LOCUS       NM_017142               4601 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Rattus norvegicus adenylate cyclase 8 (Adcy8), mRNA.
ACCESSION   NM_017142
VERSION     NM_017142.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4601)
  AUTHORS   Falcon,D., Calderon-Sanchez,E.M., Mayoral-Gonzalez,I.,
            Martin-Bornez,M., Dominguez-Rodriguez,A., Gutierrez-Carretero,E.,
            Ordonez-Fernandez,A., Rosado,J.A. and Smani,T.
  TITLE     Inhibition of adenylyl cyclase 8 prevents the upregulation of Orai1
            channel, which improves cardiac function after myocardial
            infarction
  JOURNAL   Mol Ther 32 (3), 646-662 (2024)
   PUBMED   38291755
  REMARK    GeneRIF: Inhibition of adenylyl cyclase 8 prevents the upregulation
            of Orai1 channel, which improves cardiac function after myocardial
            infarction.
REFERENCE   2  (bases 1 to 4601)
  AUTHORS   Vallin,B., Legueux-Cajgfinger,Y., Clement,N., Glorian,M., Duca,L.,
            Vincent,P., Limon,I. and Blaise,R.
  TITLE     Novel short isoforms of adenylyl cyclase as negative regulators of
            cAMP production
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1865 (9), 1326-1340 (2018)
   PUBMED   29940197
  REMARK    GeneRIF: Data show that the IL-1beta-dependent transdifferentiation
            of VSMCs is associated with the de novo expression of a new family
            of AC8 isoforms. These isoforms are catalytically inactive with
            dominant-negative effects, decreasing total cAMP production. The
            inhibitory effect of AC8E on adenylyl cyclases (ACs) activity is
            accompanied by the formation of heterodimers between AC8E and
            functional ACs.
REFERENCE   3  (bases 1 to 4601)
  AUTHORS   Bernabucci,M. and Zhuo,M.
  TITLE     Calcium activated adenylyl cyclase AC8 but not AC1 is required for
            prolonged behavioral anxiety
  JOURNAL   Mol Brain 9 (1), 60 (2016)
   PUBMED   27234425
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4601)
  AUTHORS   Raoux,M., Vacher,P., Papin,J., Picard,A., Kostrzewa,E., Devin,A.,
            Gaitan,J., Limon,I., Kas,M.J., Magnan,C. and Lang,J.
  TITLE     Multilevel control of glucose homeostasis by adenylyl cyclase 8
  JOURNAL   Diabetologia 58 (4), 749-757 (2015)
   PUBMED   25403481
REFERENCE   5  (bases 1 to 4601)
  AUTHORS   Dou,H., Wang,C., Wu,X., Yao,L., Zhang,X., Teng,S., Xu,H., Liu,B.,
            Wu,Q., Zhang,Q., Hu,M., Wang,Y., Wang,L., Wu,Y., Shang,S., Kang,X.,
            Zheng,L., Zhang,J., Raoux,M., Lang,J., Li,Q., Su,J., Yu,X., Chen,L.
            and Zhou,Z.
  TITLE     Calcium influx activates adenylyl cyclase 8 for sustained insulin
            secretion in rat pancreatic beta cells
  JOURNAL   Diabetologia 58 (2), 324-333 (2015)
   PUBMED   25381556
REFERENCE   6  (bases 1 to 4601)
  AUTHORS   Parkinson,N.A. and Bolsover,S.R.
  TITLE     A nuclear location for Ca2+-activated adenylyl cyclases I and III
            in neurones
  JOURNAL   Brain Res Mol Brain Res 91 (1-2), 43-49 (2001)
   PUBMED   11457491
REFERENCE   7  (bases 1 to 4601)
  AUTHORS   Schaefer,M.L., Wong,S.T., Wozniak,D.F., Muglia,L.M., Liauw,J.A.,
            Zhuo,M., Nardi,A., Hartman,R.E., Vogt,S.K., Luedke,C.E., Storm,D.R.
            and Muglia,L.J.
  TITLE     Altered stress-induced anxiety in adenylyl cyclase type
            VIII-deficient mice
  JOURNAL   J Neurosci 20 (13), 4809-4820 (2000)
   PUBMED   10864938
REFERENCE   8  (bases 1 to 4601)
  AUTHORS   Wong,S.T., Athos,J., Figueroa,X.A., Pineda,V.V., Schaefer,M.L.,
            Chavkin,C.C., Muglia,L.J. and Storm,D.R.
  TITLE     Calcium-stimulated adenylyl cyclase activity is critical for
            hippocampus-dependent long-term memory and late phase LTP
  JOURNAL   Neuron 23 (4), 787-798 (1999)
   PUBMED   10482244
REFERENCE   9  (bases 1 to 4601)
  AUTHORS   Cali,J.J., Parekh,R.S. and Krupinski,J.
