LOCUS       NM_016990               3826 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus adducin 1 (Add1), mRNA.
ACCESSION   NM_016990
VERSION     NM_016990.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3826)
  AUTHORS   Kugelmann,D., Waschke,J. and Radeva,M.Y.
  TITLE     Adducin is involved in endothelial barrier stabilization
  JOURNAL   PLoS One 10 (5), e0126213 (2015)
   PUBMED   25978380
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3826)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3826)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 3826)
  AUTHORS   Procino,G., Romano,F., Torielli,L., Ferrari,P., Bianchi,G.,
            Svelto,M. and Valenti,G.
  TITLE     Altered expression of renal aquaporins and alpha-adducin
            polymorphisms may contribute to the establishment of salt-sensitive
            hypertension
  JOURNAL   Am J Hypertens 24 (7), 822-828 (2011)
   PUBMED   21451595
  REMARK    GeneRIF: Altered expression of renal aquaporins and alpha-adducin
            polymorphisms may contribute to the establishment of salt-sensitive
            hypertension.
REFERENCE   5  (bases 1 to 3826)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   6  (bases 1 to 3826)
  AUTHORS   Tripodi,G., Casari,G., Tisminetzky,S., Bianchi,G., Devescovi,G.,
            Muro,A., Tuteja,R. and Baralle,F.E.
  TITLE     Characterisation and chromosomal localisation of the rat alpha- and
            beta-adducin-encoding genes
  JOURNAL   Gene 166 (2), 307-311 (1995)
   PUBMED   8543181
REFERENCE   7  (bases 1 to 3826)
  AUTHORS   Seidel,B., Zuschratter,W., Wex,H., Garner,C.C. and
            Gundelfinger,E.D.
  TITLE     Spatial and sub-cellular localization of the membrane
            cytoskeleton-associated protein alpha-adducin in the rat brain
  JOURNAL   Brain Res 700 (1-2), 13-24 (1995)
   PUBMED   8624703
REFERENCE   8  (bases 1 to 3826)
  AUTHORS   Dong,L., Chapline,C., Mousseau,B., Fowler,L., Ramsay,K.,
            Stevens,J.L. and Jaken,S.
  TITLE     35H, a sequence isolated as a protein kinase C binding protein, is
            a novel member of the adducin family
  JOURNAL   J Biol Chem 270 (43), 25534-25540 (1995)
   PUBMED   7592723
REFERENCE   9  (bases 1 to 3826)
  AUTHORS   Hughes,C.A. and Bennett,V.
  TITLE     Adducin: a physical model with implications for function in
            assembly of spectrin-actin complexes
  JOURNAL   J Biol Chem 270 (32), 18990-18996 (1995)
   PUBMED   7642559
REFERENCE   10 (bases 1 to 3826)
  AUTHORS   Mische,S.M., Mooseker,M.S. and Morrow,J.S.
  TITLE     Erythrocyte adducin: a calmodulin-regulated actin-bundling protein
            that stimulates spectrin-actin binding
  JOURNAL   J Cell Biol 105 (6 Pt 1), 2837-2845 (1987)
   PUBMED   3693401
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC107657.1.
