LOCUS       NM_001164103            4194 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus adducin 3 (Add3), transcript variant 1, mRNA.
ACCESSION   NM_001164103
VERSION     NM_001164103.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4194)
  AUTHORS   Fan,L., Gao,W., Liu,Y., Jefferson,J.R., Fan,F. and Roman,R.J.
  TITLE     Knockout of gamma-Adducin Promotes
            NG-Nitro-L-Arginine-Methyl-Ester-Induced Hypertensive Renal Injury
  JOURNAL   J Pharmacol Exp Ther 377 (1), 189-198 (2021)
   PUBMED   33414130
  REMARK    GeneRIF: Knockout of gamma-Adducin Promotes
            N(G)-Nitro-L-Arginine-Methyl-Ester-Induced Hypertensive Renal
            Injury.
REFERENCE   2  (bases 1 to 4194)
  AUTHORS   Gao,W., Liu,Y., Fan,L., Zheng,B., Jefferson,J.R., Wang,S.,
            Zhang,H., Fang,X., Nguyen,B.V., Zhu,T., Roman,R.J. and Fan,F.
  TITLE     Role of gamma-adducin in actin cytoskeleton rearrangements in
            podocyte pathophysiology
  JOURNAL   Am J Physiol Renal Physiol 320 (1), F97-F113 (2021)
   PUBMED   33308016
  REMARK    GeneRIF: Role of gamma-adducin in actin cytoskeleton rearrangements
            in podocyte pathophysiology.
            GeneRIF: Reduced ADD3 function in FHH rats alters baseline podocyte
            pathophysiology by rearrangement of the actin cytoskeleton at the
            onset of proteinuria in young animals.
REFERENCE   3  (bases 1 to 4194)
  AUTHORS   Fan,F., Geurts,A.M., Pabbidi,M.R., Ge,Y., Zhang,C., Wang,S.,
            Liu,Y., Gao,W., Guo,Y., Li,L., He,X., Lv,W., Muroya,Y., Hirata,T.,
            Prokop,J., Booz,G.W., Jacob,H.J. and Roman,R.J.
  TITLE     A Mutation in gamma-Adducin Impairs Autoregulation of Renal Blood
            Flow and Promotes the Development of Kidney Disease
  JOURNAL   J Am Soc Nephrol 31 (4), 687-700 (2020)
   PUBMED   32029431
  REMARK    GeneRIF: A Mutation in gamma-Adducin Impairs Autoregulation of
            Renal Blood Flow and Promotes the Development of Kidney Disease.
            GeneRIF: A mutation in ADD3 that alters ACTIN binding causes renal
            vascular dysfunction and promotes the susceptibility to kidney
            disease.
REFERENCE   4  (bases 1 to 4194)
  AUTHORS   Fan,F., Pabbidi,M.R., Ge,Y., Li,L., Wang,S., Mims,P.N. and
            Roman,R.J.
  TITLE     Knockdown of Add3 impairs the myogenic response of renal afferent
            arterioles and middle cerebral arteries
  JOURNAL   Am J Physiol Renal Physiol 312 (6), F971-F981 (2017)
   PUBMED   27927653
  REMARK    GeneRIF: Add3 may play a causal role in the impaired myogenic
            response and autoregulation in the renal and cerebral circulation
            in hypertensive rats.
            GeneRIF: Mutation of Add3 may play a causal role in the impaired
            myogenic response and blood flow autoregulation in the renal and
            cerebral circulation.
REFERENCE   5  (bases 1 to 4194)
  AUTHORS   Revenu,C., Ubelmann,F., Hurbain,I., El-Marjou,F., Dingli,F.,
            Loew,D., Delacour,D., Gilet,J., Brot-Laroche,E., Rivero,F.,
            Louvard,D. and Robine,S.
  TITLE     A new role for the architecture of microvillar actin bundles in
            apical retention of membrane proteins
  JOURNAL   Mol Biol Cell 23 (2), 324-336 (2012)
   PUBMED   22114352
REFERENCE   6  (bases 1 to 4194)
  AUTHORS   Tripodi,G., Szpirer,C., Reina,C., Szpirer,J. and Bianchi,G.
  TITLE     Polymorphism of gamma-adducin gene in genetic hypertension and
            mapping of the gene to rat chromosome 1q55
  JOURNAL   Biochem Biophys Res Commun 237 (3), 685-689 (1997)
   PUBMED   9299427
REFERENCE   7  (bases 1 to 4194)
  AUTHORS   Dong,L., Chapline,C., Mousseau,B., Fowler,L., Ramsay,K.,
            Stevens,J.L. and Jaken,S.