  TITLE     Splice variants of type VIII adenylyl cyclase. Differences in
            glycosylation and regulation by Ca2+/calmodulin
  JOURNAL   J Biol Chem 271 (2), 1089-1095 (1996)
   PUBMED   8557635
REFERENCE   10 (bases 1 to 4601)
  AUTHORS   Cali,J.J., Zwaagstra,J.C., Mons,N., Cooper,D.M. and Krupinski,J.
  TITLE     Type VIII adenylyl cyclase. A Ca2+/calmodulin-stimulated enzyme
            expressed in discrete regions of rat brain
  JOURNAL   J Biol Chem 269 (16), 12190-12195 (1994)
   PUBMED   8163524
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L26986.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L26986.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132276,
                                           SAMEA5756307 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4601
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q33"
     gene            1..4601
                     /gene="Adcy8"
                     /gene_synonym="Ac8"
                     /note="adenylate cyclase 8"
                     /db_xref="GeneID:29241"
                     /db_xref="RGD:2036"
     exon            1..1727
                     /gene="Adcy8"
                     /gene_synonym="Ac8"
                     /inference="alignment:Splign:2.1.0"
     CDS             777..4523
                     /gene="Adcy8"
                     /gene_synonym="Ac8"
                     /EC_number="4.6.1.1"
                     /note="ATP pyrophosphate-lyase 8; adenylate cyclase type
                     VIII; ca(2+)/calmodulin-activated adenylyl cyclase; type
                     VIII adenylyl cyclase; adenylate cyclase 8 (brain);
                     adenylyl cyclase 8"
                     /codon_start=1
                     /product="adenylate cyclase type 8"
                     /protein_id="NP_058838.1"
                     /db_xref="GeneID:29241"
                     /db_xref="RGD:2036"
                     /translation="MELSDVHCLSGSEELYTIHPTPPAADGGSGSRPQRLLWQTAVRH
                     ITEQRFIHGHRGGGGGGSRKASNPAGSGPNHHAPQLSSDSVLPLYSLGSGERAHNTGG
                     TKVFPERSGSGSASGSGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKS
                     RDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTG
                     IEVVICALVVVRKDTTSHTYLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLF
                     ATYSMLPLPLTWAILAGLGTSLLQVTLQVLIPRLAVFSINQVLAQVVLFMCMNTAGIF
                     ISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVED
                     EHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEH
                     HCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRFVRSRTKHDVDMRIGIH
                     SGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLSGDYNVEEGH
                     GKERNEFLRKHNIETYLIKQPEESLLSLPEDIVKESVSCSDRRNSGATFTEGSWSPEL
                     PFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTIDLRSGDKLRR
                     EHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRLMPMTI
                     QFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINETYLARNVIIFASILINFLGAV
                     INILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVLKL
                     AVLLIMIAIYALLTETIYAGLFLSYDNLNHSGEDFLGTKEASLLLMAMFLLAVFYHGQ
                     QLEYTARLDFLWRVQAKEEINEMKDLREHNENMLRNILPGHVARHFLEKDRDNEELYS
                     QSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKI
                     KTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNFELRIGI
                     SHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDY
                     RGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSLNRQR
                     QKQLLNENSNSGIIKSHYNRRTLLTPSGPEPGAQAEGTDKSDLP"
     exon            1728..1877
                     /gene="Adcy8"
                     /gene_synonym="Ac8"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..2008
                     /gene="Adcy8"
                     /gene_synonym="Ac8"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2120
                     /gene="Adcy8"
