LOCUS       NM_053396               4164 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus adenylate cyclase 7 (Adcy7), mRNA.
ACCESSION   NM_053396 XM_001056453 XM_001063157 XM_001063214 XM_226333
VERSION     NM_053396.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4164)
  AUTHORS   Alhaidan,Y., Christesen,H.T., Lundberg,E., Balwi,M.A.A. and
            Brusgaard,K.
  TITLE     CRISPR/Cas9 ADCY7 Knockout Stimulates the Insulin Secretion Pathway
            Leading to Excessive Insulin Secretion
  JOURNAL   Front Endocrinol (Lausanne) 12, 657873 (2021)
   PUBMED   34177802
  REMARK    GeneRIF: CRISPR/Cas9 ADCY7 Knockout Stimulates the Insulin
            Secretion Pathway Leading to Excessive Insulin Secretion.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4164)
  AUTHORS   Ehrlich,A.T., Furuyashiki,T., Kitaoka,S., Kakizuka,A. and
            Narumiya,S.
  TITLE     Prostaglandin E receptor EP1 forms a complex with dopamine D1
            receptor and directs D1-induced cAMP production to adenylyl cyclase
            7 through mobilizing G(betagamma) subunits in human embryonic
            kidney 293T cells
  JOURNAL   Mol Pharmacol 84 (3), 476-486 (2013)
   PUBMED   23842570
REFERENCE   3  (bases 1 to 4164)
  AUTHORS   Jiang,L.I., Sternweis,P.C. and Wang,J.E.
  TITLE     Zymosan activates protein kinase A via adenylyl cyclase VII to
            modulate innate immune responses during inflammation
  JOURNAL   Mol Immunol 54 (1), 14-22 (2013)
   PUBMED   23178822
REFERENCE   4  (bases 1 to 4164)
  AUTHORS   Jiang,L.I., Wang,J.E. and Sternweis,P.C.
  TITLE     Regions on adenylyl cyclase VII required for selective regulation
            by the G13 pathway
  JOURNAL   Mol Pharmacol 83 (3), 587-593 (2013)
   PUBMED   23229509
REFERENCE   5  (bases 1 to 4164)
  AUTHORS   Duan,B., Davis,R., Sadat,E.L., Collins,J., Sternweis,P.C., Yuan,D.
            and Jiang,L.I.
  TITLE     Distinct roles of adenylyl cyclase VII in regulating the immune
            responses in mice
  JOURNAL   J Immunol 185 (1), 335-344 (2010)
   PUBMED   20505140
REFERENCE   6  (bases 1 to 4164)
  AUTHORS   Ostrom,R.S., Naugle,J.E., Hase,M., Gregorian,C., Swaney,J.S.,
            Insel,P.A., Brunton,L.L. and Meszaros,J.G.
  TITLE     Angiotensin II enhances adenylyl cyclase signaling via
            Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in
            cardiac fibroblasts
  JOURNAL   J Biol Chem 278 (27), 24461-24468 (2003)
   PUBMED   12711600
REFERENCE   7  (bases 1 to 4164)
  AUTHORS   Nelson,E.J., Hellevuo,K., Yoshimura,M. and Tabakoff,B.
  TITLE     Ethanol-induced phosphorylation and potentiation of the activity of
            type 7 adenylyl cyclase. Involvement of protein kinase C delta
  JOURNAL   J Biol Chem 278 (7), 4552-4560 (2003)
   PUBMED   12454008
REFERENCE   8  (bases 1 to 4164)
  AUTHORS   Yan,S.Z., Beeler,J.A., Chen,Y., Shelton,R.K. and Tang,W.J.
  TITLE     The regulation of type 7 adenylyl cyclase by its C1b region and
            Escherichia coli peptidylprolyl isomerase, SlyD
  JOURNAL   J Biol Chem 276 (11), 8500-8506 (2001)
   PUBMED   11113152
REFERENCE   9  (bases 1 to 4164)
  AUTHORS   Wackym,P.A., Troyanovskaya,M. and Popper,P.
  TITLE     Adenylyl cyclase isoforms in the vestibular periphery of the rat
  JOURNAL   Brain Res 859 (2), 378-380 (2000)
   PUBMED   10719090
REFERENCE   10 (bases 1 to 4164)
  AUTHORS   Suzuki,Y., Shen,T., Miyamoto,N., Defer,N., Matsuoka,I. and
            Hanoune,J.