            
            On Oct 31, 2005 this sequence version replaced NM_016990.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC107657.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3826
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..3826
                     /gene="Add1"
                     /note="adducin 1"
                     /db_xref="GeneID:24170"
                     /db_xref="RGD:2041"
     exon            1..41
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            42..256
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..2269
                     /gene="Add1"
                     /note="erythrocyte adducin subunit alpha; alpha-ADD;
                     adducin 1 (alpha)"
                     /codon_start=1
                     /product="alpha-adducin"
                     /protein_id="NP_058686.2"
                     /db_xref="GeneID:24170"
                     /db_xref="RGD:2041"
                     /translation="MNGDTRAAVVTSPPPTTAPHKERYFDRVDENNPEYLRERNMAPD
                     LRQDFNMMEQKKRVSMILQSPAFCEELESMIQEQFKKGKNPTGLLALQQIADFMTASV
                     PNVYPAAPQGGMAALNMSLGMVTPVNDLRGSDSIAYDKGEKLLRCKLAAFYRLADLFG
                     WSQLIYNHITTRVNSEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDRGSTNLGVNQ
                     AGFTLHSAIYAARPDAKCIVHIHTPAGAAVSAMKCGLLPISPEALSLGEVAYHDYHGI
                     LVDEEEKILIQKNLGPKSKVLILRNHGLVSVGESVEEAFYYIHNLVVACEIQVRTLAS
                     AGGPDNLVLLDPGKYKAKSRSPGTPAGEGSGSPPKWQIGEQEFEALMRMLDNLGYRTG
                     YPYRYPALRERSKKYSDVEVPASVTGHSFASDGDSGTCSPLRHSFQKQQREKTRWLNS
                     GRGDDASEEGQNGSSPKSKTKWTKEDGHRTSTSAVPNLFVPLNTNPKEVQEMRNKIRE
                     QNLQDIKTAGPQSQVLCGVMMDRSLVQGELVTASKAIIEKEYQPHVIVSTTGPNPFNT
                     LTDRELEEYRREVERKQKGSEENLDETREQKEKSPPDQSAVPNTPPSTPVKLEGGLPQ
                     EPTSRDGSDATTSKPTPPDLSPDEPSEALAFPTVAEEAHASPDTTQPLAEADPEPASA
                     SAPGAEEVASPATEEGSPMDPGSDGSPGKSPSKKKKKFRTPSFLKKSKKKSDS"
     exon            257..419
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            420..571
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            572..652
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            653..802
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            803..946
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1045
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1222
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1474
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1576
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1666
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1823
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..1922
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..3802
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacccggga agctgtgcgc ttttcccgat tctccgcgga ggatcctaga aacattgtgc
       61 aatgaatggt gacacgcggg ccgcagtggt gacctcacca cctccaacca cagcccctca
      121 caaggagagg tactttgaca gagtcgatga gaacaatcca gaatatttgc gggagaggaa
      181 catggcacca gaccttcgtc aggacttcaa tatgatggag cagaagaaga gggtgtctat
      241 gattctgcag agtcccgcct tctgtgaaga gctggagtct atgatacagg agcagtttaa
      301 gaaggggaag aaccctacag gcctgttggc attacagcag attgcggatt tcatgacggc
      361 gagtgtgccc aatgtctacc cggcagctcc acaaggagga atggccgccc tgaacatgag
      421 tcttggtatg gttactcctg tgaatgacct tagaggatct gattctattg catatgacaa
      481 gggggagaag ttactgcgat gtaagctggc agcattttac agactagcag acctctttgg
      541 ctggtctcag cttatctaca atcacatcac aaccagagtg aactctgagc aggagcactt
      601 cctcatcgtg cctttcggac ttctctacag tgaagtgact gcgtccagcc tggttaaggt
      661 caatctacaa ggagacatag tagaccgcgg aagtactaac ctgggagtca accaggccgg
      721 cttcaccttg cactcggcca tttatgctgc acgaccagat gccaagtgca ttgtgcacat
