LOCUS       NM_001270582            6151 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus ADCYAP receptor type I (Adcyap1r1), transcript
            variant 5, mRNA.
ACCESSION   NM_001270582
VERSION     NM_001270582.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6151)
  AUTHORS   Feher,M., Marton,Z., Szabo,A., Kocsa,J., Kormos,V., Hunyady,A.,
            Kovacs,L.A., Ujvari,B., Berta,G., Farkas,J., Furedi,N., Gaszner,T.,
            Pytel,B., Reglodi,D. and Gaszner,B.
  TITLE     Downregulation of PACAP and the PAC1 Receptor in the Basal Ganglia,
            Substantia Nigra and Centrally Projecting Edinger-Westphal Nucleus
            in the Rotenone model of Parkinson's Disease
  JOURNAL   Int J Mol Sci 24 (14), 11843 (2023)
   PUBMED   37511603
  REMARK    GeneRIF: Downregulation of PACAP and the PAC1 Receptor in the Basal
            Ganglia, Substantia Nigra and Centrally Projecting Edinger-Westphal
            Nucleus in the Rotenone model of Parkinson's Disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6151)
  AUTHORS   Tasma,Z., Siow,A., Harris,P.W.R., Brimble,M.A., O'Carroll,S.J.,
            Hay,D.L. and Walker,C.S.
  TITLE     PAC1, VPAC1, and VPAC2 Receptor Expression in Rat and Human
            Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor
            Antibodies
  JOURNAL   Int J Mol Sci 23 (22), 13797 (2022)
   PUBMED   36430275
  REMARK    GeneRIF: PAC1, VPAC1, and VPAC2 Receptor Expression in Rat and
            Human Trigeminal Ganglia: Characterization of PACAP-Responsive
            Receptor Antibodies.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6151)
  AUTHORS   Minnig,M.A., Blasio,A., Ferragud,A., Sami,Y.N., Erhard,E.E.,
            Clark,R.H., DiLeo,A., Giuliano,C., Everitt,B.J., Cottone,P. and
            Sabino,V.
  TITLE     Pituitary adenylate cyclase-activating polypeptide type 1 receptor
            within the nucleus accumbens core mediates excessive alcohol
            drinking in alcohol-preferring rats
  JOURNAL   Neuropharmacology 212, 109063 (2022)
   PUBMED   35460713
  REMARK    GeneRIF: Pituitary adenylate cyclase-activating polypeptide type 1
            receptor within the nucleus accumbens core mediates excessive
            alcohol drinking in alcohol-preferring rats.
REFERENCE   4  (bases 1 to 6151)
  AUTHORS   Maunze,B., Bruckner,K.W., Desai,N.N., Chen,C., Chen,F., Baker,D.
            and Choi,S.
  TITLE     Pituitary adenylate cyclase-activating polypeptide receptor
            activation in the hypothalamus recruits unique signaling pathways
            involved in energy homeostasis
  JOURNAL   Am J Physiol Endocrinol Metab 322 (3), E199-E210 (2022)
   PUBMED   35001657
  REMARK    GeneRIF: Pituitary adenylate cyclase-activating polypeptide
            receptor activation in the hypothalamus recruits unique signaling
            pathways involved in energy homeostasis.
REFERENCE   5  (bases 1 to 6151)
  AUTHORS   Johnson,G.C., Parsons,R.L., May,V. and Hammack,S.E.
  TITLE     Pituitary adenylate cyclase-activating polypeptide-induced PAC1
            receptor internalization and recruitment of MEK/ERK signaling
            enhance excitability of dentate gyrus granule cells
  JOURNAL   Am J Physiol Cell Physiol 318 (5), C870-C878 (2020)
   PUBMED   32186931
  REMARK    GeneRIF: we examined the direct effects of PACAP on dentate gyrus
            (DG) granule cells in brain slices using whole cell patch
            recordings in current clamp mode. PACAP significantly increased the
            intrinsic excitability of DG granule cells via PAC1 receptor
            activation.
REFERENCE   6  (bases 1 to 6151)
  AUTHORS   Spengler,D., Waeber,C., Pantaloni,C., Holsboer,F., Bockaert,J.,
            Seeburg,P.H. and Journot,L.