  TITLE     Changes in the expression of adenylyl cyclases in the rat uterus
            during the course of pregnancy
  JOURNAL   Biol Reprod 57 (4), 778-782 (1997)
   PUBMED   9314580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On or before May 1, 2009 this sequence version replaced
            XM_001063214.1, XM_001063157.1, XM_226333.4, XM_001056453.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.20068.1,
                                           SRR26643292.60730.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               JAXUCZ010000019.1  34936374-34936544   c
            172-375             JAXUCZ010000019.1  34934031-34934234   c
            376-543             JAXUCZ010000019.1  34933036-34933203   c
            544-693             JAXUCZ010000019.1  34932194-34932343   c
            694-842             JAXUCZ010000019.1  34931740-34931888   c
            843-954             JAXUCZ010000019.1  34930810-34930921   c
            955-1082            JAXUCZ010000019.1  34929026-34929153   c
            1083-1241           JAXUCZ010000019.1  34927631-34927789   c
            1242-1374           JAXUCZ010000019.1  34927350-34927482   c
            1375-1566           JAXUCZ010000019.1  34925136-34925327   c
            1567-1601           JAXUCZ010000019.1  34924852-34924886   c
            1602-1682           JAXUCZ010000019.1  34924363-34924443   c
            1683-1755           JAXUCZ010000019.1  34924153-34924225   c
            1756-1853           JAXUCZ010000019.1  34923043-34923140   c
            1854-1938           JAXUCZ010000019.1  34921383-34921467   c
            1939-2064           JAXUCZ010000019.1  34921023-34921148   c
            2065-2163           JAXUCZ010000019.1  34920231-34920329   c
            2164-2339           JAXUCZ010000019.1  34919437-34919612   c
            2340-2508           JAXUCZ010000019.1  34918646-34918814   c
            2509-2664           JAXUCZ010000019.1  34918124-34918279   c
            2665-2811           JAXUCZ010000019.1  34917578-34917724   c
            2812-2916           JAXUCZ010000019.1  34916927-34917031   c
            2917-3031           JAXUCZ010000019.1  34916604-34916718   c
            3032-3156           JAXUCZ010000019.1  34915515-34915639   c
            3157-4164           JAXUCZ010000019.1  34914322-34915329   c
FEATURES             Location/Qualifiers
     source          1..4164
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     gene            1..4164
                     /gene="Adcy7"
                     /note="adenylate cyclase 7"
                     /db_xref="GeneID:84420"
                     /db_xref="RGD:619966"
     CDS             1..3303
                     /gene="Adcy7"
                     /EC_number="4.6.1.1"
                     /note="adenylyl cyclase 7"
                     /codon_start=1
                     /product="adenylate cyclase type 7"
                     /protein_id="NP_445848.1"
                     /db_xref="GeneID:84420"
                     /db_xref="RGD:619966"
                     /translation="MPAKGRYFLNEGDEGPKQAALYEKYRLTSQHGPLLLLLLLVAVA
                     TCIALVSIVFSHEDLRRHQAVLGTAFFMLTLFVALYVLVYVECLAQRWLRVLALLTWA
                     CLMILGSVLMWDSLENEAYAWEQVPFFLFIVFVVYVLLPLSTRAAIAVGVASTISHLL
                     VFGAVTRAFKTSMSSTQLGLQLLANAVILLGGNFTGAFHKHQLQDASRDLFIYTVKCI
                     QIRRKLRVEKRQQENLLLSVLPAHISMGMKLAIIERLKEGGDRHYTPDNNFHSLYVKR
                     HQNVSILYADIVGFTRLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYC
                     VSGLPVSLPTHARNCVKMGLDICEAIKQVREATGVDISMRVGIHSGNVLCGVIGLRKW
                     QYDVWSHDVSLANRMEAAGVPGRVHITEATLNHLDKAYEVEDGHGEQRDPYLKEMNIR
                     TYLVIDPRSQQPPLPSHHLSKPKGDATLKMRASVRVTRYLESWGAARPFAHLNHRESV
                     SSSEIPIPNGRRQKAIPLRRHRAPDRSASPKGRLEDDCDDEMLSAIEGLSSTRPCCSK