                     /gene_synonym="Ac8"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2248
                     /gene="Adcy8"
                     /gene_synonym="Ac8"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2407
                     /gene="Adcy8"
                     /gene_synonym="Ac8"
                     /inference="alignment:Splign:2.1.0"
     exon            2408..2678
                     /gene="Adcy8"
                     /gene_synonym="Ac8"
                     /inference="alignment:Splign:2.1.0"
     exon            2679..2876
                     /gene="Adcy8"
                     /gene_synonym="Ac8"
                     /inference="alignment:Splign:2.1.0"
     exon            2877..2977
                     /gene="Adcy8"
                     /gene_synonym="Ac8"
                     /inference="alignment:Splign:2.1.0"
     exon            2978..3179
                     /gene="Adcy8"
                     /gene_synonym="Ac8"
                     /inference="alignment:Splign:2.1.0"
     exon            3180..3269
                     /gene="Adcy8"
                     /gene_synonym="Ac8"
                     /inference="alignment:Splign:2.1.0"
     exon            3270..3442
                     /gene="Adcy8"
                     /gene_synonym="Ac8"
                     /inference="alignment:Splign:2.1.0"
     exon            3443..3521
                     /gene="Adcy8"
                     /gene_synonym="Ac8"
                     /inference="alignment:Splign:2.1.0"
     exon            3522..3680
                     /gene="Adcy8"
                     /gene_synonym="Ac8"
                     /inference="alignment:Splign:2.1.0"
     exon            3681..3827
                     /gene="Adcy8"
                     /gene_synonym="Ac8"
                     /inference="alignment:Splign:2.1.0"
     exon            3828..3920
                     /gene="Adcy8"
                     /gene_synonym="Ac8"
                     /inference="alignment:Splign:2.1.0"
     exon            3921..4035
                     /gene="Adcy8"
                     /gene_synonym="Ac8"
                     /inference="alignment:Splign:2.1.0"
     exon            4036..4601
                     /gene="Adcy8"
                     /gene_synonym="Ac8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagaactcg cgctgtcagt atttgctctg gaagtggcca caaccaggaa ggaaccgaag
       61 agagagcttc atccagcaca cctccaaatt aactgtttgg tgacttgtta gtgttaagga
      121 taccaccttt ctcctgccct cccgcggggc gccctgccac ctcaccatca cccacacctc
      181 ctgcctcatc gcgcccgcct ccagctcctc cccgactccc catgccggcg caatggagtt
      241 atccgaaggg cgatgattgc agccacagct gctaacttag cacccatcct agccatcggt
      301 cacccttggc cagcctttct gcagccgccg agacgtgggc gtccagagtc cagtgccgca
      361 gccaggaccc gcccgacgcg cagcagaagc gcggcgccca ggcgcctctt agagaagact
      421 gcgccaagac gctgagccta gagccagccc aggagcttga gcgcagaaag ggactgcgtg
      481 gctcagagtg ccgaggattt cgtggacaaa tagccaccac tttcactgcg tatcccaacg
      541 gagctgattg gcgggaaggt ggcttgccag tacgcagggg tccactgcaa tctgccagga
      601 gccccttgct ctcgggctca ctatgacttg acctgtgggg gccctgctca gggctcctgc
      661 aatcgagcag cctaggaaag aggggatcgc tgccaagcgg ccttcgggtc tctaaaaacc
      721 cctacccgca actgccacaa ccagtgtctg agcctccctc cctgcggacc ccagccatgg
      781 aactctcgga tgtgcactgc cttagcggca gcgaggaact ctataccatt cacccgacgc
      841 ccccggccgc ggacggcggg agcggctctc ggccgcagcg gctgctgtgg cagacggcgg
      901 tgcggcacat caccgagcag cgcttcatcc acggccaccg aggcggcggc ggcgggggct
      961 cccgcaaagc ctcgaaccct gcgggcagcg gaccaaacca ccacgcgccg cagctgtcta
     1021 gcgactcggt gctgcctctc tattctctgg gctccggaga gcgagcgcac aacaccggtg
     1081 gcaccaaagt ctttccggaa cgcagcggga gcggcagtgc cagtggcagc gggggtgggg
     1141 gcgacttggg cttcctgcac cttgactgtg ccccaagtaa ctcggatttc ttcctcaatg
     1201 ggggatacag ctaccgtggg gtcattttcc caaccctacg caactccttc aagtctcggg
     1261 atctggagcg cctctatcaa cgctatttcc tgggccagag gcgcaaatcg gaggtagtga
     1321 tgaacgtgct ggatgtacta accaaactca cccttctagt ccttcacttg agcctagcct
