LOCUS       NM_016989               1262 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus adenylate cyclase activating polypeptide 1
            (Adcyap1), mRNA.
ACCESSION   NM_016989 XM_346860
VERSION     NM_016989.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1262)
  AUTHORS   Maugeri,G., D'Amico,A.G., Magri,B., Giunta,S., Saccone,S.,
            Federico,C., Bucolo,C., Musumeci,G. and D'Agata,V.
  TITLE     Protective effect of pituitary adenylate cyclase activating
            polypeptide in diabetic keratopathy
  JOURNAL   Peptides 170, 171107 (2023)
   PUBMED   37775045
  REMARK    GeneRIF: Protective effect of pituitary adenylate cyclase
            activating polypeptide in diabetic keratopathy.
REFERENCE   2  (bases 1 to 1262)
  AUTHORS   Chen,Q., Zhang,X.Y., Wang,Y.P., Fu,Y.J., Cao,F., Xu,Y.N.,
            Kong,J.G., Tian,N.X., Xu,Y. and Wang,Y.
  TITLE     Unveiling adcyap1 as a protective factor linking pain and nerve
            regeneration through single-cell RNA sequencing of rat dorsal root
            ganglion neurons
  JOURNAL   BMC Biol 21 (1), 235 (2023)
   PUBMED   37880634
  REMARK    GeneRIF: Unveiling adcyap1 as a protective factor linking pain and
            nerve regeneration through single-cell RNA sequencing of rat dorsal
            root ganglion neurons.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1262)
  AUTHORS   Broome,S.T., Mandwie,M., Gorrie,C.A., Musumeci,G., Marzagalli,R.
            and Castorina,A.
  TITLE     Early Alterations of PACAP and VIP Expression in the Female Rat
            Brain Following Spinal Cord Injury
  JOURNAL   J Mol Neurosci 73 (9-10), 724-737 (2023)
   PUBMED   37646964
  REMARK    GeneRIF: Early Alterations of PACAP and VIP Expression in the
            Female Rat Brain Following Spinal Cord Injury.
REFERENCE   4  (bases 1 to 1262)
  AUTHORS   Feher,M., Marton,Z., Szabo,A., Kocsa,J., Kormos,V., Hunyady,A.,
            Kovacs,L.A., Ujvari,B., Berta,G., Farkas,J., Furedi,N., Gaszner,T.,
            Pytel,B., Reglodi,D. and Gaszner,B.
  TITLE     Downregulation of PACAP and the PAC1 Receptor in the Basal Ganglia,
            Substantia Nigra and Centrally Projecting Edinger-Westphal Nucleus
            in the Rotenone model of Parkinson's Disease
  JOURNAL   Int J Mol Sci 24 (14), 11843 (2023)
   PUBMED   37511603
  REMARK    GeneRIF: Downregulation of PACAP and the PAC1 Receptor in the Basal
            Ganglia, Substantia Nigra and Centrally Projecting Edinger-Westphal
            Nucleus in the Rotenone model of Parkinson's Disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1262)
  AUTHORS   Liu,M., He,F., Shao,M., Li,T., Wang,L., Wang,Y. and Xu,W.
  TITLE     PACAP inhibition alleviates neuropathic pain by modulating Nav1.7
            through the MAPK/ERK signaling pathway in a rat model of chronic
            constriction injury
  JOURNAL   Neuropeptides 99, 102327 (2023)
   PUBMED   36842389
  REMARK    GeneRIF: PACAP inhibition alleviates neuropathic pain by modulating
            Nav1.7 through the MAPK/ERK signaling pathway in a rat model of
            chronic constriction injury.
REFERENCE   6  (bases 1 to 1262)
  AUTHORS   Hurley,J.D., Gardiner,J.V., Jones,P.M. and Bloom,S.R.
  TITLE     Cloning and molecular characterization of complementary
            deoxyribonucleic acid corresponding to a novel form of pituitary
            adenylate cyclase-activating polypeptide messenger ribonucleic acid
            in the rat testis
  JOURNAL   Endocrinology 136 (2), 550-557 (1995)
   PUBMED   7835287
REFERENCE   7  (bases 1 to 1262)
  AUTHORS   Nguyen,T.D., Heintz,G.G. and Wolfe,M.S.
  TITLE     Structural characterization of PACAP receptors on rat liver plasma
            membranes
  JOURNAL   Am J Physiol 265 (5 Pt 1), G811-G818 (1993)
   PUBMED   8238511
REFERENCE   8  (bases 1 to 1262)
  AUTHORS   Gaylinn,B.D., Harrison,J.K., Zysk,J.R., Lyons,C.E., Lynch,K.R. and
            Thorner,M.O.
  TITLE     Molecular cloning and expression of a human anterior pituitary
            receptor for growth hormone-releasing hormone
  JOURNAL   Mol Endocrinol 7 (1), 77-84 (1993)
   PUBMED   7680413
REFERENCE   9  (bases 1 to 1262)
  AUTHORS   Ogi,K., Kimura,C., Onda,H., Arimura,A. and Fujino,M.