  TITLE     Differential signal transduction by five splice variants of the
            PACAP receptor
  JOURNAL   Nature 365 (6442), 170-175 (1993)
   PUBMED   8396727
REFERENCE   7  (bases 1 to 6151)
  AUTHORS   Morrow,J.A., Lutz,E.M., West,K.M., Fink,G. and Harmar,A.J.
  TITLE     Molecular cloning and expression of a cDNA encoding a receptor for
            pituitary adenylate cyclase activating polypeptide (PACAP)
  JOURNAL   FEBS Lett 329 (1-2), 99-105 (1993)
   PUBMED   8394834
REFERENCE   8  (bases 1 to 6151)
  AUTHORS   Hashimoto,H., Ishihara,T., Shigemoto,R., Mori,K. and Nagata,S.
  TITLE     Molecular cloning and tissue distribution of a receptor for
            pituitary adenylate cyclase-activating polypeptide
  JOURNAL   Neuron 11 (2), 333-342 (1993)
   PUBMED   8394723
REFERENCE   9  (bases 1 to 6151)
  AUTHORS   Hosoya,M., Onda,H., Ogi,K., Masuda,Y., Miyamoto,Y., Ohtaki,T.,
            Okazaki,H., Arimura,A. and Fujino,M.
  TITLE     Molecular cloning and functional expression of rat cDNAs encoding
            the receptor for pituitary adenylate cyclase activating polypeptide
            (PACAP)
  JOURNAL   Biochem Biophys Res Commun 194 (1), 133-143 (1993)
   PUBMED   7687425
REFERENCE   10 (bases 1 to 6151)
  AUTHORS   Pisegna,J.R. and Wank,S.A.
  TITLE     Molecular cloning and functional expression of the pituitary
            adenylate cyclase-activating polypeptide type I receptor
  JOURNAL   Proc Natl Acad Sci U S A 90 (13), 6345-6349 (1993)
   PUBMED   8392197
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            D16465.1, JAXUCZ010000004.1, Z23279.1 and CR475040.1.
            
            Transcript Variant: This variant (5) lacks two alternate in-frame
            exons compared to variant (1). The resulting isoform (d) has the
            same N- and C-termini but is shorter compared to isoform a.
            Variants 4 and 5 both encode the same isoform (d).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.23141.1, Z23279.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               D16465.1           1-111
            112-4330            JAXUCZ010000004.1  85968578-85972796
            4331-4465           D16465.1           113-247
            4466-4480           Z23279.1           1-15
            4481-8699           JAXUCZ010000004.1  85968578-85972796
            8700-9976           Z23279.1           17-1293
            9977-14195          JAXUCZ010000004.1  85968578-85972796
            14196-14406         Z23279.1           1295-1505
            14407-18625         JAXUCZ010000004.1  85968578-85972796
            18626-18805         CR475040.1         1-180               c
FEATURES             Location/Qualifiers
     source          1..6151
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..6151
                     /gene="Adcyap1r1"
                     /gene_synonym="PAC1-R; PACAP-R1; PACAP-R1A; PACAPR1;
                     PACAPR1A"
                     /note="ADCYAP receptor type I"
                     /db_xref="GeneID:24167"
                     /db_xref="RGD:2038"
     exon            1..261
                     /gene="Adcyap1r1"
                     /gene_synonym="PAC1-R; PACAP-R1; PACAP-R1A; PACAPR1;
                     PACAPR1A"
                     /inference="alignment:Splign:2.1.0"