     1381 cggctcccat ggaccctctc aagggcatcc tgctaggctt tttcactggc atcgaggtgg
     1441 tgatctgcgc cctcgtggtg gtcaggaagg acaccacctc ccacacttac ctgcaataca
     1501 gcggcgtggt cacttgggtg gctatgacca cccagattct ggcagcaggc ctgggctatg
     1561 ggcttctggg cgacggcata ggctacgtgc tttttacact cttcgccacc tacagcatgc
     1621 ttccgctgcc tctcacctgg gccatcttgg ccggcctggg cacatccttg ctgcaagtca
     1681 cacttcaagt gctcataccc agactagcgg tcttttccat caaccaggtc ctggcccagg
     1741 tggtgctctt catgtgcatg aatacagcag gcatcttcat cagttacctt tcagaccgcg
     1801 cccagcggca ggccttcctg gagacccgga ggtgtgtgga ggccaggctc cgcctggaga
     1861 cagagaacca aagacaggag cggcttgtgc tctctgtgct ccccaggttt gtcgtcctag
     1921 aaatgatcaa tgacatgacc aatgtggagg acgagcacct gcagcatcag ttccaccgca
     1981 tctacatcca tcgctacgag aacgtcagta ttctttttgc agatgtcaaa ggatttacca
     2041 acctctctac gaccttgtct gctcaggagc ttgtcaggat gctcaacgag ctctttgcca
     2101 gatttgatcg gctggcccat gagcatcact gtcttcgcat taaaatcctg ggggactgct
     2161 actactgtgt gtcaggactg cctgagcccc gccaggacca tgctcattgc tgtgttgaaa
     2221 tgggcctcag catgatcaaa actatcaggt ttgtgaggtc cagaacgaag catgatgttg
     2281 acatgcgaat tggaatccat tcaggctctg tgctgtgtgg tgtgttgggc ctgagaaaat
     2341 ggcagtttga tgtctggtct tgggatgtgg acatcgcaaa caaacttgaa tctggaggaa
     2401 tccctgggag aattcacatt tccaaagcca cactggattg cctcagtggt gactataatg
     2461 tggaagaggg ccacggtaag gagaggaatg aattcttgag gaagcataat atagagacct
     2521 atttgattaa gcagcccgag gagagtttgc tatccttgcc tgaagatata gttaaggagt
     2581 cggtgagctg ctcggacagg agaaacagtg gggcaacgtt cacagaagga tcctggagcc
     2641 cagaactgcc attcgacaac atcgtgggca aacagaatac tctggctgcc ctaacaagaa
     2701 attcaataaa tctgcttcca aaccatctcg cacaagcttt gcatgtccag tctgggcctg
     2761 aggaaattaa caagagaata gagcatacca tcgacttgcg gagtggcgat aagttgagaa
     2821 gagagcatat caagccattc tcactgatgt ttaaagactc cagcctggag cacaagtatt
     2881 ctcaaatgcg ggatgaagta ttcaagtcaa acttggtctg tgcatttatc gttcttctgt
     2941 ttatcactgc gattcaaagt ttgcttcctt cttcgaggct gatgcctatg accatccagt
     3001 tctccatcct gatcatgctg cactccgccc tggtcctcat caccacggca gaagactata
     3061 agtgtctgcc tctcattctc cgcaaaacct gttgttggat taacgagacc tatttggccc
     3121 gcaacgtcat catctttgct tccatcttga ttaatttcct gggagccgtc ataaatattc
     3181 tgtggtgtga ttttgacaag tcgataccct tgaagaacct gactttcaat tcctcagctg
     3241 tgtttacaga tatctgctcc tacccagagt actttgtctt cactggggtg ttggccatgg
     3301 tgacgtgtgc agtatttctc cggcttaact ctgtcctgaa gctggctgtg ctgctcatta
     3361 tgatcgccat ctacgccctg ctgacagaga ccatctatgc aggtctcttt ctgagttatg
     3421 acaacctgaa ccacagtgga gaagattttc tggggaccaa ggaggcatca ctgctactga
     3481 tggccatgtt ccttcttgct gtattctacc atggacagca gctggagtac acagcccgcc
     3541 tagatttcct gtggcgagta caggccaaag aggagatcaa cgagatgaag gacttgaggg
     3601 aacacaatga gaacatgctt cgcaatatct tacccggcca cgtggcccgc cacttcctgg
     3661 agaaagacag agacaatgag gagctgtatt ctcaatccta tgatgccgtt ggggtaatgt
     3721 ttgcctccat tcctggattt gcagactttt actctcagac agaaatgaac aaccagggag
     3781 tggaatgtct gcgcttgctg aatgagatca ttgctgactt tgatgagtta cttggagagg
     3841 accgctttca ggacatagag aagattaaga ccattggtag tacatacatg gctgtctcag
     3901 gactgtcacc agagaaacag caatgtgaag ataaatgggg acatttgtgt gccctggctg
     3961 acttctctct tgccctgact gaaagcatac aagagatcaa caagcattcg ttcaacaatt
     4021 ttgaactccg tattggcatc agccatggct cagtggtagc aggtgtaatt ggcgctaaga
     4081 aaccacagta tgacatttgg ggtaaaactg tgaacttggc aagccgaatg gacagcacag
     4141 gagtgagtgg ccggatccaa gttcctgagg agacctatct catcctgaag gatcagggct
     4201 ttgccttcga ctaccgggga gagatatatg tgaagggcat cagcgaacaa gaagggaaaa
     4261 tcaaaacata ttttctcctg ggacgagtcc aacccaaccc attcatctta cccccaagaa
     4321 gacttcctgg gcagtactct ctggctgcag ttgtccttgg gcttgtccag tctctcaaca
     4381 ggcaaaggca gaagcaacta ctcaatgaga acagcaactc tggcatcatc aagagccatt
     4441 acaaccggcg gactttgcta acgccaagtg ggccagagcc tggagcacag gctgaaggca
     4501 ctgacaaatc cgatttgcca taaaagcatt ttctttgtgt ttctttctct ttttttgtat
     4561 ttcttttata tataaaataa atatactaat aaaaaggttt g
//
