LOCUS       NM_001109880            2523 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus adducin 2 (Add2), transcript variant 1, mRNA.
ACCESSION   NM_001109880
VERSION     NM_001109880.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2523)
  AUTHORS   Engmann,O., Giralt,A., Gervasi,N., Marion-Poll,L., Gasmi,L.,
            Filhol,O., Picciotto,M.R., Gilligan,D., Greengard,P., Nairn,A.C.,
            Herve,D. and Girault,J.A.
  TITLE     DARPP-32 interaction with adducin may mediate rapid environmental
            effects on striatal neurons
  JOURNAL   Nat Commun 6, 10099 (2015)
   PUBMED   26639316
  REMARK    GeneRIF: Darpp32 interaction with beta-adducin may be the molecular
            pathway by which environmental changes may rapidly alter
            responsiveness of striatal neurons involved in the reward system.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2523)
  AUTHORS   Xu,T., Liu,W., Yang,C., Ba,X., Wang,X., Jiang,Y. and Zeng,X.
  TITLE     Lipid raft-associated beta-adducin is required for PSGL-1-mediated
            neutrophil rolling on P-selectin
  JOURNAL   J Leukoc Biol 97 (2), 297-306 (2015)
   PUBMED   25425738
REFERENCE   3  (bases 1 to 2523)
  AUTHORS   Valencia,D.M., Naranjo,C.A., Parra,M.V., Caro,M.A., Valencia,A.V.,
            Jaramillo,C.J. and Bedoya,G.
  TITLE     [Association and interaction of AGT, AGTR1, ACE, ADRB2, DRD1, ADD1,
            ADD2, ATP2B1, TBXA2R and PTGS2 genes on the risk of hypertension in
            Antioquian population]
  JOURNAL   Biomedica 33 (4), 598-614 (2013)
   PUBMED   24652215
REFERENCE   4  (bases 1 to 2523)
  AUTHORS   Bednarek,E. and Caroni,P.
  TITLE     beta-Adducin is required for stable assembly of new synapses and
            improved memory upon environmental enrichment
  JOURNAL   Neuron 69 (6), 1132-1146 (2011)
   PUBMED   21435558
REFERENCE   5  (bases 1 to 2523)
  AUTHORS   Sonoyama,K., Greenstein,A.S., Micheletti,R., Ferrari,P.,
            Schiavone,A., Aghamohammadzadeh,R., Withers,S.B., Tripodi,G.,
            Ferrandi,M. and Heagerty,A.M.
  TITLE     Mutation in the beta adducin subunit causes tissue-specific damage
            to myogenic tone
  JOURNAL   J Hypertens 29 (3), 466-474 (2011)
   PUBMED   21150638
  REMARK    GeneRIF: Mutations in the beta subunit of the adducin protein
            result in damage to renal artery myogenic tone and this is
            associated with renal damage as manifest by proteinuria.
REFERENCE   6  (bases 1 to 2523)
  AUTHORS   Kuhlman,P.A., Hughes,C.A., Bennett,V. and Fowler,V.M.
  TITLE     A new function for adducin. Calcium/calmodulin-regulated capping of
            the barbed ends of actin filaments
  JOURNAL   J Biol Chem 271 (14), 7986-7991 (1996)
   PUBMED   8626479
REFERENCE   7  (bases 1 to 2523)
  AUTHORS   Tripodi,G., Casari,G., Tisminetzky,S., Bianchi,G., Devescovi,G.,
            Muro,A., Tuteja,R. and Baralle,F.E.
  TITLE     Characterisation and chromosomal localisation of the rat alpha- and
            beta-adducin-encoding genes
  JOURNAL   Gene 166 (2), 307-311 (1995)
   PUBMED   8543181
REFERENCE   8  (bases 1 to 2523)
  AUTHORS   Hughes,C.A. and Bennett,V.
  TITLE     Adducin: a physical model with implications for function in
            assembly of spectrin-actin complexes
  JOURNAL   J Biol Chem 270 (32), 18990-18996 (1995)
   PUBMED   7642559
REFERENCE   9  (bases 1 to 2523)
  AUTHORS   Tripodi,G., Piscone,A., Borsani,G., Tisminetzky,S., Salardi,S.,
            Sidoli,A., James,P., Pongor,S., Bianchi,G. and Baralle,F.E.
  TITLE     Molecular cloning of an adducin-like protein: evidence of a
            polymorphism in the normotensive and hypertensive rats of the Milan
            strain
  JOURNAL   Biochem Biophys Res Commun 177 (3), 939-947 (1991)
   PUBMED   2059221
REFERENCE   10 (bases 1 to 2523)
  AUTHORS   Mische,S.M., Mooseker,M.S. and Morrow,J.S.