                     SDDFHTFGPIFLEKGFEREYRLVPIPRARYDFACASLVFVCILLVHLLVMPRMATLGL
                     SFGLVACLLGLVLSFCFATEFSRCLPARSTLQAISESVETQPLLRLSLVVVTVGSLLT
                     VAIINMPLTFNPGPEQPGDNETSPLAARNRVGTPCELLPYYTCSCVLGFIACSVFLRM
                     SLELKAMLLTVALVAYLLLFNLSPCWQVSGNSTETNSTHRTRRLLSAEQSMNSHTLAL
                     GAQMTAPSPSSCLERDLKTMINFYLVLFYATLILLSRQIDYYCRLDCLWKKKFKKEHE
                     EFETMENVNRLLLENVLPAHVAAHFIGDKAAEDWYHQSYDCVCVMFASVPDFKVFYTE
                     CDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVPSGHENQ
                     DLERKHVHIGVLVEFSMALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYD
                     IWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFVC
                     TDTAKFQGLGLN"
     exon            1..171
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            172..375
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            376..543
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            544..693
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            694..842
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            843..954
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1082
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1241
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1374
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1566
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1601
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1682
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1755
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1853
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1938
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2064
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2163
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2339
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2508
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..2664
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            2665..2811
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            2812..2916
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            2917..3031
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            3032..3156
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            3157..4164
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgccagcca aggggcgcta cttcctaaat gagggtgacg aaggccccaa gcaggcagcg
       61 ctctatgaga agtacaggct caccagccag cacgggccac tgctgctcct gctcctcctg
      121 gtggctgtgg ccacctgcat cgccctcgtc agcatcgtct tcagccatga ggatctccgc
      181 agacaccagg ctgtcctggg cactgcgttc ttcatgctga cgctgtttgt ggctctctat
      241 gtgctggtgt atgttgagtg cctagcacag cgatggctgc gcgtcttggc tctactcacc
      301 tgggcttgcc tcatgatact aggctccgtg ctgatgtggg actccttgga gaatgaagcc
      361 tatgcgtggg agcaggtgcc tttcttcctg ttcatcgtct ttgtggtgta cgtactgttg
      421 cctctcagca cgagggcagc tatcgcggtg ggcgtagcct ccaccatctc ccatctcctg
      481 gtgtttggag ctgtgacaag agccttcaag acatccatgt ccagcacaca gctggggctg
      541 cagctcctgg ccaatgccgt tatccttctg ggtgggaact tcaccggtgc cttccacaag
      601 caccagcttc aggacgcttc gagggatctc ttcatctaca ccgtcaagtg tatccagatc
      661 cgccggaagc ttcgcgtgga gaagcgccag caggagaacc tgctgctttc agtgctccca
      721 gctcacatct ccatgggtat gaagctggcc atcattgaac gcctcaaaga gggtggtgac
      781 cgccactaca cgcctgacaa caactttcac agcctctatg tcaagcggca ccagaacgtc
      841 agcatcttgt atgcagacat cgtgggtttc acgaggctgg ccagcgactg ctctcccaag
      901 gagctagtgg tggtgctcaa cgagctgttt gggaagtttg accagattgc caaggccaac
      961 gagtgcatgc ggatcaagat cctgggtgac tgctactact gcgtgtcagg cctgcctgtg
     1021 tcgctgccca cgcacgcccg caactgtgtg aagatgggtc tggacatatg tgaggccatt
     1081 aagcaggtgc gtgaggccac cggagtggac atcagcatgc gtgtgggcat tcactctggg