  TITLE     Molecular cloning and characterization of cDNA for the precursor of
            rat pituitary adenylate cyclase activating polypeptide (PACAP)
  JOURNAL   Biochem Biophys Res Commun 173 (3), 1271-1279 (1990)
   PUBMED   2268329
REFERENCE   10 (bases 1 to 1262)
  AUTHORS   Miyata,A., Arimura,A., Dahl,R.R., Minamino,N., Uehara,A., Jiang,L.,
            Culler,M.D. and Coy,D.H.
  TITLE     Isolation of a novel 38 residue-hypothalamic polypeptide which
            stimulates adenylate cyclase in pituitary cells
  JOURNAL   Biochem Biophys Res Commun 164 (1), 567-574 (1989)
   PUBMED   2803320
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB786482.1, M63006.1 and BG664825.1.
            
            On Feb 23, 2007 this sequence version replaced NM_016989.1.
            
            Sequence Note: The sequence M63006.1 is from a chimeric clone. Only
            the adenylate cyclase activating polypeptide 1 sequence region was
            propagated into this RefSeq record.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760389,
                              SAMEA5760434 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-295               CB786482.1         13-307
            296-987             M63006.1           572-1263
            988-1158            BG664825.1         198-368
            1159-1262           M63006.1           1435-1538
FEATURES             Location/Qualifiers
     source          1..1262
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q38"
     gene            1..1262
                     /gene="Adcyap1"
                     /gene_synonym="Pacap"
                     /note="adenylate cyclase activating polypeptide 1"
                     /db_xref="GeneID:24166"
                     /db_xref="RGD:2037"
     exon            1..295
                     /gene="Adcyap1"
                     /gene_synonym="Pacap"
                     /inference="alignment:Splign:2.1.0"
     exon            296..403
                     /gene="Adcyap1"
                     /gene_synonym="Pacap"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..824
                     /gene="Adcyap1"
                     /gene_synonym="Pacap"
                     /note="pituitary adenylate cyclase activating polypeptide
                     1; pituitary adenylate cyclase-activating polypeptide
                     precursor (Pacap); adenylate cyclase activating
                     polypeptide 1 (pituitary)"
                     /codon_start=1
                     /product="pituitary adenylate cyclase-activating
                     polypeptide precursor"
                     /protein_id="NP_058685.1"
                     /db_xref="GeneID:24166"
                     /db_xref="RGD:2037"
                     /translation="MTMCSGARLALLVYGIIMHNSVSCSPAAGLSFPGIRPEEEAYDQ
                     DGNPLQDFYDWDPPGAGSPASALRDAYALYYPADRRDVAHEILNEAYRKVLDQLSARK
                     YLQSMVARGMGENLAAAAVDDRAPLTKRHSDGIFTDSYSRYRKQMAVKKYLAAVLGKR
                     YKQRVKNKGRRIAYL"
     exon            404..535
                     /gene="Adcyap1"
                     /gene_synonym="Pacap"
                     /inference="alignment:Splign:2.1.0"
     exon            536..634
                     /gene="Adcyap1"
                     /gene_synonym="Pacap"
                     /inference="alignment:Splign:2.1.0"
     exon            635..1262
                     /gene="Adcyap1"
                     /gene_synonym="Pacap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccactctgc tccccctccc tttggctgct cgcccactct gtcttctaca tctctctcct
       61 cgcccacttc cttcggtgtc acgctccctc ctagttttgt gcgtctacaa agttttgagc
      121 ggaattttag cttcggcaaa caagtccccc cagctcctcc agctaattcc cgcgacttct
      181 ctccagacac cagctccaga cagtgactga tgcctctctg gttgtgattc cagcgcagaa
      241 actcgaagga gccctttgcc cgccgtccta tttagtcaac tctttcctag ccgcgaatga
      301 ccatgtgtag cggagcaagg ttggccctgt tggtctacgg gataataatg cataacagcg
      361 tctcctgttc acctgccgcc ggactcagct tccctgggat cagaccagaa gaagaggctt
      421 acgatcagga cggaaacccg ctgcaagact tctacgactg ggaccctccg ggcgcaggga
      481 gccccgcctc cgcgctgcgt gacgcctacg ccctttacta cccagccgac aggagagatg
      541 tcgcccacga aatccttaac gaagcctacc gcaaagtctt ggaccagctg tccgccagga
      601 agtacctgca gtccatggtg gccaggggca tgggcgagaa cctcgccgcc gccgcggtgg
      661 acgaccgggc accccttacc aaacgccact cggacggcat cttcacagac agctatagcc
      721 gctaccgaaa acaaatggct gtcaagaaat acttggcggc cgtgctaggg aaaaggtata
      781 aacagagggt taaaaacaaa ggacgccgaa tagcgtactt gtagcgatga gttgccagct
      841 accgtgtgta taaaatgaaa agtcgttttc caaattgact gaccagtcat cactcatgtg
      901 ttctttccaa acatgtattt atgtatcaag taaagccatt aaatgactat tttgataata
      961 atattgtttt tctttttacg aagcactaga gaatgcacag atatactttg tggaccaatt
     1021 attgatatat attataagta tatattaaga atatatatag gtatagcaga gagcaattca
     1081 taagcgtgca caaagattga aaattcgcct gagctgttta tgtttttata taaaatgaat
     1141 agagaaaata gacaaccatt gttttgaata ttactcctat ttttgtaaac tggaattaaa
     1201 ggatagtatt tttatccaca accggcttga agataccaat aatggccatt tgtacaaaaa
     1261 aa
//