     exon            262..385
                     /gene="Adcyap1r1"
                     /gene_synonym="PAC1-R; PACAP-R1; PACAP-R1A; PACAPR1;
                     PACAPR1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             338..1741
                     /gene="Adcyap1r1"
                     /gene_synonym="PAC1-R; PACAP-R1; PACAP-R1A; PACAPR1;
                     PACAPR1A"
                     /note="isoform d precursor is encoded by transcript
                     variant 5; pituitary adenylate cyclase-activating
                     polypeptide type IA receptor; PACAP type IA receptor;
                     adenylate cyclase activating polypeptide 1 (pituitary)
                     receptor type I; adenylate cyclase activating polypeptide
                     1 type 1 receptor; ADCYAP receptor type 1; adenylate
                     cyclase activating polypeptide 1 receptor type 1;
                     pituitary adenylate cyclase activating polypeptide 1
                     receptor (1); pituitary adenylate cyclase activating
                     polypeptide receptor; PACAP-R-1A; adenylate cyclase
                     activating polypeptide 1 receptor 1; PACAP type I
                     receptor; pituitary adenylate cyclase-activating
                     polypeptide type I receptor"
                     /codon_start=1
                     /product="pituitary adenylate cyclase-activating
                     polypeptide type I receptor isoform d precursor"
                     /protein_id="NP_001257511.1"
                     /db_xref="GeneID:24167"
                     /db_xref="RGD:2038"
                     /translation="MARVLQLSLTALLLPVAIAMHSDCIFKKEQAMCLERIQRANDLM
                     GLNESSPGCPGMWDNITCWKPAQVGEMVLVSCPEVFRIFNPDQVWMTETIGDSGFADS
                     NSLEITDMGVVGRNCTEDGWSEPFPHYFDACGFDDYEPESGDQDYYYLSVKALYTVGY
                     STSLATLTTAMVILCRFRKLHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSSHC
                     FVSTVECKAVMVFFHYCVVSNYFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTP
                     TVCVTVWAVLRLYFDDAGCWDMNDSTALWWVIKGPVVGSIMVNFVLFIGIIIILVQKL
                     QSPDMGGNESSIYLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQG
                     FVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFTMDFKHRHPSLASSGVNGGTQLSILSK
                     SSSQLRMSSLPADNLAT"
     exon            386..491
                     /gene="Adcyap1r1"
                     /gene_synonym="PAC1-R; PACAP-R1; PACAP-R1A; PACAPR1;
                     PACAPR1A"
                     /inference="alignment:Splign:2.1.0"
     exon            492..599
                     /gene="Adcyap1r1"
                     /gene_synonym="PAC1-R; PACAP-R1; PACAP-R1A; PACAPR1;
                     PACAPR1A"
                     /inference="alignment:Splign:2.1.0"
     exon            600..620
                     /gene="Adcyap1r1"
                     /gene_synonym="PAC1-R; PACAP-R1; PACAP-R1A; PACAPR1;
                     PACAPR1A"
                     /inference="alignment:Splign:2.1.0"
     exon            621..662
                     /gene="Adcyap1r1"
                     /gene_synonym="PAC1-R; PACAP-R1; PACAP-R1A; PACAPR1;
                     PACAPR1A"