  TITLE     Erythrocyte adducin: a calmodulin-regulated actin-bundling protein
            that stimulates spectrin-actin binding
  JOURNAL   J Cell Biol 105 (6 Pt 1), 2837-2845 (1987)
   PUBMED   3693401
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M63894.1, AF130338.1 and DY315967.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06680412,
                              SAMN06680413 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1780              M63894.1           1-1780
            1781-2118           AF130338.1         1-338
            2119-2523           DY315967.1         126-530
FEATURES             Location/Qualifiers
     source          1..2523
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..2523
                     /gene="Add2"
                     /gene_synonym="beta-ADD"
                     /note="adducin 2"
                     /db_xref="GeneID:24171"
                     /db_xref="RGD:2042"
     exon            1..54
                     /gene="Add2"
                     /gene_synonym="beta-ADD"
                     /inference="alignment:Splign:2.1.0"
     exon            55..153
                     /gene="Add2"
                     /gene_synonym="beta-ADD"
                     /inference="alignment:Splign:2.1.0"
     exon            154..370
                     /gene="Add2"
                     /gene_synonym="beta-ADD"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..2365
                     /gene="Add2"
                     /gene_synonym="beta-ADD"
                     /note="isoform a is encoded by transcript variant 1;
                     adducin-63; erythrocyte adducin subunit beta; adducin
                     beta; adducin 2 (beta); beta-adducin"
                     /codon_start=1
                     /product="beta-adducin isoform a"
                     /protein_id="NP_001103350.1"
                     /db_xref="GeneID:24171"
                     /db_xref="RGD:2042"
                     /translation="MSEDTVPEAASPPPSQGQHYFDRFSEDDPEYLRLRNRAADLRQD
                     FNLMEQKKRVTMILQSPSFREELEGLIQEQMKKGNNSSNIWALRQIADFMASTSHAVF
                     PASSMNFSMMTPINDLHTADSLNLAKGERLMRCKISSVYRLLDLYGWAQLSDTYVTLR
                     VSKEQDHFLISPKGVSCSEVTASSLIKVNILGEVVEKGSSCFPVDTTGFSLHSAIYAA
                     RPDVRCAIHLHTPATAAVSAMKCGLLPVSHNALLVGDMAYYDFNGEMEQEADRINLQK
                     CLGPTCKILVLRNHGMVALGDTVEEAFYKVFHLQAACEVQVSALSSAGGTENLILLEQ
                     EKHRPHEVGSVQWAGSTFGPMQKSRLGEHEFEALMRMLDNLGYRTGYTYRHPFVQEKT
                     KHKSEVEIPATVTAFVFEEDGVPVPALRQHAQKQQKEKTRWLNTPNTYLRVNVADEVQ
                     RNMGSPRPKTTWMKADEVEKSSSGMPIRIENPNQFVPLYTDPQEVLDMRNKIREQNRQ
                     DIKSAGPQSQLLASVIAEKSRSPSTESQLASKGDADTKDELEETVPNPFSQLTDQELE
                     EYKKEVERKKLEQEQEGEKDAATEEPGSPVKSTPASPVQSPTRAGTKSPAVSPSKASE
                     DAKKTEVSEANTEPEPEKPEGVVVNGKEEEPSVEEVLSKGPGQMTTNADTDGDSYKDK
                     TESVTSGPLSPEGSPSKSPSKKKKKFRTPSFLKKSKKKEKVES"
     exon            371..509
                     /gene="Add2"
                     /gene_synonym="beta-ADD"
                     /inference="alignment:Splign:2.1.0"
     exon            510..661
                     /gene="Add2"
                     /gene_synonym="beta-ADD"
                     /inference="alignment:Splign:2.1.0"
     exon            662..742
                     /gene="Add2"
                     /gene_synonym="beta-ADD"
                     /inference="alignment:Splign:2.1.0"
     exon            743..892
                     /gene="Add2"
                     /gene_synonym="beta-ADD"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1036
                     /gene="Add2"
                     /gene_synonym="beta-ADD"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1135
                     /gene="Add2"
                     /gene_synonym="beta-ADD"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1312
                     /gene="Add2"
                     /gene_synonym="beta-ADD"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1570
