt
       61 taagtttcac ctcacctccg aggtctgcag tgcgctcttc tattttacca cacagaagta
      121 aatctgagga ggctgcccag tgctgaagag aaaggcaaag ccactcaaac ctgaagaaat
      181 gaaatcgtca aggactgtca cgctctactt tgtgcttatt gtgatttgtt cctcagaagc
      241 tacatggagc aggccagcag agcccattgt ccatcctttg attctccaag aacatgaact
      301 agcaggggaa gagctactga ggccaaaaag agcagttgca gtgggtggtc ctgtggcaga
      361 agaatacacc gtggatgttg agatcagttt tgaaaatgtc tccttcctgg agtccatcag
      421 agctcactta aacagcctcc gttttccagt tcaggggaac ggcactgaca ttttgagtat
      481 ggcaatgact acagtctgca ctcctactgg gaatgacctc ttgtgcttct gcgagaaagg
      541 ctaccagtgg cctgaggaaa ggtgtctctc ctctctcact tgtcaagagc atgacagcgc
      601 cctgccaggc cgatactgca attgtctgaa aggacttcct ccccaaggac ctttctgcca
      661 gctcccagaa acatacatta ccttaaaaat caaagtcaga ctgaacatag gatttcaaga
      721 agacctagag aacacatcct ctgccctcta taggtcctac aagactgatc tggaaagagc
      781 gttccgagcg ggttacagaa ctttaccagg attcagatcg gtgactgtga cacagttcac
      841 caagggcagc gtggttgtgg actacatagt cgaggttgca tcggcaccac tgcctggatc
      901 aattcataaa gccaatgagc aagtcataca gaacctcaac cagacttaca aaatggacta
      961 caactccttc caaggaacac caagcaatga aacaaagttc actgtgacac cagagttcat
     1021 ctttgaagga gacaatgtaa ctctggaatg cgaaagtgaa ttcgtgtcct ccaacacatc
     1081 ttggttctat ggagaaaaac ggtctgacat ccagaacagt gacaaattct ccattcacac
     1141 ctcaatcatc aacaatataa gcctggtcac ccgcctcact attttcaact tcacacagca
     1201 tgatgcaggc ttatatggtt gcaatgtgac actggatatt tttgaatatg ggacagtcag
     1261 aaaattagat gtcactccca tccggatttt ggccaaggaa gagagaaagg tggtgtgtga
     1321 caataaccct atatcgttga actgctgcag cgagaatatc gcgaactgga gcagaatcga
     1381 gtggaaacag gaggggaaaa taaacattga agggacccca gaaacagacc tagagtctag
     1441 ctgcagcact tatacactca aggcagatgg aacccagtgt cccagtggtt cttctggaac
     1501 aacagtcatc tacacatgtg agttcgtcag cgtctacgga gccaaaggca gtaagaacat
     1561 agccgtgacc ttcacctctg tagccaacct aacaataacc ccggacccaa tttctgtttc
     1621 tgagggacaa agcttttcta taacttgcct cagcgatgtg agtagctttg atgaggtgta
     1681 ctggaacact tccgctggta ttaaaatcca tccaaggttt tataccatga ggaggtatcg
     1741 ggatggagca gagtcggtgc tgacggtgaa gacctccacc agagagtgga acggaaccta
     1801 ccactgcata tttagatata agaattcata cagcatagcc accaaagatg tcactgttca
     1861 ccctctgcct ctggagtcag acatcatgat ggatcctttg gaagccagtg gtctgtgcac
     1921 cagttcccat cagttcaagt gctgcataga agagaacgat ggggaagagt acattgtgac
     1981 tttccacgtg gattcctcat cctttcctgc tgaaagagaa gttattggca agcaggcatg
     2041 ctacacatac agtctcccag gaaagttacc atcacggtgt cccaaagaca ttgacgtgtt
     2101 ctgccacttt accaatgcag ccaacagctc agtccggagc ccatctatga agcttaccct
     2161 tgttccaggg aagaatatca catgccagga tcccatcata ggtattgggg aacctgggaa
     2221 agtcatccag aagctgtgcc agtttgcagg tgtttctaga agccctggac agaccattgg
     2281 tggaaccgtc acttataaat gtgtaggctc ccagtggaag gaggagacaa gggcctgcat
     2341 atcagcccca atcaatggtt tgctccagtt ggccaaggct ttgatcaaga gcccctccca
     2401 ggatcagaag ctccctaaat acctgcggga cctttctgtt agcactggga aggaagaaca
     2461 ggatatacgc tcgtcgcccg ggagcctggg agccatcatc agcatccttg atttgctttc