                     /inference="alignment:Splign:2.1.0"
     exon            663..772
                     /gene="Adcyap1r1"
                     /gene_synonym="PAC1-R; PACAP-R1; PACAP-R1A; PACAPR1;
                     PACAPR1A"
                     /inference="alignment:Splign:2.1.0"
     exon            773..870
                     /gene="Adcyap1r1"
                     /gene_synonym="PAC1-R; PACAP-R1; PACAP-R1A; PACAPR1;
                     PACAPR1A"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1003
                     /gene="Adcyap1r1"
                     /gene_synonym="PAC1-R; PACAP-R1; PACAP-R1A; PACAPR1;
                     PACAPR1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1157
                     /gene="Adcyap1r1"
                     /gene_synonym="PAC1-R; PACAP-R1; PACAP-R1A; PACAPR1;
                     PACAPR1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1218
                     /gene="Adcyap1r1"
                     /gene_synonym="PAC1-R; PACAP-R1; PACAP-R1A; PACAPR1;
                     PACAPR1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1288
                     /gene="Adcyap1r1"
                     /gene_synonym="PAC1-R; PACAP-R1; PACAP-R1A; PACAPR1;
                     PACAPR1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1380
                     /gene="Adcyap1r1"
                     /gene_synonym="PAC1-R; PACAP-R1; PACAP-R1A; PACAPR1;
                     PACAPR1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1510
                     /gene="Adcyap1r1"
                     /gene_synonym="PAC1-R; PACAP-R1; PACAP-R1A; PACAPR1;
                     PACAPR1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1552
                     /gene="Adcyap1r1"
                     /gene_synonym="PAC1-R; PACAP-R1; PACAP-R1A; PACAPR1;
                     PACAPR1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..6148
                     /gene="Adcyap1r1"
                     /gene_synonym="PAC1-R; PACAP-R1; PACAP-R1A; PACAPR1;
                     PACAPR1A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcctcgct ccgattcccg gctgcgactg gcggaggctc tggagcaacg cggtcccggt
       61 gtgcaatacg cacacgccgc ggcgcaggga cacagacccg actgcccgcg gccacacgca
      121 ccgagagacc aggctcggcg cgcgctccgc ggcgcacacg ctccagccgg tgcggctctg
      181 ggcgcggatt cgcgggttgc gcgccctcct gcacattcag tcccggcgcc cagcagtctg
      241 gaccggcccg gagaccagca gcaagtggac agtggcaggc ggtgactgaa tctccaagtc
      301 tggaaacaat agccagagat agtggctggg aagcaccatg gccagagtcc tgcagctctc
      361 cctgactgct ctcctgctgc ctgtggctat tgctatgcac tctgactgca tcttcaagaa
      421 ggagcaagcc atgtgcctgg agaggatcca gagggccaac gacctgatgg gactaaacga
      481 gtcttcccca ggttgccctg gcatgtggga caatatcaca tgttggaagc cagctcaagt
      541 aggtgagatg gtccttgtaa gctgccctga ggtcttccgg atcttcaacc cggaccaagt
      601 ctggatgaca gaaaccatag gagattctgg ttttgccgat agtaattcct tggagatcac
      661 agacatgggg gtcgtgggcc ggaactgcac agaggacggc tggtcggagc ccttccccca
      721 ctacttcgat gcttgtgggt ttgatgatta tgagcctgag tctggagatc aggattatta
      781 ctacctgtcg gtgaaggctc tctacacagt cggctacagc acttccctcg ccaccctcac
      841 tactgccatg gtcatcttgt gccgcttccg gaagctgcat tgcactcgca acttcatcca
      901 catgaacctg tttgtatcct tcatgctgag ggctatctcc gtcttcatca aggactggat