  TITLE     35H, a sequence isolated as a protein kinase C binding protein, is
            a novel member of the adducin family
  JOURNAL   J Biol Chem 270 (43), 25534-25540 (1995)
   PUBMED   7592723
REFERENCE   8  (bases 1 to 4194)
  AUTHORS   Chapline,C., Ramsay,K., Klauck,T. and Jaken,S.
  TITLE     Interaction cloning of protein kinase C substrates
  JOURNAL   J Biol Chem 268 (10), 6858-6861 (1993)
   PUBMED   8463212
REFERENCE   9  (bases 1 to 4194)
  AUTHORS   Lebowitz,M.S. and Pedersen,P.L.
  TITLE     Regulation of the mitochondrial ATP synthase/ATPase complex: cDNA
            cloning, sequence, overexpression, and secondary structural
            characterization of a functional protein inhibitor
  JOURNAL   Arch Biochem Biophys 301 (1), 64-70 (1993)
   PUBMED   8442667
REFERENCE   10 (bases 1 to 4194)
  AUTHORS   Pinto-Correia,C., Goldstein,E.G., Bennett,V. and Sobel,J.S.
  TITLE     Immunofluorescence localization of an adducin-like protein in the
            chromosomes of mouse oocytes
  JOURNAL   Dev Biol 146 (2), 301-311 (1991)
   PUBMED   1864459
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB757924.1, U35775.1, FM038946.1, FM072500.1, AW141606.1,
            CB725075.1, CK596161.1, FM059497.1, CF111029.1 and AA899625.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                CB757924.1         50-79
            31-128              CB757924.1         81-178
            129-129             CB757924.1         180-180
            130-201             U35775.1           46-117
            202-457             FM038946.1         271-526
            458-838             FM072500.1         293-673
            839-1224            AW141606.1         1-386               c
            1225-1912           U35775.1           1142-1829
            1913-2087           CB725075.1         319-493
            2088-2315           U35775.1           1909-2136
            2316-2887           CK596161.1         103-674
            2888-3277           FM059497.1         340-729
            3278-3925           CF111029.1         841-1488
            3926-4194           AA899625.1         1-269               c
FEATURES             Location/Qualifiers
     source          1..4194
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..4194
                     /gene="Add3"
                     /note="adducin 3"
                     /db_xref="GeneID:25230"
                     /db_xref="RGD:2043"
     exon            1..199
                     /gene="Add3"
                     /inference="alignment:Splign:2.1.0"
     exon            200..411
                     /gene="Add3"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..2334
                     /gene="Add3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     potein kinase C binding protein 35H; adducin-like protein
                     70; protein kinase C-binding protein 35H; gamma-adducin;
                     adducin 3 (gamma)"
                     /codon_start=1
                     /product="gamma-adducin isoform 1"
                     /protein_id="NP_001157575.1"
                     /db_xref="GeneID:25230"
                     /db_xref="RGD:2043"
                     /translation="MSSDTSQAVITTPPPPSMPHKERYFDRINESDPEYLRERNMSPD
                     LRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHDPTGLLALQQIADYIMANS
                     FTGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLADLFGWAHLANTY
                     ISVRVSKEQDHIIIIPRGLSFSEATASALVKVNIIGEVVDQGSTNLKIDHSGFSPHAA
                     IYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLILGDVAYYDYQGSLDEEEERI
                     ELQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQMACEIQVQAVAGAGGVDNLL
                     ILDLQKYKAFTHGVAMTGGGGVNMGSHQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHP
                     LVREKPRHKSDVEIPATVTAFSFEDDSVPLSPLKYMAQRQQREKTRWLNSPNTYMKVN
                     VPEESRNGETSPRTKITWMKAEDPSKVSSGTPIKIEDPNQFVPLNTNPTEVLEKRNKI
                     REQNRYDLKTAGPQSQLLAGIVVDKPPSTMRFEDDDQGPPAPPNPFSHLMEGELEEYT
                     KTIERKQQGLDDAEQESLSDDAASVSQIQSQTQSPQSVPERLEENHELFSKSFTSVDV
                     PVIVNGKDEMHDVEDELAQRVSRLTTSTTIENIEITIKSPDRTEEVLSPDGSPSKSPS
                     KKKKKFRTPSFLKKNKKKEKVEA"
     exon            412..550
                     /gene="Add3"
                     /inference="alignment:Splign:2.1.0"
     exon            551..702
                     /gene="Add3"
                     /inference="alignment:Splign:2.1.0"
     exon            703..783
                     /gene="Add3"
                     /inference="alignment:Splign:2.1.0"
     exon            784..933
                     /gene="Add3"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1077
                     /gene="Add3"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1176
                     /gene="Add3"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1359
                     /gene="Add3"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1617
                     /gene="Add3"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1737
                     /gene="Add3"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1824
                     /gene="Add3"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1948
                     /gene="Add3"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2044
                     /gene="Add3"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..4177
                     /gene="Add3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccaagccag cgcctcacgg caaccgtgga gtctctaagt cacacacttt acaactcagc
       61 attgggagaa gcagccgccg ctgccgctgc tccgcggctg cagtgggttt cagtgcagca
      121 ttgcagaatc cacacctagc cgggaagacg gacacgcgtc ggctcccctg cacgcaaagc
      181 agctttggat cgcctgcagg gaagaagact ggaagcatga gttcagacac cagccaagcg
      241 gtgatcacca cccctcctcc tcccagcatg cctcacaaag agaggtattt tgaccgaatc
      301 aatgaaagtg acccagaata ccttcgagag aggaacatgt ctcctgatct acggcaggac
      361 ttcaatatga tggagcagag gaagcgagtc actcagatcc tgcagagtcc tgcctttcgg
      421 gaagacctag agtgcctcat ccaagaacag atgaagaaag gccacgaccc gaccggattg
      481 ctagcgttac agcagatcgc cgactacatc atggccaact ccttcaccgg tttttcttca
      541 cctcccctga gtcttggcat ggtcactcct attaatgacc ttcctggtgc agacacatcc
      601 tcgtatgtga agggagagaa gctcactcgt tgcaaactcg ccagcctgta cagactcgca
      661 gatctgtttg ggtgggcaca tctggcaaat acatacatct cggtacgagt aagtaaggag
      721 caggaccaca tcataatcat ccccagaggc ctctctttct ctgaagccac agcctctgct
      781 ctggtgaagg tcaacataat aggagaagtg gtggaccagg ggagtactaa tttgaaaatt
      841 gaccactcag gattcagtcc ccatgctgca atctattcaa cccgtcccga tgtgaagtgt
      901 gtgatacaca tccacaccct cgctacagca gctgtgtctt ccatgaagtg tgggatcctt
      961 ccaatttccc aagagtctct catcctggga gatgtagcct attatgacta ccaggggtcg
     1021 cttgatgagg aggaggaaag aatcgaactt cagaaagttc tgggtccaag ctgtaaggtg
     1081 ctggtcctca ggaaccatgg cgtggtagct cttggagaaa cacttgagga ggctttccac
     1141 tacatcttca atgtacagat ggcctgtgag attcaggtgc aggctgtagc aggggcaggg
     1201 ggagtggaca atcttctcat actggatctt cagaaataca aagctttcac ccacggtgtt
     1261 gccatgactg gaggaggcgg tgtgaatatg ggttcccatc agaagtggaa agttggcgag