                     /gene="Add2"
                     /gene_synonym="beta-ADD"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1690
                     /gene="Add2"
                     /gene_synonym="beta-ADD"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1780
                     /gene="Add2"
                     /gene_synonym="beta-ADD"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1934
                     /gene="Add2"
                     /gene_synonym="beta-ADD"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2060
                     /gene="Add2"
                     /gene_synonym="beta-ADD"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2523
                     /gene="Add2"
                     /gene_synonym="beta-ADD"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggccacagg cactgcctcc ttcatttgtg ggagtctaca aggatggagg atagttccca
       61 cccggctgtg tgaagtgtgg ctgtgccagc cctcctagtt gtgaagacct ggcactgagg
      121 acagagactg gacaggcctg gttcatccta ctgggttccg ggagtggact gaagccttag
      181 caggagcatg agtgaggaca cggtccccga ggcagcctca ccgccaccct ctcaggggca
      241 gcactacttt gaccggttct ctgaggatga ccctgaatac ttgcgacttc gcaaccgtgc
      301 agctgacctg cgacaagact tcaacctgat ggagcagaag aaacgggtca ccatgatcct
      361 gcagagccct tctttcaggg aggagctgga aggcctcatc caggaacaga tgaagaaggg
      421 taacaactcc tccaacatct gggccctccg acagatcgcg gacttcatgg ccagcacctc
      481 ccacgcagtc ttcccagctt cctccatgaa cttctccatg atgacaccca tcaatgacct
      541 ccacactgcc gactccctga acctggccaa gggggagagg cttatgcggt gcaagatcag
      601 cagtgtctac cgtcttctgg acctctatgg ctgggcgcag ctcagcgaca cctatgtcac
      661 gctgagagtg agcaaggagc aggaccactt cctgatcagc cccaaagggg tttcctgcag
      721 tgaggtcacg gcatccagcc tgattaaggt gaacattcta ggagaggtcg tggagaaggg
      781 cagcagttgc ttcccagtgg acaccaccgg cttcagtctg cactcagcca tctatgcggc
      841 caggccggac gtgcggtgtg ccatccacct gcacacgcct gccacagcag cggtgtcagc
      901 tatgaagtgt ggcctcctgc ctgtctccca taatgccctg ctggtggggg acatggccta
      961 ctatgacttc aatggggaaa tggagcagga agctgatcga atcaacttgc agaagtgcct
     1021 tggacccacc tgcaagattc tggtgctaag aaaccatggt atggtcgccc tgggtgacac
     1081 cgtggaggaa gctttctaca aggtcttcca cctgcaggct gcgtgtgagg tacaggtgtc
     1141 ggctctgtcc agcgctgggg ggaccgagaa cctcatcctc ctggagcaag agaaacaccg
     1201 tccgcatgag gtgggctctg tgcagtgggc cggcagcacc tttgggccca tgcagaagag
     1261 ccggctggga gagcatgaat ttgaagccct catgaggatg ctcgacaact taggctacag
     1321 aacaggctat acgtaccgcc accccttcgt ccaagagaaa accaaacaca aaagtgaagt
     1381 ggagatccca gccacggtca ctgcctttgt gttcgaagag gatggtgtcc cagtccctgc
     1441 tctgcgccag cacgcccaaa agcagcagaa ggaaaagacc cgctggctta acactcccaa
     1501 cacctacctg agggtgaatg tggccgacga ggtgcagagg aacatgggca gtccccgacc
     1561 gaagaccacg tggatgaagg ctgatgaagt ggaaaagtcc agcagcggca tgcccatacg
     1621 gattgaaaac ccaaaccaat ttgtgcctct ctacactgac ccccaagaag tgctggacat
     1681 gaggaacaag attcgagaac aaaaccgaca agatataaag tcagccgggc ctcagtctca
     1741 gctcttggcc agcgtcatcg ccgagaagag ccggagtccg tctacagaga gccagctggc
     1801 gtccaagggc gatgcagata ccaaagatga attggaggag acggtgccca accccttcag
     1861 ccaactcact gaccaggagc tggaggagta caagaaggag gtggaaagga agaagctaga
     1921 acaggagcaa gaaggggaga aggacgcagc cacagaggag cctggttcac ctgtaaagtc
     1981 cacacctgcg tctcctgtgc agagcccaac gagggcaggg accaagagtc cagcggtctc
     2041 tccttccaag gcttcagagg atgccaagaa gacagaagtc agcgaagcca acacagagcc
     2101 tgagccagag aaaccagaag gggtggtggt gaatgggaag gaggaggagc cgagtgtgga
     2161 agaggtcctc agcaaaggac cgggccagat gactaccaat gctgacactg atggcgacag
     2221 ttacaaggac aaaaccgagt cagttaccag tggccccttg tccccagagg gctcgccctc
     2281 taagtcaccc tccaaaaaga aaaagaaatt ccgaaccccc tccttcctga agaagagcaa
     2341 gaagaaggag aaggtggaat cctgattagt ggctcagtgg gtcctgatgc atccctgccc
     2401 tccttcctta ccttctccca actctgaccc tgaagccagg gccaaggagg gcaagaggag
     2461 atcctgggat cacactcaga ggggaactta gagcctgcct tcccagagca gccaggtgtc
     2521 ttg
//