      961 cttgtacgcc gagcaggaca gcagtcactg cttcgtttcc accgtggagt gcaaagctgt
     1021 catggttttc ttccactact gcgtggtgtc caactacttc tggctgttca ttgaaggcct
     1081 gtacctcttt acactgctgg tggagacctt cttccctgag aggagatatt tctactggta
     1141 caccatcatc ggctggggga cacctactgt gtgtgtaaca gtgtgggctg tgctgaggct
     1201 ctattttgat gatgcaggat gctgggatat gaatgacagc acagctctgt ggtgggtgat
     1261 caaaggcccc gtggttggct ctataatggt taactttgtg cttttcatcg gcatcatcat
     1321 catccttgta cagaagctgc agtccccaga catgggaggc aacgagtcca gcatctactt
     1381 acggctggcc cgctccaccc tactgctcat cccactcttc ggaatccact acacagtatt
     1441 cgccttctct ccagagaacg tcagcaagag ggaaagactt gtgtttgagc ttgggctggg
     1501 ctccttccag ggctttgtgg tggctgtact ctactgcttc ttgaatgggg aggtacaggc
     1561 agagattaag aggaaatgga ggagctggaa ggtgaaccgt tacttcacta tggacttcaa
     1621 gcaccggcac ccgtccctgg ccagcagtgg agtaaatggg ggaacccagc tgtccatcct
     1681 gagcaagagc agctcccagc tccgcatgtc cagcctcccg gccgacaact tggccacctg
     1741 aggcctgtct ccctcctcct tctgcacagg ctggggctgc gggccagtgc ctgagcatgt
     1801 ttgtgcctct cccctctcct tgggcaggcc ctgggtagga agctgggctc ctccccaaag
     1861 gggaagagag agatagggta taggctgata ttgctcctcc tgtttgggtc ccacctactg
     1921 tgattcattg agcctgattt gacatgtaaa tacacctcaa atttggaaag ttgccccatc
     1981 tctgccccca acccatgccc ctgctcacct ctgccaggcc ccagctcaac ctactgtgtc
     2041 aaggccagcc tcagtgatag tctgatccca ggtacaaggc cttgtgagct gaggctgaaa
     2101 ggcctgtttt ggagaggctg gggtagtgcc caccccagca gcctttcagc aaattgactt
     2161 tggatgtgga cccttctcag cctgtaccaa gtactgcagt tggctaggga tgcagctcag
     2221 tttcctgagc atcctttgga gcaggtcaac ctgaggctcc ttttgcttac ccgacatcta
     2281 agttgtccag gtgctcggct cctgtgtgcc tggatgacag gagggctccg gggtctttca
     2341 gtcaaagact tacattgagg tggggtgaga gtcagagaaa agttctggtg cttttcattt
     2401 gttctaagag ctgagagcca ggaatgcaga gtcaattggg aaggagatgg gatagctgat
     2461 gatcttacca tgtccatgac tgtgcccctg attcaagacc ggatcatgtg gtggctttat
     2521 ttctacactt cttgtccaca atggacagtc tgaggaagct cttctttcag ccacaacaac
     2581 cacagaaagc cctttcttct cccctctcgt ttctccataa gtcaaagcca tgtttagaac
     2641 ggaccagcca ccttgtgatg aaatcactga gttctgaagc aactttcaat ttccacgagc
     2701 caagtcctgg gtccagggac gcccccacag ccccacctct actaactaca aggattccta
     2761 catgccgctc ccagcctgga cacaattact aaactcagaa ttttctgcaa gacttcctcc
     2821 atgtgccctt gacatttggg tcactcctgg gccctcttag ggtgtttgga agtgatactg
     2881 tgtttatcat gtgcatgggc agaagctgct gatggaagga gtggtggctc ttccagtgcc
     2941 cgtcttcgct ctccagctgg aagttgcaca gccataacct aagactttaa aataaggcca
     3001 catccagatt tgggaagata gagggggaaa ctagtgccat ggggccacct ggcccagctc
     3061 actccacgta gatgcttgtt cttgtccccg cctctgtgga tgtgttcatg attgtgccct
     3121 gcaatgcatg gggagtgtgg gatggtgcct tgcttgctgt tgtattaagt agaaggagtt
     3181 ctaggagact tgagacagtg tttctgaagg agccattaga aagactggag aaggttctag
     3241 ttggtatgat ttagagatgt gttctgtgtt cttgaccagt gaagtaagtt cttgggtctt
     3301 tggcaaagct ggaaagggaa aggacctcct tgttctttcc cagaaacatt tagtggcttg
     3361 gaccagtcac tgaggatact cattgctctt ctcccctgca ccctacccat cctctcccct
     3421 gctctgagaa acaggttgtc agccaaacaa gactcagttg atccccttgc actttggaca
     3481 attctaggaa gcccaagctg tttagcagaa gccttggttc aggattccag ctgggttcat