     1141 aatgtcctgt gtggggtcat cgggctccgc aagtggcagt atgacgtgtg gtcccatgac
     1201 gtgtccctgg ccaacaggat ggaggcagct ggagtccctg gccgggtgca catcacagag
     1261 gcgacactga atcacctgga caaggcatac gaggtggagg acgggcacgg ggagcagcgc
     1321 gacccctatc tgaaagagat gaacatccgt acctacttgg tgattgaccc ccggagtcag
     1381 cagccgcccc tacccagcca ccacctgtcc aagcccaagg gggatgcaac tctgaagatg
     1441 cgggcttccg tgcgtgtaac ccgctatctg gagtcctggg gggcagcgcg gccctttgca
     1501 cacctcaacc accgggagag cgtgagcagc agtgagatcc ccatccccaa cggacggagg
     1561 cagaaggcca ttcctctgcg tcgacaccgt gcccctgata ggagtgcatc ccccaaggga
     1621 cgcctggaag atgactgtga tgacgagatg ctgtcagcca ttgaggggct cagctccacc
     1681 aggccctgct gctccaagtc tgatgacttc cacacctttg gtcccatctt cctggagaag
     1741 ggctttgagc gtgagtaccg cctggtgccc atcccccggg ctcgctatga cttcgcctgt
     1801 gccagccttg tcttcgtctg catcctgctt gtccacctcc tagtgatgcc caggatggca
     1861 actctgggct tgtcctttgg gctggtggcc tgcctgctgg ggctggttct aagcttctgc
     1921 tttgctactg agttctcgag gtgccttcca gcccgaagta cactccaggc catctcggag
     1981 agtgtggaga cacagcccct gctcagactt tccctggttg tggtgactgt tggcagctta
     2041 ctgactgttg ccatcatcaa catgccactg acatttaacc caggcccaga gcagcctgga
     2101 gacaatgaga caagcccact ggctgcaagg aacagagttg ggaccccatg tgaactcctc
     2161 ccgtactaca cctgcagctg cgtcctgggc ttcattgcat gctctgtttt cctgcggatg
     2221 agcctggaac tgaaggccat gttgctgacg gtggccttgg tggcctacct gctgctcttc
     2281 aacctctccc catgctggca ggtctcaggc aacagcacag agaccaacag cacacacagg
     2341 acacgtcggc tcctgtctgc agaacaaagc atgaacagcc acacccttgc tctgggggct
     2401 cagatgactg ccccctcccc cagcagttgt ttagagagag acctgaagac catgatcaac
     2461 ttctacctgg tcctgttcta tgccaccctc atcttgctgt ctagacagat tgactattac
     2521 tgccgcttgg actgtctgtg gaagaagaag tttaagaagg agcatgagga gtttgaaaca
     2581 atggagaatg tgaaccgcct cctcctagag aatgttctgc cagcacatgt ggctgcccac
     2641 ttcatcggtg acaaggcagc tgaggactgg taccatcaat cttatgactg tgtctgtgtc
     2701 atgtttgcat ccgttccgga cttcaaagtg ttctatactg agtgtgatgt caacaaagaa
     2761 ggattggagt gccttcgcct gctgaatgag atcattgctg attttgacga gctgctgctg
     2821 aagcccaagt tcagtggtgt ggagaagatc aagaccattg gcagcaccta catggctgct
     2881 gcagggctca gtgtcccctc aggacatgag aaccaggacc tggagcggaa gcatgtgcac
     2941 attggtgtct tggtggagtt tagcatggcc ctgatgagca agctggatgg aatcaacagg
     3001 cactccttca actccttccg cctccgagtt ggcataaacc acggccctgt gattgctgga
     3061 gtgattggcg cacgcaagcc tcagtatgac atctggggaa acacagtcaa tgttgccagc
     3121 cgcatggaga gcaccggaga gcttgggaag atccaggtta ccgaggagac gtgcaccatc
     3181 ctccagggac tgggatattc ttgtgagtgc cgtgggctca tcaacgtcaa aggcaaaggg
     3241 gagctgcgga cttactttgt ttgtacagac actgccaagt ttcaagggct ggggctaaac
     3301 tgaggtgtct ggtggtttgt ctccttccct gagggagccc tgcctgctgc agatggctgt
     3361 ggcttctttg gacctgcact acaggatggc tgactgtaca tcagattttt tgaagcagct
     3421 actgtgcggt acacagaggc tctgtgcttc agctacttta ggctgggttc ctttccaggg
     3481 tgctgaggaa gagactttag gacatgtatc ttggtggcca gtgaacagca tacctgggga
     3541 ggaaaacctc tactggctac aggaggctca gccaggctgt ctagcatggg ctgatgcccc
     3601 cccttcctcc tcccatcaaa cctaccaagg gatgctagtc tctcaattag gcgttctggc
     3661 aaatggagtt caaaactgcg tatcggtggg taatctcaga gaaaacgtct gatcgacact
     3721 tgtcactttt accatctctg gcttatgttt gaagtggacg ttgtaaatgg gagtttcatc
     3781 ttcatactga ctcttagatg ctagacaaag atctcatttc tagtgtattt tctcttgttg
     3841 accatggact acccatacat aggactgctg ttcagtgtca gcttacagga ccagcttggc
     3901 tgcagggaca gagttctaag gaatggggct cttagcaaga cataagcagc agcaaagctt
     3961 caaatttgca atcaagcatt tttttttttt ttgatgcaag tcttttggga cgaggttcag
     4021 gaagttcaga gtctagaaat gaggtatatg atgtttcggt tcttcagtct gcactttatt
     4081 ttgaagagag ggtcagccta ggttggtctt aaatttttaa cctgtttcag tctctagagt
     4141 gcttcaatta cagatgtgca ctac
//