      781 tcacacacca gcaggggctg cggtctctgc aatgaagtgt gggctcttgc ctatttcccc
      841 ggaggcgctt tcccttggag aggttgctta tcatgactat catggcattc tggttgatga
      901 agaggaaaaa attttgattc agaagaatct gggccctaaa agcaaggttc tcattctccg
      961 gaatcacggg ctcgtgtcag ttggagagag tgtggaggag gccttctatt atatccacaa
     1021 ccttgtggtt gcatgtgaga tccaggttcg aactctggca agtgctggag gaccagacaa
     1081 cttagttctg ctggatcctg ggaagtacaa agccaaatcc cgttctccag ggactccagc
     1141 aggggaaggc tctggatcac ctcccaagtg gcagattggg gagcaggaat ttgaagctct
     1201 tatgcggatg ctcgataatc tgggctacag aactggctac ccctatcgat accctgctct
     1261 gagagagaga tctaaaaagt acagcgatgt ggaagtccct gccagtgtca ccggccactc
     1321 ctttgctagt gacggcgatt cgggcacttg ctcgccgctc agacacagtt ttcagaagca
     1381 gcagcgagag aagacaagat ggctgaactc tggccggggt gatgacgctt ctgaggaggg
     1441 gcagaacgga agcagtccca agtcgaagac taagtggact aaagaggatg gacatagaac
     1501 ttccacctct gctgtcccta acctgtttgt tccattgaac actaacccaa aagaggtcca
     1561 ggagatgagg aacaagattc gagagcagaa cttacaggac attaagacgg caggacctca
     1621 gtcgcaggtt ttgtgtggtg tgatgatgga cagaagcctt gtccaggggg agctcgtgac
     1681 ggcctccaaa gccatcattg agaaggaata ccagcctcat gtaattgtga gcaccacagg
     1741 tcccaacccc ttcaacacgc tcacagaccg tgaactagag gaataccgcc gagaggtgga
     1801 gcggaagcag aagggctctg aagagaacct ggacgagaca agagagcaga aagagaagag
     1861 tcctccagac cagtcagctg ttcccaacac tccgcccagc actcccgtca agcttgaagg
     1921 aggccttccc caggagccga catccaggga tggcagcgat gccaccacct ccaagccgac
     1981 tccccctgac ctctcccctg atgagccttc agaagcactt gccttcccaa cagtggcaga
     2041 ggaagcccat gcttccccag acaccactca gccccttgct gaggctgacc ctgagccagc
     2101 ctcagcctca gctccaggag ctgaagaggt agcctcccct gccactgagg aggggtctcc
     2161 catggaccct ggcagcgatg ggtctccagg caagtcccca tccaagaaga agaagaagtt
     2221 ccgcaccccg tccttcctga agaagagcaa gaagaagagt gactcctgaa ggcccaccct
     2281 gcatactgtc gtgtctgaag gcctggctct gccaggactc cctcctctgt cttgtgttct
     2341 gtcctctcgt gtaatggaat gcaaaaagcc aagacctcca tgtaactaga gccccctccc
     2401 atgtatggtc agcccctgca ccagtgctaa cccagtgtgt gctcagcccc tctaccctgg
     2461 gccttgggtt ctgtggggag ttgggcttag cctgcacctg tgagttgtgc ccccctgcag
     2521 gagggggaca ctgaatcctg gtcctggctg gaaggcatag gaggcttctg ccagctctgg
     2581 ttacagcgtc accctcctga gccttgcctc tcactctcct ttctgtcgtg agtattgaat
     2641 tgtctgctca gtttccctcc accctgtgga gtctcaggtg gctgatttgg actcggcttt
     2701 gctggcatcc tctgctccgt gatgtcagtt atccccatac acaggtatcc acatacccca
     2761 gccatggtct gagaaaacac tctcatgtcc atccgcggcc cacactgtgg ctgccttaaa
     2821 gacatgggtt aagtctgctg ccctagcagt gagcaaccct ttgtataccc agcacaacgc
     2881 tatgcatggt ctaactgatg accccatgac caaaaccaca ttcaggcgct catagttgac
     2941 cttaccgggg tcttgcattc ccatcttagg gaacagatac caggaggggg aggagtcctt
     3001 tctaaaactt tgtttcagca ggtttgcgat ttagcctcca tttttactgt gaacttgaat
     3061 aggccacttt ttgcgttagt ttttgttgta gagcctatga cagactgcag cagaacactc
     3121 ttgacttgtg tggggaggtt ttgtaggaac agggaccata actcagtctg aacgatgccc
     3181 tggttttgat agggatggta actcatggtt gaagctggct ttggaggtgc catctaatgt
     3241 cttgcatcat tcatggagcc catgaccttc ttggtcatcc cttatgaatt tttacctaac
     3301 ttttatccct ggaaaagggc ttgaaactgc tttagtgagt ggggaagccg agtgtcaggt
     3361 ggaatcctaa ggggccttgt tccaggagct gccactgcca gcctgactag gagagggagc
     3421 ctgctggggc cctccatgcc cctgctgggt tgggcctcat agagcgggtg ctcggatgtg
     3481 gacagaaccc tgtgatctcc caatggggca ccaagcagga ccccacagcc tgctgtactg
     3541 ctagtcccac tagtcaccac ggtggcctga gctctcacct ggtcctgagt cccctcatct
     3601 ggactcctcc tcgtcttcct tctggccctt cctttatccc acatatgcaa tgatttctca
     3661 cttttgtagt ctaatctttg tattacacac ggaatatcgc tgcatatatg gacagacttg
     3721 gaggacaggt cctgtgtgtc ctttcctcgt cgtaacaggt cttactcaca aataaaagtc
     3781 tttaagcagt ttctttgtct aaaaaaaaaa aaaaaaaaaa aaaaaa
//