     3541 gactgtgaac acaatgtgcc ctgtgctggg ccacaacttc cttgcttgaa aggaaggagt
     3601 gaggtggttt ctagtgcctc tccaggttct gtgttagtta aaaactaagg caggtaaacc
     3661 gagatgcatc cttgtgaaaa tcatttaagg tgtgcgtgca agcgtgtgtg cctctgtgta
     3721 catgagtgtg tgtgtgcgtg cgtgtgtgca tgcgtgtgtg cctctgtgta catgagtgtg
     3781 tgggtgcgtg cgtgcgtgtc tgtgtgtgtg tgtgtgtgtg tgtgcgcgtg catgcgtgcg
     3841 tgcgtgcgtg cgtgcgtgcg tgtgtgtatt gaggggaatg acattccatt tattttccca
     3901 tttggatacc acatgctatc caaagctggt agagcagagg gaagctcggg ccacggacct
     3961 ttgagtgggg cctcaggcat gatgtgcaga cctagtcttc tatgccaggc agggacaggt
     4021 tgcctgtggc accctccatc tgaggtgcac cccttgggct atgaacctca ttcacttgtc
     4081 gtcaccccca ccagtgggtc tgcttcactg tggaaggaaa aactgtgact ttttagttgc
     4141 attactgcaa aatagcaaaa atcggataac ctgagccccg ctgcttcctg tgccatgggc
     4201 ctgtgtcctc ctaaaacgtc caggttcctg ttgctttgtt tttctgtctg aaggaatcct
     4261 tttgttagtc tcctgagcag atgtacctga aggagtctgc atgttccatg agggtctggc
     4321 tctcaggctg caggcagtga agggacagca cgaggctggg taaagccctt cccccttgac
     4381 cctcttacat agtgcaagca ataagactta ttgatttgtg tgtatcccag tgtacatctg
     4441 ggcttctgtc taaacaccaa ccatcttctc ttggaatggg ccccaggcaa ggcttgtgtt
     4501 aatatagcct ggacccggaa aagggaaaag gttaaggaaa tcctgtcctg taggtgaaaa
     4561 gggcttcatg ggtttgcaaa cctggaggca agaacagcgg gtttaagggg catccagcca
     4621 gtgcaagatt attcctggga agtgaggtct tgctctatga aaccttaaag gccaaatgga
     4681 ccatcccact ttggggatga ggacatccct gtccttatct ctgtcaaaac tgtccagcta
     4741 cagagtaagc agcaagtgtc aggagaggat gtggtcctca gagtatggta ttccacatag
     4801 gaatgcctag gctgtcagga agccagaggg acttagaggt gctgcagctt tgagcctctg
     4861 tatgcaccat gcttaagatc tgactgctct ctcagtgtac agcgaggagg ttttccctga
     4921 catgctcagt atccctcaat gagtcctttc ttaaccctca tttcccccaa actgacttct
     4981 ctggggagct gggatggggc ttggccaggg acaggtgtgg aaataaccct gcacctgttg
     5041 cccagttcag ggcctctgct gtttggtctg taccctctct tccttggagg gaaagctaca
     5101 agagactctc tttttaactc cttgagtacc ctttgccccc caccaagaga agacagcaag
     5161 tcctctgaca ctgcaagttt cccttgagcc tagggaactg ggaaaccagg tgggcctagc
     5221 ctgtttttga attgcattga attgaagtct accggtattg cacagccctg catgtgaacc
     5281 agatgcaaca ctccaagcag ctgtggaatg caaggtacct tttgcaggag tggctgtacc
     5341 tacagaaagc ccaggagtcc acagttcagt gcagcagaag caacagagtt ggcctggtgt
     5401 aaggatacct actagcaaac atggcctctc catctcttct aggactccac acttccctac
     5461 cctcaaaccc gaggtggcta tggttacacc attatctacc ctcaagctag ggatgaggtg
     5521 gaggtgaaat gctccctgtg ggtttataag ccctgaaaac aacattgctg tgtgttcatt
     5581 cttagaggga agaccctttg cagcctgtcc agtgctttga gcccttctgg gttaacccgt
     5641 tggtaaaacc accagcatga atgtgaggat gaggccagag ggctctggtg gacatcaaat
     5701 cccagcttta ccaccatcac tgtttagttt gctttgaagg taaggacgag gagaactctg
     5761 ctgtgagcag ctccgtgctg tctgcctagg aatccttcaa tggtatggga cactcctcaa
     5821 gtgaaccaaa tgcccattct ttctccctcc cctgaactcc aggtcctgtg ctgtgtctgt
     5881 actcagccgt gtgtgttttg tctgctgtct gtctcctgag gcttagcatc tgtcagggct
     5941 ggggtggttc agcccttggt actccagatg tggttccagg ctcactcgtg ggagctggac
     6001 cggtctgggt ttaatctccc acaatgaaga taaaccccat ggacctcact gctactgctg
     6061 cctccattaa cgctgtactc acaccttgtc tgggatttta aggatgtcaa actgctgtag
     6121 atgactcaat aaatgtctta tcgttttcaa a
//