     1321 attgagtttg aagggctcat gagaaccctg gacaacttgg gctacagaac aggctacgca
     1381 tacaggcatc ctctagttcg agagaagcct cggcacaaga gtgacgtgga gatcccagca
     1441 actgtgactg cattctcctt tgaagatgat agtgtgccac tctctcccct caagtacatg
     1501 gcacagagac agcagcgtga aaaaacaaga tggctgaatt ctccaaatac atacatgaaa
     1561 gtgaatgtgc cggaggagtc ccggaacggg gaaactagtc ccaggaccaa aataacgtgg
     1621 atgaaagcag aggacccctc taaagttagt agtggaacac ctatcaaaat tgaagatccc
     1681 aatcagtttg ttcctctaaa cacgaacccg actgaggtgc tggagaagag aaataagatt
     1741 cgggaacaga atcgctatga cctgaagaca gcagggccac agtctcagct gctggcgggg
     1801 atcgttgtgg acaaaccgcc ttctaccatg cggtttgaag acgatgatca gggcccacca
     1861 gcccctccta acccattcag tcatctcatg gaaggagaac ttgaagaata tacgaagaca
     1921 atcgagagaa agcagcaagg cctggacgac gctgagcagg agtcactgtc agatgatgct
     1981 gcatctgttt cacaaattca gtctcaaact cagtcaccgc aaagtgtccc tgagagatta
     2041 gaagaaaacc acgagctgtt ttccaagagc ttcacctctg tggatgtgcc tgtcattgtg
     2101 aatggcaagg acgagatgca cgatgttgaa gacgagctcg ctcagcgcgt cagcaggctc
     2161 acgacgagca ccaccataga gaacatcgag atcaccatca agtccccaga cagaactgaa
     2221 gaggtcctgt cacccgatgg ctcgccttca aagtcaccat ccaagaaaaa gaagaaattc
     2281 cgcacacctt cttttctcaa aaagaacaaa aaaaaggaga aagttgaggc ctaagtagtc
     2341 tttctgtaat ttgtacatta cattgtggca ttgcacagtt aaataccata ttttagttaa
     2401 tcgttaatat acggtggtag agcatattgg gggtatatag caaactggac tttaaaactg
     2461 gaaagaggtt ttactaaaag gaaaaatatt attgaaaact ttcaaattca tctcttttta
     2521 tatgtccaaa agtgactgac cttttcagca gctgctggtt ttacttagcc ctcccctctt
     2581 agagcacggt taccactgct ctttaacaga tgctgcctgg taatcaggct ctccagcata
     2641 gcgttggaga ggaactgcca gtgagcgaga gagtttactt ctctacagct gcttcacttg
     2701 ctgaccagat acactgttac catggttatg gactgtactt tggggtcccc attgtttcca
     2761 ggggcattaa tgaaatgctt taaaagctac aacaagaatc tagaacatta gtatacattg
     2821 gcacatcatt ttttttaatg ttttatgaaa agatttgttt ggaattttac tcatagtatg
     2881 aaattccctt acctggagta actgtttgcc aaaaaagtca ttttaataaa ctatgatttt
     2941 tgaagaactt ccttttttat tagtttagaa agccccttat ttttcataga ggggattttg
     3001 tacacataat atgagttatt tagtttaact cttgcaaaaa acaatttttg tatgttaaaa
     3061 tgtttgtata ccttcagtat aaggtgtcat gtgcatttta gccaatcagt taggagtaaa
     3121 gcatgcctga ggcttctcct gagcataatt cacgagtcca gggacacagc atccaaaggg
     3181 aaggcatatg aggtctgaag tcgcgtgtga accgtgtaac gtattgcgct tagtatcgct
     3241 gatggctgaa gagcatctca taaggaggcg acaagatgaa gaggctgaag tgggagggag
     3301 agtgagggag aggacgggag tggagagcga cctgacagta atggagtcca cagcagaatg
     3361 tggagatcga cttacggaaa ataaggccca aatttctaaa atctacttcc tgccaaaatc
     3421 aatgtcttgg ttgacatttg agttttaaaa gaggtttaaa gtgtacgtcc ttttagaagg
     3481 cggcactaga ataaaccagc cagtccaatc ccaccagcga gaaaactacc acatcttgat
     3541 ttttgcagac ttaaattttc ttttaacttc ctttctactg taaatacaaa tttaaatcta
     3601 gatttaatat agttttctcc attttcccaa gtaatgtcac agatcactgt aaatgaatga
     3661 tcccaatact cagtgagtgg aagcaaaacg cctggcgggt aagttggcat gcagacgtga
     3721 cgtgaccgca gtgctccctg ggctggttct gtctgagcgt gtgatgccgc agacgtcgcc
     3781 gtagacctca ctaactactg gaacctgtta gtctcctagt gggaacgttg aatcgggaac
     3841 tgtgtgaggg ttttatgttc tgcatcactt tcgttgtatt acacatgtgt agacacagta
     3901 acctgtgaat tgtcctcttc cataactttt aaagaaaata tatatatata tctaaatgaa
     3961 tgcagtgtgc ataaatattt tttaaacaca gcagtaaact attgcacctt tttgctaatg
     4021 cttctcttta cttgctttga cataatgaat gagccgtgaa ctcagtatcc tgtggaaaaa
     4081 tgtgtaaaag ttatctgata ttgctcttag atgttatgct aattaatgtt aaatcacaat
     4141 aaacagtatt ttaaatatat gcatttggta taatgagaaa aaaaaaaaaa aaaa
//