     2521 aacagttccc actcaagtga attcagaaat gatgagggat atacttgcta ccattaatgt
     2581 catcttagac aagtccacct tgaactcctg ggagaagtta ctacagcaac agagcaacca
     2641 gagctctcag ttcctgcagt cagtggagag gttttccaaa gcgctcgagc tgggagacag
     2701 cacccctccc ttcctcttcc accctaatgt tcagatgaag agcatggtga taaaacgtgg
     2761 ccacgcccaa atgtaccaac agaaatttgt cttcacagac tctgacctat ggggtgatgt
     2821 agccattgat gagtgtcagc tgggaagctt gcagcctgat tcatcgatcg ttactgtggc
     2881 tttcccaact ctcaaagcca tcctggccca ggatggacag agaaagacac cctccaacag
     2941 cctagtaatg accaccactg tcagccataa tatcgtcaag ccttttagga tttctatgac
     3001 attcaagaac aaccatcgtt cgggtggcaa gccacagtgt gtcttctgga acttcagcct
     3061 tgccaataat acagggggct gggatagcag tgggtgcact gtggaagatg atggtaggga
     3121 caatagggac agagtcttct gcaagtgtaa ccacctgacg tcattctcca ttctcatgtc
     3181 cccagactcc ccagacccag gatctctttt aaaaatactt ctggatatca tttcttacat
     3241 cgggttgggc ttttccatag tcagcttagc tgcctgtcta gttgtggaag ccatggtgtg
     3301 gaaatcagtg accaagaacc gaacttccta tatgcgccac atctgcatcg tcaacattgc
     3361 cctttgcctt ctgattgctg acatctggtt cattgtggct ggtgctatcc atgatgggca
     3421 ttacccactc aacgaaacag cctgtgtggc cgccacattc ttcattcact tcttctacct
     3481 cagtgtcttc ttctggatgc taactctggg cctcatgctc ttctaccggc tgattttcat
     3541 tctacatgac gcgagcaagt ccacgcagaa agccattgcc ttttctctag gctatggctg
     3601 tccactcatt atctcatcca tcacagtggg ggttacacag ccacaggaag tttacatgag
     3661 gaagaatgca tgttggctca actgggagga caccagagca ctgctggctt ttgccatccc
     3721 agcgttgatt attgtggtgg tgaacgtgag catcacagtt gtggtcatca ccaagatcct
     3781 aaggccctcc gtcggagaca agccaggcaa gcaggagaag agcagcctat tccagatcag
     3841 caagagcatt ggagtcctca cgccactctt ggggctcact tggggttttg gtctggccac
     3901 agtgatccag gggagcaatg ctgtgttcca catcatattt actctcctca atgcctttca
     3961 ggggctcttc attttgctct ttggctgcct ctgggatcag aaggtacagg aagctttgct
     4021 gcataagttt tcattgtcaa ggtggtcttc tcaacactca aagtcaacat ccttaggttc
     4081 atcaacacct gtgttttcga tgagttctcc gatatcccga agatttaata atctttttgg
     4141 taaaacagga acatataacg tttccacccc agagacaacc agctcatccg tggaaaattc
     4201 ctctagtgct tactcattgc tcaactagga ccagataatg ccaaattcac aggagctctc
     4261 agaaataggg cccctgccaa gaaaagggac ccatatccaa atctatgggt aaagtgttct
     4321 ctctgcagac ttctgggagc agatgctgaa gagactcttt gaatagagaa gatgctttct
     4381 tttgtaaaga cagactaaat gtttaatttt gctcccaccc ctatcccttg tgtaatgcca
     4441 aatatgtata gtatttaaaa gaaccctccc acaaggctca acctttctct gtgtattgta
     4501 aaatagaaaa ttgagagttt tacacacaca cacacacaca cacacacaca cacacacaca
     4561 caccccattg gctacaaaga taaaagctga ttgaaacagt aagtaaaaag tgagtatcca
     4621 gaatttcagt gaattcaaga aaggaaggag tggggagggg agagaaagga tgatataatg
     4681 gaaggtagga atgaagggaa ggagggaggg gtgagatagg aaggaaggaa ggatgatgta
     4741 gaaaacgtta gggagcacat caatttccac aattgtgatc taatatggct actcatctac
     4801 cacagccctg ggaatgaaat atatggctta aaaaaggaaa atgagatgaa accatgggga
     4861 atgtaggtaa gtttctgatc tttccctggc taaaaggata aaagacagag gagggaaagt
     4921 agaaaagaaa gtaggaggga aagat
//
